scholarly journals DNA Interaction with a Polyelectrolyte Monolayer at Solution—Air Interface

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2820
Author(s):  
Nikolay S. Chirkov ◽  
Richard A. Campbell ◽  
Alexander V. Michailov ◽  
Petr S. Vlasov ◽  
Boris A. Noskov
Keyword(s):  
Surface Pressure ◽  
Surface Film ◽  
Building Blocks ◽  
Dna Interaction ◽  
Compression Isotherm ◽  
Initial Surface ◽  
Engineering Research ◽  
Air Interface ◽  
Novel Approach ◽  
New Perspective

The formation of ordered 2D nanostructures of double stranded DNA molecules at various interfaces attracts more and more focus in medical and engineering research, but the underlying intermolecular interactions still require elucidation. Recently, it has been revealed that mixtures of DNA with a series of hydrophobic cationic polyelectrolytes including poly(N,N-diallyl-N-hexyl-N-methylammonium) chloride (PDAHMAC) form a network of ribbonlike or threadlike aggregates at the solution—air interface. In the present work, we adopt a novel approach to confine the same polyelectrolyte at the solution—air interface by spreading it on a subphase with elevated ionic strength. A suite of techniques–rheology, microscopy, ellipsometry, and spectroscopy–are applied to gain insight into main steps of the adsorption layer formation, which results in non-monotonic kinetic dependencies of various surface properties. A long induction period of the kinetic dependencies after DNA is exposed to the surface film results only if the initial surface pressure corresponds to a quasiplateau region of the compression isotherm of a PDAHMAC monolayer. Despite the different aggregation mechanisms, the micromorphology of the mixed PDAHMAC/DNA does not depend noticeably on the initial surface pressure. The results provide new perspective on nanostructure formation involving nucleic acids building blocks.

scholarly journals A novel approach to the computation of one-loop three- and four-point functions: I. The real mass case

2019 ◽  
Vol 2019 (11) ◽  
Author(s):  
J Ph Guillet ◽  
E Pilon ◽  
Y Shimizu ◽  
M S Zidi
Keyword(s):  
Building Blocks ◽  
The Real ◽  
Alternative Method ◽  
Novel Approach ◽  
Reduction Methods ◽  
Real Mass ◽  
Novel Method ◽  
Algebraic Reduction ◽  
The One ◽  
Mass Case

Abstract This article is the first of a series of three presenting an alternative method of computing the one-loop scalar integrals. This novel method enjoys a couple of interesting features as compared with the method closely following ’t Hooft and Veltman adopted previously. It directly proceeds in terms of the quantities driving algebraic reduction methods. It applies to the three-point functions and, in a similar way, to the four-point functions. It also extends to complex masses without much complication. Lastly, it extends to kinematics more general than that of the physical, e.g., collider processes relevant at one loop. This last feature may be useful when considering the application of this method beyond one loop using generalized one-loop integrals as building blocks.

scholarly journals Synthesis of 4-Substituted-1,2-Dihydroquinolines by Means of Gold-Catalyzed Intramolecular Hydroarylation Reaction of N-Ethoxycarbonyl-N-Propargylanilines

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3366
Author(s):  
Antonio Arcadi ◽  
Andrea Calcaterra ◽  
Giancarlo Fabrizi ◽  
Andrea Fochetti ◽  
Antonella Goggiamani ◽  
...  
Keyword(s):  
Building Blocks ◽  
Fine Tuning ◽  
Para Position ◽  
Cyclization Product ◽  
Synthetic Route ◽  
Substituted Anilines ◽  
Novel Approach ◽  
High Yields

An alternative Au(I)-catalyzed synthetic route to functionalized 1,2-dihydroquinolines is reported. This novel approach is based on the use of N-ethoxycarbonyl protected-N-propargylanilines as building blocks that rapidly undergo the IMHA reaction affording the 6-endo cyclization product in good to high yields. In the presence of N-ethoxycarbonyl-N-propargyl-meta-substituted anilines, the regiodivergent cyclization at the ortho-/para-position is achieved by the means of catalyst fine tuning.

