scholarly journals Mixed Micellization and Spectroscopic Studies of Anti-Allergic Drug and Non-Ionic Surfactant in the Presence of Ionic Liquid

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2756 ◽  
Author(s):  
Naved Azum ◽  
Malik Abdul Rub ◽  
Abdullah M. Asiri
Keyword(s):  
Ionic Liquid ◽  
Micelle Formation ◽  
Theoretical Models ◽  
Spectroscopic Studies ◽  
Ionic Surfactant ◽  
Surfactant Mixtures ◽  
Mixed Micellization ◽  
Diphenhydramine Hydrochloride ◽  
Synergistic Behavior ◽  
Drug Efficiency

In drug delivery, surfactants are used to reduce side effects and to increase drug efficiency. The present work aimed to study the interaction of diphenhydramine hydrochloride (anti-allergic drug) with TX–45 (non-ionic surfactant) in the absence and presence of ionic liquid (1-hexyl-3-methylimidazolium chloride). The physicochemical parameters were estimated by the surface tension measurement. Various theoretical models (Clint, Rubingh, Motomura, and Maeda) were applied to determine the attractive behavior between drug and surfactant mixtures at the surface and in bulk. The drug and surfactant mixtures exhibit synergistic behavior in the absence and presence of ionic liquid. Several energetic parameters were also estimated with the assistance of regular solution approximation and pseudo phase separation model that indicate micelle formation and adsorption of surfactant at the surface is thermodynamically advantageous. The morphology of pure and mixture of amphiphiles has been estimated by the Tanford and Israelachvili theories. UV-visible spectroscopy was used to quantify the attractive behavior of the drug with surfactant with the help of a binding constant (K).

scholarly journals Mixed Micelle Formation and Co-adsorption of Anionic/Non-ionic Surfactant Mixtures on Rutile

1996 ◽  
Vol 13 (5) ◽  
pp. 377-395 ◽  
Author(s):  
Ajay K. Vanjara ◽  
Sharad G. Dixit
Keyword(s):  
Mixed Micelle ◽  
Co Adsorption ◽  
Micelle Formation ◽  
Ionic Surfactant ◽  
Surfactant Mixtures ◽  
Mixed Micellization ◽  
Mixed Micelle Formation ◽  
Brij 58 ◽  
Solid Liquid Interface ◽  
Solid Liquid

Mixed micelle formation between the anionic surfactant p-dodecyl benzene sulphonate and the non-ionic surfactants Brij-58, Brij-78 and Brij-99, having the same number of oxyethylene units but a varying number of hydrophobic groups, has been studied using surface tension and NMR spectroscopic measurements. Both hydrophobic–hydrophobic and hydrophilic–hydrophilic interactions play an important role in mixed micelle formation leading to greater non-ideality. The effect of mixed micelle interactions on the adsorption of these surfactants from their mixtures on rutile have been investigated using adsorption and zeta potential measurements. Adsorption above the CMC level is dictated by the relatively higher tendency of mixed micellization over mixed aggregation at the solid/liquid interface.

scholarly journals Thermodynamic and Interfacial Properties of DTABr/CTABr Mixed Surfactant Systems in Ethanolamine/Water Mixtures: A Conductometry Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Olaseni Segun Esan ◽  
Medinat Olubunmi Osundiya ◽  
Christopher Olumuyiwa Aboluwoye ◽  
Owoyomi Olanrewaju ◽  
Jide Ige
Keyword(s):  
Mixed Micelle ◽  
Mixed Solvent ◽  
Pure Water ◽  
Micelle Formation ◽  
Theoretical Models ◽  
Solvent System ◽  
Synergistic Interaction ◽  
Surfactant Mixtures ◽  
Mixed Micelle Formation ◽  
Free Energy Of Micellization

Mixed-micelle formation in the binary mixtures of dodecyltrimethylammonium bromide (DTABr) and cetyltrimethylammonium bromide (CTABr) surfactants in water-ethanolamine mixed solvent systems has been studied by conductometric method in the temperature range of 298.1 to 313.1 K at 5 K intervals. It was observed that the presence of ethanolamine forced the formation of mixed micelle to lower total surfactant concentration than in water only. The synergistic interaction was quantitatively investigated using the theoretical models of Clint and Rubingh. The interaction parameter β12 was negative at all the mole fractions of DTABr in the surfactant mixtures indicating a strong synergistic interaction, with the presence of ethanolamine in the solvent system resulting in a more enhanced synergism in micelle formation than in water only. The free energy of micellization ΔGM values was more negative in water-ethanolamine mixed solvent system than in pure water indicating more spontaneity in mixed micelle formation in the presence of ethanolamine than in pure water.

