scholarly journals Improved Antibiotic Detection in Raw Milk Using Machine Learning Tools over the Absorption Spectra of a Problem-Specific Nanobiosensor

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4552
Author(s):  
Pablo Gutiérrez ◽  
Sebastián E. Godoy ◽  
Sergio Torres ◽  
Patricio Oyarzún ◽  
Ignacio Sanhueza ◽  
...  
Keyword(s):  
Machine Learning ◽  
Milk Sample ◽  
Learning Algorithm ◽  
State Of The Art ◽  
Raw Milk ◽  
Detection Algorithm ◽  
Learning Tools ◽  
Antibiotic Detection ◽  
Biosensor System ◽  
Spectral Detection

In this article we present the development of a biosensor system that integrates nanotechnology, optomechanics and a spectral detection algorithm for sensitive quantification of antibiotic residues in raw milk of cow. Firstly, nanobiosensors were designed and synthesized by chemically bonding gold nanoparticles (AuNPs) with aptamer bioreceptors highly selective for four widely used antibiotics in the field of veterinary medicine, namely, Kanamycin, Ampicillin, Oxytetracycline and Sulfadimethoxine. When molecules of the antibiotics are present in the milk sample, the interaction with the aptamers induces random AuNP aggregation. This phenomenon modifies the initial absorption spectrum of the milk sample without antibiotics, producing spectral features that indicate both the presence of antibiotics and, to some extent, its concentration. Secondly, we designed and constructed an electro-opto-mechanic device that performs automatic high-resolution spectral data acquisition in a wavelength range of 400 to 800 nm. Thirdly, the acquired spectra were processed by a machine-learning algorithm that is embedded into the acquisition hardware to determine the presence and concentration ranges of the antibiotics. Our approach outperformed state-of-the-art standardized techniques (based on the 520/620 nm ratio) for antibiotic detection, both in speed and in sensitivity.

IMPROVED TOW-END DETECTION FOR FIBER PLACEMENT INSPECTION USING MACHINE LEARNING

2021 ◽  
Author(s):  
ADRIANA W. (AGNES) BLOM-SCHIEBER ◽  
WEI GUO ◽  
EKTA SAMANI ◽  
ASHIS BANERJEE
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Image Data ◽  
Detection Algorithm ◽  
Automated Inspection ◽  
Machine Learning Algorithm ◽  
Fiber Placement ◽  
Inspection Systems ◽  
Automated Fiber Placement ◽  
The University

A machine learning approach to improve the detection of tow ends for automated inspection of fiber-placed composites is presented. Automated inspection systems for automated fiber placement processes have been introduced to reduce the time it takes to inspect plies after they are laid down. The existing system uses image data from ply boundaries and a contrast-based algorithm to locate the tow ends in these images. This system fails to recognize approximately 10% of the tow ends, which are then presented to the operator for manual review, taking up precious time in the production process. An improved tow end detection algorithm based on machine learning is developed through a research project with the Boeing Advanced Research Center (BARC) at the University of Washington. This presentation shows the preprocessing, neural network and post‐processing steps implemented in the algorithm, and the results achieved with the machine learning algorithm. The machine learning algorithm resulted in a 90% reduction in the number of undetected tows compared to the existing system.

scholarly journals Accurate prediction of DNA N4-methylcytosine sites via boost-learning various types of sequence features

BMC Genomics ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhixun Zhao ◽  
Xiaocai Zhang ◽  
Fang Chen ◽  
Liang Fang ◽  
Jinyan Li
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Case Studies ◽  
Learning Algorithm ◽  
State Of The Art ◽  
Learning Algorithms ◽  
Feature Space ◽  
Sequence Features ◽  
Independent Test ◽  
Benchmark Datasets

