Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid

Oana Hosu; Madalina M. Barsan; Robert Săndulescu; Cecilia Cristea; Christopher M. A. Brett

doi:10.3390/s21041161

Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid

Sensors ◽

10.3390/s21041161 ◽

2021 ◽

Vol 21 (4) ◽

pp. 1161

Author(s):

Oana Hosu ◽

Madalina M. Barsan ◽

Robert Săndulescu ◽

Cecilia Cristea ◽

Christopher M. A. Brett

Keyword(s):

Carbon Nanotubes ◽

Methylene Blue ◽

Choline Chloride ◽

Electrochemical Techniques ◽

Simultaneous Detection ◽

Deep Eutectic Solvent ◽

Differential Pulse ◽

Electrochemical Determination ◽

Optimal Conditions ◽

Aminosalicylic Acid

A novel hybrid composite of conductive poly(methylene blue) (PMB) and carbon nanotubes (CNT) was prepared for the detection of 5-aminosalicylic acid (5-ASA). Electrosynthesis of PMB with glassy carbon electrode (GCE) or with carbon nanotube modified GCE was done in ethaline deep eutectic solvent of choline chloride mixed with ethylene glycol and a 10% v/v aqueous solution. Different sensor architectures were evaluated in a broad range of pH values in a Britton-Robinson (BR) buffer using electrochemical techniques, chronoamperometry (CA), and differential pulse voltammetry (DPV), to determine the optimum sensor configuration for 5-ASA sensing. Under optimal conditions, the best analytical performance was obtained with CNT/PMBDES/GCE in 0.04 M BR buffer pH 7.0 in the range 5–100 µM 5-ASA using the DPV method, with an excellent sensitivity of 9.84 μA cm−2 μM−1 (4.9 % RSD, n = 5) and a detection limit (LOD) (3σ/slope) of 7.7 nM, outclassing most similar sensors found in the literature. The sensitivity of the same sensor obtained in CA (1.33 μA cm−2 μM−1) under optimal conditions (pH 7.0, Eapp = +0.40 V) was lower than that obtained by DPV. Simultaneous detection of 5-ASA and its analogue, acetaminophen (APAP), was successfully realized, showing a catalytic effect towards the electro-oxidation of both analytes, lowering their oxidation overpotential, and enhancing the oxidation peak currents and peak-to-peak separation as compared with the unmodified electrode. The proposed method is simple, sensitive, easy to apply, and economical for routine analysis.

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Electrochemical Behavior and Determination of Chlorogenic Acid Based on Carbon Nanotubes Modified Screen-Printed Electrode

10.20944/preprints201608.0076.v1 ◽

2016 ◽

Author(s):

Xiao-Yan Ma ◽

Hong-Qiao Yang ◽

Hua-Bing Xiong ◽

Xiao-Fen Li ◽

Jing-Ting Gao ◽

...

Keyword(s):

Carbon Nanotubes ◽

Differential Pulse ◽

Electrochemical Determination ◽

Optimal Conditions ◽

Linear Regression Equation ◽

Screen Printed Electrode ◽

Redox Peak ◽

Pulse Voltammetry ◽

Screen Printed

In this paper, carbon nanotubes modified screen-printed electrode (CNTs/SPE) was prepared and the CNTs/SPE was employed for the electrochemical determination of antioxidant substance Chlorogenic acids (CGAs). A pair of well-defined redox peak of CGA was observed at the CNTs/SPE in 0.10 mol∙L-1 acetic acid-sodium acetate buffer (pH 6.2) and electrode process is adsorption-controlled. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) method for the determination of CGA were proposed based on the CNTs/SPE. Under the optimal conditions, the proposed method exhibited linear ranges from 4.73×10-7 to 4.45×10-5 mol∙L-1, the linear regression equation was Ipa(µA) = 4.1993 C (mol∙L-1)+1.1039 (r = 0.9976) and the detection limit for CGA could reach 3.25×10-6 mol∙L-1. The recovery of matrine was 94.74~106.65% (RSD = 2.92%) in coffe beans. The proposed method is quick, sensitive, reliable, and can be used for the determination of CGA.

