scholarly journals 2-(Dimethylamino)ethyl Methacrylate/(2-Hydroxyethyl) Methacrylate/α-Tricalcium Phosphate Cryogels for Bone Repair, Preparation and Evaluation of the Biological Response of Human Trabecular Bone-Derived Cells and Mesenchymal Stem Cells

Polymers ◽  
2014 ◽  
Vol 6 (10) ◽  
pp. 2510-2525 ◽  
Author(s):  
Tiago Volkmer ◽  
Joana Magalhães ◽  
Vania Sousa ◽  
Luis Santos ◽  
Elena Burguera ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Trabecular Bone ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Biological Response ◽  
Hydroxyethyl Methacrylate ◽  
Ethyl Methacrylate ◽  
Human Trabecular Bone ◽  
Preparation And Evaluation

scholarly journals Current Application of Beta-Tricalcium Phosphate in Bone Repair and Its Mechanism to Regulate Osteogenesis

2021 ◽  
Vol 8 ◽  
Author(s):  
Haiping Lu ◽  
Yinghong Zhou ◽  
Yaping Ma ◽  
Lan Xiao ◽  
Wenjun Ji ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Loss ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Blood Clot ◽  
Current Evidence ◽  
Angiogenic Growth Factors ◽  
Current Application ◽  
Beta Tricalcium Phosphate

Large segmental bone loss and bone resection due to trauma and/or the presence of tumors and cysts often results in a delay in healing or non-union. Currently, the bone autograft is the most frequently used strategy to manage large bone loss. Nevertheless, autograft harvesting has limitations, namely sourcing of autograft material, the requirement of an invasive procedure, and susceptibility to infection. These disadvantages can result in complications and the development of a bone substitute materials offers a potential alternative to overcome these shortcomings. Among the biomaterials under consideration to date, beta-tricalcium phosphate (β-TCP) has emerged as a promising material for bone regeneration applications due to its osteoconductivity and osteoinductivity properties as well as its superior degradation in vivo. However, current evidence suggests the use β-TCP can in fact delay bone healing and mechanisms for this observation are yet to be comprehensively investigated. In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). 3D and 4D printed β-TCP-based scaffolds have also been reviewed. We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration.

Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study

2019 ◽  
Vol 70 (6) ◽  
pp. 1983-1987
Author(s):  
Cristian Trambitas ◽  
Anca Maria Pop ◽  
Alina Dia Trambitas Miron ◽  
Dorin Constantin Dorobantu ◽  
Flaviu Tabaran ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bioactive Glass ◽  
Bone Repair ◽  
Bone Defects ◽  
Calvarial Bone ◽  
Specific Protocol ◽  
Repair Mechanisms ◽  
Male Wistar Rats

Large bone defects are a medical concern as these are often unable to heal spontaneously, based on the host bone repair mechanisms. In their treatment, bone tissue engineering techniques represent a promising approach by providing a guide for osseous regeneration. As bioactive glasses proved to have osteoconductive and osteoinductive properties, the aim of our study was to evaluate by histologic examination, the differences in the healing of critical-sized calvarial bone defects filled with bioactive glass combined with adipose-derived mesenchymal stem cells, compared to negative controls. We used 16 male Wistar rats subjected to a specific protocol based on which 2 calvarial bone defects were created in each animal, one was filled with Bon Alive S53P4 bioactive glass and adipose-derived stem cells and the other one was considered control. At intervals of one week during the following month, the animals were euthanized and the specimens from bone defects were histologically examined and compared. The results showed that this biomaterial was biocompatible and the first signs of osseous healing appeared in the third week. Bone Alive S53P4 bioactive glass could be an excellent bone substitute, reducing the need of bone grafts.

How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow

2005 ◽  
Vol 1049 (1) ◽  
pp. 97-106 ◽  
Author(s):  
CARL A. GREGORY ◽  
WILLIAM G. GUNN ◽  
EMIGDIO REYES ◽  
ANGELA J. SMOLARZ ◽  
JAMES MUNOZ ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Wnt Signaling ◽  
Bone Repair

scholarly journals Bone repair with differentiated osteoblasts from adipose-derived stem cells in hydroxyapatite/tricalcium phosphate in vivo

2016 ◽  
Vol 7 (1) ◽  
pp. 62 ◽  
Author(s):  
Hamid Bahramian ◽  
Batool Hashemibeni ◽  
Leila Dehghani ◽  
Farzaneh Sadeghi ◽  
Ebrahim Esfandiari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Adipose Derived Stem Cells

Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells

Biomaterials ◽  
2010 ◽  
Vol 31 (36) ◽  
pp. 9452-9461 ◽  
Author(s):  
Le Wang ◽  
Hongbin Fan ◽  
Zhi-Yong Zhang ◽  
Ai-Ju Lou ◽  
Guo-Xian Pei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tricalcium Phosphate

scholarly journals Mesenchymal stem cells overexpressing Ihh promote bone repair

2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Shasha Zou ◽  
Tingting Chen ◽  
Yanan Wang ◽  
Ruhui Tian ◽  
Lingling Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Repair

Optimal supplementation of dexamethasone for clinical purposed expansion of mesenchymal stem cells for bone repair

2011 ◽  
Vol 16 (5) ◽  
pp. 606-612 ◽  
Author(s):  
Dae Gyu Park ◽  
Kyung Gon Kim ◽  
Tae-Jin Lee ◽  
Joo-Young Kim ◽  
Eon Gi Sung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Repair

Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal Stem Cells and Beta-Tricalcium Phosphate

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Valentina Fatale ◽  
Stefano Pagnoni ◽  
Albino Emidio Pagnoni ◽  
Pier Carmine Passarelli ◽  
Andrea Netti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Maxillary Sinus ◽  
Tricalcium Phosphate ◽  
Sinus Lift ◽  
Beta Tricalcium Phosphate
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