scholarly journals Multi-Site Photoplethysmographic and Electrocardiographic System for Arterial Stiffness and Cardiovascular Status Assessment

Sensors ◽  
2019 ◽  
Vol 19 (24) ◽  
pp. 5570 ◽  
Author(s):  
David Perpetuini ◽  
Antonio Maria Chiarelli ◽  
Lidia Maddiona ◽  
Sergio Rinella ◽  
Francesco Bianco ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Light Emitting Diode ◽  
Single Pulse ◽  
High Signal ◽  
Silicon Photomultiplier ◽  
Light Emitting ◽  
Status Assessment ◽  
Ecg Leads ◽  
Development And Validation

The development and validation of a system for multi-site photoplethysmography (PPG) and electrocardiography (ECG) is presented. The system could acquire signals from 8 PPG probes and 10 ECG leads. Each PPG probe was constituted of a light-emitting diode (LED) source at a wavelength of 940 nm and a silicon photomultiplier (SiPM) detector, located in a back-reflection recording configuration. In order to ensure proper optode-to-skin coupling, the probe was equipped with insufflating cuffs. The high number of PPG probes allowed us to simultaneously acquire signals from multiple body locations. The ECG provided a reference for single-pulse PPG evaluation and averaging, allowing the extraction of indices of cardiovascular status with a high signal-to-noise ratio. Firstly, the system was characterized on optical phantoms. Furthermore, in vivo validation was performed by estimating the brachial-ankle pulse wave velocity (baPWV), a metric associated with cardiovascular status. The validation was performed on healthy volunteers to assess the baPWV intra- and extra-operator repeatability and its association with age. Finally, the baPWV, evaluated via the developed instrumentation, was compared to that estimated with a commercial system used in clinical practice (Enverdis Vascular Explorer). The validation demonstrated the system’s reliability and its effectiveness in assessing the cardiovascular status in arterial ageing.

scholarly journals Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 725
Author(s):  
Saeyeong Jeon ◽  
Youjin Lee ◽  
Daeho Ryu ◽  
Yoon Kyung Cho ◽  
Yena Lee ◽  
...  
Keyword(s):  
Light Emitting Diode ◽  
Neural Recording ◽  
Electrophysiological Recording ◽  
Light Emitting ◽  
Technological Advances ◽  
Neuroscience Research ◽  
Cell Type Specific ◽  
Novel Design

During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.

scholarly journals High-speed high-resolution laser diode-based photoacoustic microscopy for in vivo microvasculature imaging

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Xiufeng Li ◽  
Victor T C Tsang ◽  
Lei Kang ◽  
Yan Zhang ◽  
Terence T W Wong
Keyword(s):  
High Resolution ◽  
High Speed ◽  
High Performance ◽  
Continuous Wave ◽  
Signal To Noise Ratio ◽  
Cost Effective ◽  
High Signal ◽  
Photoacoustic Microscopy ◽  
Mouse Ear

AbstractLaser diodes (LDs) have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy (PAM). However, the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized simultaneously. In this paper, we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD, operating at a pulsed mode, with a repetition rate of 30 kHz, as an excitation source. A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise ratio. By optimizing the optical system, a high lateral resolution of 4.8 μm has been achieved. In vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system.

scholarly journals In vitro and in vivo Efficacy of New Blue Light Emitting Diode Phototherapy Compared to Conventional Halogen Quartz Phototherapy for Neonatal Jaundice

2005 ◽  
Vol 20 (1) ◽  
pp. 61 ◽  
Author(s):  
Yun Sil Chang ◽  
Jong Hee Hwang ◽  
Hyuk Nam Kwon ◽  
Chang Won Choi ◽  
Sun Young Ko ◽  
...  
Keyword(s):  
Blue Light ◽  
Neonatal Jaundice ◽  
Light Emitting Diode ◽  
In Vivo Efficacy ◽  
Light Emitting

scholarly journals Methods for Voltage-Sensitive Dye Imaging of Rat Cortical Activity With High Signal-to-Noise Ratio

2007 ◽  
Vol 98 (1) ◽  
pp. 502-512 ◽  
Author(s):  
Michael T. Lippert ◽  
Kentaroh Takagaki ◽  
Weifeng Xu ◽  
Xiaoying Huang ◽  
Jian-Young Wu
Keyword(s):  
Dynamic Range ◽  
Signal To Noise Ratio ◽  
Field Potential ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
High Signal ◽  
Blue Dye ◽  
Voltage Sensitive Dye ◽  
Imaging Device

We describe methods to achieve high sensitivity in voltage-sensitive dye (VSD) imaging from rat barrel and visual cortices in vivo with the use of a blue dye RH1691 and a high dynamic range imaging device (photodiode array). With an improved staining protocol and an off-line procedure to remove pulsation artifact, the sensitivity of VSD recording is comparable with that of local field potential recording from the same location. With this sensitivity, one can record from ∼500 individual detectors, each covering an area of cortical tissue 160 μm in diameter (total imaging field ∼4 mm in diameter) and a temporal resolution of 1,600 frames/s, without multiple-trial averaging. We can record 80–100 trials of intermittent 10-s trials from each imaging field before the VSD signal reduces to one half of its initial amplitude because of bleaching and wash-out. Taken together, the methods described in this report provide a useful tool for visualizing evoked and spontaneous waves from rodent cortex.

