scholarly journals pH-Responsive Tumor-Targetable Theranostic Nanovectors Based on Core Crosslinked (CCL) Micelles with Fluorescence and Magnetic Resonance (MR) Dual Imaging Modalities and Drug Delivery Performance

Polymers ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 226 ◽  
Author(s):  
Sidan Tian ◽  
Guhuan Liu ◽  
Xiaorui Wang ◽  
Guoying Zhang ◽  
Jinming Hu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Imaging Modalities ◽  
Ph Responsive ◽  
Delivery Performance ◽  
Dual Imaging

pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (Gd2O3@MSNs) for synergistic drug delivery and magnetic resonance imaging enhancement

2019 ◽  
Vol 7 (43) ◽  
pp. 6840-6854 ◽  
Author(s):  
Kewu He ◽  
Jiajia Li ◽  
Yuxian Shen ◽  
Yongqiang Yu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Gadolinium Oxide ◽  
Imaging Modalities ◽  
Ph Responsive ◽  
Resonance Imaging

Theranostic platforms that combine therapeutic and imaging modalities have received increasing interest.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

2016 ◽  
Vol 4 (6) ◽  
pp. 1100-1107 ◽  
Author(s):  
Ruiqing Liu ◽  
Shuang Liang ◽  
Cun Jiang ◽  
Li Zhang ◽  
Tianmeng Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Emulsion Polymerization ◽  
Gadolinium Oxide ◽  
Antitumor Drug ◽  
Ph Responsive ◽  
Polymeric Particles ◽  
Polymeric Particle

Paramagnetic, luminescent, and temperature/pH-responsive polymeric particles with MR/optical imaging and antitumor drug delivery capability are prepared by emulsifier-free emulsion polymerization.

Theranostic tumor targeted nanoparticles combining drug delivery with dual near infrared and 19 F magnetic resonance imaging modalities

2016 ◽  
Vol 12 (7) ◽  
pp. 1873-1884 ◽  
Author(s):  
Hieu Vu-Quang ◽  
Mads Sloth Vinding ◽  
Thomas Nielsen ◽  
Marcus Görge Ullisch ◽  
Niels Chr. Nielsen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Near Infrared ◽  
Imaging Modalities ◽  
Resonance Imaging ◽  
Targeted Nanoparticles
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