scholarly journals New Hybrid Bioactive Composites for Bone Substitution

Processes ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 335 ◽  
Author(s):  
Anna Ślósarczyk ◽  
Joanna Czechowska ◽  
Ewelina Cichoń ◽  
Aneta Zima
Keyword(s):  
Phase Composition ◽  
Physicochemical Properties ◽  
Mechanical Strength ◽  
Organic Materials ◽  
Setting Time ◽  
Bone Substitutes ◽  
Bone Implant ◽  
Load Bearing ◽  
Implant Materials ◽  
Bioactive Composites

Recently, intensive efforts have been undertaken to find new, superior biomaterial solutions in the field of hybrid inorganic–organic materials. In our studies, biomicroconcretes containing hydroxyapatite (HAp)–chitosan (CTS) granules dispersed in an α tricalcium phospahate (αTCP) matrix were investigated. The influence of CTS content and the size of granules on the physicochemical properties of final bone implant materials (setting time, porosity, mechanical strength, and phase composition) were evaluated. The obtained materials were found to be promising bone substitutes for use in non-load bearing applications.

Study on Physicochemical Properties of the Carbonated Hydroxyapatite Bone Cement

2007 ◽  
Vol 280-283 ◽  
pp. 1545-1548
Author(s):  
Li Min Dong ◽  
Chen Wang ◽  
Jie Mo Tian ◽  
Jian Pan ◽  
Qing Feng Zan
Keyword(s):  
Compressive Strength ◽  
Phase Composition ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Pore Size ◽  
Setting Time ◽  
Mineral Phase ◽  
Carbonated Hydroxyapatite ◽  
Natural Bone ◽  
Ft Ir

Carbonated hydroxyapatite (CHA) bone cement is capable of self-setting and has the component similar to the mineral phase of natural bone. But it is compact in structure and short of cavity, which limits new bone growing into CHA bone cement. In this paper, the foaming method was adopted to prepare the porous CHA. The setting time, compressive strength, porosity and pore size of the CHA were examined. The phase composition of the CHA was tested with XRD and FT-IR. The microstructure of the CHA was observed with SEM. The results show that setting time of 7~19 minutes, compressive strength of 26~32MPa, pore size of 100~200µm, porosity of 50~60%.

scholarly journals CHARACTERIZATION OF 3D-PRINTING FILAMENT WITH EXTRUDER MELTING TEMPERATURE VARIATION FOR BONE IMPLANT FROM KUPANG SHELL

2022 ◽  
Vol 2 (2) ◽  
pp. 73
Author(s):  
Ananda Maulidha Kusumastuti ◽  
Adik Roni Setiawan ◽  
Asalina Putri Agung Shaliha ◽  
Deden Eko Wiyono ◽  
Achmad Ferdiansyah Pradana Putra
Keyword(s):  
3D Printing ◽  
Mechanical Strength ◽  
Melting Temperature ◽  
Organic Materials ◽  
Bone Implants ◽  
Bone Implant ◽  
Bone Damage ◽  
Mussel Shells

<p><em>The number of bone damage in Indonesia continues to increase. Bone implant is one of the medical treatment methods performed on bone damage. Organic and non-organic materials can be used as bone implants. Non-organic materials are stronger, but not biocompatible, while organic materials are biocompatible, but brittle. The addition of polycaprolactone polymer (PCL) can increase the mechanical strength of 3D printing bone implant filaments. Extruder melting temperature is one of the factors that affect the quality of PCL-HAp filaments for bone implants. Studies related to temperature variations in PCL-HAp materials have not been widely studied. Therefore, it is necessary to characterize 3D printing filaments with variations in the melting temperature of the extruder as bone implants from mussel shells with temperature variables of 65<sup>o</sup>C, 75<sup>o</sup>C, and 85<sup>o</sup>C. From this study, the optimum point was found at the melting extruder temperature of 75<sup>o</sup>C with the results of a diameter of 1.810 and mechanical strength which showed an increase in tensile strength and Young's modulus of PCL-HAp composite in all variables compared to pure PCL. The SEM test showed a rough surface on the filaments that could increase the proliferation and adhesion of good cells for the growth of bone tissue.</em></p>

scholarly journals Effect of Flue Gas Desulfurization Gypsum on the Properties of Calcium Sulfoaluminate Cement Blended with Ground Granulated Blast Furnace Slag

