scholarly journals The Synergy of Thermally Reduced Graphene Oxide in Amperometric Urea Biosensor: Application for Medical Technologies

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4496
Author(s):  
Julija Razumiene ◽  
Vidute Gureviciene ◽  
Ieva Sakinyte ◽  
Laurynas Rimsevicius ◽  
Valdas Laurinavicius
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Point Of Care ◽  
High Sensitivity ◽  
Non Invasive ◽  
Reduced Graphene ◽  
Analytical Recovery ◽  
Relative Standard ◽  
Spent Dialysate ◽  
Biosensor Application

Thermally reduced graphene oxide (TRGO) is a graphene-based nanomaterial that has been identified as promising for the development of amperometric biosensors. Urease, in combination with TRGO, allowed us to create a mediator-free amperometric biosensor with the intention of precise detection of urea in clinical trials. Beyond simplicity of the technology, the biosensor exhibited high sensitivity (2.3 ± 0.1 µA cm−2 mM−1), great operational and storage stabilities (up to seven months), and appropriate reproducibility (relative standard deviation (RSD) about 2%). The analytical recovery of the TRGO-based biosensor in urine of 101 ÷ 104% with RSD of 1.2 ÷ 1.7% and in blood of 92.7 ÷ 96.4%, RSD of 1.0 ÷ 2.5%, confirmed that the biosensor is acceptable and reliable. These properties allowed us to apply the biosensor in the monitoring of urea levels in samples of urine, blood, and spent dialysate collected during hemodialysis. Accuracy of the biosensor was validated by good correlation (R = 0.9898 and R = 0.9982) for dialysate and blood, utilizing approved methods. The advantages of the proposed biosensing technology could benefit the development of point-of-care and non-invasive medical instruments.

An Electrochemically Reduced Copper/Reduced Graphene Oxide Film Modified Electrode for Sensitive Non-Enzymatic Glucose Detection in Human Serum

2021 ◽  
Author(s):  
Sopit Phetsang ◽  
Pinit Kidkhunthod ◽  
Narong Chanlek ◽  
Jaroon Jakmunee ◽  
Pitchaya Mungkornasawakul ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Human Serum ◽  
Reduced Graphene Oxide ◽  
Modified Electrode ◽  
Electrocatalytic Activity ◽  
Glucose Sensor ◽  
Electrochemical Sensors ◽  
High Sensitivity ◽  
Detection Range ◽  
Reduced Graphene

Abstract Numerous studies suggest that modification with functional nanomaterials can enhance the electrode electrocatalytic activity, sensitivity, and selectivity of the electrochemical sensors. Here, a highly sensitive and cost-effective disposable non-enzymatic glucose sensor based on copper(II)/reduced graphene oxide modified screen-printed carbon electrode is demonstrated. Facile fabrication of the developed sensing electrodes is carried out by the adsorption of copper(II) onto graphene oxide modified electrode, then following the electrochemical reduction. The proposed sensor illustrates good electrocatalytic activity toward glucose oxidation with a wide linear detection range from 0.10 mM to 12.5 mM, low detection limit of 65 µM, and high sensitivity of 172 µA mM− 1 cm− 2 along with satisfactory anti-interference ability, reproducibility, stability, and the acceptable recoveries for the detection of glucose in a human serum sample (95.6–106.4%). The copper(II)/reduced graphene oxide based sensor with the superior performances is a great potential for the quantitation of glucose in real samples.

scholarly journals Ammonia Gas Detection by Tannic Acid Functionalized and Reduced Graphene Oxide at Room Temperature

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Sweejiang Yoo ◽  
Xin Li ◽  
Yuan Wu ◽  
Weihua Liu ◽  
Xiaoli Wang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Gas Sensor ◽  
Tannic Acid ◽  
Room Temperature ◽  
Gas Sensing ◽  
High Sensitivity ◽  
Gas Detection ◽  
Ammonia Gas ◽  
Reduced Graphene

Reduced graphene oxide (rGO) based chemiresistor gas sensor has received much attention in gas sensing for high sensitivity, room temperature operation, and reversible. Here, for the first time, we present a promising chemiresistor for ammonia gas detection based on tannic acid (TA) functionalized and reduced graphene oxide (rGOTA functionalized). Green reductant of TA plays a major role in both reducing process and enhancing the gas sensing properties ofrGOTA functionalized. Our results showrGOTA functionalizedonly selective to ammonia with excellent respond, recovery, respond time, and recovery times.rGOTA functionalizedelectrical resistance decreases upon exposure to NH3where we postulated that it is due to n-doping by TA and charge transfer betweenrGOTA functionalizedand NH3through hydrogen bonding. Furthermore,rGOTA functionalizedhinders the needs for stimulus for both recovery and respond. The combination of greener sensing material and simplicity in overall sensor design provides a new sight for green reductant approach of rGO based chemiresistor gas sensor.

