scholarly journals Effect of Hydrogen Bond Donors and Acceptors on CO2 Absorption by Deep Eutectic Solvents

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1533
Author(s):  
Tausif Altamash ◽  
Abdulkarem Amhamed ◽  
Santiago Aparicio ◽  
Mert Atilhan
Keyword(s):  
Carbon Dioxide ◽  
Hydrogen Bond ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Gas Absorption ◽  
Carbon Dioxide Absorption ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
Natural Deep Eutectic Solvents ◽  
Absorption Performance

The effects of a hydrogen bond acceptor and hydrogen bond donor on carbon dioxide absorption via natural deep eutectic solvents were studied in this work. Naturally occurring non-toxic deep eutectic solvent constituents were considered; choline chloride, b-alanine, and betaine were selected as hydrogen bond acceptors; lactic acid, malic acid, and fructose were selected as hydrogen bond donors. Experimental gas absorption data were collected via experimental methods that uses gravimetric principles. Carbon dioxide capture data for an isolated hydrogen bond donor and hydrogen bond acceptor, as well as natural deep eutectic solvents, were collected. In addition to experimental data, a theoretical study using Density Functional Theory was carried out to analyze the properties of these fluids from the nanoscopic viewpoint and their relationship with the macroscopic behavior of the system, and its ability for carbon dioxide absorption. The combined experimental and theoretical reported approach work leads to valuable discussions on what is the effect of each hydrogen bond donor or acceptor, as well as how they influence the strength and stability of the carbon dioxide absorption in deep eutectic solvents. Theoretical calculations explained the experimental findings, and combined results showed the superiority of the hydrogen bond acceptor role in the gas absorption process, with deep eutectic solvents. Specifically, the cases in which choline chloride was used as hydrogen bond acceptor showed the highest absorption performance. Furthermore, it was observed that when malic acid was used as a hydrogen bond donor, it led to low carbon dioxide solubility performance in comparison to other studied deep eutectic solvents. The cases in which lactic acid was used as a hydrogen bond donor showed great absorption performance. In light of this work, more targeted, specific, deep eutectic solvents can be designed for effective and alternative carbon dioxide capture and management.

scholarly journals Review on Carbon Dioxide Absorption by Choline Chloride/Urea Deep Eutectic Solvents

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Rima J. Isaifan ◽  
Abdukarem Amhamed
Keyword(s):  
Carbon Dioxide ◽  
Hydrogen Bond ◽  
Ionic Liquids ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Absorption Capacity ◽  
Carbon Dioxide Absorption ◽  
Hydrogen Bond Donor ◽  
Separation Processes ◽  
Hydrogen Bond Acceptor

In the recent past few years, deep eutectic solvents (DESs) were developed sharing similar characteristics to ionic liquids but with more advantageous features related to preparation cost, environmental impact, and efficiency for gas separation processes. Amongst many combinations of DES solvents that have been prepared, reline (choline chloride as the hydrogen bond acceptor mixed with urea as the hydrogen bond donor) was the first DES synthesized and is still the one with the lowest melting point. Choline chloride/urea DES has proven to be a promising solvent as an efficient medium for carbon dioxide capture when compared with amine alone or ionic liquids under the same conditions. This review sheds light on the preparation method, physical and chemical characteristics, and the CO2 absorption capacity of choline chloride/urea DES under different temperatures and pressures reported up to date.

scholarly journals Amino Acid-Based Deep Eutectic Solvents in Biomass Processing - Recent Advances

2021 ◽  
Author(s):  
Gustavo Gomes ◽  
Renan Mattioli ◽  
Julio Cezar Pastre
Keyword(s):  
Hydrogen Bond ◽  
Amino Acid ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Chemical Conversion ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
Platform Chemicals ◽  
Biomass Processing ◽  
Solvent Systems