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The Electrochemical Analysis of Cadmium in Choline Chloride/Urea Deep Eutectic Solvent Electrolyte at Carbon Nanotubes Modified Electrode

International Journal of Electrochemical Science ◽

10.20964/2016.07.36 ◽

2016 ◽

pp. 6306-6314 ◽

Cited By ~ 6

Author(s):

Jinting Gao ◽

Keyword(s):

Carbon Nanotubes ◽

Modified Electrode ◽

Choline Chloride ◽

Deep Eutectic Solvent ◽

Electrochemical Analysis

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A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

Microchimica Acta ◽

10.1007/s00604-020-04267-x ◽

2020 ◽

Vol 187 (5) ◽

Cited By ~ 4

Author(s):

Jagriti Sethi ◽

Michiel Van Bulck ◽

Ahmed Suhail ◽

Mina Safarzadeh ◽

Ana Perez-Castillo ◽

...

Keyword(s):

Graphene Oxide ◽

Reduced Graphene Oxide ◽

Limit Of Detection ◽

Electrochemical Techniques ◽

Differential Pulse ◽

Electrochemical Determination ◽

Label Free ◽

Reduced Graphene ◽

Electrochemically Reduced Graphene Oxide

AbstractA label-free biosensor is developed for the determination of plasma-based Aβ1–42 biomarker in Alzheimer’s disease (AD). The platform is based on highly conductive dual-layer of graphene and electrochemically reduced graphene oxide (rGO). The modification of dual-layer with 1-pyrenebutyric acid N-hydroxysuccinimide ester (Pyr-NHS) is achieved to facilitate immobilization of H31L21 antibody. The effect of these modifications were studied with morphological, spectral and electrochemical techniques. The response of the biosensor was evaluated using differential pulse voltammetry (DPV). The data was acquired at a working potential of ~ 180 mV and a scan rate of 50 mV s−1. A low limit of detection (LOD) of 2.398 pM is achieved over a wide linear range from 11 pM to 55 nM. The biosensor exhibits excellent specificity over Aβ1–40 and ApoE ε4 interfering species. Thus, it provides a viable tool for electrochemical determination of Aβ1–42. Spiked human and mice plasmas were used for the successful validation of the sensing platform in bio-fluidic samples. The results obtained from mice plasma analysis concurred with the immunohistochemistry (IHC) and magnetic resonance imaging (MRI) data obtained from brain analysis.

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The Anodic Behaviour of Bulk Copper in Ethaline and 1-Butyl-3-Methylimidazolium Chloride

Applied Sciences ◽

10.3390/app9204401 ◽

2019 ◽

Vol 9 (20) ◽

pp. 4401 ◽

Cited By ~ 4

Author(s):

Karim ◽

Aziz ◽

Brza ◽

Abdullah ◽

Kadir

Keyword(s):

Electrochemical Impedance ◽

Choline Chloride ◽

Metallic Copper ◽

Electrochemical Techniques ◽

Deep Eutectic Solvent ◽

Molar Ratio ◽

Interfacial Region ◽

Dissolution Mechanism ◽

Spectroscopic Techniques ◽

Electrochemical Dissolution

The anodic dissolution of bulk metallic copper was conducted in ionic liquids (ILs)—a deep eutectic solvent (DES) ((CH3)3NC2H4OH) comprised of a 1:2 molar ratio mixture of choline chloride Cl (ChCl), and ethylene glycol (EG)—and imidazolium-based ILs, such as C4mimCl, using electrochemical techniques, such as cyclic voltammetry, anodic linear sweep voltammetry, and chronopotentiometry.To investigate the electrochemical dissolution mechanism, electrochemical impedance spectroscopy (EIS) was used. In addition to spectroscopic techniques, for instance, UV-visible spectroscopy, microscopic techniques, such as atomic force microscopy (AFM), were used. The significant industrial importance of metallic copper has motivated several research groups to deal with such an invaluable metal. It was confirmed that the speciation of dissolved copper from the bulk phase at the interface region is [CuCl3]− and [CuCl4]2− in such chloride-rich media, and the EG determine the structure of the interfacial region in the electrochemical dissolution process. A super-saturated solution was produced at the electrode/solution interface and CuCl2 was deposited on the metal surface.

