scholarly journals Evolution of Nitrogen-Based Alkylating Anticancer Agents

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 377
Author(s):  
Fredrik Lehmann ◽  
Johan Wennerberg
Keyword(s):  
Anticancer Agents ◽  
Alkylating Agents ◽  
Anticancer Therapy ◽  
Mechanisms Of Action ◽  
Drug Resistant ◽  
Significant Progress ◽  
Solid Malignancies ◽  
Alkylating Activity ◽  
Therapy Strategies ◽  
Anticancer Drug Development

Despite the significant progress in anticancer drug development over recent years, there is a vital need for newer agents with unique, but still effective, mechanisms of action in order to treat the disease, particularly the highly aggressive and drug-resistant types. Alkylating agents, in particular nitrogen-based alkylators, are commonly used to treat hematological and solid malignancies; they exert their antineoplastic effects at all phases of the cell cycle and prevent reproduction of tumor cells. Certain alkylating agents have been designed to be more lipophilic, enabling the compound to penetrate the cell and enhance its alkylating activity against tumors. This review details the evolution of currently available alkylating agents and their profiles, with a focus on nitrogen-based alkylating agents, as important anticancer therapy strategies.

Recent Advances in β-lactam Derivatives as Potential Anticancer Agents

2020 ◽  
Vol 20 (16) ◽  
pp. 1468-1480
Author(s):  
Xinfen Zhang ◽  
Yanshu Jia
Keyword(s):  
Anticancer Agents ◽  
Mechanisms Of Action ◽  
Pharmacological Properties ◽  
Drug Resistant ◽  
Therapeutic Application ◽  
Lead Compounds ◽  
Potential Therapeutic Application ◽  
Made In ◽  
Critical Aspects ◽  
Control And Eradication

Cancer, accounts for around 10 million deaths annually, is the second leading cause of death globally. The continuous emergency of drug-resistant cancers and the low specificity of anticancer agents are the main challenges in the control and eradication of cancers, so it is imperative to develop novel anticancer agents. Immense efforts have been made in developing new lead compounds and novel chemotherapeutic strategies for the treatment of various forms of cancers in recent years. β-Lactam derivatives constitute versatile and attractive scaffolds for the drug discovery since these kinds of compounds possess a variety of pharmacological properties, and some of them exhibited promising potency against both drug-sensitive and drug-resistant cancer cell lines. Thus, β-lactam moiety is a useful template for the development of novel anticancer agents. This review will provide an overview of β-lactam derivatives with the potential therapeutic application for the treatment of cancers covering articles published between 2000 and 2020. The mechanisms of action, the critical aspects of design and structureactivity relationships are also discussed.

Quinoline-based compounds with potential activity against drug-resistant cancers

2020 ◽  
Vol 20 ◽  
Author(s):  
Huan-Ting Li ◽  
Xiaoyong Zhu
Keyword(s):  
Drug Resistance ◽  
Anticancer Agents ◽  
Anticancer Agent ◽  
Short Review ◽  
Therapeutic Strategies ◽  
Mechanisms Of Action ◽  
Review Article ◽  
Drug Resistant ◽  
Structure Activity ◽  
Potential Activity

: Drug resistance is the major cause of the failure of cancer chemotherapy, so one of the most important features in developing effective cancer therapeutic strategies is to overcome drug resistance. Quinoline moiety has become one of the most privileged structural motifs in anticancer agent discovery since its derivatives possess potential activity against various cancers including drug-resistant cancers. Several quinoline-based compounds which are represented by Anlotinib, Bosutinib, Lenvatinib, and Neratinib have already been applied in clinical practice to fight against cancers, so quinoline-based compounds are potential anticancer agents. The present short review article provides an overview about the recent advances of quinoline-based compounds with potential activity against drug-resistant cancers. The structure-activity relationship and mechanisms of action are also discussed.

Recent Progress of Benzimidazole Hybrids for Anticancer Potential

2020 ◽  
Vol 27 (35) ◽  
pp. 5970-6014 ◽  
Author(s):  
Md. Jawaid Akhtar ◽  
Mohammad Shahar Yar ◽  
Vinod Kumar Sharma ◽  
Ahsan Ahmed Khan ◽  
Zulphikar Ali ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Alkylating Agents ◽  
American Chemical Society ◽  
Chemical Society ◽  
Benzimidazole Derivatives ◽  
Progressive Development ◽  
Anticancer Properties ◽  
Naturally Occurring ◽  
Nitrogenous Base

This review presents the detailed account of factors leading to cancer and design strategy for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for cancer treatment in Cancer facts and figures 2017 American Chemical Society has shown progressive development in fighting cancer. Researchers all over the world in both developed and developing countries are in a continuous effort to tackle this serious concern. Benzimidazole and its derivatives showed a broad range of biological activities due to their resemblance with naturally occurring nitrogenous base i.e. purine. The review discussed benzimidazole derivatives showing anticancer properties through a different mechanism viz. intercalation, alkylating agents, topoisomerases, DHFR enzymes, and tubulin inhibitors. Benzimidazole derivatives act through a different mechanism and the substituents reported from the earlier and recent research articles are prerequisites for the synthesis of targeted based benzimidazole derivatives as anticancer agents. The review focuses on an easy comparison of the substituent essential for potency and selectivity through SAR presented in figures. This will further provide a better outlook or fulfills the challenges faced in the development of novel benzimidazole derivatives as anticancer.

Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs

2019 ◽  
Vol 19 (9) ◽  
pp. 1080-1102 ◽  
Author(s):  
Ghansham S. More ◽  
Asha B. Thomas ◽  
Sohan S. Chitlange ◽  
Rabindra K. Nanda ◽  
Rahul L. Gajbhiye
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Nitrogen Mustard ◽  
Alkylating Agents ◽  
Cross Linking ◽  
Nitrogen Mustards ◽  
Information Leaflets ◽  
Anti Cancer ◽  
Approved Drugs

Background & Objective: :Nitrogen mustard derivatives form one of the major classes of anti-cancer agents in USFDA approved drugs list. These are polyfunctional alkylating agents which are distinguished by a unique mechanism of adduct formation with DNA involving cross-linking between guanine N-7 of one strand of DNA with the other. The generated cross-linking is irreversible and leads to cell apoptosis. Hence it is of great interest to explore this class of anticancer alkylating agents.Methods::An exhaustive list of reviews, research articles, patents, books, patient information leaflets, and orange book is presented and the contents related to nitrogen mustard anti-cancer agents have been reviewed. Attempts are made to present synthesis schemes in a simplified manner. The mechanism of action of the drugs and their side effects are also systematically elaborated.Results::This review provides a platform for understanding all aspects of such drugs right from synthesis to their mechanism of action and side effects, and lists USFDA approved ANDA players among alkylating anticancer agents in the current market.Conclusion: :Perusing this article, generic scientists will be able to access literature information in this domain easily to gain insight into the nitrogen mustard alkylating agents for further ANDA development. It will help the scientific and research community to continue their pursuit for the design of newer and novel heterocyclic alkylating agents of this class in the coming future.

Potential Anticancer Agents.1XLIII. Analogs of Chlorambucil. IV.2Synthesis of Isochlorambucil and Related Benzylic Type Alkylating Agents

1961 ◽  
Vol 26 (1) ◽  
pp. 148-152 ◽  
Author(s):  
W. A. SKINNER ◽  
ABELARDO P. MARTINEZ ◽  
HELEN F. GRAM ◽  
LEON GOODMAN ◽  
B. R. BAKER
Keyword(s):  
Anticancer Agents ◽  
Alkylating Agents

scholarly journals Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3438
Author(s):  
Tianxi Li ◽  
Lulu Li ◽  
Fangyuan Du ◽  
Lei Sun ◽  
Jichao Shi ◽  
...  
Keyword(s):  
Mechanisms Of Action ◽  
Antifungal Drugs ◽  
Drug Resistant ◽  
Important Research ◽  
Factors Affecting ◽  
Natural Substances ◽  
Therapeutic Drugs ◽  
Antifungal Peptides ◽  
Control Work ◽  
And Control

Harmful fungi in nature not only cause diseases in plants, but also fungal infection and poisoning when people and animals eat food derived from crops contaminated with them. Unfortunately, such fungi are becoming increasingly more resistant to traditional synthetic antifungal drugs, which can make prevention and control work increasingly more difficult to achieve. This means they are potentially very harmful to human health and lifestyle. Antifungal peptides are natural substances produced by organisms to defend themselves against harmful fungi. As a result, they have become an important research object to help deal with harmful fungi and overcome their drug resistance. Moreover, they are expected to be developed into new therapeutic drugs against drug-resistant fungi in clinical application. This review focuses on antifungal peptides that have been isolated from bacteria, fungi, and other microorganisms to date. Their antifungal activity and factors affecting it are outlined in terms of their antibacterial spectra and effects. The toxic effects of the antifungal peptides and their common solutions are mentioned. The mechanisms of action of the antifungal peptides are described according to their action pathways. The work provides a useful reference for further clinical research and the development of safe antifungal drugs that have high efficiencies and broad application spectra.

Potential Anticancer Agents.1LXVIII. Synthesis of Alkylating Agents Derived from 3-Amino-3-deoxy-D-allose

1962 ◽  
Vol 27 (1) ◽  
pp. 202-204 ◽  
Author(s):  
ELMER J. REIST ◽  
ROLAND R. SPENCER ◽  
LEON GOODMAN ◽  
B. R. BAKER
Keyword(s):  
Anticancer Agents ◽  
Alkylating Agents
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