scholarly journals Translational Research in Osteogenesis Imperfecta and Cell Therapy

Proceedings ◽  
2021 ◽  
Vol 72 (1) ◽  
pp. 3
Author(s):  
Vrisha Madhuri ◽  
Sowmya Ramesh ◽  
Renita Raymond ◽  
Agnes Selina ◽  
Lakshmi Loganathan
Keyword(s):  
Cell Therapy ◽  
Osteogenesis Imperfecta ◽  
Translational Research ◽  
Christian Medical College ◽  
Multiple Fractures ◽  
Medical College ◽  
Regulatory Processes ◽  
The Individual ◽  
Pediatric Orthopedic ◽  
Brittle Bones

On 6 and 7 of February 2019, Center for Stem cell Research (CSCR) and Pediatric orthopedic Unit at Christian Medical College (CMC), Vellore, conducted a meet on Translational Research in Osteogenesis Imperfecta and Cell Therapy. Osteogenesis Imperfecta (OI) is a disease in which the individual has weak brittle bones which fracture easily, resulting in multiple fractures throughout their childhood. Children become deformed and often do not walk or grow normally. The meeting was conducted to highlight the newer advances and therapies for osteogenesis imperfecta and bring regulatory processes and challenges that need to be addressed.

scholarly journals Osteogenesis imperfecta: a case report

2014 ◽  
Vol 43 (1) ◽  
pp. 30-32
Author(s):  
Ratu Rumana Binte Rahman ◽  
Shamasunnahar Begum
Keyword(s):  
Osteogenesis Imperfecta ◽  
Pulmonary Hypoplasia ◽  
Bone Fragility ◽  
Lower Limbs ◽  
Inherited Disease ◽  
Multiple Fractures ◽  
X Ray ◽  
Medical College ◽  
Minimal Trauma ◽  
Hallmark Feature

Osteogenesis Imperfecta is a inherited disease of connective tissue. Its hallmark feature is bone fragility with a tendency to fracture from minimal trauma or from the work of bearing weight against gravity. The disorder may occur in one out of 20,000 to one out of 60,000 live births, affecting both male and female of all races. We present a 38 year lady who gave birth to baby with osteogenesis imperfecta in Sir Salimullah Medical College & Mitford Hospital, Dhaka. Both lower limbs appeared shortened with thick musculo-cutaneous folds. Both the femoral shafts were shortened, deformed and fragmented. Both the humeral and fibular shafts were deformed and the presentation was breech. Her sclerae was blue. X-ray showed multiple fractures in humerus, femur and ribs and also right sided pulmonary hypoplasia. DOI: http://dx.doi.org/10.3329/bmj.v43i1.21376 Bangladesh Med J. 2014 January; 43 (1): 30-32

scholarly journals Bilateral Distal Humeral Fracture in a patient with Osteogenesis imperfecta During the Covid Pandemic– A Rare Case Report

2020 ◽  
pp. 187
Author(s):  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Genetic Disorder ◽  
Humeral Fracture ◽  
Distal Humerus ◽  
Low Bone Mass ◽  
Multiple Fractures ◽  
Bone Deformity ◽  
Rare Case Report ◽  
History Of ◽  
Brittle Bones

Introduction: Osteogenesis imperfecta (OI) is a genetic disorder which is characterised by bone deformity, low bone mass, connective tissue manifestations and brittle bones with history of multiple fractures. Although recurrent fractures are known in patient with OI, the occurrence of bilateral simultaneous fracture of humerus is quite rare. Presenting complaint and investigations: The patient had a fall in the outdoors during a storm during the height of covid pandemic and sustained injury to both arms. Radiographs revealed comminuted fracture of left distal humerus and transverse extraarticular supracondylar fracture of right humerus. Diagnoses, therapeutics interventions, and outcomes: Although, conservative measures were advised as per the guidelines for orthopaedic surgery during the covid pandemic for most of the fractures, the decision to operate was made considering the morbid obesity and hampered mobility due to bilateral above elbow plaster.The patient underwent staged open reduction and internal fixation of both distal humerus with anatomical locking plates in a span of 2 weeks. She recovered uneventfully with a good functional range of movements and resumed her routine activities. Conclusion: The treatment for complex and unusual fractures should be individualised and should take into consideration of patient’s general condition and safety.

