scholarly journals Study of the Relationship between Taste Sensor Response and the Amount of Epigallocatechin Gallate Adsorbed Onto a Lipid-Polymer Membrane

Sensors ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 6241-6249 ◽  
Author(s):  
Yuhei Harada ◽  
Yusuke Tahara ◽  
Kiyoshi Toko
Keyword(s):  
Epigallocatechin Gallate ◽  
Polymer Membrane ◽  
Sensor Response ◽  
The Relationship ◽  
Taste Sensor

Sounding Characteristics that Yield Significant Convective Inhibition Errors due to Ascent Rate and Sensor Response of In Situ Profiling Systems

2020 ◽  
Vol 37 (7) ◽  
pp. 1163-1172
Author(s):  
Adam L. Houston ◽  
Jason M. Keeler
Keyword(s):  
Deep Convection ◽  
Static Stability ◽  
Sensor Response ◽  
First Order ◽  
Ascent Rate ◽  
Convective Inhibition ◽  
Free Parameters ◽  
Convection Initiation ◽  
The Relationship

AbstractAccurate measurements of the convective inhibition (CIN) associated with capping inversions are critical to forecasts of deep convection initiation. The goal of this work is to determine the sounding characteristics most vulnerable to CIN errors arising from hysteresis associated with sensor response and ascent rate of profiling systems. This examination uses 5058 steady-state analytic soundings prescribed using three free parameters that control inversion depth, static stability, and moisture content. A theoretical well-aspirated first-order sensor mounted on a platform that does not disturb its environment is “flown” in these soundings. Sounding characteristics that result in the largest relative CIN errors are also the characteristics that result in the smallest CIN. Because they are more likely to support deep convection initiation, it is particularly critical that environments with small CIN are represented accurately. The relationship between relative CIN error and CIN exists because sounding characteristics that contribute to large CIN do not proportionally increase the CIN error. Analysis also considers CIN intervals with (operationally important) CIN on the threshold between environments that will and will not support deep convection initiation. For these soundings, CIN error is found to be largest for deep, dry inversions characterized by small static stability.

scholarly journals Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics

2020 ◽  
Vol 21 (12) ◽  
pp. 4213 ◽  
Author(s):  
Yoshitomo Honda ◽  
Anqi Huang ◽  
Tomonari Tanaka ◽  
Xiaoyu Han ◽  
Beiyuan Gao ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Epigallocatechin Gallate ◽  
Underlying Mechanism ◽  
Gelatin Sponge ◽  
Cell Numbers ◽  
Promising Strategy ◽  
Stress Induced Premature Senescence ◽  
The Relationship ◽  
Hematoxylin Eosin

Despite advances in bone regenerative medicine, the relationship between stress-induced premature senescence (SIPS) in cells and bone regeneration remains largely unknown. Herein, we demonstrated that the implantation of a lipopolysaccharide (LPS) sustained-release gelatin sponge (LS-G) increases the number of SIPS cells and that the elimination of these cells promotes bone formation in critical-sized bone defects in the rat calvaria. Histological (hematoxylin–eosin and SA-β-gal) and immunohistological (p16 and p21 for analyzing cellular senescence and 4-HNE for oxidation) staining was used to identify SIPS cells and elucidate the underlying mechanism. Bone formation in defects were analyzed using microcomputed tomography, one and four weeks after surgery. Parallel to LS-G implantation, local epigallocatechin gallate (EGCG) administration, and systemic senolytic (dasatinib and quercetin: D+Q) administration were used to eliminate SIPS cells. After LS-G implantation, SA-β-gal-, p16-, and p21-positive cells (SIPS cells) accumulated in the defects. However, treatment with LS-G+EGCG and LS-G+D+Q resulted in lower numbers of SIPS cells than that with LS-G in the defects, resulting in an augmentation of newly formed bone. We demonstrated that SIPS cells induced by sustained stimulation by LPS may play a deleterious role in bone formation. Controlling these cell numbers is a promising strategy to increase bone regeneration.

scholarly journals Development of a Sensor with a Lipid/Polymer Membrane Comprising Na+ Ionophores to Evaluate the Saltiness Enhancement Effect

Sensors ◽  
2019 ◽  
Vol 19 (23) ◽  
pp. 5251 ◽  
Author(s):  
Futa Nakatani ◽  
Tomofumi Ienaga ◽  
Xiao Wu ◽  
Yusuke Tahara ◽  
Hidekazu Ikezaki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Citric Acid ◽  
Polymer Membranes ◽  
Branched Chain Amino Acids ◽  
Polymer Membrane ◽  
Enhancement Effect ◽  
Sodium Ions ◽  
Taste Response ◽  
Branched Chain ◽  
Taste Sensor

