scholarly journals A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

Sensors ◽  
2020 ◽  
Vol 20 (20) ◽  
pp. 5847
Author(s):  
Aaryashree ◽  
Yuuto Takeda ◽  
Momoe Kanai ◽  
Akihiko Hatano ◽  
Yasuo Yoshimi ◽  
...  
Keyword(s):  
Differential Pulse ◽  
Sensor Chip ◽  
Therapeutic Drug ◽  
Carbon Paste ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Single Use ◽  
Mip Sensor ◽  
Response Current ◽  
Time Required

An inexpensive disposable electrochemical drug sensor for the detection of drugs (vancomycin, meropenem, theophylline, and phenobarbital) is described. Molecularly imprinted polymer (MIP) templated with the target drugs was immobilized on the surface of graphite particles using a simple radical polymerization method and packed into the working electrode of a three-electrode ceramic-based chip sensor. Differential pulse voltammetry (DPV) was used to determine the relationship between the response current and the concentration of the targeted drug while using one sensor chip for one single operation. The time required for each DPV measurement was less than 2 min. Concentrations corresponding to the therapeutic range of these drugs in plasma were taken into account while performing DPV. In all the cases, the single-used MIP sensor showed higher sensitivity and linearity than non-imprinted polymer. The selectivity test in drugs with a structure similar to that of the target drugs was performed, and it was found that MIP-based sensors were more selective than the untreated ones. Additionally, the test in whole blood showed that the presence of interfering species had an insignificant effect on the diagnostic responses of the sensor. These results demonstrate that the disposable MIP-sensor is promising for quick and straightforward therapeutic drug monitoring to prevent the toxic side effects and the insufficient therapeutic effect due to the overdose and underdose, respectively.

scholarly journals Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls

Sensors ◽  
2019 ◽  
Vol 19 (20) ◽  
pp. 4433 ◽  
Author(s):  
Giulia Moro ◽  
Davide Cristofori ◽  
Fabio Bottari ◽  
Elti Cattaruzza ◽  
Karolien De Wael ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Electrochemical Sensors ◽  
Differential Pulse ◽  
Complete Characterization ◽  
In Situ Monitoring ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Heterogeneous Distribution ◽  
Molecularly Imprinted ◽  
Mip Sensor

There is a growing interest in the technological transfer of highly performing electrochemical sensors within portable analytical devices for the in situ monitoring of environmental contaminants, such as perfluorooctanesulfonic acid (PFOS). In the redesign of biomimetic sensors, many parameters should be taken into account from the working conditions to the electrode surface roughness. A complete characterization of the surface modifiers can help to avoid time-consuming optimizations and better interpret the sensor responses. In the present study, a molecularly imprinted polymer electrochemical sensor (MIP) for PFOS optimized on gold disk electrodes was redesigned on commercial gold screen-printed electrodes. However, its performance investigated by differential pulse voltammetry was found to be poor. Before proceeding with further optimization, a morphological study of the bare and modified electrode surfaces was carried out by scanning electron microscopy–energy-dispersive X-ray spectrometry (SEM–EDS), atomic force microscopy (AFM) and profilometry revealing an heterogeneous distribution of the polymer strongly influenced by the electrode roughness. The high content of fluorine of the target-template molecule allowed to map the distribution of the molecularly imprinted polymer before the template removal and to define a characterization protocol. This case study shows the importance of a multi-analytical characterization approach and identify significant parameters to be considered in similar redesigning studies.

A Sensitive and Selective Electrochemical Sensor for Sulfadimethoxine Based on Electropolymerized Molecularly Imprinted Poly (o-aminophenol) Film

2020 ◽  
Vol 16 (4) ◽  
pp. 413-420 ◽  
Author(s):  
Youyuan Peng ◽  
Qiaolan Ji
Keyword(s):  
Electrochemical Sensor ◽  
Polymer Film ◽  
Water Samples ◽  
Differential Pulse ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Long Term Stability ◽  
Multi Walled Carbon Nanotubes ◽  
Aquaculture Water ◽  
Walled Carbon Nanotubes