scholarly journals Synergistic Solubilization of Phenanthrene by Mixed Micelles Composed of Biosurfactants and a Conventional Non-Ionic Surfactant

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4327
Author(s):  
Jianfei Liu ◽  
Yuru Wang ◽  
Huifang Li
Keyword(s):  
Aqueous Solubility ◽  
Mixed System ◽  
Synthetic Surfactant ◽  
Ionic Surfactant ◽  
Mixed Surfactant ◽  
Surfactant Mixtures ◽  
Water Partition Coefficient ◽  
Synergistic Behavior ◽  
Triton X ◽  
Mixture System

This study investigated the solubilization capabilities of rhamnolipids biosurfactant and synthetic surfactant mixtures for the application of a mixed surfactant in surfactant-enhanced remediation. The mass ratios between Triton X-100 and rhamnolipids were set at 1:0, 9:1, 3:1, 1:1, 1:3, and 0:1. The ideal critical micelle concentration values of the Triton X-100/rhamnolipids mixture system were higher than that of the theoretical predicted value suggesting the existence of interactions between the two surfactants. Solubilization capabilities were quantified in term of weight solubilization ratio and micellar-water partition coefficient. The highest value of the weight solubilization ratio was detected in the treatment where only Triton X-100 was used. This ratio decreased with the increase in the mass of rhamnolipids in the mixed surfactant systems. The parameters of the interaction between surfactants and the micellar mole fraction in the mixed system have been determined. The factors that influence phenanthrene solubilization, such as pH, ionic strength, and acetic acid concentration have been discussed in the paper. The aqueous solubility of phenanthrene increased linearly with the total surfactant concentration in all treatments. The mixed rhamnolipids and synthetic surfactants showed synergistic behavior and enhanced the solubilization capabilities of the mixture, which would extend the rhamnolipids application.

scholarly journals Interaction of Diphenhydramine Hydrochloride with Cationic and Anionic Surfactants: Mixed Micellization and Binding Studies

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1214
Author(s):  
Naved Azum ◽  
Malik Abdul Rub ◽  
Sulaiman Yahya Alfaifi ◽  
Abdullah M. Asiri
Keyword(s):  
Cetylpyridinium Chloride ◽  
Sodium Dodecyl ◽  
Stoichiometric Ratio ◽  
Surfactant Mixtures ◽  
Binding Studies ◽  
Ideal Behavior ◽  
Mixed Micellization ◽  
Theoretical Approaches ◽  
Diphenhydramine Hydrochloride ◽  
Cationic And Anionic Surfactants

The focus of the present work is to evaluate the interactions of an anti-allergic drug (diphenhydramine hydrochloride, DPH) with anionic (sodium dodecyl sulfate, SDS) and cationic (cetylpyridinium chloride, CPC) surfactants in the aqueous medium. The mixed micellization behavior and surface properties of drug-surfactant mixtures have been examined by surface tension measurements. Various theoretical approaches were applied to explore the synergistic or non-ideal behavior of the current mixed systems. Furthermore, the binding studies of drug with surfactants have been elaborated by UV–visible spectroscopy. Benesi–Hildebrand (B-H) theory was used to compute stoichiometric ratio, binding constant, and free energy change for the drug-surfactant mixtures. The outputs are deliberated taking into consideration the use of surfactants as capable drug delivery agents for DPH and hence advance bioavailability.

The high-resolution spectroscopy of dissociating molecules

1990 ◽  
Vol 332 (1625) ◽  
pp. 297-307 ◽  
Keyword(s):  
High Resolution ◽  
Energy Flow ◽  
Energy State ◽  
Reaction Dynamics ◽  
Theoretical Models ◽  
Spectroscopic Studies ◽  
High Resolution Spectroscopy ◽  
Bond Breaking ◽  
Vibrational Levels ◽  
Dynamical Constraints

Results from spectroscopic studies of the vibrational levels of dissociating molecules and from state-selected, state-resolved photofragmentation spectroscopy are presented. The extent of energy flow among the modes of a molecule is explored through the couplings, or lack thereof, revealed by high-resolution spectroscopy. The dynamics of energy flow during bond breaking are revealed by photofragment excitation spectroscopy and by product energy state distributions. These completely resolved data provide sensitive tests of dynamical constraints such as vibrational or rotational adiabaticity and thus of theoretical models for unimolecular reaction dynamics.

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