scholarly journals A Cognitive Method for Automatically Retrieving Complex Information on a Large Scale

Sensors ◽  
2020 ◽  
Vol 20 (11) ◽  
pp. 3057 ◽  
Author(s):  
Yongyue Wang ◽  
Beitong Yao ◽  
Tianbo Wang ◽  
Chunhe Xia ◽  
Xianghui Zhao
Keyword(s):  
Large Scale ◽  
Misleading Information ◽  
Intelligent Sensor ◽  
Cognitive Reasoning ◽  
Complex Information ◽  
Retrieval Systems ◽  
Sensor Technique ◽  
Previous State ◽  
Novel Method ◽  
The Given

Modern retrieval systems tend to deteriorate because of their large output of useless and even misleading information, especially for complex search requests on a large scale. Complex information retrieval (IR) tasks requiring multi-hop reasoning need to fuse multiple scattered text across two or more documents. However, there are two challenges for multi-hop retrieval. To be specific, the first challenge is that since some important supporting facts have little lexical or semantic relationship with the retrieval query, the retriever often omits them; the second challenge is that once a retriever chooses misinformation related to the query as the entities of cognitive graphs, the retriever will fail. In this study, in order to improve the performance of retrievers in complex tasks, an intelligent sensor technique was proposed based on a sub-scope with cognitive reasoning (2SCR-IR), a novel method of retrieving reasoning paths over the cognitive graph to provide users with verified multi-hop reasoning chains. Inspired by the users’ process of step-by-step searching online, 2SCR-IR includes a dynamic fusion layer that starts from the entities mentioned in the given query, explores the cognitive graph dynamically built from the query and contexts, gradually finds relevant supporting entities mentioned in the given documents, and verifies the rationality of the retrieval facts. Our experimental results show that 2SCR-IR achieves competitive results on the HotpotQA full wiki and distractor settings, and outperforms the previous state-of-the-art methods by a more than two points absolute gain on the full wiki setting.

Enzymatic Synthesis of 15N-L-aspartic Acid Using Recombinant Aspartase from Escherichia Coli K12

2008 ◽  
Vol 59 (11) ◽  
Author(s):  
Iulia Lupan ◽  
Sergiu Chira ◽  
Maria Chiriac ◽  
Nicolae Palibroda ◽  
Octavian Popescu
Keyword(s):  
Amino Acids ◽  
Aspartic Acid ◽  
Enzymatic Synthesis ◽  
Large Scale ◽  
Recombinant Dna ◽  
Industrial Enzymes ◽  
Recombinant Dna Technology ◽  
Bacterial Fermentation ◽  
Natural Protein ◽  
Novel Method

Amino acids are obtained by bacterial fermentation, extraction from natural protein or enzymatic synthesis from specific substrates. With the introduction of recombinant DNA technology, it has become possible to apply more rational approaches to enzymatic synthesis of amino acids. Aspartase (L-aspartate ammonia-lyase) catalyzes the reversible deamination of L-aspartic acid to yield fumaric acid and ammonia. It is one of the most important industrial enzymes used to produce L-aspartic acid on a large scale. Here we described a novel method for [15N] L-aspartic synthesis from fumarate and ammonia (15NH4Cl) using a recombinant aspartase.

scholarly journals A Novel Method to Predict Drug-Target Interactions Based on Large-Scale Graph Representation Learning

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2111
Author(s):  
Bo-Wei Zhao ◽  
Zhu-Hong You ◽  
Lun Hu ◽  
Zhen-Hao Guo ◽  
Lei Wang ◽  
...  
Keyword(s):  
Drug Target ◽  
Large Scale ◽  
Computational Models ◽  
Structural Information ◽  
Characteristic Curve ◽  
Representation Learning ◽  
Graph Representation ◽  
Convolutional Network ◽  
Novel Method

