scholarly journals Development of Coplanar Electro-Wetting Based Microfluidic Sorter to Select Micro-Particles in High Volume Throughput at Milliliter Amount within Twenty Minutes

Sensors ◽  
2018 ◽  
Vol 18 (9) ◽  
pp. 2941 ◽  
Author(s):  
Yuanyu Chen ◽  
Shauchun Wang
Keyword(s):  
Computer Control ◽  
High Volume ◽  
The Other ◽  
Control Board ◽  
Inlet Channel ◽  
Lower Channel ◽  
Micro Particles ◽  
Solution Droplet ◽  
Electro Wetting ◽  
To Receive

This paper reports the work of developing one coplanar microfluidic sorter while using the electro-wetting on dielectrics (EWOD) technique. When connected with delivery capillary to receive sample solution containing micro-particles, this device can select about 10 micro-particles in high volume throughput of milliliter amount within 20 min, to potentially match the requirement of efficiently determining the low amounts of bacteria in concentrated food and environmental samples, of which the typical bacteria density is 10 colony forming unit or less, much smaller than that of clinical pathogen samples. This coplanar T-shape EWOD device contains two fluidic channels, one inlet channel and the other collection channel stemmed from the middle of inlet channel. When the solution droplet falls from the delivery capillary to the entrance end of inlet channel, the droplet is driven to the intersection of two channels. The droplet containing fluorescent particle will be diverted to the lower channel to collect. Otherwise, the non-fluorescent droplet keeps moving toward the other end of inlet channel to waste zone. The particle fluorescence is collected through microscope lens to detect with one photomultiplier tube. The detected signals trigger the personal computer control board to active each EWOD electrode to direct the droplet moving directions. When the solution of 1 mL containing about 10 fluorescent micro-particles is delivered into this sorting device, nearly all the particles were correctly directed into collection zone in 20 min.

Global Economic Crisis of 2008-2009: Sources and Roots

2009 ◽  
pp. 18-31
Author(s):  
G. Rapoport ◽  
A. Guerts
Keyword(s):  
Oil And Gas ◽  
Trade Deficit ◽  
Developed Countries ◽  
The Other ◽  
Energy Resources ◽  
Market Mechanisms ◽  
Production Output ◽  
The One ◽  
To Receive ◽  
Partial Destruction

In the article the global crisis of 2008-2009 is considered as superposition of a few regional crises that occurred simultaneously but for different reasons. However, they have something in common: developed countries tend to maintain a strong level of social security without increasing the real production output. On the one hand, this policy has resulted in trade deficit and partial destruction of market mechanisms. On the other hand, it has clashed with the desire of several oil and gas exporting countries to receive an exclusive price for their energy resources.

Rapid Failure Analysis of Low-Yielding Electrical Test Structures Using E-beam Physical and Voltage Contrast Inspection

2013 ◽  
Author(s):  
Oliver D. Patterson ◽  
Deborah A. Ryan ◽  
Xiaohu Tang ◽  
Shuen Cheng Lei
Keyword(s):  
Failure Analysis ◽  
Defect Detection ◽  
High Volume ◽  
The Other ◽  
Defect Inspection ◽  
Electrical Test ◽  
Detection Mode ◽  
Rapid Generation ◽  
Voltage Contrast ◽  
Additional Support

Abstract In-line E-beam inspection may be used for rapid generation of failure analysis (FA) results for low yielding test structures. This approach provides a number of advantages: 1) It is much earlier than traditional FA, 2) de-processing isn’t required, and 3) a high volume of sites can be processed with the additional support of an in-line FIB. Both physical defect detection and voltage contrast inspection modes are useful for this application. Voltage contrast mode is necessary for isolation of buried defects and is the preferred approach for opens, because it is faster. Physical defect detection mode is generally necessary to locate shorts. The considerations in applying these inspection modes for rapid failure analysis are discussed in the context of two examples: one that lends itself to physical defect inspection and the other, more appropriately addressed with voltage contrast inspection.