Background: As a broad-spectrum antibiotic of the sulfonamide family, Sulfadimethoxine (SDM) has been widely utilized for therapeutic and growth-promoting purposes in animals. However, the use of SDM can cause residual problems. Even a low concentration of SDM in the aquatic system can exert toxic effects on target organisms and green algae. Therefore, the quantitation of SDM residues has become an important task. Methods: The present work describes the development of a sensitive and selective electrochemical sensor for sulfadimethoxine based on molecularly imprinted poly(o-aminophenol) film. The molecular imprinted polymer film was fabricated by electropolymerizing o-aminophenol in the presence of SDM after depositing carboxylfunctionalized multi-walled carbon nanotubes onto a glassy carbon electrode surface. SDM can be quickly removed by electrochemical methods. The imprinted polymer film was characterized by cyclic voltammetry, differential pulse voltammetry and scanning electron microscopy. Results: Under the selected optimal conditions, the molecularly imprinted sensor shows a linear range from 1.0 × 10-7 to 2.0 × 10-5 mol L-1 for SDM, with a detection limit of 4.0 × 10-8 mol L-1. The sensor was applied to the determination of SDM in aquaculture water samples successfully, with the recoveries ranging from 95% to 106%. Conclusion: The proposed sensor exhibited a high degree of selectivity for SDM in comparison to other structurally similar molecules, along with long-term stability, good reproducibility and excellent regeneration capacity. The sensor may offer a feasible strategy for the analysis of SDM in aquaculture water samples.

Determination of meloxicam in plasma samples using a highly selective and sensitive voltammetric sensor based on carbon paste electrodes modified by molecularly imprinted polymer nanoparticle–multiwall carbon nanotubes

2015 ◽  
Vol 7 (4) ◽  
pp. 1280-1292 ◽  
Author(s):  
Saman Azodi-Deilami ◽  
Ebadullah Asadi ◽  
Majid Abdouss ◽  
Fardin Ahmadi ◽  
Alireza Hassani Najafabadi ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Multiwall Carbon Nanotubes ◽  
Voltammetric Sensor ◽  
Plasma Samples ◽  
Carbon Paste ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Carbon Paste Electrodes ◽  
Multiwall Carbon

A highly selective voltammetric sensor for the determination of meloxicam using a MIP@MWCNT–CPE is introduced.

Electrochemical Detection of Fenthion Insecticide in Olive Oils by a Sensitive Non-Enzymatic Biomimetic Sensor Enhanced with Metal Nanoparticles

2021 ◽  
Vol 5 (1) ◽  
pp. 64
Author(s):  
Youssra Aghoutane ◽  
Nezha El Bari ◽  
Zoubida Laghrari ◽  
Benachir Bouchikhi
Keyword(s):  
Electrochemical Impedance ◽  
Differential Pulse ◽  
Organophosphate Insecticide ◽  
Imprinted Polymer ◽  
High Recovery ◽  
Molecularly Imprinted ◽  
Olive Oils ◽  
Pulse Voltammetry ◽  
Biomimetic Sensor

Fenthion, an organophosphate insecticide, is a cholinesterase inhibitor and is highly toxic. An electrochemical sensor based on molecularly imprinted polymer is developed here for its detection. For this purpose, 2-aminothiophenol mixed with gold nanoparticles was immobilized on screen-printed gold electrodes. The FEN pattern was then fixed before being covered with 2-aminothiophenol. Cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy methods were used for the electrochemical characterization. The low detection limit was 0.05 mg/Kg over a range of 0.01–17.3 µg/mL. The sensor was successfully applied for the determination of FEN in olive oil samples with high recovery values.

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 9154-9166 ◽  
Author(s):  
Sina Farzaneh ◽  
Ebadullah Asadi ◽  
Majid Abdouss ◽  
Azam Barghi-Lish ◽  
Saman Azodi-Deilami ◽  
...  
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Polymer Nanoparticles ◽  
Therapeutic Drug ◽  
Phase Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

The aim of this study was to prepare efficient imprinted polymer nanoparticles from an olanzapine template for the controlled release of olanzapine as a therapeutic drug for CNS diseases.

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