Abstract Background DNA N4-methylcytosine (4mC) is a critical epigenetic modification and has various roles in the restriction-modification system. Due to the high cost of experimental laboratory detection, computational methods using sequence characteristics and machine learning algorithms have been explored to identify 4mC sites from DNA sequences. However, state-of-the-art methods have limited performance because of the lack of effective sequence features and the ad hoc choice of learning algorithms to cope with this problem. This paper is aimed to propose new sequence feature space and a machine learning algorithm with feature selection scheme to address the problem. Results The feature importance score distributions in datasets of six species are firstly reported and analyzed. Then the impact of the feature selection on model performance is evaluated by independent testing on benchmark datasets, where ACC and MCC measurements on the performance after feature selection increase by 2.3% to 9.7% and 0.05 to 0.19, respectively. The proposed method is compared with three state-of-the-art predictors using independent test and 10-fold cross-validations, and our method outperforms in all datasets, especially improving the ACC by 3.02% to 7.89% and MCC by 0.06 to 0.15 in the independent test. Two detailed case studies by the proposed method have confirmed the excellent overall performance and correctly identified 24 of 26 4mC sites from the C.elegans gene, and 126 out of 137 4mC sites from the D.melanogaster gene. Conclusions The results show that the proposed feature space and learning algorithm with feature selection can improve the performance of DNA 4mC prediction on the benchmark datasets. The two case studies prove the effectiveness of our method in practical situations.

scholarly journals A review on machine learning for neutrino experiments

2020 ◽  
Vol 35 (33) ◽  
pp. 2043005
Author(s):  
Fernanda Psihas ◽  
Micah Groh ◽  
Christopher Tunnell ◽  
Karl Warburton
Keyword(s):  
Machine Learning ◽  
Neutrino Physics ◽  
State Of The Art ◽  
Machine Learning Algorithms ◽  
Current Status ◽  
Learning Tools ◽  
The Standard Model ◽  
Challenges And Opportunities ◽  
Machine Learning Applications ◽  
Neutrino Experiments

Neutrino experiments study the least understood of the Standard Model particles by observing their direct interactions with matter or searching for ultra-rare signals. The study of neutrinos typically requires overcoming large backgrounds, elusive signals, and small statistics. The introduction of state-of-the-art machine learning tools to solve analysis tasks has made major impacts to these challenges in neutrino experiments across the board. Machine learning algorithms have become an integral tool of neutrino physics, and their development is of great importance to the capabilities of next generation experiments. An understanding of the roadblocks, both human and computational, and the challenges that still exist in the application of these techniques is critical to their proper and beneficial utilization for physics applications. This review presents the current status of machine learning applications for neutrino physics in terms of the challenges and opportunities that are at the intersection between these two fields.

Automatic microseismic event picking via unsupervised machine learning

2020 ◽  
Vol 222 (3) ◽  
pp. 1750-1764 ◽  
Author(s):  
Yangkang Chen
Keyword(s):  
Machine Learning ◽  
Clustering Algorithm ◽  
Learning Algorithm ◽  
State Of The Art ◽  
The State ◽  
Training Data ◽  
Supervised Machine Learning ◽  
Machine Learning Algorithm ◽  
Unsupervised Machine Learning ◽  
Earthquake Data

SUMMARY Effective and efficient arrival picking plays an important role in microseismic and earthquake data processing and imaging. Widely used short-term-average long-term-average ratio (STA/LTA) based arrival picking algorithms suffer from the sensitivity to moderate-to-strong random ambient noise. To make the state-of-the-art arrival picking approaches effective, microseismic data need to be first pre-processed, for example, removing sufficient amount of noise, and second analysed by arrival pickers. To conquer the noise issue in arrival picking for weak microseismic or earthquake event, I leverage the machine learning techniques to help recognizing seismic waveforms in microseismic or earthquake data. Because of the dependency of supervised machine learning algorithm on large volume of well-designed training data, I utilize an unsupervised machine learning algorithm to help cluster the time samples into two groups, that is, waveform points and non-waveform points. The fuzzy clustering algorithm has been demonstrated to be effective for such purpose. A group of synthetic, real microseismic and earthquake data sets with different levels of complexity show that the proposed method is much more robust than the state-of-the-art STA/LTA method in picking microseismic events, even in the case of moderately strong background noise.

