scholarly journals Analysis of Reference Ranges of Total Serum Protein in Namibia: Clinical Implications

Proteomes ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 7
Author(s):  
Josephine N. Henok ◽  
Benjamin I. Okeleye ◽  
Elizabeth I. Omodanisi ◽  
Seteno K. O. Ntwampe ◽  
Yapo G. Aboua
Keyword(s):  
Serum Protein ◽  
Reference Range ◽  
Clinical Laboratory ◽  
Geographical Location ◽  
Cross Sectional Study ◽  
Total Serum Protein ◽  
Total Serum ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Clinical Difference

A reference range is an essential part of clinical laboratory test interpretation and patient care. The levels of total serum protein (TSP) are measured in sera to assess nutritional, liver, and kidney disorders. This study determined the TSP reference range with respect to gender, age, and region in Namibia. A retrospective cross-sectional study was conducted to determine the TSP reference range among 78,477 healthy participants within the ages of less than one year to more than 65 yrs in 14 regions of Namibia. The reference range of TSP was 51–91 g/L for females and 51–92 g/L for males. A reduced TSP range of 48.00–85.55 g/L (2.5–97.5 percentiles) was established at <1–5 years and increased towards adolescence. An uttermost range of 54–93 g/L was observed from 36–65 years of age. At the age >65 years; a steady decline in the reference range (51.00–89 g/L) was recorded. An upper TSP range of 53–92 g/L (2.5–97.5 percentiles) was detected in Erongo, Zambezi, Hardap, Kavango East, and a comparable trend was also seen in Omusati with a 54–91 g/L range. Meanwhile; a reduced TSP range of 50–89 g/L was identified in Ohangwena. This study showed that gender, age, and geographical location can impact TSP levels with a significant clinical difference (p < 0.05) between each category.

Urinary microalbumin/creatinine ratios: reference range in uncomplicated pregnancy

2003 ◽  
Vol 104 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Jason WAUGH ◽  
Stephen C. BELL ◽  
Mark D. KILBY ◽  
Paul C. LAMBERT ◽  
Claire N. BLACKWELL ◽  
...  
Keyword(s):  
Reference Range ◽  
Point Of Care ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Reference Ranges ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Albumin Creatinine Ratio ◽  
Mortality And Morbidity ◽  
Uncomplicated Pregnancy

During uncomplicated pregnancy, the development of proteinuria is accepted as a poor prognostic sign and is associated with increasing maternal and perinatal mortality and morbidity. Physiological proteinuria increases with increasing gestation and one of its largest constituents is albumin. The reference range for the (micro)albumin/creatinine ratio (ACR) has not been described for normal pregnancy. This prospective cross-sectional study describes the gestation-specific 95% reference ranges for urinary microalbumin concentration, creatinine concentration and ACR in uncomplicated pregnancy. There is a significant increase (P = 0.016) in the ACR in the third trimester. The mean difference is 0.091mg of albumin/mmol of creatinine (95% confidence interval, 0.014–0.168). Our results describe the first well-defined gestation-specific 95% reference range for a point-of-care measurement of the ACR. These data are essential if such testing is to be employed in antenatal care.

Kinetic Determination of Total Serum Protein with a Centrifugal Analyzer

1974 ◽  
Vol 20 (3) ◽  
pp. 392-394 ◽  
Author(s):  
Thomas R Koch ◽  
George F Johnson ◽  
Max E Chilcote
Keyword(s):  
Kinetic Analysis ◽  
Serum Protein ◽  
Analytical Method ◽  
Clinical Laboratory ◽  
Total Serum Protein ◽  
Total Serum ◽  
Kinetic Determination ◽  
First Order

Abstract A kinetic biuret assay of total serum protein on the "CentrifiChem" centrifugal analyzer is shown to be rapid, accurate, and reasonably precise, and accommodates the most desirable analytical method and standardization currently available. Kinetic analysis of compounds undergoing first-order reactions is a useful type of analysis that is of significant advantage to the clinical laboratory.

scholarly journals Race specific nomograms: time for change?