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Simultaneous detection of Dopamine and Serotonin in real complex matrices

Current Analytical Chemistry ◽

10.2174/1573411016999200518084746 ◽

2020 ◽

Vol 16 ◽

Author(s):

Florina Truţă ◽

Mihaela Tertisa ◽

Cecilia Cristea ◽

Florin Graur

Keyword(s):

Carbon Nanotubes ◽

Gold Nanoparticles ◽

Simultaneous Detection ◽

Multiwall Carbon Nanotubes ◽

Differential Pulse ◽

Sensitive Detection ◽

Complex Matrices ◽

Simple Method ◽

Starting Point ◽

Highly Sensitive Detection

Background: Neurotransmitters are chemical messengers with crucial implication in human body. Perturbations in concentration of neurotransmitters can affect a multitude of mental and physical functions, such as heart rate, sleep, appetite and mood. Thus, the sensitive detection of these compounds is a real need for a new generation of treatments. Method: Two important neurotransmitters namely dopamine and serotonin were investigated in this study for simultaneous detection using differential pulse voltammetry. The optimization of several surface parameters were performed in order to choose the best electrode material for electrochemical oxidation of targets. Screen printed electrodes based on carbon, gold and platinum and modified with different nanomaterials (carbon nanotubes, gold nanoparticles and carbon nanotubes decorated with gold nanoparticles) were tested. Results: Carbon-based electrodes modified with multiwall carbon nanotubes and gold nanoparticles were chosen after the optimization protocol. Linear correlations between the analytic signals obtained and the concentration of dopamine and serotonin respectively were obtained with good sensitivity and the detection limits were 0.3 µM for dopamine and 0.8 µM for serotonin with no significant reciprocal influences. Selectivity studies were also performed, as well as tests in real samples (e.g. human serum, tears and saliva) complex matrices for which acceptable recoveries were obtained. Conclusion: The results obtained within this study can be considered as an important starting point for the development of a fast and simple method for selective and highly sensitive detection of neurotransmitters, with possible applications in the diagnosis of different pathologies and for monitoring the effectiveness of the applied drug treatment.

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Simultaneous Detection and Estimation of Catechol, Hydroquinone, and Resorcinol in Binary and Ternary Mixtures Using Electrochemical Techniques

International Journal of Analytical Chemistry ◽

10.1155/2015/862979 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Md. Uzzal Hossain ◽

Md. Toufiqur Rahman ◽

Md. Qamrul Ehsan

Keyword(s):

Cyclic Voltammetry ◽

Electrochemical Techniques ◽

Simultaneous Detection ◽

Differential Pulse ◽

Ternary Mixtures ◽

Carbon Electrode ◽

Polyglutamic Acid ◽

Dihydroxybenzene Isomers ◽

Binary And Ternary Mixtures ◽

Pulse Voltammetry

Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were performed with a glassy carbon electrode (GCE) modified with polyglutamic acid (PGA) on the three dihydroxybenzene isomers, catechol (CT), hydroquinone (HQ), and resorcinol (RS). At bare GCE, these isomers exhibited voltammograms with highly overlapped redox peaks that impeded their simultaneous detection in binary and ternary mixtures. On the contrary, at PGA modified GCE binary and ternary mixtures of the dihydroxybenzene isomers showed well-resolved redox peaks in both CV and DPV experiments. This resolving ability of PGA modified GCE proves its potential to be exploited as an electrochemical sensor for the simultaneous detection of these isomers.

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Simultaneous Detection of Hydroquinone and Catechol Using Platinum Nanoparticles Decorated Graphene/Poly-Cyclodextrin/Multiwalled Carbon Nanotubes (MWCNTs) Nanocomposite Based Biosensor

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2018.16295 ◽

2018 ◽

Vol 18 (12) ◽

pp. 8118-8123 ◽

Cited By ~ 5

Author(s):

Xiaomei Huang ◽

Xiang Deng ◽

Wenjing Qi ◽

Di Wu

Keyword(s):