The Happy Valley Band: Creative (Mis)Transcription

2016 ◽  
Vol 26 ◽  
pp. 76-78
Author(s):  
David Kant
Keyword(s):  
Machine Learning ◽  
Open Source Software ◽  
Learning Process ◽  
Learning Algorithm ◽  
State Of The Art ◽  
Machine Learning Algorithm ◽  
Digital Analysis ◽  
Artistic Practice ◽  
Software Suite ◽  
Happy Valley

In the author’s work as a composer, he explores how state-of-the-art digital sound analysis can change how we listen to music. The Happy Valley Band (HVB) is a product of this exploration and encompasses a repertoire of microtonal deconstructions of pop songs, an open-source software suite and a dedicated performing ensemble. This article documents the author’s experience and artistic practice within this project—a process of translation between digital analysis, human listening and written notation, in which a machine-learning algorithm is trained to hear pop songs and the results of the machine-learning process are transcribed into musical notation and performed by instrumentalists.

scholarly journals Selection of Reliable Machine Learning Algorithms for Geophysical Applications

2020 ◽  
Author(s):  
Octavian Dumitru ◽  
Gottfried Schwarz ◽  
Dongyang Ao ◽  
Gabriel Dax ◽  
Vlad Andrei ◽  
...  
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Image Data ◽  
Data Interpretation ◽  
Computational Effort ◽  
Machine Learning Algorithms ◽  
Learning Tools ◽  
Convolutional Networks ◽  
Strong Winds

<p>During the last years, one could see a broad use of machine learning tools and applications. However, when we use these techniques for geophysical analyses, we must be sure that the obtained results are scientifically valid and allow us to derive quantitative outcomes that can be directly compared with other measurements.</p><p>Therefore, we set out to identify typical datasets that lend themselves well to geophysical data interpretation. To simplify this very general task, we concentrate in this contribution on multi-dimensional image data acquired by satellites with typical remote sensing instruments for Earth observation being used for the analysis for:</p><ul><li>Atmospheric phenomena (cloud cover, cloud characteristics, smoke and plumes, strong winds, etc.)</li> <li>Land cover and land use (open terrain, agriculture, forestry, settlements, buildings and streets, industrial and transportation facilities, mountains, etc.)</li> <li>Sea and ocean surfaces (waves, currents, ships, icebergs, coastlines, etc.)</li> <li>Ice and snow on land and water (ice fields, glaciers, etc.)</li> <li>Image time series (dynamical phenomena, their occurrence and magnitude, mapping techniques)</li> </ul><p>Then we analyze important data characteristics for each type of instrument. One can see that most selected images are characterized by their type of imaging instrument (e.g., radar or optical images), their typical signal-to-noise figures, their preferred pixel sizes, their various spectral bands, etc.</p><p>As a third step, we select a number of established machine learning algorithms, available tools, software packages, required environments, published experiences, and specific caveats. The comparisons cover traditional “flat” as well as advanced “deep” techniques that have to be compared in detail before making any decision about their usefulness for geophysical applications. They range from simple thresholding to k-means, from multi-scale approaches to convolutional networks (with visible or hidden layers) and auto-encoders with sub-components from rectified linear units to adversarial networks.</p><p>Finally, we summarize our findings in several instrument / machine learning algorithm matrices (e.g., for active or passive instruments). These matrices also contain important features of the input data and their consequences, computational effort, attainable figures-of-merit, and necessary testing and verification steps (positive and negative examples). Typical examples are statistical similarities, characteristic scales, rotation invariance, target groupings, topic bagging and targeting (hashing) capabilities as well as local compression behavior.</p>

scholarly journals Accurate Heuristic Terrain Prediction in Powered Lower-Limb Prostheses Using Onboard Sensors

2020 ◽  
Author(s):  
Roman Stolyarov ◽  
Matt Carney ◽  
Hugh Herr
Keyword(s):  
Machine Learning ◽  
Ankle Joint ◽  
Heuristic Algorithm ◽  
Lower Limb ◽  
Learning Algorithm ◽  
State Of The Art ◽  
Measurement Unit ◽  
Machine Learning Algorithm ◽  
Ground Slope ◽  
Powered Prosthesis

