scholarly journals Stem Cell Therapy for Thromboangiitis Obliterans (Buerger’s Disease)

Processes ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 1408
Author(s):  
Biraja C. Dash ◽  
Hassan Peyvandi ◽  
Kaiti Duan ◽  
Edward Richardson ◽  
Sifon U. Ndon ◽  
...  
Keyword(s):  
Stem Cell ◽  
Current Knowledge ◽  
Young Male ◽  
Therapeutic Angiogenesis ◽  
Treatment Modalities ◽  
Thromboangiitis Obliterans ◽  
Buerger’S Disease ◽  
Ischemic Lesion ◽  
Buerger's Disease ◽  
Therapeutic Modalities

Buerger’s disease or Thromboangiitis Obliterans (TAO) is a nonatherosclerotic segmental vascular disease which affects small and medium arteries and veins in the upper and lower extremities. Based on pathological findings, TAO can be considered as a distinct form of vasculitis that is most prevalent in young male smokers. There is no definitive cure for this disease as therapeutic modalities are limited in number and efficacy. Surgical bypass has limited utility and 24% of patients will ultimately require amputation. Recently, studies have shown that therapeutic angiogenesis and immunomodulatory approaches through the delivery of stem cells to target tissues are potential options for ischemic lesion treatment. In this review, we summarize the current knowledge of TAO treatment and provide an overview of stem cell-based treatment modalities.

scholarly journals Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease)

2019 ◽  
Author(s):  
Hassan Peyvandi ◽  
Biraja C. Dash ◽  
Sifon U. Ndon ◽  
Kyle Steven Gabrick ◽  
Athena Alipour Alipour ◽  
...  
Keyword(s):  
Stem Cell ◽  
Current Knowledge ◽  
Young Male ◽  
Therapeutic Angiogenesis ◽  
Current Status ◽  
Treatment Modalities ◽  
Thromboangiitis Obliterans ◽  
Buerger’S Disease ◽  
Ischemic Lesion ◽  
Buerger's Disease

Buerger's disease or Thromboangiitis Obliterans (TAO) is a nonatherosclerotic segmental vascular disease which affects small and medium arteries and veins in the upper and lower extremities. Based on pathological findings, TAO can be considered as a distinct form of vasculitis that is most prevalent in young male smokers. There is no definitive cure for this disease as therapeutic modalities are limited in number and efficacy. Surgical bypass has limited utility and 24% of patients will ultimately require amputation. Recently, studies have shown that therapeutic angiogenesis and immunomodulatory approaches through the delivery of cells to target tissues are potential options for ischemic lesion treatment. In this review, we summarize the current knowledge of TAO treatment and provide an overview of stem cell-based treatment modalities.

scholarly journals Buerger’s disease in female: rare case report

2018 ◽  
Vol 5 (4) ◽  
pp. 1571
Author(s):  
Abhijit A. Bhoyate ◽  
Lekshmi Priya R. ◽  
Vidyanand Tripathi ◽  
Piyushkumar Agrawal ◽  
G. S. Moirangthem
Keyword(s):  
Case Report ◽  
Vascular Disease ◽  
Rare Case ◽  
Young Male ◽  
Thromboangiitis Obliterans ◽  
Buerger’S Disease ◽  
Buerger's Disease ◽  
Rare Case Report ◽  
Arteries And Veins

Thromboangiitis obliterans (Bureger’s disease) is a vascular disease characterized by a segmental, non-atherosclerotic inflammation of the small and medium-sized arteries and veins of the distal extremities mostly affecting young male smokers and rarely females. Only a few cases with histologic proof of the disease in females have ever been recorded in literature. We report a rare case of Buerger’s disease in a 55 years old female.

scholarly journals Treatment of Buerger’s disease (Thromboangiitis obliterans) with autologous adipose tissue-derived mesenchymal stem cell: Report of three cases

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 2016
Author(s):  
Sun Teak Jeong ◽  
Jeong Chan Ra
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Adverse Drug Events ◽  
Smoking History ◽  
Thromboangiitis Obliterans ◽  
Inflammatory Disorder ◽  
Life Questionnaire ◽  
Buerger’S Disease ◽  
Buerger's Disease