Carbon Nanotubes ◽

Electrochemical Biosensor ◽

Simultaneous Detection ◽

Multiwall Carbon Nanotubes ◽

Electrochemical Determination ◽

Multiwalled Carbon ◽

Platinum Particles ◽

Pulse Voltammetry ◽

Multiwall Carbon

Graphene cyclodextrin prepolymer (pre-CD)-multiwall carbon nanotubes (Gr-CDP-MWCNTs) nanocomposites modified on glassy carbon electrode (Gr-CDP-MWCNTs/GCE) are prepared and then platinum particles (PtNPs) are electrodeposited on it. The simultaneous determination of hydroquinone (HQ) and catechol (CC) at PtNPs/Gr-CDP-MWCNTs/GCE is reported in the present work. Synergistic effect of nanomaterials, host-guest chemical reaction ability of CDP, the stacking interaction between detected molecules and Gr-MWCNTs surface are considered as the main reasons of successfully simultaneous detection of HQ and CC. Cyclic voltammetry (CV), scanning electron microscopy (SEM) and different pulse voltammetry (DPV) are employed to characterize the proposed PtNPs/Gr-CDP-MWCNTs electrochemical biosensor. The prepared PtNPs/Gr-CDP-MWCNTs sensor shows linear response ranges of 0.05–27.2 μM and 0.1–27.2 μM and have low detection limits (S/N = 3) of 0.015 μM and 0.03 μM for simultaneous electrochemical determination of HQ and CC, respectively. It is also applied for the measurement of HQ and CC in local river water samples with recoveries from 98.0 to 102.0% and from 99.3 to 101.5%.

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Solar Exfoliated Graphene Oxide: A Platform for Electrochemical Sensing of Epinephrine

Current Analytical Chemistry ◽

10.2174/1573411015666190104110928 ◽

2020 ◽

Vol 16 (4) ◽

pp. 393-403 ◽

Cited By ~ 1

Author(s):

Renjini Sadhana ◽

Pinky Abraham ◽

Anithakumary Vidyadharan

Keyword(s):

Cyclic Voltammetry ◽

Graphene Oxide ◽

Glassy Carbon Electrode ◽

Glassy Carbon ◽

Simultaneous Detection ◽

Differential Pulse ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Reduced Graphene ◽

Pulse Voltammetry

Introduction: In this study, solar exfoliated graphite oxide modified glassy carbon electrode was used for the anodic oxidation of epinephrine in a phosphate buffer medium at pH7. The modified electrode showed fast response and sensitivity towards Epinephrine Molecule (EP). The electrode was characterized electrochemically through Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV). Area of the electrode enhanced three times during modification and studies reveal that the oxidation process of EP occurs by an adsorption controlled process involving two electrons. The results showed a detection limit of 0.50 ± 0.01μM with a linear range up to 100 μM. The rate constant calculated for the electron transfer reaction is 1.35 s-1. The electrode was effective for simultaneous detection of EP in the presence of Ascorbic Acid (AA) and Uric Acid (UA) with well-resolved signals. The sensitivity, selectivity and stability of the sensor were also confirmed. Methods: Glassy carbon electrode modified by reduced graphene oxide was used for the detection and quantification of epinephrine using cyclic voltammetry and differential pulse voltammetry. Results: The results showed an enhancement in the electrocatalytic oxidation of epinephrine due to the increase in the effective surface area of the modified electrode. The anodic transfer coefficient, detection limit and electron transfer rate constant of the reaction were also calculated. Conclusion: The paper reports the determination of epinephrine using reduced graphene oxide modified glassy carbon electrode through CV and DPV. The sensor exhibited excellent reproducibility and repeatability for the detection of epinephrine and also its simultaneous detection of ascorbic acid and uric acid, which coexist in the biological system.

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The polarographic and voltammetric determination of 2,6-dicyano-4-nitro-2'-acetylamino-4'-diethylaminoazobenzene

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19901508 ◽

1990 ◽

Vol 55 (6) ◽

pp. 1508-1517 ◽

Cited By ~ 1

Author(s):

Jiří Barek ◽

Dagmar Civišová ◽

Ashutosh Ghosh ◽

Jiří Zima

Keyword(s):

Azo Dye ◽

Differential Pulse ◽

Differential Pulse Polarography ◽

Determination Limit ◽

Polarographic Reduction ◽

Hanging Mercury Drop Electrode ◽

Optimal Conditions ◽

Pulse Polarography ◽

Pulse Voltammetry

The polarographic reduction of the title azo dye was studied and optimal conditions were found for its analytical utilization in the concentration range 1 . 10-6 - 1 . 10-7 mol l-1 using differential pulse polarography and 1 . 10-6 - 1 . 10-8 mol l-1 using fast scan differential pulse voltammetry or linear scan voltammetry at a hanging mercury drop electrode. When the latter technique is combined with adsorptive accumulation of the studied substance on the surface of the hanging mercury drop, the determination limit can be further decreased to 3 . 10-9 mol l-1.

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