scholarly journals Breast Cancer Histopathology Image Classification Using an Ensemble of Deep Learning Models

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4373 ◽  
Author(s):  
Zabit Hameed ◽  
Sofia Zahia ◽  
Begonya Garcia-Zapirain ◽  
José Javier Aguirre ◽  
Ana María Vanegas

Breast cancer is one of the major public health issues and is considered a leading cause of cancer-related deaths among women worldwide. Its early diagnosis can effectively help in increasing the chances of survival rate. To this end, biopsy is usually followed as a gold standard approach in which tissues are collected for microscopic analysis. However, the histopathological analysis of breast cancer is non-trivial, labor-intensive, and may lead to a high degree of disagreement among pathologists. Therefore, an automatic diagnostic system could assist pathologists to improve the effectiveness of diagnostic processes. This paper presents an ensemble deep learning approach for the definite classification of non-carcinoma and carcinoma breast cancer histopathology images using our collected dataset. We trained four different models based on pre-trained VGG16 and VGG19 architectures. Initially, we followed 5-fold cross-validation operations on all the individual models, namely, fully-trained VGG16, fine-tuned VGG16, fully-trained VGG19, and fine-tuned VGG19 models. Then, we followed an ensemble strategy by taking the average of predicted probabilities and found that the ensemble of fine-tuned VGG16 and fine-tuned VGG19 performed competitive classification performance, especially on the carcinoma class. The ensemble of fine-tuned VGG16 and VGG19 models offered sensitivity of 97.73% for carcinoma class and overall accuracy of 95.29%. Also, it offered an F1 score of 95.29%. These experimental results demonstrated that our proposed deep learning approach is effective for the automatic classification of complex-natured histopathology images of breast cancer, more specifically for carcinoma images.

Usage of machine learning has been always proven potential in identifying the best solution from the set of complex variables with the highly inter-twined relationship of problems. Similarly, supervised learning approach is one essential operation under machine learning that has always contributed in the area of healthcare and diagnostics. However, there are still some problems associated with the detection and classification of complex disease condition that is yet to be solved. The proposed system introduces a novel supervised learning approach along with a novel feature extraction scheme which is more progressive and less iterative. The proposed system considers a case study to perform classification of breast cancer using Magnetic Resonance Imaging (MRI) where it is subjected to normalization first followed by a novel segmentation process that compliments the classification operation too. The study outcome shows that the proposed system offers better classification performance in contrast to existing supervised approaches.


Author(s):  
Yuejun Liu ◽  
Yifei Xu ◽  
Xiangzheng Meng ◽  
Xuguang Wang ◽  
Tianxu Bai

Background: Medical imaging plays an important role in the diagnosis of thyroid diseases. In the field of machine learning, multiple dimensional deep learning algorithms are widely used in image classification and recognition, and have achieved great success. Objective: The method based on multiple dimensional deep learning is employed for the auxiliary diagnosis of thyroid diseases based on SPECT images. The performances of different deep learning models are evaluated and compared. Methods: Thyroid SPECT images are collected with three types, they are hyperthyroidism, normal and hypothyroidism. In the pre-processing, the region of interest of thyroid is segmented and the amount of data sample is expanded. Four CNN models, including CNN, Inception, VGG16 and RNN, are used to evaluate deep learning methods. Results: Deep learning based methods have good classification performance, the accuracy is 92.9%-96.2%, AUC is 97.8%-99.6%. VGG16 model has the best performance, the accuracy is 96.2% and AUC is 99.6%. Especially, the VGG16 model with a changing learning rate works best. Conclusion: The standard CNN, Inception, VGG16, and RNN four deep learning models are efficient for the classification of thyroid diseases with SPECT images. The accuracy of the assisted diagnostic method based on deep learning is higher than that of other methods reported in the literature.


2021 ◽  
Vol 128 ◽  
pp. 103785
Author(s):  
Yongqing Jiang ◽  
Dandan Pang ◽  
Chengdong Li

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