The saltiness enhancement effect is the effect whereby saltiness is enhanced by adding specific substances to salt (sodium chloride). Since this effect can be used in the development of salt-reduced foods, a method to objectively evaluate the saltiness with this effect is required. A taste sensor with lipid/polymer membranes has been used to quantify the taste of food and beverages in recent years. The sensor electrodes of this taste sensor have the feature of selectively responding to each of the five basic tastes, which is realized by the lipid/polymer membranes. In this study, we developed a new saltiness sensor based on the lipid/polymer membrane with the aim of quantifying the saltiness enhancement effect. In addition to the conventional components of a lipid, plasticizer, and polymer supporting reagent, the membrane we developed comprises ionophores, which selectively capture sodium ions. As a result, the response of the sensor increased logarithmically with the activity of NaCl in measured samples, similarly to the taste response of humans. In addition, all of the sensor responses increased upon adding saltiness-enhancing substances, such as citric acid, tartaric acid and branched-chain amino acids (BCAAs), to NaCl samples. These findings suggest that it is possible to quantify the saltiness enhancement effect using a taste sensor with lipid/polymer membranes.

STUDI AWAL RANCANG BANGUN COLORIMETER MENGGUNAKAN SENSOR OPT101 BERBASIS SISTEM ANDROID DENGAN DISPLAY SMARTPHONE

2019 ◽  
Vol 16 (2) ◽  
pp. 155
Author(s):  
Habibi Putra ◽  
Yulkifli Yulkifli
Keyword(s):  
Light Intensity ◽  
Light Source ◽  
Inverse Relationship ◽  
Sensor Response ◽  
Sensor Output ◽  
Measuring Instrument ◽  
Measuring Device ◽  
Light Detector ◽  
Relationship Of ◽  
The Relationship

Colorimeter is a color measuring device that is a tool that can distinguish colors based on the value of the output produced. In this study a colorimeter device was made using the OPT101 sensor, an analog sensor based light detector. OPT101 sensor has characteristics if the intensity of light received is getting brighter, the greater the sensor output value and vice versa. Because of the characteristics of the sensor like that, this sensor can be used as a measuring instrument to determine the concentration of a food coloring agent. This study aims to look at investigating the relationship between the concentration value of a dye solution to the OPT101 sensor response value contained in the colorimeter tool. The dyes used are red (metile red) and blue (brilliant blue) with 10 different variations of concentration, with a range of 0.01% -0.1%. After the measurement experiments were carried out on the sample, the results obtained were almost the same as the theory, namely the relationship between the concentration value was inversely proportional to the value of the sensor output. The inverse relationship means that the more concentrated a dye solution is, the more the light intensity penetrates the substance or dims. So that the OPT101 sensor detects a dimmer light source, the sensor output value gets smaller, because the relationship of the sensor output value is directly proportional to the intensity of the received light. Based on the measurements that have been made, the results of sensor response values are obtained for the red sample with a range of data from 276,698 decreasing to 240,762, while for the blue sample from the range 9,828 it decreases to 8.75. The value for the blue sample is much smaller because the blue sample is much thicker than the red sample.

scholarly journals Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1335
Author(s):  
Hsiang Yang ◽  
Yu-Ching Wei ◽  
Wan-Chun Li ◽  
Hsin-Yung Chen ◽  
Hung-Ying Lin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Cancer ◽  
Early Stage ◽  
Protoporphyrin Ix ◽  
Epigallocatechin Gallate ◽  
Natural Compounds ◽  
New Strategy ◽  
New Treatment ◽  
The Relationship

Oral cancer (OC) is a serious health problem. Surgery is the best method to treat the disease but might reduce the quality of life of patients. Photodynamic therapy (PDT) may enhance quality of life but with some limitations. Therefore, the development of a new strategy to facilitate PDT effectiveness has become crucial. ATP-binding cassette G2 (ABCG2) is a membrane protein-associated drug resistance and stemness in cancers. Here, we examined whether ABCG2 plays an important role in regulating the treatment efficacy of PDT and whether ABCG2 inhibition by natural compounds can promote the effect of PDT in OC cells. Several head and neck cancer cells were utilized in this study. OECM1 and SAS cells were selected to investigate the relationship between ABCG2 expression and protoporphyrin IX (PpIX) accumulation. Western blot analysis, flow cytometry analysis, and survival probability were performed to determine PDT efficacy and cellular stemness upon treatment of different dietary compounds, including epigallocatechin gallate (EGCG) and curcumin. In this study, we found that ABCG2 expression varied in OC cells. Hypoglycemic culture for SAS cells enhanced ABCG2 expression as higher ABCG2 expression was associated with lower PpIX accumulation and cellular stemness in OC cells. In contrast, suppression of ABCG2 expression by curcumin and tea polyphenol EGCG led to greater PpIX accumulation and enhanced PDT treatment efficiency in OC cells. In conclusion, ABCG2 plays an important role in regulating the effect of PDT. Change in glucose concentration and treatment with natural compounds modulated ABCG2 expression, resulting in altered PDT efficacy for OC cells. These modulations raise a potential new treatment strategy for early-stage OCs.

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