Materials ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 382 ◽  
Author(s):  
Danying Gao ◽  
Zhenqing Zhang ◽  
Yang Meng ◽  
Jiyu Tang ◽  
Lin Yang
Keyword(s):  
Blast Furnace ◽  
Mechanical Strength ◽  
Flue Gas ◽  
Blast Furnace Slag ◽  
Setting Time ◽  
Flue Gas Desulfurization ◽  
Calcium Sulfoaluminate Cement ◽  
Calcium Sulfoaluminate ◽  
Granulated Blast Furnace Slag ◽  
Furnace Slag

This work aims to investigate the effect of additional flue gas desulfurization gypsum (FGDG) on the properties of calcium sulfoaluminate cement (CSAC) blended with ground granulated blast furnace slag (GGBFS). The hydration rate, setting time, mechanical strength, pore structure and hydration products of the CSAC-GGBFS mixture containing FGDG were investigated systematically. The results show that the addition of FGDG promotes the hydration of the CSAC-GGBFS mixture and improves its mechanical strength; however, the FGDG content should not exceed 6%.

scholarly journals Effect of Gold Nanoparticles and Silicon on the Bioactivity and Antibacterial Properties of Hydroxyapatite/Chitosan/Tricalcium Phosphate-Based Biomicroconcretes

Materials ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 3854
Author(s):  
Joanna Czechowska ◽  
Ewelina Cichoń ◽  
Anna Belcarz ◽  
Anna Ślósarczyk ◽  
Aneta Zima
Keyword(s):  
Gold Nanoparticles ◽  
Antibacterial Activity ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Antibacterial Properties ◽  
Bone Substitutes ◽  
Bacterial Strains ◽  
Setting Times ◽  
Biological Studies

Bioactive, chemically bonded bone substitutes with antibacterial properties are highly recommended for medical applications. In this study, biomicroconcretes, composed of silicon modified (Si-αTCP) or non-modified α-tricalcium phosphate (αTCP), as well as hybrid hydroxyapatite/chitosan granules non-modified and modified with gold nanoparticles (AuNPs), were designed. The developed biomicroconcretes were supposed to combine the dual functions of antibacterial activity and bone defect repair. The chemical and phase composition, microstructure, setting times, mechanical strength, and in vitro bioactive potential of the composites were examined. Furthermore, on the basis of the American Association of Textile Chemists and Colorists test (AATCC 100), adapted for chemically bonded materials, the antibacterial activity of the biomicroconcretes against S. epidermidis, E. coli, and S. aureus was evaluated. All biomicroconcretes were surgically handy and revealed good adhesion between the hybrid granules and calcium phosphate-based matrix. Furthermore, they possessed acceptable setting times and mechanical properties. It has been stated that materials containing AuNPs set faster and possess a slightly higher compressive strength (3.4 ± 0.7 MPa). The modification of αTCP with silicon led to a favorable decrease of the final setting time to 10 min. Furthermore, it has been shown that materials modified with AuNPs and silicon possessed an enhanced bioactivity. The antibacterial properties of all of the developed biomicroconcretes against the tested bacterial strains due to the presence of both chitosan and Au were confirmed. The material modified simultaneously with AuNPs and silicon seems to be the most promising candidate for further biological studies.

scholarly journals Enhancing the mechanical properties and cytocompatibility of magnesium potassium phosphate cement by incorporating oxygen-carboxymethyl chitosan

2020 ◽  
Author(s):  
Changtian Gong ◽  
Shuo Fang ◽  
Kezhou Xia ◽  
Jingteng Chen ◽  
Liangyu Guo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Ph Value ◽  
Setting Time ◽  
Potassium Phosphate ◽  
Carboxymethyl Chitosan ◽  
Bioactive Substances ◽  
Magnesium Potassium Phosphate Cement

