scholarly journals Biopolymer and Synthetic Polymer-Based Nanocomposites in Wound Dressing Applications: A Review

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1962
Author(s):  
Ravichandran Gobi ◽  
Palanisamy Ravichandiran ◽  
Ravi Shanker Babu ◽  
Dong-Jin Yoo
Keyword(s):  
Metal Oxide ◽  
Wound Dressing ◽  
Antimicrobial Properties ◽  
Synthetic Polymer ◽  
Research Field ◽  
Wound Dressings ◽  
Fibrous Materials ◽  
Natural Polymers ◽  
Structural And Functional Properties ◽  
Metal Metal

Biopolymers are materials obtained from a natural origin, such as plants, animals, microorganisms, or other living beings; they are flexible, elastic, or fibrous materials. Polysaccharides and proteins are some of the natural polymers that are widely used in wound dressing applications. In this review paper, we will provide an overview of biopolymers and synthetic polymer-based nanocomposites, which have promising applications in the biomedical research field, such as wound dressings, wound healing, tissue engineering, drug delivery, and medical implants. Since these polymers have intrinsic biocompatibility, low immunogenicity, non-toxicity, and biodegradable properties, they can be used for various clinical applications. The significant advancements in materials research, drug development, nanotechnology, and biotechnology have laid the foundation for changing the biopolymeric structural and functional properties. The properties of biopolymer and synthetic polymers were modified by blending them with nanoparticles, so that these materials can be used as a wound dressing application. Recent wound care issues, such as tissue repairs, scarless healing, and lost tissue integrity, can be treated with blended polymers. Currently, researchers are focusing on metal/metal oxide nanomaterials such as zinc oxide (ZnO), cerium oxide (CeO2), silver (Ag), titanium oxide (TiO2), iron oxide (Fe2O3), and other materials (graphene and carbon nanotubes (CNT)). These materials have good antimicrobial properties, as well as action as antibacterial agents. Due to the highly antimicrobial properties of the metal/metal oxide materials, they can be used for wound dressing applications.

scholarly journals Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

2019 ◽  
Vol 20 (23) ◽  
pp. 5889 ◽  
Author(s):  
Matica ◽  
Aachmann ◽  
Tøndervik ◽  
Sletta ◽  
Ostafe
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Healing Process ◽  
Antimicrobial Properties ◽  
Starting Material ◽  
Wound Dressings ◽  
Current Status ◽  
Natural Polymers ◽  
Promising Source

Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market.

scholarly journals Sintesis Hidrogel Pektin – Gelatin dengan Penambahan Ekstrak Kulit Buah Naga Sebagai Kandidat Pembalut Luka Bakar

2020 ◽  
Vol 4 (1) ◽  
pp. 53
Author(s):  
Fadhil Muhammad Tarmidzi ◽  
Inggit Kresna Maharsih ◽  
Tina Raihatul Jannah ◽  
Cici Sari Wahyuni
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Citric Acid ◽  
Wound Dressing ◽  
Wound Care ◽  
Crosslinking Agent ◽  
Wound Dressings ◽  
Esterification Reaction ◽  
Natural Polymers ◽  
Fruit Peel

Teknik pembalutan luka saat ini menerapkan metode perawatan luka modern dengan cara mempertahankan isolasi lingkungan luka dalam keadaan tertutup dan lembab. Ada beberapa jenis pembalut luka yang telah dikembangkan, salah satunya hidrogel. Hidrogel merupakan pembalut luka berbentuk lembaran yang memiliki kemampuan menyerap cairan luka dan memiliki stabilitas yang baik pada pH asam sehingga dapat digunakan untuk pengobatan luka bakar. Dalam penelitian ini, hidrogel dibuat menggunakan polimer alami seperti pektin dan gelatin. Kedua bahan tersebut dikombinasikan menggunakan metode ikatan silang dengan penambahan asam sitrat sebagai agen pengikat silang. Penambahan asam sitrat memberikan pengaruh terhadap karakteristik material hidrogel yang dihasilkan, sehingga diperlukan jumlah yang tepat agar didapatkan hidrogel dengan properti material yang baik. Hidrogel juga ditambahkan zat aktif berupa flavonoid pada ekstrak kulit buah naga agar dapat digunakan sebagai pembalut luka untuk menyembuhkan luka bakar. Dari hasil penelitian, hidrogel dengan konsentrasi asam sitrat 4% (Hidrogel CA 4%) menghasilkan nilai swelling, tensile strength, dan elongation tertinggi sebesar 890%, 0,05 Mpa, dan 200%. Hasil properti mekanik dari Hidrogel CA 4% ini dibuktikan dengan uji FTIR yang telah dilakukan, yaitu munculnya gugus karbonil C=O sebagai hasil reaksi esterifikasi yang terjadi antara polimer dengan asam sitrat di daerah serapan 1733,9 cm-1.Wound dressing technique currently applies modern wound care methods by maintaining the environmental isolation of the wound in a closed and moist state. There are several types of wound dressing that have been developed, one of them is hydrogel. Hydrogel is sheet-shaped wound dressings which have the ability to absorb exudate and have good stability acidic pH that can be used for the treatment of burns. In this study, hydrogel were made using natural polymers such as pectin and gelatin. The two polymers were combined using crosslinking method with the addition of citric acid as a crosslinking agent. The addition of citric acid has affect on the characteristics of the hydrogel material produced, therefore the right amount is needed to obtain a hydrogel with good mechanical properties. Hydrogel also added by an active substance in the form of flavonoids from dragon fruit peel extract that can be used as a wound dressing to cure burns. This study resulting hydrogel with a concentration of 4% citric acid (Hydrogel CA 4%) produced highest value of swelling, tensile strength, and elongation are 890%, 0.05 Mpa, and 200%, repectively. The mechanical properties of Hydrogel CA 4% was proved by FTIR test that had been carried out, namely the presence of C=O carbonyl group as a result of the esterification reaction that occurred between the polymers and citric acid in the absorption area of 1733.9 cm-1.

