scholarly journals Dynamic Modelling of Phosphorolytic Cleavage Catalyzed by Pyrimidine-Nucleoside Phosphorylase

Processes ◽  
2019 ◽  
Vol 7 (6) ◽  
pp. 380 ◽  
Author(s):  
Robert T. Giessmann ◽  
Niels Krausch ◽  
Felix Kaspar ◽  
Mariano Nicolas Cruz Bournazou ◽  
Anke Wagner ◽  
...  
Keyword(s):  
Experimental Data ◽  
Process Model ◽  
Time Course ◽  
Dynamic Modelling ◽  
Cascade Reactions ◽  
Process Models ◽  
Modified Nucleosides ◽  
Pyrimidine Nucleoside ◽  
Pyrimidine Nucleoside Phosphorylase ◽  
Balanced Model

Pyrimidine-nucleoside phosphorylases (Py-NPases) have a significant potential to contribute to the economic and ecological production of modified nucleosides. These can be produced via pentose-1-phosphates, an interesting but mostly labile and expensive precursor. Thus far, no dynamic model exists for the production process of pentose-1-phosphates, which involves the equilibrium state of the Py-NPase catalyzed reversible reaction. Previously developed enzymological models are based on the understanding of the structural principles of the enzyme and focus on the description of initial rates only. The model generation is further complicated, as Py-NPases accept two substrates which they convert to two products. To create a well-balanced model from accurate experimental data, we utilized an improved high-throughput spectroscopic assay to monitor reactions over the whole time course until equilibrium was reached. We examined the conversion of deoxythymidine and phosphate to deoxyribose-1-phosphate and thymine by a thermophilic Py-NPase from Geobacillus thermoglucosidasius. The developed process model described the reactant concentrations in excellent agreement with the experimental data. Our model is built from ordinary differential equations and structured in such a way that integration with other models is possible in the future. These could be the kinetics of other enzymes for enzymatic cascade reactions or reactor descriptions to generate integrated process models.

Politikvermittlung an der Schnittstelle von Unterhaltung und Information : Political communication at the interface of entertainment and information

SPIEL ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 121-145
Author(s):  
Larissa Leonhard ◽  
Anne Bartsch ◽  
Frank M. Schneider
Keyword(s):  
Information Processing ◽  
Political Participation ◽  
Knowledge Acquisition ◽  
Political Communication ◽  
Information Seeking ◽  
Process Model ◽  
Political Information ◽  
Process Models ◽  
Dual Process ◽  
Dual Process Model

This article presents an extended dual-process model of entertainment effects on political information processing and engagement. We suggest that entertainment consumption can either be driven by hedonic, escapist motivations that are associated with a superficial mode of information processing, or by eudaimonic, truth-seeking motivations that prompt more elaborate forms of information processing. This framework offers substantial extensions to existing dual-process models of entertainment by conceptualizing the effects of entertainment on active and reflective forms of information seeking, knowledge acquisition and political participation.

Toward Metamodels for Composable and Reusable Additive Manufacturing Process Models

2014 ◽  
Vol 136 (6) ◽  
Author(s):  
Paul Witherell ◽  
Shaw Feng ◽  
Timothy W. Simpson ◽  
David B. Saint John ◽  
Pan Michaleris ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Metal Powder ◽  
Manufacturing Process ◽  
Process Model ◽  
Model Development ◽  
Process Models ◽  
Powder Bed Fusion ◽  
Powder Bed ◽  
Future Work ◽  
Am Processes

In this paper, we advocate for a more harmonized approach to model development for additive manufacturing (AM) processes, through classification and metamodeling that will support AM process model composability, reusability, and integration. We review several types of AM process models and use the direct metal powder bed fusion AM process to provide illustrative examples of the proposed classification and metamodel approach. We describe how a coordinated approach can be used to extend modeling capabilities by promoting model composability. As part of future work, a framework is envisioned to realize a more coherent strategy for model development and deployment.

Geometrical Modeling Method of Process Driven by Typical Process Model

2013 ◽  
Vol 770 ◽  
pp. 361-365
Author(s):  
Yu Peng Xin ◽  
Xi Tian Tian ◽  
Li Jiang Huang ◽  
Jun Hao Geng
Keyword(s):  
Process Model ◽  
Modeling Method ◽  
Process Models ◽  
Machining Process ◽  
Process Ontology ◽  
Geometrical Modeling ◽  
Mapping Rules ◽  
Model Mapping ◽  
Generate Process ◽  
Typical Process

In order to improve the efficiency of NC machining programming, and realize the rapid establishment of blank model or middle blank model, a geometrical modeling method of process driven by typical process model was put forward. This method is based on the typical process for the establishment of typical process model, to establish a mapping between modeling operation and machining process ontology, and format model mapping rules. In the process geometrical modeling of the high similarity parts, by calling the typical process model mapping rules, can generate process models automatically. A enterprise disc type parts typical process as an example is used to verify the proposed method.

scholarly journals Business processes exceptions in relation to operational performance

2019 ◽  
Vol 25 (5) ◽  
pp. 908-922 ◽  
Author(s):  
Remco Dijkman ◽  
Oktay Turetken ◽  
Geoffrey Robert van IJzendoorn ◽  
Meint de Vries
Keyword(s):  
Business Process ◽  
Process Model ◽  
Business Processes ◽  
Process Models ◽  
Operational Performance ◽  
Normal Flow ◽  
Throughput Time ◽  
Content Type ◽  
Business Process Models ◽  
Practical Implications