The use of non-conventional solvent systems, such as deep eutectic solvents (DES), for biomass processing is a growing interest. DES are formed by two or more components, usually solids at room temperature, which can interact with each other via hydrogen bonding, from a hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD), resulting in a liquid phase. The most studied HBA in the literature is choline chloride with several HBD and their use have been extensively reviewed. However, other abundant and natural HBA can be successfully applied on the preparation of different DES, e.g., amino acids. These amino acid-based DES have been used in biomass pretreatment, providing the fractionation of the main macromolecular components by lignin solubilization. In addition, amino acid-based DES can be applied in biomass chemical conversion to obtaining platform chemicals such as furanic derivatives. Bearing this in mind, this review focuses on exploring the use of amino acid-based DES on biomass processing, from pretreatment to chemical conversion.

Deacidification of Crude Rice Bran Oil (CRBO) to Remove FFA and Preserve γ-Oryzanol Using Deep Eutectic Solvents (DES)

2019 ◽  
Vol 964 ◽  
pp. 109-114 ◽  
Author(s):  
Siti Zullaikah ◽  
Nizar Dwi Wibowo ◽  
I Made Gede Eris Dwi Wahyudi ◽  
M. Rachimoellah
Keyword(s):  
Hydrogen Bond ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Molar Ratio ◽  
Extraction Temperature ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
C 50

High content of free fatty acids (FFA) in crude rice bran oil (CRBO) needs to be separated through deacidification. Generally, deacidification process that is widely used are chemical and physical processes which causes the loss of bioactive compounds (γ-oryzanol) and un-environmentally friendly. The liquid-liquid extraction (LLE) using deep eutectic solvents (DES) to remove FFA and preserve g-oryzanol would be implemented in this study. DES with different hydrogen bond donor (HBD) and hydrogen bond acceptor (HBA) with certain molar ratio such as Choline Chloride (ChCl)-Ethylene glycol 1:2 (DES I), ChCl-Glycerol 1:1 (DES II), ChCl-Urea 1:2 (DES III), ChCl-Oxalic acid 1:2 (DES IV), and Betaine Monohydrate-Glycerol 1:8 (NADES) were used as solvent to extract FFA from dewaxed/degummed RBO (DDRBO) for certain extraction time (30, 60, 120, 180, and 240 min) and extraction temperature (30°C, 40°C, 50°C, 60°C, and 70°C) under stirring (200 rpm). Deacidification using DES I for 240 min. and temperature of 50 °C was the optimum solvent to remove FFA (19.03 ± 2.33 %) and preserve g-oryzanol (recovery of g-oryzanol was 51.30 ± 1.77 %). The results also revealed that the longer time of extraction would be increased removal of FFA and decreased recovery of g-oryzanol. The higher temperature of extraction would be increased removal of FFA. In this work, temperature of 50 °C was the best extraction temperature of FFA since DES has highest solubility at this temperature.

scholarly journals Ternary liquid–liquid equilibrium data for n-Hexane-Benzene-DES (choline chloride/ethylene glycol, choline chloride/glycerol, choline chloride/urea) at 303 K and 101.3 kPa

2020 ◽  
Vol 10 (3) ◽  
pp. 125-137
Author(s):  
Mohammed Awwalu Usman ◽  
Olumide Kayode Fagoroye ◽  
Toluwalase Olufunmilayo Ajayi ◽  
Abiola John Kehinde
Keyword(s):  
Hydrogen Bond ◽  
Ethylene Glycol ◽  
Choline Chloride ◽  
Ternary Systems ◽  
Deep Eutectic Solvents ◽  
Binary Interaction ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
Separation Factors ◽  
Lle Data