A novel transgenic murine model with persistently brittle bones simulating osteogenesis imperfecta type I

Bone ◽  
2019 ◽  
Vol 127 ◽  
pp. 646-655 ◽  
Author(s):  
Yi Liu ◽  
Jianhai Wang ◽  
Shuo Liu ◽  
Mingjie Kuang ◽  
Yaqing Jing ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Murine Model ◽  
Type I ◽  
Osteogenesis Imperfecta Type ◽  
Transgenic Murine Model ◽  
Brittle Bones ◽  
Osteogenesis Imperfecta Type I

scholarly journals Gender Determination by Linear Dimension of Permanent Canine: An Odontometric Analysis

2014 ◽  
Vol 2 (1) ◽  
pp. 23-27
Author(s):  
B Sharma ◽  
N Balaji ◽  
MK Sumathi
Keyword(s):  
Sexual Dimorphism ◽  
Sex Determination ◽  
Linear Dimension ◽  
Medical Sciences ◽  
Medical College ◽  
Type Iv ◽  
Racial Background ◽  
Significant Difference ◽  
Natural Change ◽  
The Individual

Background and objectives: Identification, an aspect of forensic anthropology, is the recognition of an individual based on the physical characteristics unique to the individual. Among the four main attributes i.e. gender, age, stature and ethnic or racial background of an individual’s biological identity, sex determination is usually the first step in the human identification process. Teeth can be used as a means of sex determination as teeth are resistant to post-mortem degradation and survive deliberate, accidental or natural change. This study was carried out with an objective to determine the sexual dimorphism of maxillary and mandibular canine by linear tooth diameter for permanent dentition in Moradabad population. Material and Methods: A total number of 40 subjects (20 Males and 20 Females) were included in this study. After obtaining an informed written consent, alginate impression was taken with help of perforated impression trays and study models were prepared with type IV dental stone. Linear (MD, BL, Crown Height) were taken with digital vernier caliper. Results: It was observed that males’ shows more mean linear crown diameter as compared to females. Also, the mesiodistal and buccolingual measurement shows statistically significant difference for all canines, being higher for males than females. Conclusion: The present study has expressed sexual dimorphism of permanent canine using Student’s test and indicate that linear dimension of maxillary canine can be used for sexual diamorphism with accuracy along with other accepted procedure for sex determination. DOI: http://dx.doi.org/10.3126/jmcjms.v2i1.11392   Janaki Medical College Journal of Medical Sciences (2014) Vol. 2 (1): 23-27

CORRELATION BETWEEN HAND LENGTH AND FOOT LENGTH IN HEALTH CARE PROFESSIONALS OF F H MEDICAL COLLEGE

2021 ◽  
pp. 35-36
Author(s):  
Chetna Thakur ◽  
Bhawani Shankar Modi ◽  
Tejendra Singh
Keyword(s):  
Health Care Professionals ◽  
P Value ◽  
Human Beings ◽  
Professional Students ◽  
Medical College ◽  
Foot Length ◽  
The Individual ◽  
The Right ◽  
Hand Length ◽  
The Relationship

Introduction: Human beings are considered to be bilaterally symmetrical. However, there is no symmetry in the length of the feet irrespective of sex or handedness. The hand length could predict bodyweight and body surface area independent of the sex of the individual. But there was no so much data available in the literature showing the relationship between hand length and foot length. Aim and objective: The present study was conducted to derive the correlation between hand length and foot length and the results demonstrate that there was highly signicant correlation between them. Material and Methods:Across sectional study was carried out on 200 healthy and normal adult professional students of either sex (100 Male and 100 Female), age between 18-25 years. Result:the hand length and foot length were compared between the right and left sides, the data showed that the signicant difference between males and females on both sides was highly signicant for all the parameters measured with p value < 0.01 Conclusion:The results of current study indicate that if the hand length is known, foot length can be predicted and if the foot length is known, hand length can be predicted and vice versa.

scholarly journals Study of variations of the anterior cerebral artery in human brain