This study describes the development and offline validation of a heuristic algorithm for accurate prediction of ground terrain in a lower limb prosthesis. This method is based on inference of the ground terrain geometry using estimation of prosthetic limb kinematics during gait with a single integrated inertial measurement unit. We asked five subjects with below-knee amputations to traverse level ground, stairs, and ramps using a high-range-of-motion powered prosthesis while internal sensor data were remotely logged. We used these data to develop two terrain prediction algorithms. The first employed a state-of-the-art machine learning approach, while the second was a directly tuned heuristic using thresholds on estimated prosthetic ankle joint translations and ground slope. We compared the performance of these algorithms using resubstitution error for the machine learning algorithm and overall error for the heuristic algorithm. Our optimal machine learning algorithm attained a resubstitution error of $3.4\%$ using 45 features, while our heuristic method attained an overall prediction error of $2.8\%$ using only 5 features derived from estimation of ground slope and horizontal and vertical ankle joint displacement. Compared with pattern recognition, the heuristic performed better on each individual subject, and across both level and non-level strides. These results demonstrate a method for heuristic prediction of ground terrain in a powered prosthesis. The method is more accurate, more interpretable, and less computationally expensive than state-of-the-art machine learning methods, and relies only on integrated prosthesis sensors. Finally, the method provides intuitively tunable thresholds to improve performance for specific walking conditions.

scholarly journals Prevention of Crypto-Ransomware Using a Pre-Encryption Detection Algorithm

Computers ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 79 ◽  
Author(s):  
S. Kok ◽  
Azween Abdullah ◽  
NZ Jhanjhi ◽  
Mahadevan Supramaniam
Keyword(s):  
Machine Learning ◽  
Phase I ◽  
Phase Ii ◽  
Learning Algorithm ◽  
False Positive Rate ◽  
Application Programming Interface ◽  
Detection Algorithm ◽  
Positive Rate ◽  
New Type ◽  
Two Phases

Ransomware is a relatively new type of intrusion attack, and is made with the objective of extorting a ransom from its victim. There are several types of ransomware attacks, but the present paper focuses only upon the crypto-ransomware, because it makes data unrecoverable once the victim’s files have been encrypted. Therefore, in this research, it was proposed that machine learning is used to detect crypto-ransomware before it starts its encryption function, or at the pre-encryption stage. Successful detection at this stage is crucial to enable the attack to be stopped from achieving its objective. Once the victim was aware of the presence of crypto-ransomware, valuable data and files can be backed up to another location, and then an attempt can be made to clean the ransomware with minimum risk. Therefore we proposed a pre-encryption detection algorithm (PEDA) that consisted of two phases. In, PEDA-Phase-I, a Windows application programming interface (API) generated by a suspicious program would be captured and analyzed using the learning algorithm (LA). The LA can determine whether the suspicious program was a crypto-ransomware or not, through API pattern recognition. This approach was used to ensure the most comprehensive detection of both known and unknown crypto-ransomware, but it may have a high false positive rate (FPR). If the prediction was a crypto-ransomware, PEDA would generate a signature of the suspicious program, and store it in the signature repository, which was in Phase-II. In PEDA-Phase-II, the signature repository allows the detection of crypto-ransomware at a much earlier stage, which was at the pre-execution stage through the signature matching method. This method can only detect known crypto-ransomware, and although very rigid, it was accurate and fast. The two phases in PEDA formed two layers of early detection for crypto-ransomware to ensure zero files lost to the user. However in this research, we focused upon Phase-I, which was the LA. Based on our results, the LA had the lowest FPR of 1.56% compared to Naive Bayes (NB), Random Forest (RF), Ensemble (NB and RF) and EldeRan (a machine learning approach to analyze and classify ransomware). Low FPR indicates that LA has a low probability of predicting goodware wrongly.

scholarly journals Towards Machine Learning-based Anomaly Detection on Time-Series Data