Identification of drug-target interactions (DTIs) is a significant step in the drug discovery or repositioning process. Compared with the time-consuming and labor-intensive in vivo experimental methods, the computational models can provide high-quality DTI candidates in an instant. In this study, we propose a novel method called LGDTI to predict DTIs based on large-scale graph representation learning. LGDTI can capture the local and global structural information of the graph. Specifically, the first-order neighbor information of nodes can be aggregated by the graph convolutional network (GCN); on the other hand, the high-order neighbor information of nodes can be learned by the graph embedding method called DeepWalk. Finally, the two kinds of feature are fed into the random forest classifier to train and predict potential DTIs. The results show that our method obtained area under the receiver operating characteristic curve (AUROC) of 0.9455 and area under the precision-recall curve (AUPR) of 0.9491 under 5-fold cross-validation. Moreover, we compare the presented method with some existing state-of-the-art methods. These results imply that LGDTI can efficiently and robustly capture undiscovered DTIs. Moreover, the proposed model is expected to bring new inspiration and provide novel perspectives to relevant researchers.

scholarly journals Comparison of Different Analytical Methods for the On-Site Analysis of Traces at Clandestine Drug Laboratories

2021 ◽  
Vol 11 (9) ◽  
pp. 3754
Author(s):  
René Reiss ◽  
Frank Hauser ◽  
Sven Ehlert ◽  
Michael Pütz ◽  
Ralf Zimmermann
Keyword(s):  
Large Scale ◽  
Ambient Pressure ◽  
Relevant Information ◽  
Information Value ◽  
Site Analysis ◽  
Complex Information ◽  
Skilled Operator ◽  
Validation Parameters ◽  
Clandestine Laboratories ◽  
To Receive

While fast and reliable analytical results are crucial for first responders to make adequate decisions, these can be difficult to establish, especially at large-scale clandestine laboratories. To overcome this issue, multiple techniques at different levels of complexity are available. In addition to the level of complexity their information value differs as well. Within this publication, a comparison between three techniques that can be applied for on-site analysis is performed. These techniques range from ones with a simple yes or no response to sophisticated ones that allows to receive complex information about a sample. The three evaluated techniques are immunoassay drug tests representing easy to handle and fast to explain systems, ion mobility spectrometry as state-of-the-art equipment that needs training and experience prior to use and ambient pressure laser desorption with the need for a highly skilled operator as possible future technique that is currently under development. In addition to the measurement of validation parameters, real case samples are investigated to obtain practically relevant information about the capabilities and limitations of these techniques for on-site operations. Results demonstrate that in general all techniques deliver valid results, but the bandwidth of information widely varies between the investigated techniques.

scholarly journals Shape My Face: Registering 3D Face Scans by Surface-to-Surface Translation

2021 ◽  
Author(s):  
Mehdi Bahri ◽  
Eimear O’ Sullivan ◽  
Shunwang Gong ◽  
Feng Liu ◽  
Xiaoming Liu ◽  
...  
Keyword(s):  
Large Scale ◽  
Training Time ◽  
3D Face ◽  
In The Wild ◽  
Previous State ◽  
Surface Translation ◽  
Visual Attention Mechanism ◽  
Diverse Data ◽  
Human Faces ◽  
Robust To Noise

AbstractStandard registration algorithms need to be independently applied to each surface to register, following careful pre-processing and hand-tuning. Recently, learning-based approaches have emerged that reduce the registration of new scans to running inference with a previously-trained model. The potential benefits are multifold: inference is typically orders of magnitude faster than solving a new instance of a difficult optimization problem, deep learning models can be made robust to noise and corruption, and the trained model may be re-used for other tasks, e.g. through transfer learning. In this paper, we cast the registration task as a surface-to-surface translation problem, and design a model to reliably capture the latent geometric information directly from raw 3D face scans. We introduce Shape-My-Face (SMF), a powerful encoder-decoder architecture based on an improved point cloud encoder, a novel visual attention mechanism, graph convolutional decoders with skip connections, and a specialized mouth model that we smoothly integrate with the mesh convolutions. Compared to the previous state-of-the-art learning algorithms for non-rigid registration of face scans, SMF only requires the raw data to be rigidly aligned (with scaling) with a pre-defined face template. Additionally, our model provides topologically-sound meshes with minimal supervision, offers faster training time, has orders of magnitude fewer trainable parameters, is more robust to noise, and can generalize to previously unseen datasets. We extensively evaluate the quality of our registrations on diverse data. We demonstrate the robustness and generalizability of our model with in-the-wild face scans across different modalities, sensor types, and resolutions. Finally, we show that, by learning to register scans, SMF produces a hybrid linear and non-linear morphable model. Manipulation of the latent space of SMF allows for shape generation, and morphing applications such as expression transfer in-the-wild. We train SMF on a dataset of human faces comprising 9 large-scale databases on commodity hardware.

