scholarly journals Preferential Incorporation of Azelaic Acid Units into the Crystalline Phase of the Copoly(Alkylene Dicarboxylate) Derived from 1,9-Nonanediol and an Equimolar Mixture of Pimelic and Azelaic Acids

Polymers ◽  
2015 ◽  
Vol 7 (9) ◽  
pp. 1871-1894 ◽  
Author(s):  
Angélica Díaz ◽  
María Casas ◽  
Jordi Puiggalí
Keyword(s):  
Azelaic Acid ◽  
Crystalline Phase ◽  
Equimolar Mixture ◽  
Preferential Incorporation

Clinical Effect of Azelaic Acid on Hyperpigmented Disorders.

1993 ◽  
Vol 55 (2) ◽  
pp. 319-322
Author(s):  
Koichiro KAMEYAMA ◽  
Chie SAKAI ◽  
Shigeo KONDO ◽  
KohZoh YONEMOTO
Keyword(s):  
Azelaic Acid ◽  
Clinical Effect

scholarly journals Histone H3 Lysine 4 Methylation Marks Postreplicative Human Cytomegalovirus Chromatin

2012 ◽  
Vol 86 (18) ◽  
pp. 9817-9827 ◽  
Author(s):  
Alexandra Nitzsche ◽  
Charlotte Steinhäußer ◽  
Katrin Mücke ◽  
Christina Paulus ◽  
Michael Nevels
Keyword(s):  
Dna Replication ◽  
Dna Synthesis ◽  
Histone Modification ◽  
Dna Polymerase ◽  
Human Cytomegalovirus ◽  
Viral Genome ◽  
Histone H3 ◽  
Viral Dna ◽  
The Impact ◽  
Preferential Incorporation

In the nuclei of permissive cells, human cytomegalovirus genomes form nucleosomal structures initially resembling heterochromatin but gradually switching to a euchromatin-like state. This switch is characterized by a decrease in histone H3 K9 methylation and a marked increase in H3 tail acetylation and H3 K4 methylation across the viral genome. We used ganciclovir and a mutant virus encoding a reversibly destabilized DNA polymerase to examine the impact of DNA replication on histone modification dynamics at the viral chromatin. The changes in H3 tail acetylation and H3 K9 methylation proceeded in a DNA replication-independent fashion. In contrast, the increase in H3 K4 methylation proved to depend widely on viral DNA synthesis. Consistently, labeling of nascent DNA using “click chemistry” revealed preferential incorporation of methylated H3 K4 into viral (but not cellular) chromatin during or following DNA replication. This study demonstrates largely selective epigenetic tagging of postreplicative human cytomegalovirus chromatin.

Contact dermatitis from an azelaic acid‐containing gel

2021 ◽  
Author(s):  
Michele Buonomo ◽  
Jenna L. Ruggiero ◽  
Erin Warshaw
Keyword(s):  
Contact Dermatitis ◽  
Azelaic Acid
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