2018 ◽  
Vol 5 (2) ◽  
pp. 420
Author(s):  
Pearl Mary Varughese ◽  
Nishanth Rajan ◽  
Manikandan Mani ◽  
Lalitha Krishnan
Keyword(s):  
Serum Bilirubin ◽  
Geographical Location ◽  
Predictive Ability ◽  
Cross Sectional Study ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Cross Sectional ◽  
South Indian ◽  
Bilirubin Metabolism ◽  
Severe Hyperbilirubinemia

Background: Hyperbilirubinemia is a common problem in neonates. Because of the genetic differences in bilirubin metabolism, an hour specific nomogram is better in each geographical location. No studies in South India for creation and validation of a nomogram for significant hyperbilirubinemia. The aim of this study was to create and validate a bilirubin nomogram in South Indian infants.Methods: A prospective cross-sectional study. The data was collected in 2 parts, over 18 months (264 infants) and 20 months (450 infants) respectively. Babies with established direct hyperbilirubinemia, polycythemia, hypothyroidism, culture proven sepsis, major congenital anomalies and jaundice on day 1 of life were excluded. For all babies, cord bilirubin (for first set of infants), total serum bilirubin values were sent at 24 hours of life and at the time of discharge. An hour specific nomogram was created with 834 bilirubin values (first set of data). The predictive ability of this nomogram and Bhutani nomogram were tested and compared using 972 total serum bilirubin values (second set of data)Results: A nomogram was created with serum bilirubin values from the first set of infants and validated it with the serum bilirubin values from the second set of infants. Bhutani nomogram was also validated. Comparing with Bhutani nomogram, our nomogram was better in predicting significant hyperbilirubinemia in our population.Conclusions: Discharging neonates without risk assessment for severe hyperbilirubinemia may be dangerous. A nomogram generated and validated with our data is an accurate tool for predicting significant hyperbilirubinemia in our population. 

Impact of posture on the "reference range" for serum proteins and calcium.

1977 ◽  
Vol 23 (7) ◽  
pp. 1343-1346 ◽  
Author(s):  
K R Humphrey ◽  
H D Gruemer ◽  
J A Lott
Keyword(s):  
Serum Protein ◽  
Reference Range ◽  
Serum Proteins ◽  
Reference Population ◽  
Total Serum Protein ◽  
Total Serum ◽  
Healthy Population ◽  
Normal Ranges ◽  
Total Serum Calcium ◽  
The Impact

Abstract The impact of water shifts due to changes in posture has been reinvestigated for serum protein and calcium concentrations in a young, healthy population. We found that generaly accepted normal ranges for total serum protein, and to a lesser degree for total serum calcium, are not acceptable as a reference range for a hospitalized population that is predominantly in a supine position. Our data indicate a smaller biological variability for total protein and calcium for a reference population in the recumbent posture as compared to the same population in the upright position.

scholarly journals The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Simone Canovi ◽  
◽  
Giulia Besutti ◽  
Efrem Bonelli ◽  
Valentina Iotti ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Laboratory Data ◽  
Organ Damage ◽  
Cross Sectional Study ◽  
Chest Ct ◽  
Arterial Oxygen ◽  
Emergency Rooms ◽  
Cross Sectional ◽  
Ct Findings ◽  
Patient Prognosis

Abstract Background Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. Methods This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. Results Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. Conclusions Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.