scholarly journals A Novel Method Facilitating the Simple and Low-Cost Preparation of Human Osteochondral Slice Explants for Large-Scale Native Tissue Analysis

2021 ◽  
Vol 22 (12) ◽  
pp. 6394
Author(s):  
Jacob Spinnen ◽  
Lennard K. Shopperly ◽  
Carsten Rendenbach ◽  
Anja A. Kühl ◽  
Ufuk Sentürk ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Viability ◽  
Large Scale ◽  
Marker Gene ◽  
Cell Swelling ◽  
Tissue Cell ◽  
Joint Research ◽  
Sample Number ◽  
Tnf Α ◽  
Novel Method

For in vitro modeling of human joints, osteochondral explants represent an acceptable compromise between conventional cell culture and animal models. However, the scarcity of native human joint tissue poses a challenge for experiments requiring high numbers of samples and makes the method rather unsuitable for toxicity analyses and dosing studies. To scale their application, we developed a novel method that allows the preparation of up to 100 explant cultures from a single human sample with a simple setup. Explants were cultured for 21 days, stimulated with TNF-α or TGF-β3, and analyzed for cell viability, gene expression and histological changes. Tissue cell viability remained stable at >90% for three weeks. Proteoglycan levels and gene expression of COL2A1, ACAN and COMP were maintained for 14 days before decreasing. TNF-α and TGF-β3 caused dose-dependent changes in cartilage marker gene expression as early as 7 days. Histologically, cultures under TNF-α stimulation showed a 32% reduction in proteoglycans, detachment of collagen fibers and cell swelling after 7 days. In conclusion, thin osteochondral slice cultures behaved analogously to conventional punch explants despite cell stress exerted during fabrication. In pharmacological testing, both the shorter diffusion distance and the lack of need for serum in the culture suggest a positive effect on sensitivity. The ease of fabrication and the scalability of the sample number make this manufacturing method a promising platform for large-scale preclinical testing in joint research.

scholarly journals A Novel Method for the Preparation of Fibrous CeO2–ZrO2–Y2O3 Compacts for Thermochemical Cycles

Crystals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 885
Author(s):  
Nicole Knoblauch ◽  
Peter Mechnich
Keyword(s):  
Large Scale ◽  
Preparation Method ◽  
Cost Effective ◽  
High Porosity ◽  
Thermochemical Cycles ◽  
Redox Cycles ◽  
Redox Kinetics ◽  
Direct Infiltration ◽  
Novel Method ◽  
Functional Components

Zirconium-Yttrium-co-doped ceria (Ce0.85Zr0.13Y0.02O1.99) compacts consisting of fibers with diameters in the range of 8–10 µm have been successfully prepared by direct infiltration of commercial YSZ fibers with a cerium oxide matrix and subsequent sintering. The resulting chemically homogeneous fiber-compacts are sinter-resistant up to 1923 K and retain a high porosity of around 58 vol% and a permeability of 1.6–3.3 × 10−10 m² at a pressure gradient of 100–500 kPa. The fiber-compacts show a high potential for the application in thermochemical redox cycling due its fast redox kinetics. The first evaluation of redox kinetics shows that the relaxation time of oxidation is five times faster than that of dense samples of the same composition. The improved gas exchange due to the high porosity also allows higher reduction rates, which enable higher hydrogen yields in thermochemical water-splitting redox cycles. The presented cost-effective fiber-compact preparation method is considered very promising for manufacturing large-scale functional components for solar-thermal high-temperature reactors.

scholarly journals A novel method for the analytical solution of fractional Zakharov–Kuznetsov equations