scholarly journals Antimicrobial Biodegradable Food Packaging Based on Chitosan and Metal/Metal-Oxide Bio-Nanocomposites: A Review

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2790 ◽  
Author(s):  
Amin Babaei-Ghazvini ◽  
Bishnu Acharya ◽  
Darren R. Korber
Keyword(s):  
Metal Oxide ◽  
Food Packaging ◽  
Antimicrobial Properties ◽  
Toxic Metal ◽  
Active Packaging ◽  
Environmental Crisis ◽  
Packaging Materials ◽  
Metal Metal ◽  
Primary Focus ◽  
Functional Components

Finding a practical alternative to decrease the use of conventional polymers in the plastic industry has become an acute concern since industrially-produced plastic waste, mainly conventional food packaging, has become an environmental crisis worldwide. Biodegradable polymers have attracted the attention of researchers as a possible alternative for fossil-based plastics. Chitosan-based packaging materials, in particular, have become a recent focus for the biodegradable food packaging sector due to their biodegradability, non-toxic nature, and antimicrobial properties. Chitosan, obtained from chitin, is the most abundant biopolymer in nature after cellulose. Chitosan is an ideal biomaterial for active packaging as it can be fabricated alone or combined with other polymers as well as metallic antimicrobial particles, either as layers or as coacervates for examination as functional components of active packaging systems. Chitosan-metal/metal oxide bio-nanocomposites have seen growing interest as antimicrobial packaging materials, with several different mechanisms of inhibition speculated to include direct physical interactions or chemical reactions (i.e., the production of reactive oxygen species as well as the increased dissolution of toxic metal cations). The use of chitosan and its metal/metal oxide (i.e., titanium dioxide, zinc oxide, and silver nanoparticles) bio-nanocomposites in packaging applications are the primary focus of discussion in this review.

scholarly journals 3D Printing of Metal/Metal Oxide Incorporated Thermoplastic Nanocomposites With Antimicrobial Properties

2020 ◽  
Vol 8 ◽  
Author(s):  
Tuerdimaimaiti Abudula ◽  
Rayyan O. Qurban ◽  
Sherifdeen O. Bolarinwa ◽  
Ahmed A. Mirza ◽  
Mirza Pasovic ◽  
...  
Keyword(s):  
3D Printing ◽  
Metal Oxide ◽  
Antimicrobial Properties ◽  
Metal Metal

scholarly journals Bio-Mediated Synthesis of Nanomaterials for Packaging Applications

2021 ◽  
pp. 96-117
Keyword(s):  
Thermal Stability ◽  
Metal Oxide ◽  
Food Packaging ◽  
Metal Oxide Nanoparticles ◽  
Antimicrobial Properties ◽  
Oxide Nanoparticles ◽  
Packaging Materials ◽  
New Variety ◽  
Metal Metal ◽  
Mechanical Tensile