Abstract In this study, deep eutectic solvents (DESs) were prepared using choline chloride as hydrogen bond acceptor (HBA) and ethylene glycol (EG) or glycerol (GLY) or urea (U) as hydrogen bond donor (HBD) and were evaluated as solvents in the extraction of benzene from n-hexane. Six of such solvents were prepared using different molar ratios of HBA: HBD and code named DES1, DES2, DES3, DES4, DES5 and DES6. Liquid–liquid equilibria (LLE) data for the ternary systems of n-hexane-benzene-DESs were measured at 303 K and 101.3 kPa. Solubility data and mutual solubilities between n-hexane and DES were measured using the traditional cloud point method. The tie lines were obtained using titration and refractive index measurements on both phases (n-hexane phase and DES-phases). The ternary systems exhibit type-1 phase behavior. The Othmer-Tobias and Hands equations were applied to examine the reliability of the LLE data. The tie-line data were correlated using the nonrandom two-liquid (NRTL) and universal quasichemical (UNIQUAC) thermodynamic models, and their corresponding binary interaction parameters were determined. The results show that the maximum separation factors were 31.24, 462.00, 15.24, 37.83, 174.60 and 126.00 for DES1, DES2, DES3, DES4, DES5 and DES6, respectively. The glycerol based DES (DES2 and DES5) show the highest separation factors and thus considered the most suitable for separating benzene from hexane. The regression coefficient for both Othmer-Tobias and Hand equations are higher than 0.99 for all DESs, indicating the reliability and consistency of the data. Both NRTL and UNIQUAC models adequately capture the experimental data.

scholarly journals Intermolecular interactions upon carbon dioxide capture in deep-eutectic solvents

2018 ◽  
Vol 20 (38) ◽  
pp. 24591-24601 ◽  
Author(s):  
Shashi Kant Shukla ◽  
Jyri-Pekka Mikkola
Keyword(s):  
Carbon Dioxide ◽  
Hydrogen Bond ◽  
Intermolecular Interactions ◽  
Carbon Dioxide Capture ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
Hydrogen Bond Acceptor Basicity

An increase in hydrogen bond acceptor basicity (β) and a decrease in hydrogen bond donor acidity (α) simultaneously promotes higher CO2 uptake in deep eutectic solvents.

scholarly journals pH, Viscosity of Hydrophobic Based Natural Deep Eutectic Solvents and the Effect of Curcumin Solubility in it

2021 ◽  
Vol 11 (6) ◽  
pp. 14620-14633
Keyword(s):  
Hydrogen Bond ◽  
Room Temperature ◽  
Water Solubility ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Molar Ratio ◽  
Hydrogen Bond Donor ◽  
Hydrogen Bond Acceptor ◽  
Natural Deep Eutectic Solvents ◽  
Self Association

Turmeric contains curcumin as one of the active constituents, which gives yellow color and possesses lots of pharmacological actions. Even though curcumin has lots of pharmacological actions till now, it has not been approved as a medicine due to its low water solubility, permeability, and poor bioavailability. Deep eutectic solvent (DES) can be prepared by simply mixing two or more solid components, [among the two one is hydrogen bond donor (HBD) and another is hydrogen bond acceptor (HBA)] at a definite molar ratio where the solid components by self-association converted into a liquid at room temperature (RT). Natural deep eutectic solvents (NADES) are a specific subgroup of DES containing primary plant-based metabolites such as organic acids, alcohols, amino acids, or sugars. In this work, natural hydrophobic DESs were prepared with Camphor, Menthol, and Thymol. This was prepared from different ratios of Menthol:Thymol 1:1 to 1:5 and 1:1 to 5:1 (MT-DES); Camphor:Thymol 1:1 to 1:5 and 1:1 to 5:1 (CT-NADES); Camphor:Menthol 1:1 to 1:5 and 1:1 to 2:1 (CM-NADES). The pH and viscosity of prepared DESs were determined with the help of a digital pH meter and Brookfield viscometer. The solubility of curcumin in different NADESs was determined at room temperature (RT) to higher temperatures. The formation of different clear DES was obtained with slight heat. There was no difference in pH for the NADESs prepared without and with heat. Regarding the viscosity CM-DES (1:1) showed less viscosity when compared to other NADESs. The solubility of curcumin was found to be nearly double when it was dissolved in NADES for 1 hr at 35-40°C compared to 48 h stirring at 500 rotations per minute (rpm) at RT. Among different NADESs, curcumin solubility was found to be more in CM (1:1) ratio when compared to other NADESs.

