scholarly journals A Lamping U-Shaped Fiber Biosensor Detector for MicroRNA

Sensors ◽  
2020 ◽  
Vol 20 (5) ◽  
pp. 1509
Author(s):  
Hsin-Yi Wen ◽  
Chun-Wei Huang ◽  
Yu-Le Li ◽  
Jing-Luen Chen ◽  
Yao-Tsung Yeh ◽  
...  
Keyword(s):  
Optical Fiber ◽  
Silicon Dioxide ◽  
Self Assembly ◽  
Transmission Loss ◽  
Limit Of Detection ◽  
Fiber Surface ◽  
Coefficient Of Determination ◽  
Wavelength Shift ◽  
Good Sensitivity ◽  
Microrna Detection

This study presents a U-shaped optical fiber developed for a facile application of microRNA detection. It is fabricated by the lamping process and packaged in a quartz tube to eliminate human negligence. In addition, silanization and electrostatic self-assembly are employed to bind gold nanoparticles and miRNA-133a probe onto the silicon dioxide of the fiber surface. For Mahlavu of hepatocellular carcinoma (HCC), detection is determined by the wavelength shift and transmission loss of a U-shaped optical fiber biosensor. The spectral sensitivity of wavelength and their coefficient of determination are found at −218.319 nm/ ng/mL and 0.839, respectively. Concurrently, the sensitivity of transmission loss and their coefficient of determination are found at 162.394 dB/ ng/mL and 0.984, respectively. A method for estimating the limit of detection of Mahlavu is at 0.0133 ng/mL. The results show that the proposed U-shaped biosensor is highly specific to miRNA-133a and possesses good sensitivity to variations in specimen concentration. As such, it could be of substantial value in microRNA detection.

scholarly journals A Miniature pH Probe Using Functional Microfiber Bragg Grating

Optics ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 202-212 ◽  
Author(s):  
Yang Ran ◽  
Peng Xiao ◽  
Yongkang Zhang ◽  
Deming Hu ◽  
Zhiyuan Xu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Ph Sensor ◽  
Fiber Surface ◽  
Bragg Grating ◽  
Wavelength Shift ◽  
Layer By Layer ◽  
Compact Size ◽  
Layer Technique ◽  
Order Of Magnitude ◽  
Ph Probes

Operando and precisely probing aqueous pH is fundamentally demanded, both in chemical and biological areas. Conventional pH probes, subjected to the larger size, are probably unfit for application in some extreme scenarios, such as a trace amount of samples. In this paper, we have further developed the pH sensor that leverages the microfiber Bragg grating with an ultra-compact size down to an order of magnitude of 10−14 m3. Using the electrostatic self-assembly layer-by-layer technique, the functional film consisting of sodium alginate, which harnesses a pH-dependent hygroscopicity, is immobilized on the fiber surface. Consequently, the alteration of aqueous pH could be quantitatively indicated by the wavelength shift of the grating resonance via the refractive index variation of the sensing film due to the water absorption or expulsion. The grating reflections involving fundamental mode and higher order mode exhibit the sensitivities of −72 pm/pH and −265 pm/pH, respectively. In addition, temperature compensation can be facilitated by the recording of the two reflections simultaneously. Furthermore, the modeling and simulation results predict the pivotal parameters of the configuration in sensitivity enhancement. The proposed proof-of-concept enriches the toolbox of pH sensor for catering to the need of detection in some extremely small spaces—for example, the living cells or the bio-tissues.

scholarly journals PfHRP2 detection using plasmonic optrodes: performance analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Médéric Loyez ◽  
Mathilde Wells ◽  
Stéphanie Hambÿe ◽  
François Hubinon ◽  
Bertrand Blankert ◽  
...  
Keyword(s):  
Optical Fiber ◽  
Limit Of Detection ◽  
Fiber Surface ◽  
Malaria Diagnosis ◽  
High Sensitivity ◽  
Cost Effective ◽  
Label Free ◽  
Multiple Receptors ◽  
Label Free Detection

Abstract Background Early malaria diagnosis and its profiling require the development of new sensing platforms enabling rapid and early analysis of parasites in blood or saliva, aside the widespread rapid diagnostic tests (RDTs). Methods This study shows the performance of a cost-effective optical fiber-based solution to target the presence of Plasmodium falciparum histidine-rich protein 2 (PfHRP2). Unclad multimode optical fiber probes are coated with a thin gold film to excite Surface Plasmon Resonance (SPR) yielding high sensitivity to bio-interactions between targets and bioreceptors grafted on the metal surface. Results Their performances are presented in laboratory conditions using PBS spiked with growing concentrations of purified target proteins and within in vitro cultures. Two probe configurations are studied through label-free detection and amplification using secondary antibodies to show the possibility to lower the intrisic limit of detection. Conclusions As malaria hits millions of people worldwide, the improvement and multiplexing of this optical fiber technique can be of great interest, especially for a future purpose of using multiple receptors on the fiber surface or several coated-nanoparticles as amplifiers.