Buerger’s disease or Thromboangiitis obliterans is an orphan vascular disease that most commonly affects nerves, small or medium-sized vessels in the upper and lower extremities, and is characterized by a non-atherosclerotic, segmental, inflammatory disorder. The etiology and the pathogenesis of the disease have not been fully elucidated. Although various interventions have been adopted recently, there is still no effective treatment for the prevention of the progression of the disease. This report presents three clinical cases that show the efficacies of autologous adipose tissue-derived mesenchymal stem cell (AdMSC) treatment in Buerger’s disease. Three male patients diagnosed with Buerger’s disease were between 46 and 55 years and had a smoking history. AdMSCs (5X106 cells/kg body weight) were injected intramuscularly into at least 38 points of the ischemic legion of the lower limb at one time. The patients were checked for safety and efficacy at one, three, and six months after AdMSC injection. No severe adverse events and no adverse drug events were observed in physical examination, vital signs, and laboratory tests for all three patients. Ulcers in the affected legs of the patients were healed completely after the treatment. Visual Analogue Scale scores and all the criteria (activities, emotional, pain, social, symptoms and total) of the King's College Hospital's Vascular Quality of Life Questionnaire (VascuQOL) of all the patients were improved from baseline to six months follow-up. Digital Infrared Thermal Imaging showed the gradual alleviation of lesions in the leg. Angiogenesis in the affected limbs was identified by CT-Angiography after AdMSC injection. The present cases show the improvement in patients with Buerger’s disease with the observation of angiogenesis after intramuscular injection of autologous AdMSCs. This suggests that autologous AdMSC can be an effective alternative treatment for Buerger’s disease.

scholarly journals Intestinal thromboangiitis obliterans: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Swastik Sourav Mishra ◽  
Tushar Subhadarshan Mishra ◽  
Suvradeep Mitra ◽  
Pankaj Kumar
Keyword(s):  
Acute Abdomen ◽  
Enterocutaneous Fistula ◽  
Young Male ◽  
Thromboangiitis Obliterans ◽  
Prior History ◽  
Buerger’S Disease ◽  
Buerger's Disease ◽  
Diffuse Abdominal Pain ◽  
Feeding Jejunostomy ◽  
History Of

Abstract Background Thromboangiitis obliterans or Buerger’s disease is a form of peripheral vascular disease in young male smokers. The involvement of the intestine occurs in only about 2% of the cases, when they may present as acute abdomen due to mesenteric ischemia. The uncommonness of the condition makes it a less suspected differential diagnosis, leading to a delay in appropriate management, thereby increasing chances of morbidity or mortality. Cessation of smoking is known to stall the disease progression including visceral involvement, but may not always be the case as happened in the case being presented. Case presentation Our Indian Hindu male patient, a known smoker, presented with diffuse abdominal pain along with bouts of vomiting and loose motions. He had a prior history of amputation of the right foot, 4 years before. At presentation he had abdominal distension with diffuse tenderness and guarding. An omental band attached to the tip of the appendix was discovered at the initial exploration along with dilated proximal bowel loops, for which a release of the omental band along with appendectomy was done. He developed an enterocutaneous fistula on the 6th postoperative day for which he had to be reexplored, and multiple jejunal perforations were found. Segmental jejunal resection and a Roux-en-Y gastrojejunostomy with distal ileostomy were done along with a feeding jejunostomy. The patient however again had feculent discharge from the wound for which a third exploration was done. The gastrojejunostomy and feeding jejunostomy sites were leaky, both of which were repaired primarily. The patient developed septicemia which progressed to refractory septic shock, and he ultimately succumbed to his illness on the 23rd postoperative day of the index surgery. Conclusion Acute abdomen in a young man who is a chronic smoker and having an antecedent history of amputation of some part of an extremity for a nontraumatic cause should raise the suspicion of Buerger’s disease of the intestine. Although it is a progressive disease and the situation has already progressed by the time intestinal symptoms manifest, early detection may give some scope of salvage and decrease the morbidity and mortality.

scholarly journals Unusual Association of Uveitis and Buerger’s Disease

2020 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Young Male ◽  
Thromboangiitis Obliterans ◽  
Ocular Involvement ◽  
Buerger’S Disease ◽  
Buerger's Disease ◽  
Unusual Association ◽  
Unusual Combination

Buerger’s disease or thromboangiitis obliterans TAO is a rare arteriopathy, which usually affects young male smokers and is classically responsible for ischemia of the extremities [1]. Ocular involvement is rarely described in the literature. We report an unusual combination of uveitis with TAO in a young man.

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