Purpose Business process models describe the way of working in an organization. Typically, business process models distinguish between the normal flow of work and exceptions to that normal flow. However, they often present an idealized view. This means that unexpected exceptions – exceptions that are not modeled in the business process model – can also occur in practice. This has an effect on the efficiency of the organization, because information systems are not developed to handle unexpected exceptions. The purpose of this paper is to study the relation between the occurrence of exceptions and operational performance. Design/methodology/approach The paper does this by analyzing the execution logs of business processes from five organizations, classifying execution paths as normal or exceptional. Subsequently, it analyzes the differences between normal and exceptional paths. Findings The results show that exceptions are related to worse operational performance in terms of a longer throughput time and that unexpected exceptions relate to a stronger increase in throughput time than expected exceptions. Practical implications These findings lead to practical implications on policies that can be followed with respect to exceptions. Most importantly, unexpected exceptions should be avoided by incorporating them into the process – and thus transforming them into expected exceptions – as much as possible. Also, as not all exceptions lead to longer throughput times, continuous improvement should be employed to continuously monitor the occurrence of exceptions and make decisions on their desirability in the process. Originality/value While work exists on analyzing the occurrence of exceptions in business processes, especially in the context of process conformance analysis, to the best of the authors’ knowledge this is the first work that analyzes the possible consequences of such exceptions.

NUMERICAL ESTIMATION OF MOISTURE CONTENT IN SPRAY DRIED JUICE POWDER

2016 ◽  
Vol 78 (8-3) ◽  
Author(s):  
Aliyu Bello A. ◽  
Arshad Ahmad ◽  
Adnan Ripin ◽  
Olagoke Oladokun
Keyword(s):  
Experimental Data ◽  
Moisture Content ◽  
Diffusion Model ◽  
Process Model ◽  
Small Error ◽  
Operating Conditions ◽  
Balance Model ◽  
Pineapple Juice ◽  
Droplet Drying ◽  
Spray Dried

The moisture contents of powders is an important parameter that affects the quality and commercial value of spray dried products. The utility of predicted moisture content values from two droplet drying models were compared with experimental data for spray dried pineapple juice, using the Ranz-Marshal and its modified variants for the heat and mass transfer correlations. The droplet Diffusion model, using the Zhifu correlation, gave estimates with errors of about 8% at 165 oC, 9% at 171 oC, 26% at 179 oC and 2% at 185 oC. The Ranz-Marshal correlation also gave comparable results with this model while results using the Downing and modified Ranz-Marshall correlations widely diverged. The Energy balance model predicted completely dried juice particles, and short drying times, in contrast to the experimental data. The small error sizes of the Diffusion model improves on the wide error sizes of an earlier process model, making is useful as a first approximation choice, for spray drier design and simulation, especially for juices under comparable operating conditions.

scholarly journals Pengujian Unit Plugin Pemberian Anotasi Efek Secara Semantik pada Proses Bisnis BPMN

2021 ◽  
Vol 6 (3) ◽  
pp. 170
Author(s):  
Hilman Nuril Hadi
Keyword(s):  
Business Process ◽  
Process Model ◽  
Business Processes ◽  
Process Models ◽  
Unit Testing ◽  
Business Process Model ◽  
Testing Technique ◽  
Modeling Tools ◽  
Path Testing ◽  
Future Business

Business process model was created to make it easier for business process stakeholders to communicate and discuss the structure of the process more effectively and efficiently. Business process models can also be business artifacts and media that can be analyzed further to improve and maintain organizational competitiveness. To analyze business processes in a structured manner, the effect/results of the execution of business processes will be one of the important information. The effect/result of the execution of certain activities or a business process as a whole are useful for managing business processes, including for improvements related to future business processes. This effect annotation approach needs to be supported by business process modeling tools to assist business analysts in managing business processes properly. In previous research, the author has developed a plugin that supports business analysts to describe the effects semantically attached to activities in the Business Process Model and Notation (BPMN) business process model. In this paper, the author describes the unit testing process and its results on the plugin of semantic effect annotation that have been developed. Unit testing was carried out using the basic path testing technique and has obtained three test paths. The results of unit test for plugin are also described in this paper.

scholarly journals Improving the performance of process discovery algorithms by instance selection

2020 ◽  
Vol 17 (3) ◽  
pp. 927-958
Author(s):  
Mohammadreza Sani ◽  
Sebastiaan van Zelst ◽  
Aalst van der
Keyword(s):  
Process Model ◽  
Business Processes ◽  
Process Models ◽  
Instance Selection ◽  
Event Data ◽  
Process Discovery ◽  
Selection Strategies ◽  
Speed Up ◽  
The Right ◽  
Discovery Algorithms

Process discovery algorithms automatically discover process models based on event data that is captured during the execution of business processes. These algorithms tend to use all of the event data to discover a process model. When dealing with large event logs, it is no longer feasible using standard hardware in limited time. A straightforward approach to overcome this problem is to down-size the event data by means of sampling. However, little research has been conducted on selecting the right sample, given the available time and characteristics of event data. This paper evaluates various subset selection methods and evaluates their performance on real event data. The proposed methods have been implemented in both the ProM and the RapidProM platforms. Our experiments show that it is possible to considerably speed up discovery using instance selection strategies. Furthermore, results show that applying biased selection of the process instances compared to random sampling will result in simpler process models with higher quality.

scholarly journals Data Model and Software Architecture for Business Process Model Generator

2018 ◽  
Vol 2 (4-2) ◽  
pp. 349
Author(s):  
Ivaylo Kamenarov ◽  
Katalina Grigorova
Keyword(s):  
Software Architecture ◽  
Business Process ◽  
Data Model ◽  
Process Model ◽  
Process Models ◽  
Process Chain ◽  
Business Process Models ◽  
Model Generator ◽  
The Individual ◽  
Natural Way

This paper describes the internal data model for a business process generator. Business process models are stored in an Event-driven process chain notation that provides a natural way to link the individual elements of a process. There is a software architecture that makes it easy to communicate with users as well as external systems.

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