scholarly journals Compiling Life-Oriented Moral Education Textbooks for Elementary Schools in China: The Mimetic Approach in Morality and Law

2021 ◽  
pp. 209653112098296
Author(s):  
Yan Tang
Keyword(s):  
Elementary Schools ◽  
Moral Education ◽  
Life Events ◽  
Theoretical Perspective ◽  
Building Blocks ◽  
Learning Activities ◽  
Design Approach ◽  
New Approach ◽  
Novel Approach

Purpose: This study explores a novel approach to compiling life-oriented moral textbooks for elementary schools in China, specifically focusing on Morality and Law. Design/Approach/Methods: Adopting Aristotle’s Poetics as its theoretical perspective, this study illustrates and analyzes the mimetic approach used in compiling the life-oriented moral education textbook, Morality and Law. Findings: The mimetic approach involves imitating children's real activities, thoughts, and feelings in textbooks. The mimetic approach to compiling life-oriented moral textbooks comprises three strategies: constructing children's life events as building blocks for textbook compilation, designing an intricate textual device exposing the wholeness of children's life actions, and designing inward learning activities leading to children's inner worlds. Originality/Value: From the perspective of Aristotle's Poetics, the approach to compilation in Morality and Law can be defined as mimetic. And the compilation activity in the life-oriented moral education textbook also can be described as a processes of mimesis. So this article presents a new approach to compile moral education textbooks, and  an innovative way to understand the nature of one compiling activity.

Sentiment Analysis on UAV-aided Product Comments Based on Machine Learning: From Sentence to Document Level

2020 ◽  
Author(s):  
JINGYANG CAO ◽  
Shirong Yin ◽  
Guoxu Zhang
Keyword(s):  
Machine Learning ◽  
Sentiment Analysis ◽  
Accurate Result ◽  
Supervised Machine Learning ◽  
Hotel Management ◽  
Novel Approach ◽  
Online Comments ◽  
New Perspective ◽  
The Relationship ◽  
Document Level

Abstract This paper presents a novel approach to analyze the sentiment of the product comments from sentence to document level and apply to the customers sentiment analysis on UAV-aided product comments for hotel management. In order to realize the effiffifficient sentiment analysis, a cascaded sentence-to-document sentiment classifification method is investigated. Initially, a supervised machine learning method is applied to explore the sentiment polarity of the sentence (SPS). Afterward, the contribution of the sentence to document (CSD) is calculated by using various statistical algorithms. Lastly, the sentiment polarity of the document (SPD) is determined by the SPS as well as its contribution. Comparative experiments have been established on the basis of hotel online comments, and the outcomes indicate that the proposed method not only raises the effiffifficiency in attaining a more accurate result but also assists immensely in regards to the B5G wireless communication supported by the UAV. The fifindings provide a new perspective that sentence position and its sentiment similarity with document (sentiment condition) dramatically disclose the relationship between sentence and document.

A Novel Approach to Segmentation Using Customer Locations Data and Intelligent Techniques

2018 ◽  
pp. 1792-1810
Author(s):  
Başar Öztayşi ◽  
Ugur Gokdere ◽  
Esra Nur Simsek ◽  
Ceren Salkin Oner
Keyword(s):  
Clustering Algorithm ◽  
Customer Segmentation ◽  
Location Based Services ◽  
Location Data ◽  
Novel Approach ◽  
Product Service ◽  
Fuzzy C Means Clustering ◽  
Initial Segmentation ◽  
Application Data ◽  
New Perspective

Customer segmentation has been one of hottest topics of marketing efforts. The traditional sources of data used for segmentation are demographics, monetary value of transactions, types of product/service selected. Today, data gathered by location based services can also be used for customer segmentation. In this chapter a real world case study is summarized and the initial segmentation results are presented. As the application, data gathered from beacons sited in 4000 locations and Fuzzy c-means clustering algorithm are used. The steps of the application are as follows: (1) Categorization of the shops, (2) Summarization of the location data, (3) Applying fuzzy clustering technique, (4) Analyzing the results and profiling. Results show that customers' location data can provide a new perspective to customer segmentation.

