scholarly journals Current Advancements in Transdermal Biosensing and Targeted Drug Delivery

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1028 ◽  
Author(s):  
Prem Pandey ◽  
Shubhangi Shukla ◽  
Shelby Skoog ◽  
Ryan Boehm ◽  
Roger Narayan
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Targeted Drug Delivery ◽  
Reverse Iontophoresis ◽  
Drug Molecules ◽  
Amphiphilic Drug ◽  
Novel Approach ◽  
Barrier To Entry ◽  
And Performance ◽  
Iontophoretic Delivery

In this manuscript, recent advancements in the area of minimally-invasive transdermal biosensing and drug delivery are reviewed. The administration of therapeutic entities through the skin is complicated by the stratum corneum layer, which serves as a barrier to entry and retards bioavailability. A variety of strategies have been adopted for the enhancement of transdermal permeation for drug delivery and biosensing of various substances. Physical techniques such as iontophoresis, reverse iontophoresis, electroporation, and microneedles offer (a) electrical amplification for transdermal sensing of biomolecules and (b) transport of amphiphilic drug molecules to the targeted site in a minimally invasive manner. Iontophoretic delivery involves the application of low currents to the skin as well as the migration of polarized and neutral molecules across it. Transdermal biosensing via microneedles has emerged as a novel approach to replace hypodermic needles. In addition, microneedles have facilitated minimally invasive detection of analytes in body fluids. This review considers recent innovations in the structure and performance of transdermal systems.

scholarly journals Biophysical characterization of DNA origami nanostructures reveals inaccessibility to intercalation binding sites

2019 ◽  
Author(s):  
Helen L. Miller ◽  
Sonia Contera ◽  
Adam J.M. Wollman ◽  
Adam Hirst ◽  
Katherine E. Dunn ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Single Molecule ◽  
Targeted Drug Delivery ◽  
Binding Sites ◽  
Dna Origami ◽  
Target Cells ◽  
Dna Nanostructures ◽  
Synthetic Dna ◽  
Drug Molecules ◽  
Targeted Drug

AbstractIntercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted drug delivery. This is due to the excellent biocompatibility of synthetic DNA nanostructures, and high potential for flexible programmability including facile drug release into or near to target cells. Such favourable properties may enable high initial loading and efficient release for a predictable number of drug molecules per nanostructure carrier, important for efficient delivery of safe and effective drug doses to minimise non-specific release away from target cells. However, basic questions remain as to how intercalation-mediated loading depends on the DNA carrier structure. Here we use the interaction of dyes YOYO-1 and acridine orange with a tightly-packed 2D DNA origami tile as a simple model system to investigate intercalation-mediated loading. We employed multiple biophysical techniques including single-molecule fluorescence microscopy, atomic force microscopy, gel electrophoresis and controllable damage using low temperature plasma on synthetic DNA origami samples. Our results indicate that not all potential DNA binding sites are accessible for dye intercalation, which has implications for future DNA nanostructures designed for targeted drug delivery.

A new approach to local drug delivery bubbling under the surface

2019 ◽  
Vol 11 (503) ◽  
pp. eaay3582
Author(s):  
Eoin O’Cearbhaill
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Targeted Drug Delivery ◽  
Local Drug Delivery ◽  
New Approach ◽  
Targeted Drug

Ultrasound is coupled with a needle-based minimally invasive electrode to enhance targeted drug delivery to superficial tumors.

Current Nanoparticle Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review

2020 ◽  
Vol 26 (11) ◽  
pp. 1128-1137 ◽  
Author(s):  
Mohammad A. Ansari ◽  
Ill-Min Chung ◽  
Govindasamy Rajakumar ◽  
Mohammad A. Alzohairy ◽  
Mohammad N. Alomary ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Therapeutic Agents ◽  
Vital Role ◽  
Drug Molecules ◽  
Brain Drug Delivery ◽  
Anti Cancer ◽  
The Central Nervous System ◽  
The Brain

: Nanoparticles (NPs) are unique may be organic or inorganic, play a vital role in the development of drug delivery targeting the central nervous system (CNS). Intranasal drug delivery has shown to be an efficient strategy with attractive application for drug delivery to the CNS related diseases, such as Parkinson's disease, Alzheimer 's disease and brain solid tumors. Blood brain barrier (BBB) and blood-cerebrospinal fluid barriers are natural protective hindrances for entry of drug molecules into the CNS. Nanoparticles exhibit excellent intruding capacity for therapeutic agents and overcome protective barriers. By using nanotechnology based NPs targeted, drug delivery can be improved across BBB with discharge drugs in a controlled manner. NPs confer safe from degradation phenomenon. Several kinds of NPs are used for nose to the brain (N2B) enroute, such as lipidemic nanoparticles, polymeric nanoparticles, inorganic NPs, solid lipid NPs, dendrimers. Among them, popular lipidemic and polymeric NPs are discussed, and their participation in anti-cancer activity has also been highlighted in this review.