scholarly journals Rationally Designing Simple Rod-Like Amphiphilic NIR-Emissive AIE Probes for Precise In-Vivo Detection of Aβ Fibrils/Plaques at A Super-Early Stage

2021 ◽  
Author(s):  
Yipu Wang ◽  
Dong Mei ◽  
Xinyi Zhang ◽  
Da-Hui Qu ◽  
Ju Mei ◽  
...  
Keyword(s):  
High Performance ◽  
Ex Vivo ◽  
Early Stage ◽  
Signal To Noise Ratio ◽  
High Signal ◽  
In Vivo Detection ◽  
Different Strains ◽  
Aβ Fibrils

With increase of social aging, Alzheimer's disease (AD) has been one of the serious diseases threatening human health. The occurrence of A<i>β </i>fibrils<i> </i>or plaques is recognized as the hallmark of AD.<i> </i>Currently, optical imaging has stood out to be a promising technique for the imaging of A<i>β</i> fibrils/plaques and the diagnosis of AD. However, restricted by their poor blood-brain barrier (BBB) penetrability, short-wavelength excitation and emission, and aggregation-caused quenching (ACQ) effect, the clinically used gold-standard optical probes such as <a>thioflavin</a> T (ThT) and thioflavin S (ThS), are not effective enough in the early diagnosis of AD <i>in vivo</i>. Herein, we put forward an “all-in-one” design principle and demonstrate its feasibility in developing high-performance fluorescent probes which are specific to A<i>β</i> fibrils/plaques and promising for super-early <i>in</i>-<i>vivo</i> diagnosis of AD. As a proof of concept, a simple rod-like amphiphilic NIR fluorescent AIEgen, i.e., AIE-CNPy-AD, is developed by taking the specificity, BBB penetration ability, deep-tissue penetration capacity, high signal-to-noise ratio (SNR) into consideration. AIE-CNPy-AD is constituted by connecting the electron-donating and accepting moieties through single bonds and tagging with a propanesulfonate tail, giving rise to the NIR fluorescence, aggregation-induced emission (AIE) effect, amphiphilicity, and rod-like structure, which in turn result in high binding-affinity and excellent specificity to A<i>β</i> fibrils/plaques, satisfactory ability to penetrate BBB and deep tissues, ultrahigh SNR and sensitivity, and high-fidelity imaging capability. <i>In-vitro, ex-vivo,</i> and <i>in-vivo</i> <a>identifying of A<i>β</i> fibrils/plaques</a> in different strains of mice indicate that AIE-CNPy-AD holds the universality to the detection of A<i>β</i> fibrils/plaques. It is noteworthy that AIE-CNPy-AD is even able to trace the small and sparsely distributed A<i>β</i> fibrils/plaques in very young AD model mice such as 4-month-old APP/PS1 mice which are reported to be the youngest mice to have A<i>β</i> deposits in brains, suggesting its great potential in diagnosis and intervention of AD at a super-early stage.

Retinal damage related to high-intensity light-emitting diode exposure: An in vivo study

2021 ◽  
Author(s):  
Marcela Emílio de Araújo ◽  
Marina Bozzini Paies ◽  
Ana Beatriz Arrais ◽  
Fernando Ladd Lobo ◽  
Ruthnaldo Rodrigues Melo de Lima ◽  
...  
Keyword(s):  
High Intensity ◽  
Light Emitting Diode ◽  
In Vivo Study ◽  
Retinal Damage ◽  
Light Emitting ◽  
High Intensity Light

scholarly journals A Full-Duplex LED-to-LED Visible Light Communication System

Electronics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1713
Author(s):  
Hyunwoo Jung ◽  
Sung-Man Kim
Keyword(s):  
Visible Light ◽  
Bit Error Rate ◽  
Error Rate ◽  
Signal To Noise Ratio ◽  
Light Emitting Diode ◽  
Visible Light Communication ◽  
Full Duplex ◽  
Signal To Noise ◽  
Light Emitting ◽  
Half Duplex

We experimentally demonstrated full-duplex light-emitting diode (LED)-to-LED visible light communication (VLC) using LEDs as the transmitter and receiver. Firstly, we investigated the performance dependency on the wavelengths of the LED transmitter and receiver by measuring the rise time and signal-to-noise ratio (SNR). Through the investigation, we were able to choose the optimal LED color set for LED-to-LED VLC using Shannon’s channel capacity law. The bit error rate (BER) results of full-duplex and half-duplex LED-to-LED VLC systems with the optimal LED sets are shown to compare the performance. Furthermore, we discuss major distortions and signal losses in the full-duplex LED-to-LED VLC system.

scholarly journals Reflectance-Based Organic Pulse Meter Sensor for Wireless Monitoring of Photoplethysmogram Signal

