scholarly journals Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

Sensors ◽  
2020 ◽  
Vol 20 (3) ◽  
pp. 646 ◽  
Author(s):  
Munezza Ata Khan ◽  
Mohammad Mujahid
Keyword(s):  
Interleukin 6 ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
High Specificity ◽  
Detection Methods ◽  
Optical Biosensors ◽  
Integrated Electronics ◽  
Life Threatening ◽  
And Performance ◽  
Commercial Applications

Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.

scholarly journals Detectivity optimization to detect of ultraweak light fluxes with an EM-CCD as binary photon counter array

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ibtissame Khaoua ◽  
Guillaume Graciani ◽  
Andrey Kim ◽  
François Amblard
Keyword(s):  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Photon Counting ◽  
Detection Methods ◽  
Strong Nonlinearity ◽  
Wide Range ◽  
Depth Analysis ◽  
Spatially Extended ◽  
Extended Sources ◽  
Photon Counting Mode

AbstractFor a wide range of purposes, one faces the challenge to detect light from extremely faint and spatially extended sources. In such cases, detector noises dominate over the photon noise of the source, and quantum detectors in photon counting mode are generally the best option. Here, we combine a statistical model with an in-depth analysis of detector noises and calibration experiments, and we show that visible light can be detected with an electron-multiplying charge-coupled devices (EM-CCD) with a signal-to-noise ratio (SNR) of 3 for fluxes less than $$30\,{\text{photon}}\,{\text{s}}^{ - 1} \,{\text{cm}}^{ - 2}$$ 30 photon s - 1 cm - 2 . For green photons, this corresponds to 12 aW $${\text{cm}}^{ - 2}$$ cm - 2 ≈ $$9{ } \times 10^{ - 11}$$ 9 × 10 - 11 lux, i.e. 15 orders of magnitude less than typical daylight. The strong nonlinearity of the SNR with the sampling time leads to a dynamic range of detection of 4 orders of magnitude. To detect possibly varying light fluxes, we operate in conditions of maximal detectivity $${\mathcal{D}}$$ D rather than maximal SNR. Given the quantum efficiency $$QE\left( \lambda \right)$$ Q E λ of the detector, we find $${ \mathcal{D}} = 0.015\,{\text{photon}}^{ - 1} \,{\text{s}}^{1/2} \,{\text{cm}}$$ D = 0.015 photon - 1 s 1 / 2 cm , and a non-negligible sensitivity to blackbody radiation for T > 50 °C. This work should help design highly sensitive luminescence detection methods and develop experiments to explore dynamic phenomena involving ultra-weak luminescence in biology, chemistry, and material sciences.

scholarly journals The 1.3mm Full-Stokes Polarization System at CARMA

2015 ◽  
Vol 04 (01n02) ◽  
pp. 1550005 ◽  
Author(s):  
Charles L. H. Hull ◽  
Richard L. Plambeck
Keyword(s):  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Position Angle ◽  
Low Noise ◽  
Low Noise Amplifiers ◽  
Beam Polarization ◽  
Circular Polarizer ◽  
Angle Measurements ◽  
Millimeter Wavelengths ◽  
And Performance

The CARMA 1.3[Formula: see text]mm polarization system consists of dual-polarization receivers that are sensitive to right- (R) and left-circular (L) polarization, and a spectral-line correlator that measures all four cross polarizations ([Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text]) on each of the 105 baselines connecting the 15 telescopes. Each receiver comprises a single feed horn, a waveguide circular polarizer, an orthomode transducer (OMT), two heterodyne mixers, and two low-noise amplifiers (LNAs), all mounted in a cryogenically cooled dewar. Here we review the basics of polarization observations, describe the construction and performance of key receiver components (circular polarizer, OMT, and mixers — but not the correlator), and discuss in detail the calibration of the system, particularly the calibration of the R–L phase offsets and the polarization leakage corrections. The absolute accuracy of polarization position angle measurements was checked by mapping the radial polarization pattern across the disk of Mars. Transferring the Mars calibration to the well-known polarization calibrator 3C286, we find a polarization position angle of [Formula: see text] for 3C286 at 225[Formula: see text]GHz, consistent with other observations at millimeter wavelengths. Finally, we consider what limitations in accuracy are expected due to the signal-to-noise ratio, dynamic range, and primary beam polarization.

