scholarly journals PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3471
Author(s):  
Se Min Kim ◽  
Madhumita Patel ◽  
Rajkumar Patel
Keyword(s):  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Inner Core ◽  
Biomedical Application ◽  
Periodontal Regeneration ◽  
Core Shell ◽  
Primary Role ◽  
Biomedical Polymers ◽  
Shell Particles

Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of sequence-controlled release and provide protection of drugs. Among other biomedical polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell nano/microparticles and summarizes various drug-delivery systems based on these particles for cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and periodontal regeneration.

Overview of polyethylene glycol-based materials with a special focus on core-shell particles for drug delivery application

2021 ◽  
Vol 27 ◽  
Author(s):  
Nasrullah Shah ◽  
Manzoor Hussain ◽  
Touseef Rehan ◽  
Abbas Khan ◽  
Zubair Ullah Khan
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Water Soluble ◽  
Core Shell ◽  
Special Focus ◽  
Tissue Engineering Scaffolds ◽  
Shell Nanoparticles ◽  
Composites Materials ◽  
Shell Particles ◽  
Core Shell Nanoparticles

: Polyethylene glycols (PEG) are water-soluble nonionic polymeric molecules. PEG and PEG-based materials are used for various important applications such as solvents, adhesives, adsorbents, drug delivery agents, tissue engineering scaffolds, etc. The coating of nanoparticles with PEG forms core-shell nanoparticles. The PEG-based core-shell nanoparticles are synthesized for the development of high-quality drug delivery systems. In the present review, we first explained the basics and various applications of PEGs and PEG-based composites materials and then concentrated on the PEG-based core-shell nanoparticles for biomedical applications specifically their use in drug delivery.

One-step synthesis of polymer core–shell particles with a carboxylated ruthenium complex: a potential tool for biomedical applications

2013 ◽  
Vol 1 (17) ◽  
pp. 2236 ◽  
Author(s):  
Elisângela M. Linares ◽  
André Formiga ◽  
Lauro T. Kubota ◽  
Fernando Galembeck ◽  
Stefan Thalhammer
Keyword(s):  
Biomedical Applications ◽  
Ruthenium Complex ◽  
Core Shell ◽  
One Step ◽  
Shell Particles ◽  
Potential Tool

Bio-Inspired Hydrogel-Calcium Carbonate Core-Shell Particles

2006 ◽  
Vol 988 ◽  
Author(s):  
Yi-Yeoun Kim ◽  
John W Catino ◽  
Gary P Tomaino ◽  
Sherman D Cox
Keyword(s):  
Calcium Carbonate ◽  
Shell Thickness ◽  
Room Temperature ◽  
Core Shell ◽  
Time Resolved ◽  
Liquid Precursor ◽  
Mineral Phases ◽  
Encapsulation Process ◽  
Shell Particles

AbstractIn this report, we present a bio-inspired encapsulation process to create nanocluster-assembled core-shell particles under aqueous, room temperature and non-toxic conditions. The approach to synthesize calcium carbonate core-shell particles is accomplished by employing a Polymer-Induced Liquid-Precursor (PILP) process. We demonstrate the amorphous mineral precursor is coated around a core of hydrogel nanoparticles, and subsequently solidified and crystallized. The synthesized core-shell particles are 300∼500nm diameter and ∼100 nm shell-thickness. We investigate the role of the hydrogel core of the particle using time-resolved XRD, thermal-XRD and thermal analysis. The organic hydrogel appears to influence the transformation of mineral phases, stabilizing the amorphous phase of calcium carbonate.

Role of vacancy and metal doping on combustive oxidation of Zr/ZrO2 core-shell particles

2010 ◽  
Vol 604 (23-24) ◽  
pp. 2116-2128 ◽  
Author(s):  
Hyunwook Kwak ◽  
Santanu Chaudhuri
Keyword(s):  
Core Shell ◽  
Metal Doping ◽  
Shell Particles

One-step reactivity-driven synthesis of core–shell structured electrically conducting particles for biomedical applications

2016 ◽  
Vol 4 (32) ◽  
pp. 5429-5436 ◽  
Author(s):  
Jifu Mao ◽  
Ze Zhang
Keyword(s):  
Emulsion Polymerization ◽  
Biomedical Applications ◽  
Core Shell ◽  
One Pot ◽  
Electrically Conducting ◽  
One Step ◽  
The Difference ◽  
Shell Particles

A simple one-pot and one-step emulsion polymerization of conductive and functional core–shell particles is reported, based on the difference in reactivity between pyrrole and its derivative.

Thermal Conductivity of Suspensions Based on Core–Shell Particles

2016 ◽  
Vol 138 (6) ◽  
Author(s):  
G. I. Sukhinin ◽  
M. A. Serebryakova ◽  
S. A. Novopashin
Keyword(s):  
Thermal Conductivity ◽  
Analytical Solution ◽  
Thermal Resistance ◽  
Thermal Conduction ◽  
Interfacial Thermal Resistance ◽  
Core Shell ◽  
Kapitza Resistance ◽  
First Case ◽  
Shell Particles

An analytical solution of the problem of the thermal conductivity of a suspension containing core–shell particles was found. Solutions were found under the thickness of the shell tending to zero while the thermal conductivity of the shell was tending to zero and infinity. In the first case, the solution is shown to be equivalent to the solution that takes into account Kapitza interfacial thermal resistance. The role of contact Kapitza resistance in the processes of the thermal conduction of nanofluids is discussed.

Magnetic Properties of Fe3O4/CoFe2O4 Composite Nanoparticles with Core/Shell Architecture

2020 ◽  
Vol 65 (10) ◽  
pp. 904
Author(s):  
V. O. Zamorskyi ◽  
Ya. M. Lytvynenko ◽  
A. M. Pogorily ◽  
A. I. Tovstolytkin ◽  
S. O. Solopan ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Spinel Ferrite ◽  
Composite Nanoparticles ◽  
Core Shell ◽  
Cofe2o4 Nanoparticles ◽  
Core Diameter ◽  
The Core ◽  
Shell Particles ◽  
Interface Parameters ◽  
Shell Composite

Magnetic properties of the sets of Fe3O4(core)/CoFe2O4(shell) composite nanoparticles with a core diameter of about 6.3 nm and various shell thicknesses (0, 1.0, and 2.5 nm), as well as the mixtures of Fe3O4 and CoFe2O4 nanoparticles taken in the ratios corresponding to the core/shell material contents in the former case, have been studied. The results of magnetic research showed that the coating of magnetic nanoparticles with a shell gives rise to the appearance of two simultaneous effects: the modification of the core/shell interface parameters and the parameter change in both the nanoparticle’s core and shell themselves. As a result, the core/shell particles acquire new characteristics that are inherent neither to Fe3O4 nor to CoFe2O4. The obtained results open the way to the optimization and adaptation of the parameters of the core/shell spinel-ferrite-based nanoparticles for their application in various technological and biomedical domains.

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