scholarly journals pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3197
Author(s):  
Younghyun Shin ◽  
Dajung Kim ◽  
Yiluo Hu ◽  
Yohan Kim ◽  
In Ki Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Hek 293 ◽  
Natural Polysaccharide ◽  
293 Cells

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

PNIPAAM/SA pH-responsive microcapsules based on chemical and non-covalent crosslinking

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Zhengdong Fei ◽  
Dong Zheng ◽  
Ping Fan ◽  
Feng Chen ◽  
Mingqiang Zhong
Keyword(s):  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Doxorubicin Hydrochloride ◽  
Ph Responsive ◽  
Covalent Crosslinking ◽  
Stomach Acid ◽  
Accurate Treatment ◽  
Polymerization Method

AbstractA triple interpenetrating polymer network (IPN) with dual responses to temperature and pH was constructed based on chemical crosslinking and electrostatic interaction. In this IPN, CaCO3 microspheres were used as the kernel and PNIPAAM/sodium alginate microcapsules were prepared by the inverse emulsion polymerization method. Research results demonstrated that CaCO3 kernels were decomposed into Ca2+ and CO2 at pH 1.2. Such decomposition facilitated the formation of triple IPN of Ca2+ crosslinking. Moreover, microcapsules were expanded by tension of CO2 and the volume increased to 3.55 × 105 times that of the original microcapsules, with capsules remaining an intact morphology. These microcapsules loading doxorubicin hydrochloride (DOX) stability and responses to environment were investigated. No drug overflow was observed at pH 7.4, indicating the high stability of microcapsules. However, DOX was released gradually in the simulated human stomach acid with a weak solution of hydrochloric acid (pH 1.2, 37 °C). This showed that the prepared microcapsules were feasible for drug-loaded capsules and the controlled drug release behavior could relieve side effects of drugs to human body. Moreover, it will help to increase the drug utilization and realize accurate treatment.

Synthesis and Properties of Thermo- and pH-Responsive PVA/P(DEA-co-MAA) Intelligent Semi-IPN Hydrogels

2012 ◽  
Vol 466-467 ◽  
pp. 229-233
Author(s):  
Nai Yan Zhang ◽  
Jiang Yu ◽  
Shou Jun Cai
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Radical Copolymerization ◽  
Unique Property ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Ph Responsive ◽  
Free Radical Copolymerization

A series of temperature- and pH-responsive poly(vinyl alcohol)/poly(N, N-diethylacrylamide-co-methacrylic acid) PVA/P(DEA-co-MAA) intelligent semi-IPN hydrogels were synthesized by free-radical copolymerization techniques and semi-interpenetrating polymer network techniques. The effects of the feed components, temperature and pH on the swelling behavior of the hydrogels were studied in detail. This unique property makes them very useful for biomedical applications such as on-off switches for modulated drug delivery and tissue engineering. With the increase of PVA content, the thermo- and pH-responsive of the semi-IPN hydrogel improved.

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

2010 ◽  
Vol 148-149 ◽  
pp. 1449-1452 ◽  
Author(s):  
Kui Lin Deng ◽  
Yu Bo Gou ◽  
Jian Zuo ◽  
Li Rong Dong ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Network ◽  
Phosphate Buffer Solution ◽  
Interpenetrating Polymer Network ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Beads ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

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