Comparative Study of Photovoltaic and Photoconductive Detection Methods for Liquid-Phase Photoionization

1994 ◽  
Vol 48 (9) ◽  
pp. 1102-1110 ◽  
Author(s):  
John W. Judge ◽  
Victoria L. McGuffin
Keyword(s):  
Liquid Phase ◽  
Dynamic Range ◽  
Laser Pulse Energy ◽  
Signal To Noise Ratio ◽  
Solute Concentration ◽  
Separation Distance ◽  
Detection Methods ◽  
Linear Dynamic Range ◽  
Polar Solvents ◽  
Linear Dynamic

The photovoltaic method for the detection of liquid-phase photoionization in the absence of an applied electric field is compared to the traditional photoconductive method. Each system is characterized by means of signal and signal-to-noise ratio measurements with respect to laser pulse energy, applied voltage, electrode separation distance, solute concentration, and solvent composition. Although both techniques exhibit similar detection limits (1 × 10−7 M) for solutes in polar solvents such as methanol and water, the photovoltaic technique has a more extensive linear dynamic range (103). Moreover, this technique allows detection of solutes in ionic solutions with comparable detectability and linearity.

An Over 120dB Dynamic Range Linear Response Single Exposure CMOS Image Sensor with Two-stage Lateral Overflow Integration Trench Capacitors

2020 ◽  
Vol 2020 (7) ◽  
pp. 143-1-143-6 ◽  
Author(s):  
Yasuyuki Fujihara ◽  
Maasa Murata ◽  
Shota Nakayama ◽  
Rihito Kuroda ◽  
Shigetoshi Sugawa
Keyword(s):  
Linear Response ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Cmos Image Sensor ◽  
Image Sensor ◽  
Signal To Noise ◽  
Single Exposure ◽  
Two Stage ◽  
Noise Ratio ◽  
Maximum Signal

This paper presents a prototype linear response single exposure CMOS image sensor with two-stage lateral overflow integration trench capacitors (LOFITreCs) exhibiting over 120dB dynamic range with 11.4Me- full well capacity (FWC) and maximum signal-to-noise ratio (SNR) of 70dB. The measured SNR at all switching points were over 35dB thanks to the proposed two-stage LOFITreCs.

Enhancements of Non-contact Measurements of Electrical Waveforms on the Proximity of a Signal Surface Using Groups of Pulses

2002 ◽  
Author(s):  
Fenglei Du ◽  
Greg Bridges ◽  
D.J. Thomson ◽  
Rama R. Goruganthu ◽  
Shawn McBride ◽  
...  
Keyword(s):  
Integrated Circuits ◽  
Integrated Circuit ◽  
Signal To Noise Ratio ◽  
Electrostatic Force ◽  
Single Pulse ◽  
Electric Signal ◽  
Measurement Instruments ◽  
Cycle Times ◽  
Force Microscopy ◽  
And Performance

Abstract With the ever-increasing density and performance of integrated circuits, non-invasive, accurate, and high spatial and temporal resolution electric signal measurement instruments hold the key to performing successful diagnostics and failure analysis. Sampled electrostatic force microscopy (EFM) has the potential for such applications. It provides a noninvasive approach to measuring high frequency internal integrated circuit signals. Previous EFMs operate using a repetitive single-pulse sampling approach and are inherently subject to the signal-to-noise ratio (SNR) problems when test pattern duty cycle times become large. In this paper we present an innovative technique that uses groups of pulses to improve the SNR of sampled EFM systems. The approach can easily provide more than an order-ofmagnitude improvement to the SNR. The details of the approach are presented.

scholarly journals Food Allergen Detection Methods: A Coordinated Approach

2004 ◽  
Vol 87 (6) ◽  
pp. 1383-1390 ◽  
Author(s):  
Philip R Goodwin
Keyword(s):  
Hazard Analysis ◽  
Adult Population ◽  
Control Point ◽  
Cost Effective ◽  
Test Methods ◽  
Detection Methods ◽  
Critical Control Point ◽  
Life Threatening ◽  
Monitoring And Surveillance ◽  
Analytical Approaches

Abstract The levels (1–2%) and increasing severity of allergic responses to food in the adult population are well documented, as is the phenomenon of even higher (3–8%) and apparently increasing incidence in children, albeit that susceptibility decreases with age. Problematic foods include peanut, milk, eggs, tree nuts, and sesame, but the list is growing as awareness continues to rise. The amounts of such foods that can cause allergic reactions is difficult to gauge; however, the general consensus is that ingestion of low parts per million is sufficient to cause severe reactions in badly affected individuals. Symptoms can rapidly—within minutes—progress from minor discomfort to severe, even life-threatening anaphylactic shock in those worst affected. Given the combination of high incidence of atopy, potential severity of response, and apparently widespread instances of “hidden” allergens in the food supply, it is not surprising that this issue is increasingly subject to legislative and regulatory scrutiny. In order to assist in the control of allergen levels in foods to acceptable levels, analysts require a combination of test methods, each designed to produce accurate, timely, and cost-effective analytical information. Such information contributes significantly to Hazard Analysis Critical Control Point programs to determine food manufacturers’ risk and improves the accuracy of monitoring and surveillance by food industry, commercial, and enforcement laboratories. Analysis thereby facilitates improvements in compliance with labeling laws with concomitant reductions in risks to atopic consumers. This article describes a combination of analytical approaches to fulfill the various needs of these 3 analytical communities.