Task Ontology-Based Human-Computer Interaction

2009 ◽  
pp. 950-960
Author(s):  
Kazuhisa Seta
Keyword(s):  
Problem Solving ◽  
Real World ◽  
Practical Knowledge ◽  
Building Blocks ◽  
Research Field ◽  
Knowledge Based Systems ◽  
Engineering Research ◽  
Knowledge Based ◽  
Task Ontology ◽  
Problem Solving Task

In ontological engineering research field, the concept of “task ontology” is well-known as a useful technology to systemize and accumulate the knowledge to perform problem-solving tasks (e.g., diagnosis, design, scheduling, and so on). A task ontology refers to a system of a vocabulary/ concepts used as building blocks to perform a problem-solving task in a machine readable manner, so that the system and humans can collaboratively solve a problem based on it. The concept of task ontology was proposed by Mizoguchi (Mizoguchi, Tijerino, & Ikeda, 1992, 1995) and its validity is substantiated by development of many practical knowledge-based systems (Hori & Yoshida, 1998; Ikeda, Seta, & Mizoguchi, 1997; Izumi &Yamaguchi, 2002; Schreiber et al., 2000; Seta, Ikeda, Kakusho, & Mizoguchi, 1997). He stated: …task ontology characterizes the computational architecture of a knowledge-based system which performs a task. The idea of task ontology which serves as a system of the vocabulary/concepts used as building blocks for knowledge-based systems might provide an effective methodology and vocabulary for both analyzing and synthesizing knowledge-based systems. It is useful for describing inherent problem-solving structure of the existing tasks domain-independently. It is obtained by analyzing task structures of real world problem. ... The ultimate goal of task ontology research is to provide a theory of all the vocabulary/concepts necessary for building a model of human problem solving processes. (Mizoguchi, 2003) We can also recognize task ontology as a static user model (Seta et al., 1997), which captures the meaning of problem-solving processes, that is, the input/output relation of each activity in a problem-solving task and its effects on the real world as well as on the humans’ mind.

A Branch-and-Bound-Based Crossover Operator for the Traveling Salesman Problem

2019 ◽  
Vol 13 (3) ◽  
pp. 1-18
Author(s):  
Thomas Weise ◽  
Yan Jiang ◽  
Qi Qi ◽  
Weichen Liu
Keyword(s):  
Branch And Bound ◽  
Building Blocks ◽  
Extensive Study ◽  
The Body ◽  
Traveling Salesman ◽  
Crossover Operator ◽  
Novel Approach ◽  
Comparison Results ◽  
Population Sizes ◽  
The Traveling Salesman Problem

In this article, the new crossover operator BBX for Evolutionary Algorithms (EAs) for traveling salesman problems (TSPs) is introduced. It uses branch-and-bound to find the optimal combination of the (directed) edges present in the parent solutions. The offspring solutions created are at least as good as their parents and are only composed of parental building blocks. The operator is closer to the ideal concept of crossover in EAs than existing operators. This article provides the most extensive study on crossover operators on the TSP, comparing BBX to ten other operators on the 110 instances of the TSPLib benchmark set in EAs with four different population sizes. BBX, with its better ability to reuse and combine building blocks, surprisingly does not generally outperform the other operators. However, it performs well in certain scenarios. Besides presenting a novel approach to crossover on the TSP, the study significantly extends and refines the body of knowledge on the field with new conclusions and comparison results.