scholarly journals Deep eutectic solvent pretreatment for enhancing biochemical conversion of switchgrass

2017 ◽  
Author(s):  
◽  
Maryam Al Ameri
Keyword(s):  
Hydrogen Bond ◽  
Acetic Acid ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Green Solvent ◽  
Biomass Recalcitrance ◽  
Hydrogen Bond Donor ◽  
Excellent Performance ◽  
Hydrogen Bond Acceptor

In this study, green solvent-based pretreatment was developed for improving the conversion of switchgrass to acetoin. Deep eutectic solvents (DESs), comprising choline chloride (ChCl) as a hydrogen-bond acceptor (HBA) and various chemical as a hydrogen-bond donor (HBD), were used to pretreat switchgrass. Different HBD groups, including polyalcohol, amid, diazole, and carboxylic acid, were used to synthesize DESs. The DESs using ChCl-formic acid and ChCl-lactic acid-acetic acid showed excellent performance in enhancing switchgrass digestibility. The obtained hydrolysate was successfully detoxified by using overliming detoxification, which was further used for acetoin fermentation by Bacillus licheniformis (NRRL B-642). The yield and titer of the produced acetoin were 0.377 g/g and 19.6 g/L, respectively. Our research demonstrates that DES pretreatment is an effective method for reducing biomass recalcitrance and improving the conversion of biomass into chemicals.

scholarly journals Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1619 ◽  
Author(s):  
Maša Islamčević Razboršek ◽  
Milena Ivanović ◽  
Peter Krajnc ◽  
Mitja Kolar
Keyword(s):  
Hydrogen Bond ◽  
Phenolic Compounds ◽  
Choline Chloride ◽  
Dry Weight ◽  
Deep Eutectic Solvents ◽  
Ultrasound Assisted Extraction ◽  
Hydrogen Bond Acceptor ◽  
Mean Values ◽  
Natural Deep Eutectic Solvents ◽  
The Individual

For the isolation of selected phenolic compounds from dried chokeberries, natural deep eutectic solvents (NADESs) were investigated as a green alternative to conventionally used extraction solvents. Four types of NADESs were synthesised, with choline chloride as the hydrogen bond acceptor in combination with different hydrogen bond donors (sugars, organic acid and urea). Ultrasound-assisted extraction was used to improve the extractability of the phenolic compounds and the results were compared to those obtained with 80% methanol as the extraction media. The highest values of total phenols and total flavonoids were found in the extract obtained with choline chloride–fructose NADES (36.15 ± 3.39 mg gallic acid g−1 dry weight (DW) and 4.71 ± 0.33 mg rutin g−1 DW, respectively). The extraction recoveries for the individual phenolic compounds depended strongly on the phenolic compound’s structure, with relative mean values between 70% and 97%.

scholarly journals Integration of Choline Chloride-Based Natural Deep Eutectic Solvents and Macroporous Resin for Green Production of Enriched Oil Palm Flavonoids as Natural Wound Healing Agents

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1802
Author(s):  
Mohamad Shazeli Che Zain ◽  
Jen Xen Yeoh ◽  
Soo Yee Lee ◽  
Adlin Afzan ◽  
Khozirah Shaari
Keyword(s):  
Hydrogen Bond ◽  
Wound Healing ◽  
Oil Palm ◽  
Choline Chloride ◽  
Radical Scavenging ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Acceptor ◽  
Molar Ratios ◽  
Natural Deep Eutectic Solvents ◽  
Water Contents