scholarly journals Hybrid Integrated Nanophotonic Silicon-based Structures

2019 ◽  
Vol 29 (4) ◽  
pp. 481
Author(s):  
Thi Hong Cam Hoang ◽  
Thanh Binh Pham ◽  
Thuy Van Nguyen ◽  
Van Dai Pham ◽  
Huy Bui ◽  
...  
Keyword(s):  
Optical Fiber ◽  
Fiber Laser ◽  
Limit Of Detection ◽  
Signal To Noise Ratio ◽  
Optical Signal ◽  
Integrated System ◽  
Laser Structure ◽  
Wavelength Shift ◽  
On Chip ◽  
Silicon Based

We report nanophotonic silicon-based devices for hybrid integration: 1D photonic crystal (PhC) on optical fiber, i. e. fiber Bragg grating (FBG) sensing probe integrated in fiber laser structure for chemical sensors and slotted planar 2D PhC cavity combined with carbon nanotube (CNT) towards light nanosources. The experiments have been carried out by integrating 1D PhC on optical fiber in fiber laser structure. This structure possesses many advantages including high resolution for wavelength shift, high optical signal-to-noise ratio (OSNR) of about 50~dB, the small full width at half-maximum (FWHM) of about 0.014~nm therefore its accuracy is enhanced, as well as the precision and capability are achieved for remote sensing. Low nitrate concentration in water from 0 to 80 ppm has been used to demonstrate its sensing ability in the experiment. The proposed sensor can work with good repeatability, rapid response, and its sensitivity can be obtained of \(3.2\times 10^{ - 3}\) nm/ppm with the limit of detection (LOD) of 3~ppm. For 2D PhC cavity, enhancement of photoluminescence of CNT emission is observed. The semiconducting single-walled carbon nanotubes (s-SWNTs) solution was prepared by polymer-sorted method and coupled with the confined modes in silicon slotted PhC cavities. The enhancement ratio of 1.15 is obtained by comparing between the PL peaks at two confined modes of the cavity. The PL enhancement result of the integrated system shows the potential for the realization of on-chip nanoscale sources.

scholarly journals Nano- and Micropatterning on Optical Fibers by Bottom-Up Approach: The Importance of Being Ordered

2021 ◽  
Vol 11 (7) ◽  
pp. 3254
Author(s):  
Marco Pisco ◽  
Francesco Galeotti
Keyword(s):  
Optical Fiber ◽  
Optical Fibers ◽  
Self Assembly ◽  
Ordered Structures ◽  
Bottom Up ◽  
Photonic Structures ◽  
Fiber Technology ◽  
Optical Fiber Probes ◽  
Fiber Probes ◽  
Self Assembled

The realization of advanced optical fiber probes demands the integration of materials and structures on optical fibers with micro- and nanoscale definition. Although researchers often choose complex nanofabrication tools to implement their designs, the migration from proof-of-principle devices to mass production lab-on-fiber devices requires the development of sustainable and reliable technology for cost-effective production. To make it possible, continuous efforts are devoted to applying bottom-up nanofabrication based on self-assembly to decorate the optical fiber with highly ordered photonic structures. The main challenges still pertain to “order” attainment and the limited number of implementable geometries. In this review, we try to shed light on the importance of self-assembled ordered patterns for lab-on-fiber technology. After a brief presentation of the light manipulation possibilities concerned with ordered structures, and of the new prospects offered by aperiodically ordered structures, we briefly recall how the bottom-up approach can be applied to create ordered patterns on the optical fiber. Then, we present un-attempted methodologies, which can enlarge the set of achievable structures, and can potentially improve the yielding rate in finely ordered self-assembled optical fiber probes by eliminating undesired defects and increasing the order by post-processing treatments. Finally, we discuss the available tools to quantify the degree of order in the obtained photonic structures, by suggesting the use of key performance figures of merit in order to systematically evaluate to what extent the pattern is really “ordered”. We hope such a collection of articles and discussion herein could inspire new directions and hint at best practices to fully exploit the benefits inherent to self-organization phenomena leading to ordered systems.

scholarly journals Gold-nanourchin complexed silicon dioxide-probe on gap-fingered interdigitated electrode surface for Parkinson’s Disease determination by current–volt measurement

2021 ◽  
Vol 11 ◽  
pp. 184798042098735
Author(s):  
Xiaohong Li ◽  
Wei Shi ◽  
Wenyan Zhang ◽  
Weiyao Chen ◽  
Dan Cao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Silicon Dioxide ◽  
Limit Of Detection ◽  
Detection System ◽  
Interdigitated Electrode ◽  
Limit Of Quantification ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Detection Range

Parkinson’s disease (PD) is a nervous disorder, affects physical movement, and leads to difficulty in balancing, walking, and coordination. A novel sensor is mandatory to determine PD and monitor the progress of the treatment. Neurofilament light chain (NfL) has been recognized as a good biomarker for PD and also helps to distinguish between PD and atypical PD syndromes. Immunosensor was generated by current–volt measurement on gap-fingered interdigitated electrode with silicon dioxide surface to determine NfL level. To enhance the detection, anti-NfL antibody was complexed with gold-nanourchin and immobilized on the sensing electrode. The current–volt response was gradually increased at the linear detection range from 100 fM to 1 nM. Limit of detection and sensitivity were 100 fM with the signal-to-noise ratio at n = 3 on a linear curve ( y = 0.081 x + 1.593; R 2 = 0.9983). Limit of quantification falls at 1 pM and high performance of the sensor was demonstrated by discriminating against other neurogenerative disease markers, in addition, it was reproducible even in serum-spiked samples. This method of detection system aids to measure the level of NfL and leads to determine the condition with PD.