scholarly journals Evaluating effects of focal length and viewing angle in a comparison of recent face landmark and alignment methods

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Xiang Li ◽  
Jianzheng Liu ◽  
Jessica Baron ◽  
Khoa Luu ◽  
Eric Patterson
Keyword(s):  
Focal Length ◽  
Ground Truth ◽  
Detection Methods ◽  
Viewing Angle ◽  
Deep Convolutional Neural Networks ◽  
Landmark Detection ◽  
High Performing ◽  
Detection Techniques ◽  
And Performance ◽  
Lens Focal Length

AbstractRecent attention to facial alignment and landmark detection methods, particularly with application of deep convolutional neural networks, have yielded notable improvements. Neither these neural-network nor more traditional methods, though, have been tested directly regarding performance differences due to camera-lens focal length nor camera viewing angle of subjects systematically across the viewing hemisphere. This work uses photo-realistic, synthesized facial images with varying parameters and corresponding ground-truth landmarks to enable comparison of alignment and landmark detection techniques relative to general performance, performance across focal length, and performance across viewing angle. Recently published high-performing methods along with traditional techniques are compared in regards to these aspects.

Weak Transient Electromagnetic Radiation Signal Detection Method Considering the New Watershed Image Segmentation Algorithm

2019 ◽  
Vol 34 (03) ◽  
pp. 2054009
Author(s):  
Wenjun Huo ◽  
Peng Chu ◽  
Kai Wang ◽  
Liangting Fu ◽  
Zhigang Niu ◽  
...  
Keyword(s):  
Electromagnetic Radiation ◽  
Cross Correlation ◽  
Detection Efficiency ◽  
Signal To Noise Ratio ◽  
Estimation Method ◽  
Detection Methods ◽  
Signal To Noise ◽  
Long Distance ◽  
Transient Electromagnetic ◽  
Noise Ratio

In order to study the detection methods of weak transient electromagnetic radiation signals, a detection algorithm integrating generalized cross-correlation and chaotic sequence prediction is proposed in this paper. Based on the dual-antenna test and cross-correlation information estimation method, the detection of aperiodic weak discharge signals under low signal-to-noise ratio is transformed into the estimation of periodic delay parameters, and the noise is reduced at the same time. The feasibility of this method is verified by simulation and experimental analysis. The results show that under the condition of low signal-to-noise ratio, the integrated method can effectively suppress the influence of 10 noise disturbances. It has a high detection probability for weak transient electromagnetic radiation signals, and needs fewer pulse accumulation times, which improves the detection efficiency and is more suitable for long-distance detection of weak electromagnetic radiation sources.

scholarly journals Ab initiostructure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector

2016 ◽  
Vol 72 (2) ◽  
pp. 236-242 ◽  
Author(s):  
E. van Genderen ◽  
M. T. B. Clabbers ◽  
P. P. Das ◽  
A. Stewart ◽  
I. Nederlof ◽  
...  
Keyword(s):  
Electron Diffraction ◽  
Room Temperature ◽  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Three Dimensional ◽  
Direct Methods ◽  
Liquid Nitrogen Temperature ◽  
High Dynamic Range ◽  
Electron Diffraction Data ◽  
High Signal

Until recently, structure determination by transmission electron microscopy of beam-sensitive three-dimensional nanocrystals required electron diffraction tomography data collection at liquid-nitrogen temperature, in order to reduce radiation damage. Here it is shown that the novel Timepix detector combines a high dynamic range with a very high signal-to-noise ratio and single-electron sensitivity, enablingab initiophasing of beam-sensitive organic compounds. Low-dose electron diffraction data (∼0.013 e− Å−2 s−1) were collected at room temperature with the rotation method. It was ascertained that the data were of sufficient quality for structure solution using direct methods using software developed for X-ray crystallography (XDS,SHELX) and for electron crystallography (ADT3D/PETS,SIR2014).

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