2019 ◽  
Vol 2019 (1) ◽  
Author(s):  
Rasool Shah ◽  
Hassan Khan ◽  
Dumitru Baleanu ◽  
Poom Kumam ◽  
Muhammad Arif
Keyword(s):  
Present Method ◽  
Decomposition Method ◽  
Fractional Derivatives ◽  
Adomian Decomposition Method ◽  
Current Method ◽  
Analytical Technique ◽  
Suggested Technique ◽  
Adomian Decomposition ◽  
Novel Method ◽  
The Given

AbstractIn this article, an efficient analytical technique, called Laplace–Adomian decomposition method, is used to obtain the solution of fractional Zakharov– Kuznetsov equations. The fractional derivatives are described in terms of Caputo sense. The solution of the suggested technique is represented in a series form of Adomian components, which is convergent to the exact solution of the given problems. Furthermore, the results of the present method have shown close relations with the exact approaches of the investigated problems. Illustrative examples are discussed, showing the validity of the current method. The attractive and straightforward procedure of the present method suggests that this method can easily be extended for the solutions of other nonlinear fractional-order partial differential equations.

scholarly journals Using Sentinel-2 Images to Estimate Topography, Tidal-Stage Lags and Exposure Periods over Large Intertidal Areas

2021 ◽  
Vol 13 (2) ◽  
pp. 320
Author(s):  
José P. Granadeiro ◽  
João Belo ◽  
Mohamed Henriques ◽  
João Catalão ◽  
Teresa Catry
Keyword(s):  
Large Scale ◽  
Exposure Period ◽  
Intertidal Area ◽  
Digital Elevation ◽  
Geographical Bias ◽  
Novel Method ◽  
Tidal Stage ◽  
Sentinel 2

Intertidal areas provide key ecosystem services but are declining worldwide. Digital elevation models (DEMs) are important tools to monitor the evolution of such areas. In this study, we aim at (i) estimating the intertidal topography based on an established pixel-wise algorithm, from Sentinel-2 MultiSpectral Instrument scenes, (ii) implementing a set of procedures to improve the quality of such estimation, and (iii) estimating the exposure period of the intertidal area of the Bijagós Archipelago, Guinea-Bissau. We first propose a four-parameter logistic regression to estimate intertidal topography. Afterwards, we develop a novel method to estimate tide-stage lags in the area covered by a Sentinel-2 scene to correct for geographical bias in topographic estimation resulting from differences in water height within each image. Our method searches for the minimum differences in height estimates obtained from rising and ebbing tides separately, enabling the estimation of cotidal lines. Tidal-stage differences estimated closely matched those published by official authorities. We re-estimated pixel heights from which we produced a model of intertidal exposure period. We obtained a high correlation between predicted and in-situ measurements of exposure period. We highlight the importance of remote sensing to deliver large-scale intertidal DEM and tide-stage data, with relevance for coastal safety, ecology and biodiversity conservation.

scholarly journals An evolutionary approach to the vehicle route planning in e-waste mobile collection on demand

2021 ◽  
Vol 25 (8) ◽  
pp. 6665-6680
Author(s):  
Krzysztof Szwarc ◽  
Piotr Nowakowski ◽  
Urszula Boryczka
Keyword(s):  
Tabu Search ◽  
Quality Evaluation ◽  
Memetic Algorithm ◽  
Route Planning ◽  
Memetic Algorithms ◽  
Approximate Methods ◽  
On Demand ◽  
Suboptimal Solutions ◽  
Novel Method ◽  
The Given

AbstractThe article discusses the utilitarian problem of the mobile collection of waste electrical and electronic equipment. Due to its $$\mathcal {NP}$$ NP -hard nature, implies the application of approximate methods to discover suboptimal solutions in an acceptable time. The paper presents the proposal of a novel method of designing the Evolutionary and Memetic Algorithms, which determine favorable route plans. The recommended methods are determined using quality evaluation indicators for the techniques applied herein, subject to the limits characterizing the given company. The proposed Memetic Algorithm with Tabu Search provides much better results than the metaheuristics described in the available literature.

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