Huge quantities of oil palm (Elaeis guineensis Jacq.) leaves (OPL) are generated as agricultural biomass from oil palm plantations. OPL are known to contain significant amounts of flavonoids. For maximal exploitation of these valuable antioxidant compounds, an innovative and sustainable extraction method employing natural deep eutectic solvents (NaDES) combined with ultrasonic assisted extraction was developed. Various NaDES composed of choline chloride as the hydrogen bond donor (HBD) and 1,2 propanediol (PD), 1,4 butanediol (BD), glycerol (GLY), glucose (GLU), maltose (MAL), and lactic acid (LA) as the hydrogen bond acceptor (HBA) were synthesized. The influence of these compositions, the methods of their synthesis, molar ratios, and water contents on their capacity to extract flavonoids from OPL was evaluated. Based on the results, it was found that methods which incorporate a heating step produced NaDES with the best capacity to extract OPL flavonoids. These thermal methods combined with molar ratios of 1:3 or 1:4 and water contents of 17 to 50% were found to be the optimal conditions for preparing NaDES, specifically when applied to the PD, BD, and GLY NaDES. Subsequently, UHPLC-UV/PDA-MS/MS analysis revealed NaDES extracts recovered by macroporous adsorption resin XAD7HP were able to optimally extract at least twelve luteolin and apigenin derivatives in OPL NaDES extracts prepared from glycerol and 1,4-butanediol demonstrated better and comparable efficiency as aqueous methanol in extracting flavonoids from OPL. The in vitro studies of antioxidant and wound healing properties supported these findings by exhibiting good free radical scavenging, cell proliferation, and migration activities. Additionally, the NaDES extracts also showed non-cytotoxicity effects at 1000 µg/mL and below on 3T3 fibroblast cells. Results of the study showed that NaDES could be a promising eco-friendly green solvent to extract bioactive OPL flavonoids that have great potential for applications as wound healing agents.

scholarly journals A brief review on eutectic mixture and its role in pharmaceutical field

2020 ◽  
Vol 11 (3) ◽  
pp. 3017-3023
Author(s):  
Balakrishnan I ◽  
Jawahar N ◽  
Senthil Venkatachalam ◽  
Debosmita Datta
Keyword(s):  
Drug Delivery ◽  
Hydrogen Bond ◽  
Deep Eutectic Solvent ◽  
Eutectic Mixture ◽  
Deep Eutectic Solvents ◽  
Hydrogen Bond Donor ◽  
Liquid Form ◽  
Hydrogen Bond Acceptor ◽  
Pharmaceutical Industries ◽  
Natural Deep Eutectic Solvent

Eutectic mixture (EM) is as a mixture of more than one substance that does not interact individually to create a new entity but in a particular ratio that exhibits a lower range of melting point than it had in individual. EM should be formulated in such a way that it should have major advantages in pharmaceutical industries. EM can be a mixture of Active Pharmaceutical Ingredients (APIs), or different ratios of APIs and excipients, or various excipients. Deep eutectic solvents containing APIs (API-DES) considered as an innovative approach to form different APIs in the liquid state. This new approach of liquid form is versatile and plays an important role in drug delivery. The selection of ideal hydrogen bond-donor (HBD) and hydrogen bond-acceptor (HBA) is an essential parameter. Ionic liquids (IL), derivatives of deep eutectic solvents (DES) have got much attention since it can replace harmful organic solvent by their extraordinary properties. Therapeutic deep eutectic solvents (THEDESs) are considered to be an exceptional option in the advancement of biomedicine. This can be utilized for improvising drug solubility, bioavailability as well as drug permeation through the skin. Natural deep eutectic solvent (NADES) can be considered as an alternate option, replacing harsh solvents. It has special characteristics of better biodegradability and biocompatibility. These NADES mainly used to separate and purification of natural compounds. This review focuses on the eutectic mixture and its application in the area of drug delivery systems, and pharmaceutical and pharmacological fields.

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