VP39 The Alphabet Lottery? How NICE Outcomes Vary By Appraisal Committee

2019 ◽  
Vol 35 (S1) ◽  
pp. 86-86
Author(s):  
Richard Macaulay ◽  
Lok Wan Liu ◽  
Cornelia Roibu ◽  
Andrea Berardi
Keyword(s):  
Cost Effectiveness ◽  
The Other ◽  
Appraisal Committee ◽  
Technology Appraisal ◽  
The Public ◽  
Chi Squared ◽  
C 50 ◽  
To Receive ◽  
Disciplinary Group ◽  
53 C 55

IntroductionNICE (National Institute for Health and Care Excellence) makes recommendations on the public reimbursement of medicines based on their clinical- and cost-effectiveness. The recommendation is made by an Appraisal Committee (comprising a multi-disciplinary group of independent experts) as part of a technology appraisal. There are four Appraisal Committees (A,B,C,D); this research investigates whether appraisal outcomes vary by committee.MethodsAll publicly-available Final Appraisal Determinations from NICE Single Technology Appraisals (STA) were screened (01/10/2009-14/11/2018) and key data were extracted. Homogeneity in rates of acceptance or rejection across the committees was assessed using Chi-squared tests.ResultsThe Appraisal Committee was identified for 298 technologies, 56% (168/298) of which were ‘recommended’. The number of technologies assessed by each committee was similar (A:79, B:62, C:91, D:66). However, STAs conducted by Committee D were significantly less likely to receive ‘recommended’ outcomes (A:68% [54/79], B:65% [40/62], C:53% [48/91], D:39% [26/66]; p < 0.01). STAs for oncology indications had higher ’not recommended’ outcomes than those for non-oncology indications (25% vs. 9%). The lower ‘recommendation’ rates for committee D persisted across oncology (A:60%, B:83%, C:50%, D:38%; p = 0.01) and non-oncology indications (A:73%, B:53%, C:55%, D:40%; p < 0.01). However, STAs conducted by Committee D were significantly more likely to receive ‘optimized’ recommendations (A:16%, B:21%, C:33%, D: 36%; p < 0.01) and when considering the rates of ‘recommended’ and ‘optimized’ outcomes compared to ‘only in research’ and ‘not recommended’ outcomes, no significant differences were found (A:85%, B: 85%, C:86%, D:76%; p = 0.27).ConclusionsSTAs undertaken by NICE Appraisal Committee D was associated with a significantly lower rate of ‘recommended’ outcomes but tended to an ‘optimized’ recommendation significantly more than the other committees. Further research is needed to determine if this reflects any deviation in uniform implementation of NICE methodology between Committees.

The Absence and Influence of Genesis 48 (the Blessing of Ephraim and Manasseh) in the Book of Jubilees

2017 ◽  
Vol 26 (4) ◽  
pp. 255-273
Author(s):  
Pauline P. Buisch
Keyword(s):  
The Other ◽  
Literary Influence ◽  
To Receive

While scholars have acknowledged the literary dependence of Jubilees 31 (the blessing of Levi and Judah) on Genesis 48 (the blessing of Ephraim and Manasseh), little work has been done to understand the purpose of this intentional intertextuality. This article examines the literary influence of Genesis 48, the effect of its absence, and the altered roles of Levi, Judah, and Joseph in Jubilees in order to determine why the author made the literary decision to pattern one scene of blessing after the other. This article suggests that the author's decision to omit Genesis 48 and to present not one but two similar scenes of blessing in its place is part of a larger strategy to negotiate the interpretive problem of the prominent status given to Joseph's sons in Genesis 48. By replacing Ephraim and Manasseh with Levi and Judah, but allowing Joseph to receive the double portion of land, the author of Jubilees reflects an interpretive tradition, also found in the Targums, Genesis Rabbah, and the Testaments of the Patriarchs, that understands the inheritance of Jacob to be threefold and distributed three ways—the birthright to Joseph, the priesthood to Levi, and the kingship to Judah.

Primary Uterine Cancer in Maryland: Impact of Distance on Access to Surgical Care at High-Volume Hospitals

2013 ◽  
Vol 23 (7) ◽  
pp. 1244-1251 ◽  
Author(s):  
Camille C. Gunderson ◽  
Ana I. Tergas ◽  
Aimee C. Fleury ◽  
Teresa P. Diaz-Montes ◽  
Robert L. Giuntoli
Keyword(s):  
Confidence Interval ◽  
Odds Ratio ◽  
Uterine Cancer ◽  
Multivariable Analysis ◽  
Community Setting ◽  
Surgical Care ◽  
High Volume ◽  
High Volume Hospital ◽  
To Receive ◽  
Zip Code

