scholarly journals ZnO Film Bulk Acoustic Resonator for the Kinetics Study of Human Blood Coagulation

Sensors ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. 1015 ◽  
Author(s):  
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Keyword(s):  
Blood Coagulation ◽  
Human Blood ◽  
Acoustic Resonator ◽  
Kinetics Study ◽  
Zno Film ◽  
Film Bulk Acoustic Resonator ◽  
Film Bulk ◽  
Human Blood Coagulation

Shear Mode Bulk Acoustic Viscosity Sensor for Blood Coagulation Monitoring in Oral Anticoagulant Therapy

2018 ◽  
Vol 18 (12) ◽  
pp. 8099-8104 ◽  
Author(s):  
Shuren Song ◽  
Da Chen ◽  
Hongfei Wang ◽  
Qiuquan Guo ◽  
Wangli Yu
Keyword(s):  
Blood Coagulation ◽  
Human Blood ◽  
Oral Anticoagulant ◽  
Acoustic Resonator ◽  
Shear Mode ◽  
Viscosity Change ◽  
Coagulation Monitoring ◽  
Wide Range ◽  
Film Bulk Acoustic Resonator ◽  
Film Bulk

Frequent monitoring of blood coagulation status is essential for patients receiving treatment with some oral anticoagulant agents. In this paper, we present a microelectromechanical film bulk acoustic resonator for the measurement of blood coagulation parameters. The resonator was made of an aluminum nitride piezoelectric film and operated in thickness shear resonance mode with a frequency of about 2 GHz. The resonant frequency showed a linear relationship with the viscosity of the environmental liquid over the wide range of 1–25 cP, falling within the physiological range of human blood. The coagulation process of human blood was monitored by following the frequency downshift due to the viscosity change. Therefore, the frequency response was used to determine quantitatively three clinically significant parameters being the enzymatic cascade time, the coagulation time and the clot degree. As a practical demonstration, the proposed micro-resonator was applied to monitor coagulation for one month in a patient taking the oral anticoagulant, warfarin, daily. The results measured by the resonator were consistent with those of the standard coagulometer. As a result of the excellent potential for integration, miniaturization and the availability of direct digital signals, the shear mode film bulk acoustic resonator has promising application for clinical and personal coagulation monitoring.

Real-time monitoring of human blood clotting using a lateral excited film bulk acoustic resonator

2017 ◽  
Vol 27 (4) ◽  
pp. 045013 ◽  
Author(s):  
Da Chen ◽  
Jingjng Wang ◽  
Peng Wang ◽  
Qiuquan Guo ◽  
Zhen Zhang ◽  
...  
Keyword(s):  
Real Time ◽  
Human Blood ◽  
Blood Clotting ◽  
Acoustic Resonator ◽  
Real Time Monitoring ◽  
Film Bulk Acoustic Resonator ◽  
Film Bulk

Design of a FBAR (Film Bulk Acoustic Resonator) Oscillator at 1.6 GHz

2011 ◽  
Vol 3 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Xu Zhang ◽  
Wencheng Xu ◽  
Junseok Chae
Keyword(s):  
Acoustic Resonator ◽  
Film Bulk Acoustic Resonator ◽  
Film Bulk
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