Schottky diode characteristics and 1/f noise of high sensitivity reduced graphene oxide/Si heterojunction photodetector

2016 ◽  
Vol 119 (12) ◽  
pp. 124303 ◽  
Author(s):  
Miao Zhu ◽  
Xinming Li ◽  
Xiao Li ◽  
Xiaobei Zang ◽  
Zhen Zhen ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Schottky Diode ◽  
High Sensitivity ◽  
Reduced Graphene

scholarly journals The Effect of Aptamer Concetration towards Reduced Graphene Oxide-Field Effect Transistor Surface Channel for Biosensor Application

2018 ◽  
Vol 318 ◽  
pp. 012045 ◽  
Author(s):  
Azrul Syafiq Zainol Abidin ◽  
Ruslinda Abdul Rahim ◽  
Chow Yong Huan ◽  
Nur Nasyifa Mohd Maidin ◽  
Nurul Atiqah Ahmad ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Reduced Graphene ◽  
Biosensor Application ◽  
Effect Transistor

Effect of APTES Percentage towards Reduced Graphene Oxide Screen Printed Electrode Surface for Biosensor Application

2019 ◽  
Vol 19 ◽  
pp. 1183-1188
Author(s):  
Suhaili Sabdin ◽  
Mohd Azraie Mohd Azmi ◽  
Nurul Azurin Badruzaman ◽  
Fatihatul Zuriati Makmon ◽  
Azman Abd Aziz ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Electrode Surface ◽  
Screen Printed Electrode ◽  
Reduced Graphene ◽  
Biosensor Application ◽  
Screen Printed

scholarly journals Cobalt-Dispersed Reduced Graphene Oxide Nanocomposite for the Selective lectrochemical Detection of Methyl Nicotinate

Proceedings ◽  
2019 ◽  
Vol 15 (1) ◽  
pp. 18
Author(s):  
KumarBairagi ◽  
Goyal ◽  
NishithVerma
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Electrode Materials ◽  
High Sensitivity ◽  
Polymer Nanocomposite ◽  
Differential Pulse ◽  
Methyl Nicotinate ◽  
Reduced Graphene ◽  
Phenolic Polymer ◽  
Co Nanoparticles

Methyl nicotinate (MN) is an important tuberculosis biomarker, and can be effectively measured using electrochemical methods. In this study, we have developed a novel N-doped phenolic polymer nanocomposite in situ dispersed with reduced graphene oxide and cobalt (Co)-nanoparticles as a sensor electrode (Co-rGO/PC). Co-nanoparticles were used for the MN recognition. Carbonization was performed for the reduction of GO and the synthesis of Co-nanoparticles. The prepared electrode materials were characterized using SEM, EDS, EIS, and CV. Tested using differential pulse voltammetry, Co-rGO/PC showed its pplicability (RSD < 6%) over 0.05–20.0 mg L−1 MN concentration with high sensitivity (S/N ratio = 3). The present method and materials can also be used for the development of sensors for the other biomarkers.

Tuning the direct growth of Agseeds into bimetallic Ag@Cu nanorods on surface functionalized electrochemically reduced graphene oxide: enhanced nitrite detection

RSC Advances ◽  
2015 ◽  
Vol 5 (60) ◽  
pp. 48236-48245 ◽  
Author(s):  
S. E. Jeena ◽  
P. Gnanaprakasam ◽  
Arun Dakshinamurthy ◽  
T. Selvaraju
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
High Sensitivity ◽  
Oxide Surface ◽  
Nitrite Ion ◽  
Reduced Graphene ◽  
Electrochemically Reduced Graphene Oxide ◽  
Direct Growth ◽  
1D Nanostructure ◽  
Good Detection Limit

The significant challenges in the growth of 1D nanostructure on reduced graphene oxide surface were addressed. It enabled the electrooxidation of the nitrite ion (NO2−) with high sensitivity and good detection limit of 1 nM.

Fe3O4/rGO nanocomposite: synthesis and enhanced NOxgas-sensing properties at room temperature

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 37085-37092 ◽  
Author(s):  
Ying Yang ◽  
Li Sun ◽  
Xiangting Dong ◽  
Hui Yu ◽  
Tingting Wang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Detection Limit ◽  
Response Time ◽  
Reduced Graphene Oxide ◽  
Room Temperature ◽  
Gas Sensing ◽  
High Sensitivity ◽  
Short Response Time ◽  
Reduced Graphene ◽  
Sensing Performance

Fe3O4nanoparticles-decorated reduced graphene oxide nanocomposites have been successfully synthesized using solvothermal-pyrolytic method. They have superior gas sensing performance with low detection limit, high sensitivity and short response time.

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