2013 ◽  
Vol 02 (03) ◽  
pp. 122-127
Author(s):  
Bishwajeet Saikia ◽  
Kunjalal Talukdar ◽  
Joydev Sarma ◽  
Amitav Sarma ◽  
Sandeep Madaan
Keyword(s):  
Cerebral Artery ◽  
Anterior Cerebral Artery ◽  
Cerebral Arteries ◽  
Initial Step ◽  
Circle Of Willis ◽  
Anatomical Distribution ◽  
Surgical Interventions ◽  
Medical College ◽  
The Individual ◽  
Considerable Individual Variation

Abstract Background and aims: Stroke, the most frequent expression of cerebrovascular disease is one of the leading causes of death and disability throughout the world. The manifestations are largely accounted by the anatomical distribution of the stems and branches of the circle of Willis supplying the brain. Considerable individual variation exists in the pattern and caliber of the individual vessels forming the circle of Willis, which may possibly impair the collateral blood flow. The knowledge of these variations thus, becomes essential for medical as well as surgical interventions. There may possibly be some regional variations in the cerebral arteries not mentioned in standard available texts. Thus, the regional based study of variations present becomes essential. The present study aims to focus on the variation of one of such branches, the anterior cerebral artery (ACA) in the population of Assam, India. Material and Methods: The ACAs of 70 human cadaveric brains were examined by gross dissection in the department of Anatomy and Forensic medicine in Gauhati Medical College. Results: Hypoplastic A-1 segment were found in 7% cases, Hypoplastic A-2 segment in 2.85% cases, Buttonhole formation in 8.57% cases and aneurysmal dilatation in 1.42% cases. The results were compared with that of other authors and variations noted. Conclusion: The present study of ACA using gross dissection is an initial step in providing a reference to the healthcare professionals in the region of Assam. Based on this further studies using newer imaging methods should be carried out to correlate the manifestations clinically.

Management Training for Hospital Administrators

1987 ◽  
Vol 12 (3) ◽  
pp. 65-68
Author(s):  
Benjamin M. Pulimood
Keyword(s):  
Management Training ◽  
Christian Medical College ◽  
Indian Institute ◽  
Short Term ◽  
Keen Interest ◽  
Hospital Administrators ◽  
Medical College ◽  
Term Management

Just befme taking over as the Director of Christian Medical College and Hospital, Vellore, Dr Benjamin Pulimood spent a few months at the Indian Institute of Management, Ahmedabad. He took keen interest in the PGP students and attended several seminars and courses. Major hospitals today have large budgets and immense problems of administration. Given these complexities, Dr Pulimood feels that management training would be useful for hospital administrators. He recommends short-term. management programmes for medical experts who have to administer large hospitals.

scholarly journals A few ethical issues in translational research for gene and cell therapy

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Luciana Riva ◽  
Carlo Petrini
Keyword(s):  
Gene Therapy ◽  
Cell Therapy ◽  
Translational Research ◽  
Early Phase ◽  
Ethical Issues ◽  
The United States ◽  
Cell Therapies ◽  
Biomedical Technologies ◽  
Regulatory Approach ◽  
Gene And Cell Therapy

Abstract Background Although translational research for drug development can provide patients with valuable therapeutic resources it is not without risk, especially in the early-phase trials that present the highest degree of uncertainty. With the extraordinary evolution of biomedical technologies, a growing number of innovative products based on human cells and gene therapy are being tested and used as drugs. Their use on humans poses several challenges. Methods In this work, we discuss some ethical issues related to gene and cell therapies translational research. We focus on early-phase studies analysing the regulatory approach of Europe and the United States. We report the current recommendations and guidelines of international scientific societies and European and American regulatory authorities. Results The peculiarity of human cell- or tissue-based products and gene therapy has required the development of specific regulatory tools that must be continually updated in line with the progress of the research. The ethics of translational research for these products also requires further considerations, particularly with respect to the specificity of the associated risk profiles. Conclusions An integrated ethical approach that aims for transparency and regulation of development processes, the support of independent judgment in clinical trials and the elimination of unregulated and uncontrolled grey areas of action are necessary to move gene and cell therapy forward.

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