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 87 ◽  
Author(s):  
Fahed Elsamnah ◽  
Anubha Bilgaiyan ◽  
Muhamad Affiq ◽  
Chang-Hoon Shim ◽  
Hiroshi Ishidai ◽  
...  
Keyword(s):  
Power Consumption ◽  
Structural Design ◽  
Signal To Noise Ratio ◽  
Light Emitting Diode ◽  
Light Emitting ◽  
Organic Light Emitting Diode ◽  
Wireless Monitoring ◽  
Organic Light ◽  
Reduced Power Consumption

This paper compares the structural design of two organic biosensors that minimize power consumption in wireless photoplethysmogram (PPG) waveform monitoring. Both devices were fabricated on the same substrate with a red organic light-emitting diode (OLED) and an organic photodiode (OPD). Both were designed with a circular OLED at the center of the device surrounded by OPD. One device had an OLED area of 0.06 cm2, while the other device had half the area. The gap distance between the OLED and OPD was 1.65 mm for the first device and 2 mm for the second. Both devices had an OPD area of 0.16 cm2. We compared the power consumption and signal-to-noise ratio (SNR) of both devices and evaluated the PPG signal, which was successfully collected from a fingertip. The reflectance-based organic pulse meter operated successfully and at a low power consumption of 8 µW at 18 dB SNR. The device sent the PPG waveforms, via Bluetooth low energy (BLE), to a PC host at a maximum rate of 256 kbps data throughput. In the end, the proposed reflectance-based organic pulse meter reduced power consumption and improved long-term PPG wireless monitoring.

scholarly journals Transmitter and receiver technologies for optical wireless

2020 ◽  
Vol 378 (2169) ◽  
pp. 20190182 ◽  
Author(s):  
Dominic O'Brien ◽  
Sujan Rajbhandari ◽  
Hyunchae Chun
Keyword(s):  
State Of The Art ◽  
Signal To Noise Ratio ◽  
Light Emitting Diode ◽  
High Capacity ◽  
Electrical Signal ◽  
Dominant Factor ◽  
Optical Wireless ◽  
Theme Issue ◽  
Future Directions ◽  
Light Emitting

Providing a reliable link, with sufficient signal-to-noise ratio (SNR) and bandwidth to deliver high-capacity communications is a critical challenge for optical wireless (OW) communications and understanding and jointly optimizing the performance of the transmitter and receiver subsystems is a key part of this. At the transmitter a source of light, either a laser or a light-emitting diode, must be modulated with the communications signal. The resulting emission must be directed, using optics or steering systems, as required for the particular application, and must be within any safety levels set by relevant standards. The receiver is the most critical part of any optical link, as its design is a dominant factor in determining the received SNR, which determines the capacity and ultimately the utility of the link. A receiver must collect, filter and concentrate signal radiation, then detect and amplify the resulting electrical signal. This review surveys the state-of–the-art transmitter and receiver technologies. Details of design constraints are discussed, and potential future directions discussed. This article is part of the theme issue ‘Optical wireless communication’.

scholarly journals Real-Time Healthcare Data Transmission for Remote Patient Monitoring in Patch-Based Hybrid OCC/BLE Networks

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1208 ◽  
Author(s):  
Moh. Hasan ◽  
Md. Shahjalal ◽  
Mostafa Chowdhury ◽  
Yeong Jang
Keyword(s):  
Real Time ◽  
Light Emitting Diode ◽  
Health Condition ◽  
High Signal ◽  
Network Access ◽  
Light Emitting ◽  
Healthcare Data ◽  
Led Array ◽  
Access Request ◽  
Remote Patient

Research on electronic healthcare (eHealth) systems has increased dramatically in recent years. eHealth represents a significant example of the application of the Internet of Things (IoT), characterized by its cost effectiveness, increased reliability, and minimal human eff ort in nursing assistance. The remote monitoring of patients through a wearable sensing network has outstanding potential in current healthcare systems. Such a network can continuously monitor the vital health conditions (such as heart rate variability, blood pressure, glucose level, and oxygen saturation) of patients with chronic diseases. Low-power radio-frequency (RF) technologies, especially Bluetooth low energy (BLE), play significant roles in modern healthcare. However, most of the RF spectrum is licensed and regulated, and the effect of RF on human health is of major concern. Moreover, the signal-to-noise-plus-interference ratio in high distance can be decreased to a considerable extent, possibly leading to the increase in bit-error rate. Optical camera communication (OCC), which uses a camera to receive data from a light-emitting diode (LED), can be utilized in eHealth to mitigate the limitations of RF. However, OCC also has several limitations, such as high signal-blockage probability. Therefore, in this study, a hybrid OCC/BLE system is proposed to ensure efficient, remote, and real-time transmission of a patient’s electrocardiogram (ECG) signal to a monitor. First, a patch circuit integrating an LED array and BLE transmitter chip is proposed. The patch collects the ECG data according to the health condition of the patient to minimize power consumption. Second, a network selection algorithm is developed for a new network access request generated in the patch circuit. Third, fuzzy logic is employed to select an appropriate camera for data reception. Fourth, a handover mechanism is suggested to ensure efficient network allocation considering the patient’s mobility. Finally, simulations are conducted to demonstrate the performance and reliability of the proposed system.

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