Task Ontology-Based Human-Computer Interaction

2006 ◽  
pp. 588-596
Author(s):  
Kazuhisa Seta
Keyword(s):  
Problem Solving ◽  
Real World ◽  
Practical Knowledge ◽  
Building Blocks ◽  
Research Field ◽  
Knowledge Based Systems ◽  
Engineering Research ◽  
Knowledge Based ◽  
Task Ontology ◽  
Problem Solving Task

In ontological engineering research field, the concept of “task ontology” is well-known as a useful technology to systemize and accumulate the knowledge to perform problem-solving tasks (e.g., diagnosis, design, scheduling, and so on). A task ontology refers to a system of a vocabulary/concepts used as building blocks to perform a problem-solving task in a machine readable manner, so that the system and humans can collaboratively solve a problem based on it. The concept of task ontology was proposed by Mizoguchi (Mizoguchi, Tijerino, & Ikeda, 1992, 1995) and its validity is substantiated by development of many practical knowledge-based systems (Hori & Yoshida, 1998; Ikeda, Seta, & Mizoguchi, 1997; Izumi &Yamaguchi, 2002; Schreiber et al., 2000; Seta, Ikeda, Kakusho, & Mizoguchi, 1997). He stated: …task ontology characterizes the computational architecture of a knowledge-based system which performs a task. The idea of task ontology which serves as a system of the vocabulary/concepts used as building blocks for knowledge-based systems might provide an effective methodology and vocabulary for both analyzing and synthesizing knowledge-based systems. It is useful for describing inherent problem-solving structure of the existing tasks domain-independently. It is obtained by analyzing task structures of real world problem. ... The ultimate goal of task ontology research is to provide a theory of all the vocabulary/concepts necessary for building a model of human problem solving processes. (Mizoguchi, 2003) We can also recognize task ontology as a static user model (Seta et al., 1997), which captures the meaning of problem-solving processes, that is, the input/output relation of each activity in a problem-solving task and its effects on the real world as well as on the humans’ mind.

scholarly journals Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogues of pyridoacridine alkaloids

2019 ◽  
Vol 15 ◽  
pp. 2304-2310 ◽  
Author(s):  
Benedikt C Melzer ◽  
Alois Plodek ◽  
Franz Bracher
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Novel Approach ◽  
Pyridoacridine Alkaloids

Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl∙LiCl at −40 °C. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the synthesis of heterocyclic natural products and analogues thereof. In combination with a Parham-type cyclization a novel approach to pyrido[4,3,2-mn]acridones has been worked out.

Metallic Nanowires From Carbon Nanotube Building Blocks: The Effect of Atomic Defects on the Nanotube Influencing Nanowire Growth

2003 ◽  
Author(s):  
B. Panchapakesan ◽  
Kousik Sivakumar ◽  
Shaoxin Lu
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Electric Field ◽  
Building Blocks ◽  
Model Systems ◽  
Initial Surface ◽  
Sensors And Actuators ◽  
Platinum Nanowires ◽  
Defect Sites ◽  
Current Densities

Manipulation and control of matter at the nano- and atomic level are crucial for the success of nano-scale sensors and actuators. The ability to control and synthesize multilayer structures using carbon nanotubes that will enable to build electronic devices within a nanotube is still in its infancy. In this paper, we present results on selective electric field assisted deposition of metals on carbon nanotubes realizing metallic nanowire structures. Silver and platinum nanowires has been fabricated using this approach due to its applications in chemical sensing sensing as catalytic materials to sniff toxic agents and in the area of biomedical nanotechnology for construction of artificial muscles. The electric field assisted technique allows the deposition of metals with high degree of selectivity on carbon nanotubes by manipulating the charges on the surface of the nanotubes. The thickness and the growth of the nanowires was altered by inducing defects on the initial surface of the nanotubes that affected the local current densities and electrochemical reduction of silver and platinum on those defect sites. SEM and TEM investigations revealed silver and platinum nanowires between 10 nm-100 nm in diameter. Relatively higher metal deposition was achieved in defect related sites or places where the nanotubes criss-crossed each other, due to the high current densities in these sites. The present technique is versatile and enables the fabrication of host of different types of metallic and semiconduting nanowires using carbon nanotube templates for nanoelectronics and myriad of sensor applications. Further, nanowires can also serve as model systems for studying quantum size effects in these dimensions.

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