Abstract Incorporating bioactive substances into synthetic bioceramic scaffolds is challenging. In this work, oxygen-carboxymethyl chitosan (O-CMC), a natural biopolymer that is nontoxic, biodegradable and biocompatible, was introduced into magnesium potassium phosphate cement (K-struvite) to enhance its mechanical properties and cytocompatibility. This study aimed to develop O-CMC/magnesium potassium phosphate composite bone cement (OMPC), thereby combining the optimum bioactivity of O-CMC with the extraordinary self-setting properties and mechanical intensity of the K-struvite. Our results indicated that O-CMC incorporation increased the compressive strength and setting time of K-struvite and decreased its porosity and pH value. Furthermore, OMPC scaffolds remarkably improved the proliferation, adhesion and osteogenesis related differentiation of MC3T3-E1 cells. Therefore, O-CMC introduced suitable physicochemical properties to K-struvite and enhanced its cytocompatibility for use in bone regeneration.

Development of Modelling Methods for Materials to be Used as Bone Substitutes

2007 ◽  
Vol 361-363 ◽  
pp. 903-906 ◽  
Author(s):  
R. Gabbrielli ◽  
I.G. Turner ◽  
Chris R. Bowen
Keyword(s):  
Mechanical Strength ◽  
Volume Fraction ◽  
Bone Substitutes ◽  
Gradient Material ◽  
Periodic Surfaces ◽  
Triply Periodic ◽  
Functional Gradient Material ◽  
Spatial Periodicity ◽  
Bearing Materials ◽  
Modelling Methods

The demand in the medical industry for load bearing materials is ever increasing. The techniques currently used for the manufacture of such materials are not optimized in terms of porosity and mechanical strength. This study adopts a microstructural shape design approach to the production of open porous materials, which utilizes spatial periodicity as a simple way to generate the models. A set of triply periodic surfaces expressed via trigonometric functions in the implicit form are presented. A geometric description of the topology of the microstructure is necessary when macroscopic properties such as mechanical strength, stiffness and isotropy are required to be optimised for a given value of volume fraction. A distinction between the families of structures produced is made on the basis of topology. The models generated have been used successfully to manufacture both a range of structures with different volume fractions of pores and samples of functional gradient material using rapid prototyping.

Several Common Retarders on Performance of Ultra-Early-Strength Grouting Material

2013 ◽  
Vol 477-478 ◽  
pp. 931-935
Author(s):  
Chang Zheng Sun ◽  
Xiao Ping Zhang ◽  
Hai Nan Zhao ◽  
Qiang Gao
Keyword(s):  
Mechanical Strength ◽  
Setting Time ◽  
Strength Properties ◽  
Preliminary Screening ◽  
Final Setting Time ◽  
Grouting Material ◽  
Early Strength

To explore retarders on performance of ultra-early strength grouting material, Retarder, which are commonly used in the market after a preliminary screening, are further tested and analyzed for initial fluidity, setting time and mechanical strength properties of super early strength grouting material. The results show that: When borax content is 0.4%, the initial fluidity, final setting time, workability, mechanical strength are the best.

Secondary Structures and Mechanical Properties of Biomimetic Protein Polymers

2009 ◽  
Author(s):  
Weibing Teng ◽  
Joseph Cappello ◽  
Xiaoyi Wu
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Mechanical Behavior ◽  
Half Life ◽  
Secondary Structures ◽  
Load Bearing ◽  
Protein Polymers ◽  
Human Arteries ◽  
Good Biocompatibility ◽  
Polypeptide Sequences

Silk may possess superior mechanical strength while its resilience is very poor. In contrast, elastin in human arteries is very soft but extremely durable with an estimated half-life of 70 years. By combing polypeptide sequences derived from native silk and elastin, we have produced a series of silk-elastin-like proteins (SELPs), which have displayed a set of outstanding properties such as good biocompatibility and controllable biodegradation rates [1]. In this study, we will examine the crystallization of the silk-like blocks and the crosslinking of the elastin-like blocks, as well as their influences on the mechanical behavior of SELPs. The ultimate goal of this study is to explore the potential of SELPs for applications in the engineering of load-bearing tissues such as arteries.

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