Change in lifestyle of humans in this present generation with huge dependence on packaging materials has encouraged several studies on development of new variety of packaging materials. Emphasis on replacement of existing non-biodegradable packaging materials with biodegradable materials paved the way for the use of biopolymers. Lack of properties, such as thermal stability and mechanical strength in biopolymers led to the development of biopolymer nanocomposites by adding metal/metal oxide nanoparticles as fillers into the biopolymers. Metal/metal oxide nanoparticles improve mechanical/tensile strength, thermal stability as well as antimicrobial properties of the binding and receiving polymer matrix. Bio-mediated synthesis of metal/metal oxide nanoparticles result in the development of novel packaging materials at a low cost and without releasing hazardous wastes into the environments. Novel packaging materials with metal/metal oxide nanoparticles as additives are capable of increasing the shelf life of food, in certain cases they act as indicators of quality food inside the package. Summarily, this present chapter focuses on bio-mediated synthesis of various metal/metal oxide nanoparticles and their applications in food packaging.

scholarly journals Recent Updates on Biopolymers based Wound Dressings

2021 ◽  
Vol 33 (7) ◽  
pp. 1457-1470
Author(s):  
Sonia Arora ◽  
Manju Nagpal ◽  
Malkiet Kaur
Keyword(s):  
Extracellular Matrix ◽  
Wound Dressing ◽  
Low Cost ◽  
Healing Process ◽  
Synthetic Polymer ◽  
Wound Dressings ◽  
Naturally Occurring ◽  
Current Review ◽  
Dressing Materials ◽  
Wound Dressing Materials

Wound dressing is designed to support the wound bed and protect it from the factors that may delay or impede its healing such as contamination and moisture thereby facilitating and accelerate the healing process. The material used to prepare wound dressing include natural and synthetic polymer as their combination in the form of film and sponges that may be extensively used in wound dressing material. Naturally occurring polymers having many importance because of high biocompatibility and environmentally finding properties. Polysaccharides are naturally occurring polymers that have been extensively used as wound dressing materials. Homopolysaccharide are a class of polysaccharides consists of only one type of monosaccharide. Naturally occurring polymers are used for wound dressing properties because of their extracellular matrix as good acceptance by biological system. Polysaccharide is type of naturally occurring polymers that offer the advantage of good hemocompatibility and low cost in comparison with other biopolymers. The current review intends to overview the studies in which wound dressings from naturally-occurring polymers including chitosan, silk fibroin, sodium alginate and hyaluronic acid were considered.

scholarly journals ANTIMICROBIAL PROPERTIES OF RABBIT COLLAGEN GLUE-CHITOSAN BIOMATERIAL LOADED WITH CYMBOPOGON FLEXUOSUS ESSENTIAL OIL

2021 ◽  
Vol 2021 ◽  
pp. 385-390
Author(s):  
M. Râpă ◽  
M.D. Berechet ◽  
C. Gaidău ◽  
R.R. Constantinescu ◽  
A. Moșuțiu
Keyword(s):  
Wound Healing ◽  
Essential Oil ◽  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Natural Polymers ◽  
Cymbopogon Flexuosus ◽  
Dressing Materials ◽  
Lemongrass Essential Oil ◽  
Wound Dressing Materials

One approach to develop innovative antimicrobial wound dressing materials is to use natural polymers loaded with antimicrobial agents. The valorisation of animal proteins as biomaterials with antimicrobial properties is a new concern for development of wound healing. Plant esssential oils (EO) also indicate a potential approach for new wound dressing materials able to replace the synthetic antymicrobial agents. In this paper, plant-polymeric film was prepared by casting film-forming emulsion based on lemongrass (Cymbopogon flexuosus) essential oil/Tween 80 dispersed into rabbit collagen glue hydrolysate– chitosan biomaterial. The effect of biomaterial film composition on Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10536 standard bacteria, and Candida albicans ATCC 10231 pathogenic fungus was studied according to European Pharmacopoeia 10/2020 as compared with biomaterial film without essential oil. The in vitro antibacterial tests against three bacterial strains showed that the rabbit collagen glue hydrolysate–chitosan biomaterial inhibited all the three microorganisms. The rabbit collagen hydrolysate glue-chitosan film loaded with lemongrass essential oil exhibits antimicrobial activity towards tested microorganisms but lower as compared with control. The explanation could be due to the short time of investigation, or maybe some active compounds constituents of EO, which favour the cellular proliferation. Preparation of rabbit collagen glue hydrolysate-chitosan biomaterial loaded with lemongrass essential oil is an environmentally friendly solution, which may contribute to the development of wound healing materials as an alternative to topical antimicrobial agents.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

scholarly journals The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

2021 ◽  
Vol 394 (10) ◽  
pp. 1991-2002
Author(s):  
Junchao Luo ◽  
Yin Zhang ◽  
Senbo Zhu ◽  
Yu Tong ◽  
Lichen Ji ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Biological Response ◽  
Cell Uptake ◽  
Oxide Nanoparticles ◽  
Therapeutic Effects ◽  
Superoxide Anions ◽  
Metal Metal ◽  
Cartilage Wear

AbstractThe current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.

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