scholarly journals Raman Sensing and Its Multimodal Combination with Optoacoustics and OCT for Applications in the Life Sciences

Sensors ◽  
2019 ◽  
Vol 19 (10) ◽  
pp. 2387 ◽  
Author(s):  
Merve Wollweber ◽  
Bernhard Roth
Keyword(s):  
Raman Spectroscopy ◽  
Optical Coherence Tomography ◽  
Medical Diagnosis ◽  
Life Sciences ◽  
Living Organism ◽  
Optical Coherence ◽  
Non Invasive ◽  
Multimodal Sensing ◽  
Spectroscopy Optical

Currently, many optical modalities are being investigated, applied, and further developed for non-invasive analysis and sensing in the life sciences. To befit the complexity of the study objects and questions in this field, the combination of two or more modalities is attempted. We review our work on multimodal sensing concepts for applications ranging from non-invasive quantification of biomolecules in the living organism to supporting medical diagnosis showing the combined capabilities of Raman spectroscopy, optical coherence tomography, and optoacoustics.

Development of Combined Raman Spectroscopy – Optical Coherence Tomography (RS-OCT)

2008 ◽  
Author(s):  
Chetan A. Patil ◽  
Nienke Bosschaart ◽  
Jeffry S. Nyman ◽  
Dirk J. Faber ◽  
Ton G. Van Leeuwen ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Spectroscopy Optical

A clinical probe for combined Raman spectroscopy-optical coherence tomography (RS-OCT) of the skin cancers

2010 ◽  
Author(s):  
Chetan A. Patil ◽  
Harish Krishnamoorthi ◽  
Darrel L. Ellis ◽  
Ton G. van Leeuwen ◽  
Anita Mahadevan-Jansen
Keyword(s):  
Raman Spectroscopy ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Skin Cancers ◽  
Spectroscopy Optical

scholarly journals A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

2011 ◽  
Vol 43 (2) ◽  
pp. 143-151 ◽  
Author(s):  
Chetan A. Patil ◽  
Harish Kirshnamoorthi ◽  
Darrel L. Ellis ◽  
Ton G. van Leeuwen ◽  
Anita Mahadevan-Jansen
Keyword(s):  
Raman Spectroscopy ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Skin Cancers ◽  
Clinical Instrument ◽  
Spectroscopy Optical

scholarly journals Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy

The Analyst ◽  
2020 ◽  
Vol 145 (4) ◽  
pp. 1445-1456 ◽  
Author(s):  
Fabian Placzek ◽  
Eliana Cordero Bautista ◽  
Simon Kretschmer ◽  
Lara M. Wurster ◽  
Florian Knorr ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Optical Coherence Tomography ◽  
Imaging System ◽  
Ex Vivo ◽  
Large Field ◽  
Optical Coherence ◽  
Fiber Optic Probe ◽  
Optic Probe ◽  
Muscle Invasive

Characterization of bladder biopsies, using a combined fiber optic probe-based optical coherence tomography and Raman spectroscopy imaging system that allows a large field-of-view imaging and detection and grading of cancerous bladder lesions.

scholarly journals Non-invasive three-dimensional thickness analysis of oral epithelium based on optical coherence tomography—development and diagnostic performance

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06645
Author(s):  
Charlotte Theresa Trebing ◽  
Sinan Sen ◽  
Stefan Rues ◽  
Christopher Herpel ◽  
Maria Schöllhorn ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Performance ◽  
Three Dimensional ◽  
Oral Epithelium ◽  
Optical Coherence ◽  
Non Invasive

Label-free non-invasive classification of rice seeds using optical coherence tomography assisted with deep neural network

2021 ◽  
Vol 137 ◽  
pp. 106861
Author(s):  
Deepa Joshi ◽  
Ankit Butola ◽  
Sheetal Raosaheb Kanade ◽  
Dilip K. Prasad ◽  
S.V. Amitha Mithra ◽  
...  
Keyword(s):  
Neural Network ◽  
Optical Coherence Tomography ◽  
Deep Neural Network ◽  
Optical Coherence ◽  
Label Free ◽  
Non Invasive ◽  
Rice Seeds

scholarly journals Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 217
Author(s):  
Maria Jesus Rodrigo ◽  
Amaya Pérez del Palomar ◽  
Alberto Montolío ◽  
Silvia Mendez-Martinez ◽  
Manuel Subias ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Relative Intensity ◽  
Therapeutic Option ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Aggregate Size ◽  
Daily Practice ◽  
Optical Coherence ◽  
Non Invasive ◽  
Invasive Method

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

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