Sonographic Assessment of Renal Volume in Normotensive Pregnant Women and Women With Pregnancy-Induced Hypertension in Enugu Metropolis

2021 ◽  
pp. 875647932110210
Author(s):  
Idigo Felicitas Ugochinyere ◽  
Nwankwo Sylvia Chiamaka ◽  
Abonyi Everistus Obinna ◽  
Anakwue Angel-Mary Chukwunyelu ◽  
Agbo Julius Amechi
Keyword(s):  
Reference Range ◽  
Interobserver Variability ◽  
Correct Diagnosis ◽  
Negative Relationship ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Renal Volume ◽  
Cross Sectional ◽  
Significant Difference ◽  
Induced Hypertension

Objective: Renal volume (RV) assessment during obstetric sonography is rarely considered in our locality. Understanding the changes in RV in both normotensive pregnant (NP) and pregnancy-induced hypertensive (PIH) women is important in making correct diagnosis regarding pregnancy outcome. This study is aimed at determining the RV in NP and PIH women and correlating RV with fetal gestational age (FGA), body mass index (BMI), and parity in NP women. Materials and Methods: This cross-sectional study involved 450 patients recruited at a Tertiary Hospital. A pilot study was done to determine the interobserver variability in RV measurement. RV was calculated using the following formula: L × W × AP × 0.523. Parity, BMI, and blood pressure were documented, while FGA was calculated as an average of FGAs obtained from the measurements of fetal biometric parameters. Results: Mean RV of PIH women was significantly higher than that of NP women ( P < .05). RV shows a positive significant relationship with BMI and FGA, while it shows a negative relationship with parity in NP ( P < .05). Conclusion: Reference range values of RV were generated for clinical use in our locality, while there is statistically significant difference between RV in NP and PIH women.

scholarly journals Correlation between lung infection severity and clinical laboratory indicators in patients with COVID-19: a cross-sectional study based on machine learning

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xingrui Wang ◽  
Qinglin Che ◽  
Xiaoxiao Ji ◽  
Xinyi Meng ◽  
Lang Zhang ◽  
...  
Keyword(s):  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Clinical Laboratory ◽  
Lung Infection ◽  
Cross Sectional Study ◽  
Ct Images ◽  
Sectional Study ◽  
Laboratory Examination ◽  
Cross Sectional

Abstract Background Coronavirus disease 2019 (COVID-19) has caused a global pandemic that has raised worldwide concern. This study aims to investigate the correlation between the extent of lung infection and relevant clinical laboratory testing indicators in COVID-19 and to analyse its underlying mechanism. Methods Chest high-resolution computer tomography (CT) images and laboratory examination data of 31 patients with COVID-19 were extracted, and the lesion areas in CT images were quantitatively segmented and calculated using a deep learning (DL) system. A cross-sectional study method was carried out to explore the differences among the proportions of lung lobe infection and to correlate the percentage of infection (POI) of the whole lung in all patients with clinical laboratory examination values. Results No significant difference in the proportion of infection was noted among various lung lobes (P > 0.05). The POI of total lung was negatively correlated with the peripheral blood lymphocyte percentage (L%) (r = − 0.633, P < 0.001) and lymphocyte (LY) count (r = − 0.555, P = 0.001) but positively correlated with the neutrophil percentage (N%) (r = 0.565, P = 0.001). Otherwise, the POI was not significantly correlated with the peripheral blood white blood cell (WBC) count, monocyte percentage (M%) or haemoglobin (HGB) content. In some patients, as the infection progressed, the L% and LY count decreased progressively accompanied by a continuous increase in the N%. Conclusions Lung lesions in COVID-19 patients are significantly correlated with the peripheral blood lymphocyte and neutrophil levels, both of which could serve as prognostic indicators that provide warning implications, and contribute to clinical interventions in patients.

PARALLEL STUDIES OF COMPLEMENT AND COAGULATION IV. EFFECT OF CARBON TETRACHLORIDE

1951 ◽  
Vol 29 (2) ◽  
pp. 48-58
Author(s):  
Christine E. Rice ◽  
Paul Boulanger ◽  
P. J. G. Plummer
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Serum Protein ◽  
Guinea Pigs ◽  
Fatty Degeneration ◽  
Blood Groups ◽  
Total Serum Protein ◽  
Total Serum ◽  
Coagulation Time ◽  
Complement Activity

To determine whether liver injury would result in a parallel decline in the complement titer and coagulative properties of the blood, groups of guinea pigs were given series of injections of the liver poison, carbon tetrachloride. Marked fatty degeneration of the liver, a decline in total serum protein and albumin, a decrease in complement activity, and a prolongation of coagulation time was observed in the treated animals. A general relationship was noted between the albumin-globulin ratio and the complement titer of the serum and between the complement titer and the coagulation time of the plasma.