Nanomedicine in Human Health Therapeutics and Drug Delivery

2021 ◽  
pp. 229-251
Author(s):  
Manzoor A. Mir ◽  
Basharat A. Bhat ◽  
Bashir A. Sheikh ◽  
Gulzar Ahmed Rather ◽  
Safiya Mehraj ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Human Health ◽  
Surface Area ◽  
21St Century ◽  
Targeted Drug Delivery ◽  
Large Surface Area ◽  
Drug Molecules ◽  
Significant Research ◽  
Targeted Drug

The 21st century has seen a massive spring up in the applications of nanobiotechnology. Incorporation of functionalized and modified nanostructures in various biomedical applications has generated significant research interests such as implant and tissue engineering, diagnosis, and therapy, thereby aiding in improvement of human health. The unique properties of nanoparticles including non-toxicity and biocompatibility with a large surface area make it possible to modify their surface with different chemicals including different polymers, antibodies, and drug molecules. Therefore, they are utilized for targeted drug delivery in order to carry drugs and selectively release them in desired tissues which reduces destructive effects on healthy cells. This chapter mainly covers the basic properties of nanoparticles including nanomedicine, their preparation and focuses on their diagnosis, and therapeutic applications in disease including cancer and other challenging ailments.

Bioadhesive Films AS Drug Delivery Systems

2020 ◽  
Vol 10 ◽  
Author(s):  
Inderbir Singh ◽  
Debabrata Ghosh Dastidar ◽  
Dipanjan Ghosh ◽  
Abhijit Sengupta ◽  
Tolulope O. Ajala ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Dosage Forms ◽  
Future Research ◽  
Basic Principles ◽  
Drug Molecules ◽  
And Performance ◽  
Current Area ◽  
Product Outcome ◽  
Novel Drug

: Bioadhesive films are considered as a novel drug delivery system which provides improved therapy and better patient compliance than conventional dosage forms. The type and concentration of polymer or the blend of polymers used are important factors influencing the properties of bioadhesive films and influencingthe product outcome and performance. But the modification of available polymers to synthesize polymers with improved properties is the current area of research. Furthermore, addressing the challenges in formulating bioadhesive films for transdermal delivery of a variety of different classes of drug molecules is the frontier for future research. With the advancement of synthetic chemistry and the development of newer technology like 3D printing, more and more studies are going on bioadhesive films that have opened up a bunch of opportunities in this field of research. This article reviews the current advancements in developingbio-adhesive films and provides basic principles that will be helpful to overcome the difficulties that are associated with the design of formulation.

scholarly journals Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests

2015 ◽  
Vol 28 (3) ◽  
pp. 533-538 ◽  
Author(s):  
Christian Peters ◽  
Marcus Hoop ◽  
Salvador Pané ◽  
Bradley J. Nelson ◽  
Christofer Hierold
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Targeted Drug Delivery ◽  
Device Fabrication ◽  
Magnetic Composites ◽  
Targeted Drug

scholarly journals TRANSFEROSOME: A RECENT APPROACH FOR TRANSDERMAL DRUG DELIVERY

2018 ◽  
Vol 8 (5-s) ◽  
pp. 100-104 ◽  
Author(s):  
Abhay Kumar
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ionic Surfactant ◽  
Drug Molecules ◽  
Wide Range ◽  
Targeted Drug ◽  
Novel Drug

Novel drug delivery systems are now a day is creating a new interest in development of drug deliveries. The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. Transferosomes are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers and non-ionic surfactant vesicles. It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. Transferosome possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. In this review, we have focused on transferosome with discussions on novel drug delivery systems for targeted delivery of therapeutics and important issues and challenges for future clinical applications. Keywords: Novel drug delivery systems, Transferosomes, Transdermal drug delivery, Targeted drug delivery

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