scholarly journals Fine-Tuning of Polymeric Resins and their Interfaces with Amorphous Calcium Phosphate. A Strategy for Designing Effective Remineralizing Dental Composites

Polymers ◽  
2010 ◽  
Vol 2 (4) ◽  
pp. 378-392 ◽  
Author(s):  
Joseph M. Antonucci ◽  
Drago Skrtic
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Fine Tuning ◽  
Dental Composites ◽  
Polymeric Resins

Amorphous Calcium Phosphate Based Polymeric Composites: Effects of Polymer Composition and Filler's Particle Size on Composite Properties

2005 ◽  
Vol 284-286 ◽  
pp. 737-740 ◽  
Author(s):  
Drago Skrtic ◽  
S.Y. Lee ◽  
Joseph M. Antonucci ◽  
D.W. Liu
Keyword(s):  
Particle Size ◽  
Calcium Phosphate ◽  
Physicochemical Properties ◽  
Amorphous Calcium Phosphate ◽  
Fine Tuning ◽  
Polymer Composition ◽  
Ion Release ◽  
The Matrix ◽  
Carboxylic Groups ◽  
Composite Properties

This study explores how a) the resin grafting potential for amorphous calcium phosphate (ACP) and b) particle size of ACP affects physicochemical properties of composites. Copolymers and composites were evaluated for biaxial flexure strength (BFS), degree of vinyl conversion (DC), mineral ion release and water sorption (WS). Milled ACP composites were superior to unmilled ACP composites and exhibited 62 % and 77 % higher BFS values (dry and wet state, respectively). The average DC of copolymers 24 h after curing was 80 %. DC of composites decreased 10.3 % for unmilled Zr-ACP and 4.6 % for milled Zr-ACP when compared to the corresponding copolymers. The WS increased as follows: copolymers < milled Zr-ACP composites < unmilled Zr-ACP composites. The levels of Ca and PO4 released from both types of composites increased with the increasing EBPADMA/TEGDMA ratio in the matrix. They were significantly above the minimum necessary for the redeposition of HAP to occur. No significant consumption of released calcium by the carboxylic groups of methacryloxyethyl phtahalate (MEP) occurred at a mass fraction of 2.6 % of MEP in the resin. Improvements in ACP composite’s physicochemical properties are achieved by fine tuning of the resin and improved ACP’s dispersion within the polymer matrix after ball-milling.

scholarly journals Structural and dynamical studies of acid-mediated conversion in amorphous-calcium-phosphate based dental composites

2014 ◽  
Vol 30 (10) ◽  
pp. 1113-1125 ◽  
Author(s):  
Fan Zhang ◽  
Andrew J. Allen ◽  
Lyle E. Levine ◽  
Mark D. Vaudin ◽  
Drago Skrtic ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Dental Composites

scholarly journals Structure-Composition-Property Relationships in Polymeric Amorphous Calcium Phosphate-Based Dental Composites

Materials ◽  
2009 ◽  
Vol 2 (4) ◽  
pp. 1929-1954 ◽  
Author(s):  
Justin N. O’Donnell ◽  
Gary Schumacher ◽  
Joseph Antonucci ◽  
Drago Skrtic
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Dental Composites ◽  
Composition Property

scholarly journals Reversal of Root Caries with Casein Phosphopeptide-Amorphous Calcium Phosphate and Fluoride Varnish in Xerostomia

2021 ◽  
pp. 1-10
Author(s):  
Ahmed Sleibi ◽  
Anwar R. Tappuni ◽  
Aylin Baysan
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Primary Root ◽  
Severity Index ◽  
Salivary Flow ◽  
Root Caries ◽  
Carious Lesions ◽  
Group 2 ◽  
Casein Phosphopeptide ◽  
Group 1

Different formulas of topical fluoride have been used to manage root carious lesions. This clinical trial aimed to investigate the efficacy of a dental varnish containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride compared with fluoride alone in reversing/arresting root caries in xerostomic patients over 1 year. A total of 80 patients (age range 45–92 years) with primary root caries (<i>n</i> = 184 root carious lesions) and unstimulated salivary flow rate of &#x3c;0.2 mL/min were randomly allocated to receive either dental varnish containing CPP-ACP and 5% fluoride (group 1: MI varnish; GC, Japan) (<i>n</i> = 41, 83 lesions), or dental varnish with 5% fluoride alone (group 2: NUPRO White; Dentsply, USA) (<i>n</i> = 39, 101 lesions). Clinical assessments with Severity Index (SI) for root caries, DIAGNOdent measurements, and varnish application were carried out at baseline, 3, 6, and 12 months. Standard oral hygiene instructions with 1,450 ppm fluoride toothpastes were provided for both groups. After 3 months, 63.9% (<i>n</i> = 46) of root caries in group 1 became hard (SI: 0) compared with 39.3% (<i>n</i> = 35) in group 2 (<i>p</i> &#x3c; 0.01). After 6 and 12 months, the differences in SI were insignificant (group 1, <i>n</i> = 60, 83.3%) (group 2, <i>n</i> = 66, 74.2%) (<i>p</i> = 0.36), and (group 1, <i>n</i> = 60, 89.6%) (group 2, <i>n</i> = 67, 81.7%, <i>n</i> = 1 soft, 1.2%) (<i>p</i> = 0.29), respectively. In both groups, noncavitated leathery lesions were more likely to become hard when compared to the cavitated root caries. A significant decrease in plaque index, surface roughness, lesion dimension, and DIAGNOdent readings with a significant increase in lesion distance from the gingival margin was reported in both groups (<i>p</i> &#x3c; 0.05). This study has provided evidence that fluoride dental varnish either with or without calcium and phosphate has the potential to arrest/reverse root caries, especially noncavitated lesions for patients with xerostomia.

Impacts of Initial Ca/P on Amorphous Calcium Phosphate

2021 ◽  
Author(s):  
Alexandria J. Hoeher ◽  
Sebastian T. Mergelsberg ◽  
Olaf J. Borkiewicz ◽  
F. Marc Michel
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate
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