2021 ◽  
Vol 13 (1) ◽  
pp. 35-44
Author(s):  
Daniel Vajda ◽  
Adrian Pekar ◽  
Karoly Farkas
Keyword(s):  
Machine Learning ◽  
Time Series ◽  
Anomaly Detection ◽  
Time Series Data ◽  
Short Term Memory ◽  
Learning Algorithm ◽  
State Of The Art ◽  
Detection Methods ◽  
Series Data ◽  
Rich Information

The complexity of network infrastructures is exponentially growing. Real-time monitoring of these infrastructures is essential to secure their reliable operation. The concept of telemetry has been introduced in recent years to foster this process by streaming time-series data that contain feature-rich information concerning the state of network components. In this paper, we focus on a particular application of telemetry — anomaly detection on time-series data. We rigorously examined state-of-the-art anomaly detection methods. Upon close inspection of the methods, we observed that none of them suits our requirements as they typically face several limitations when applied on time-series data. This paper presents Alter-Re2, an improved version of ReRe, a state-of-the-art Long Short- Term Memory-based machine learning algorithm. Throughout a systematic examination, we demonstrate that by introducing the concepts of ageing and sliding window, the major limitations of ReRe can be overcome. We assessed the efficacy of Alter-Re2 using ten different datasets and achieved promising results. Alter-Re2 performs three times better on average when compared to ReRe.

scholarly journals Prospective Study of a Multimodal Convulsive Seizure Detection Wearable System on Pediatric and Adult Patients in the Epilepsy Monitoring Unit

2021 ◽  
Vol 12 ◽  
Author(s):  
Francesco Onorati ◽  
Giulia Regalia ◽  
Chiara Caborni ◽  
W. Curt LaFrance ◽  
Andrew S. Blum ◽  
...  
Keyword(s):  
Machine Learning ◽  
Prospective Study ◽  
Learning Algorithm ◽  
Electrodermal Activity ◽  
Pediatric Population ◽  
Detection Algorithm ◽  
Adult Patients ◽  
Active Mode ◽  
The Impact ◽  
Epilepsy Monitoring

Background: Using machine learning to combine wrist accelerometer (ACM) and electrodermal activity (EDA) has been shown effective to detect primarily and secondarily generalized tonic-clonic seizures, here termed as convulsive seizures (CS). A prospective study was conducted for the FDA clearance of an ACM and EDA-based CS-detection device based on a predefined machine learning algorithm. Here we present its performance on pediatric and adult patients in epilepsy monitoring units (EMUs).Methods: Patients diagnosed with epilepsy participated in a prospective multi-center clinical study. Three board-certified neurologists independently labeled CS from video-EEG. The Detection Algorithm was evaluated in terms of Sensitivity and false alarm rate per 24 h-worn (FAR) on all the data and on only periods of rest. Performance were analyzed also applying the Detection Algorithm offline, with a less sensitive but more specific parameters configuration (“Active mode”).Results: Data from 152 patients (429 days) were used for performance evaluation (85 pediatric aged 6–20 years, and 67 adult aged 21–63 years). Thirty-six patients (18 pediatric) experienced a total of 66 CS (35 pediatric). The Sensitivity (corrected for clustered data) was 0.92, with a 95% confidence interval (CI) of [0.85-1.00] for the pediatric population, not significantly different (p > 0.05) from the adult population's Sensitivity (0.94, CI: [0.89–1.00]). The FAR on the pediatric population was 1.26 (CI: [0.87–1.73]), higher (p < 0.001) than in the adult population (0.57, CI: [0.36–0.81]). Using the Active mode, the FAR decreased by 68% while reducing Sensitivity to 0.95 across the population. During rest periods, the FAR's were 0 for all patients, lower than during activity periods (p < 0.001).Conclusions: Performance complies with FDA's requirements of a lower bound of CI for Sensitivity higher than 0.7 and of a FAR lower than 2, for both age groups. The pediatric FAR was higher than the adult FAR, likely due to higher pediatric activity. The high Sensitivity and precision (having no false alarms) during sleep might help mitigate SUDEP risk by summoning caregiver intervention. The Active mode may be advantageous for some patients, reducing the impact of the FAR on daily life. Future work will examine the performance and usability outside of EMUs.

Sign in / Sign up

Export Citation Format

Share Document