ObjectiveTo evaluate the influence of distance on access to high-volume surgical treatment for patients with uterine cancer in Maryland.MethodsThe Maryland Health Services Cost Review Commission database was retrospectively searched to identify primary uterine cancer surgical cases from 1994 to 2010. Race, type of insurance, year of surgery, community setting, and both surgeon and hospital volume were collected. Geographical coordinates of hospital and patient’s zip code were used to calculate primary independent outcomes of distance traveled and distance from nearest high-volume hospital (HVH). Logistic regression was used to calculate odds ratios and confidence intervals.ResultsFrom 1994 to 2010, 8529 women underwent primary surgical management of uterine cancer in Maryland. Multivariable analysis demonstrated white race, rural residence, surgery by a high-volume surgeon and surgery from 2003 to 2010 to be associated with both travel 50 miles or more to the treating hospital and residence 50 miles or more from the nearest HVH (allP< 0.05). Patients who travel 50 miles or more to the treating hospital are more likely to have surgery at a HVH (odds ratio, 6.03; 95% confidence interval, 4.67–7.79) In contrast, patients, who reside ≥50 miles from a HVH, are less likely to have their surgery at an HVH. (odds ratio, 0.37; 95% confidence interval, 0.32–0.42).ConclusionIn Maryland, 50 miles or more from residence to the nearest HVH is a barrier to high-volume care. However, patients who travel 50 miles or more seem to do so to receive care by a high-volume surgeon at an HVH. In Maryland, Nonwhites are more likely to live closer to an HVH and more likely to use these services.

The perfect Crème Brûlée v2

2022 ◽  
Author(s):  
René Bernard
Keyword(s):  
Smooth Surface ◽  
Quality Criteria ◽  
The Other ◽  
Small Parts ◽  
To Receive ◽  
Added Salt

Crème Brûlée has a short ingredient list and does not require specific skills to make, but to get it right, several steps need to be carefully executed to receive the creme, not a pudding that, that is still grainy or liquid. With a caramel crust that offers a perfectly smooth surface you can break with your spoon like ice when you tap on it. Most Crème Brûlées offer one or the other but to get everything right, requires attention to details in the making. Expected results and quality criteria: 1. Crème Brûlée is served refrigerator-cold and 3-5 min after the blow-torching the sugar. Only then you have a smooth and stable caramel surface that you can crack with your spoon. Ideally, the caramel is still pleasantly warm. 2. The creme needs to be uniform and intense yellow, no gristle-like residues in it to disturb the perfect mouth feeling. While the surface is solid, the creamy consistency remains. 3. Taste: The perfect interplay between caramel and vanilla flavors (if small parts of the crust are slightly burnt -compare image - you add just a few bitter notes that make it more interesting. The added salt intensifies the vanilla flavor. 4. The crust needs to be uniform and requires a soon to be broken up in small pieces.

1. On Annelid Tracks in the Exploration of the Millstone Grits in the South-west of the County of Clare.

1857 ◽  
Vol 3 ◽  
pp. 294-295
Author(s):  
Robert Harkness
Keyword(s):  
The Other ◽  
Perfect State ◽  
The South ◽  
Great Abundance ◽  
South West ◽  
Soft State ◽  
The One ◽  
To Receive

The author remarks that the existence of Annelida during the Palæozoic formations is manifested in two conditions. In the one, we have the shelly envelope which invests the order Tubicola, in the form of Seapolites; and in the other, the tracks of the orders Abranchia and Dorsi-branchiata are found impressed on deposits which were, at one time, in a sufficiently soft state to receive the impressions of the wanderings of these animals.Among the strata which have hitherto afforded annelid tracks, those which, in the county of Clare, represent a portion of the equivalents of the Millstone Grit, contain such tracks, in their most perfect state of preservation in great abundance; and these strata also furnish evidence concerning the circumstances which prevailed during their deposition.