A retrospective analysis of congenital anomalies in congenital hypothyroidism

2020 ◽  
Vol 33 (9) ◽  
pp. 1147-1153
Author(s):  
Fatima Ali Mazahir ◽  
Manal Mustafa Khadora
Keyword(s):  
United Arab Emirates ◽  
Congenital Hypothyroidism ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Significant Proportion ◽  
Cross Sectional Study ◽  
High Rate ◽  
Lingual Thyroid ◽  
Cross Sectional

AbstractObjectivesWe evaluated the spectrum of diseases accompanying congenital hypothyroidism (CH) in the United Arab Emirates and compared them with internationally studied patterns.MethodsThe presented retrospective cross-sectional study took place in two government tertiary care centres. In total, 204 patients with a confirmed diagnosis of CH and a minimum period of follow-up of 1 year were included. Patients with Down syndrome, infants born at <35 weeks of gestation, and babies with TORCH (Toxoplasma gondii, Other viruses [HIV, measles, etc.], Rubella, Cytomegalovirus, and Herpes simplex) infections were subsequently excluded from the study.ResultsOf the subjects with CH, 39% had associated extrathyroidal anomalies (ETAs); among these, 25% had a single anomaly. A significant proportion of Arab males were affected by CH as compared to other ethnic groups. Dyshormonogenesis was the commonest aetiological cause (55%) of CH. Males with an ectopic lingual thyroid gland had significant ETAs as compared to females of the same cohort. The most common ETAs were congenital heart disease (16%), followed by urogenital tract anomalies (14%).ConclusionsDetection of a high rate and variability of ETAs associated with CH necessitates the formulation of a structured screening programme including appropriate clinical, laboratory, and imaging tools to detect ETAs at an earlier stage.

Muscle Weight Relationship to Serum Proteins, Hemocytes, and Hepatopancreas in the Lobster, Homarus americanus

1967 ◽  
Vol 24 (11) ◽  
pp. 2339-2354 ◽  
Author(s):  
James E. Stewart ◽  
John W. Cornick ◽  
Diane M. Foley ◽  
M. F. Li ◽  
C. M. Bishop
Keyword(s):  
Serum Protein ◽  
Physiological Condition ◽  
Serum Proteins ◽  
Homarus Americanus ◽  
Total Serum Protein ◽  
Total Serum ◽  
Experimental Conditions ◽  
Muscle Weight ◽  
Beef Liver ◽  
The Relationship

Total serum protein values, hemocyte numbers, and muscle weights were determined for 216 intermolt lobsters immediately after their capture, and for 230 others held captive under a variety of dietary and environmental conditions. Average muscle values ranged from approximately 13% to the more normal 20–25% of the live animals' weight, depending upon experimental conditions. The total serum protein up to a level of 55 mg/ml was shown to be a reliable indicator of muscle weights, although the relationship was not identical for all lobster groups. It appeared to be modified chiefly by the areas from which the different groups were taken. Diet was more important than the temperatures (5 to 14 C) in affecting changes in muscle and serum protein values. Starvation caused a greater reduction (50 to 70%) in the size of the hepatopancreas than in the muscle. Histological examination of the hepatopancreatic tissue showed that the lipid content was markedly reduced upon starvation and that a degeneration of this organ was apparent for lobsters fed a beef liver and herring diet. Measurement of serum proteins would appear to be a useful technique in experiments on lobster nutrition and have value, within specified limits, for assessing the physiological condition of wild lobsters.

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