Development of an Optical Fiber Sensor with a D-shaped Fiber Bragg Grating Integrated in a Loop-mirror Optical Fiber Laser as a High Sensitivity Refractometer

2021 ◽  
Vol 32 ◽  
Author(s):  
Binh Pham Thanh ◽  
Thuy Van Nguyen ◽  
Van Hoi Pham ◽  
Huy Bui ◽  
Thi Hong Cam Hoang ◽  
...  
Keyword(s):  
Refractive Index ◽  
Optical Fiber ◽  
Fiber Laser ◽  
Fiber Bragg Grating ◽  
Limit Of Detection ◽  
Optical Fiber Sensor ◽  
High Sensitivity ◽  
Optical Signal ◽  
Bragg Grating ◽  
Loop Mirror

In this paper, we report a new type of refractometer based on a D-shaped fiber Bragg grating (FBG) integrated in a loop-mirror optical fiber laser. This proposed sensor is used in wavelength interrogation method, in which the D-shaped FBG is applied as a refractive index (RI) sensing probe and a mirror to select mode of laser. The D-shaped FBG is prepared by the removal of a portion of the fiber cladding covering the FBG by means of side-polishing technique. The D-shaped FBG sensing probe integrated in a loop-mirror optical fiber laser with saturated pump technique, the characteristics of sensing signals have been improved to obtain stable intensity, narrower bandwidth and higher optical signal-to-noise ratio compare to normal reflection configuration. The limit of detection (LOD) of this sensor can be achieved to 2.95 x 10-4 RIU in the refractive index (RI) range of 1.42-1.44. Accordingly, we believe that the proposed refractometer has a huge potential for applications in biochemical-sensing technique.

Highly sensitive refractive index sensor for detection of Hg2+ based on Fano-like resonance in metal-dielectric-metal meta-structure

2021 ◽  
Author(s):  
Shuangxiu Yuan ◽  
Xuebo Sun ◽  
Jing Li ◽  
Yan Li ◽  
Fufang Su ◽  
...  
Keyword(s):  
Refractive Index ◽  
Limit Of Detection ◽  
Wavelength Shift ◽  
Refractive Index Sensor ◽  
Large Area ◽  
Amount Of Substance ◽  
Resonance Modes ◽  
Dipole Resonance ◽  
Highly Sensitive ◽  
Fabry Perot

Abstract We experimentally and theoretically investigate Fano-like resonance in large-area Au/SiO2/Au nano-patches meta-structure, which is originating from the coupling between Fabry Perot resonance and magnetic dipole resonance modes. A highly sensitive refractive index sensor based on the lineshape analysis is obtained. The extracted wavelength shift with the amount of substance of Hg2+ changing from 10-3 pmol to 1 nmol has a linear dependence, and the sensitivity can reach to ultra-low limit of detection (LOD) as 10-3 pmol. This study may provide an approach for the development and modification in sensing.

Heat Transfer in Chemical Vapor Deposited Optical Fiber Coatings

2001 ◽  
Author(s):  
Patricia O. Iwanik ◽  
Wilson K. S. Chiu
Keyword(s):  
Heat Transfer ◽  
Optical Fiber ◽  
Gas Flow ◽  
Convection Heat Transfer ◽  
Fiber Surface ◽  
Chemical Vapor ◽  
Temperature Changes ◽  
Flow And Heat Transfer ◽  
Chemical Vapor Deposited ◽  
Fiber Coatings

Abstract A fundamental understanding of how reactor parameters influence the fiber surface temperature is essential to manufacturing high quality optical fiber coatings by chemical vapor deposition (CVD). In an attempt to better understand this process, a finite volume model has been developed to study the gas flow and heat transfer of an optical fiber as it travels through a CVD reactor. This study showed that draw speed significantly affects fiber temperature inside the reactor, with temperature changes up to 45% observed under the conditions studied. Multiple heat transfer modes contribute to this phenomena, with convection heat transfer dominating the process.

Theoretical Analysis of Sensitivity Enhancement by Graphene Usage in Optical Fiber Surface Plasmon Resonance Sensors

2019 ◽  
Vol 68 (5) ◽  
pp. 1554-1560 ◽  
Author(s):  
Arthur Aprigio de Melo ◽  
Talita Brito da Silva ◽  
Marcia Fernanda da Silva Santiago ◽  
Cleumar da Silva Moreira ◽  
Rossana Moreno Santa Cruz
Keyword(s):  
Surface Plasmon Resonance ◽  
Theoretical Analysis ◽  
Optical Fiber ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Fiber Surface ◽  
Sensitivity Enhancement ◽  
Surface Plasmon Resonance Sensors
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