Newbury

1987 ◽  
Vol 33 ◽  
pp. 103-105
Keyword(s):  
The Other ◽  
To Receive ◽  
The Church

815 Notification and confirmation by the abbot of Waverley and the priors of Waverley and [Monk] Sherborne, judges-delegate of Pope Honorius III, of the settlement before them of the action between Reading Abbey, on one side, and the abbot and convent of Préaux [Eure, Normandy] and Gervase clerk of Newbury, on the other, concerning the church of Newbury, which Reading Abbey claimed was a chapel within the parish of Thatcham. The church of Thatcham shall continue to receive 2s annually from the church of Newbury, as before, and the abbot and convent of Préaux shall pay 4s 8d annually to the abbot and convent of Reading, who shall indemnify them in respect of themselves and the clerks holding the other portions of Thatcham church [1216 × 24]Bf193r; Cf112vPd. Barfield, Thatcham, ii. 56Universis Christi fidelibus ad quos presens scriptum pervenerit abbas de Waverleg’a et eiusdem loci et de Syreburn' priores, salutem. Noveritis nos mandatum domini pape in hec verba suscepisse.

Vision-based assessment of viability of acorns using sections of their cotyledons during automated scarification procedure

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Mirosław Jabłoński ◽  
Ryszard Tadeusiewicz ◽  
Adam Piłat ◽  
Józef Walczyk ◽  
Paweł Tylek ◽  
...  
Keyword(s):  
Computer Vision ◽  
Color Image ◽  
High Volume ◽  
The Other ◽  
Assessment Criteria ◽  
High Quality ◽  
Overall Design

Abstract The goal of the research described in the article was to develop the device for the automatic scarification of acorns and computer vision-based assessment of their viability. The color image of the intersection of the tissue of cotyledons was selected as a key feature for separating healthy seeds from the spoiled ones. Because the device is being designed for the diagnosis of high volume of seeds aiming at producing high-quality seedlings, several assessment criteria of the overall design of the automaton are being assessed. The basic one is the overall accuracy of viability recognition. The other refers to particular functions implemented in the model of the device being described.

Greek Orthodox Theology of the Second Half of the XX century and Beginning of the XXI century On the Influence Latin Theological Traditionon the Opinions of St. Nicodemus Hagioreites (1749-1809)

2019 ◽  
pp. 53-74
Author(s):  
Василий Петров
Keyword(s):  
Russian Translation ◽  
The Other ◽  
Greek Orthodox ◽  
The West ◽  
Orthodox Theology ◽  
To Receive

Статья посвящена изложению взглядов различных греческих православных богословов XX-XXI вв. на проблему влияния латинской богословской традиции на мысль преподобного Никодима Святогорца (1749-1809). Наиболее ярким критиком св. Никодима выступил доктор философии Х. Яннарас в своей книге «Православие и Запад в Новейшей Греции». В работе приводятся оценки высказываний Яннараса со стороны других исследователей творчества преподобного Никодима, а также их аргументы за и против высказанной позиции. Изложению полемики вокруг наследия Святогорца предшествует небольшое историческое введение. В работе представлены взгляды двух групп богословов относительно влияния латинской схоластики на творчество св. Никодима. Одна, более многочисленная группа, считает это влияние незначительным и поверхностным, другая полагает, что латинская традиция оставила в наследии Святогорца гораздо более глубокий след. Материал для обсуждения проблемы представлен главным образом текстами одной из самых знаменитых книг св. Никодима - «Руководство к исповеди» (Ἐξομολογητάριον). Русский перевод последней увидел свет в Москве в 2017 г. В связи с этим проблема рецепции Русской Церковью богословия и аскетики одного из виднейших деятелей движения колливадов стала для нас в полный рост. The article attempts to present of the views of various Greek Orthodox theologians of the XX-XXI centuries on the problem of Latin theological tradition’s influence on the idea of St. Nicodemus the Hagiorite (1749-1809). The most prominent critic of St. Nicodemus was Ph. D. Kh. Yannaras in his book “Orthodoxy and the West in New Greece”. The paper presents various evaluations of the Yannaras’ statements of other researchers of the works of St. Nicodemus, as well as their arguments for and against the position expressed. The analysis of the polemics surrounding the legacy of the Hagioreites is preceded by a small historical introduction. The paper presents the views of two groups of theologians on the problem of the influence of Latin scholastics on the works of St. Nicodemus. The first, more numerous groups, considers this influence insignificant and superficial, the other group believes that the Latin tradition has left a much deeper mark on the heritage of the Hagioreites. Materials for discussing the problem are presented mainly by the texts of one of the most famous books of St. Nicodemus “A Guide to Confession” (Ἐξομολογητάριον). The Russian translation of the latter was published in Moscow in 2017. In this regard, the problem of how the Russian Church is to receive the theology and asceticism of one of the most prominent members of the kollivad movement has gained unprecedented prominence.

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