scholarly journals Curcumin-Functionalized Gelatin Films: Antioxidant Materials with Modulated Physico-Chemical Properties

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1824
Author(s):  
Katia Rubini ◽  
Elisa Boanini ◽  
Silvia Parmeggiani ◽  
Adriana Bigi
Keyword(s):  
Water Solubility ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Crosslinking Agent ◽  
Radical Scavenging ◽  
Chemical Properties ◽  
Mechanical Tests ◽  
Scanning Calorimetry ◽  
Gelatin Films ◽  
Physico Chemical

In this paper we used curcumin as a functionalizing agent of gelatin films with the aim to get antioxidant materials with modulated physico-chemical properties. To this aim, we prepared gelatin films at different contents of curcumin up to about 1.2 wt%. The as-prepared films, as well as glutaraldehyde crosslinked films, were submitted to several tests: swelling, water solubility, differential scanning calorimetry, X-ray diffraction, mechanical tests and curcumin release. The radical scavenging activity of the as-prepared films is similar to that of free curcumin, indicating remarkable antioxidant properties. All the other tested properties vary as a function of curcumin content and/or the presence of the crosslinking agent. In particular, the films exhibit sustained curcumin release in different solvents. Thanks to its biocompatibility, biodegradability and lack of antigenicity, gelatin uses span from food processing to packaging and biomaterials. It follows that the modulated properties exhibited by the functionalized materials developed in this work can be usefully employed in different application fields.

Enhanced solubility and permeability of naringenin across non-everted sacs of rat small intestine by lipid nanocapsules

2020 ◽  
Vol 14 ◽  
Author(s):  
Hamed Vakilzadeh ◽  
Jaleh Varshosaz ◽  
Sahel Soghrati
Keyword(s):  
Storage Stability ◽  
Radical Scavenging Activity ◽  
Thermal Studies ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Hydrodynamic Diameter ◽  
Scavenging Activity ◽  
Scanning Calorimetry ◽  
Lipid Nanocapsules ◽  
Enhanced Solubility

Background: Naringenin (NRG) has many health benefits including; anti-atherogenic, anti-inflammatory, antitumor, and anticancer activity as well as improvement of lipid metabolism. However, its use is limited due to its low solubility and bioavailability. Objectives: The aim of the present study was the preparation and optimization of NRG loaded novel lipid nanocapsules (LNCs) for improvement of NRG solubility and gut permeability. Methods: Studied variables included; Solutol® HS15 and NRG concentration and the ratio of cold diluent water to primary emulsion. The storage stability of the LNCs was evaluated for 32 days and the thermal studies were done by differential scanning calorimetry (DSC). The antioxidant properties of the NRG in LNCs were studied by measuring the 2,2- Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. The enhancement of permeation of NRG by the LNCs from the intestine was evaluated by non-everted gut sac method. Results: The optimized NRG-LNCs had a hydrodynamic diameter of 29.41±1.25 nm, low polydispersity index, and high entrapment efficiency of 99.25±2.31%. The LNCs could retain NRG radical scavenging activity, showed good storage stability, and significantly improved NRG solubility (69 fold) and permeation through non-everted rat intestinal sac (4.33 fold). Conclusion: LNCs of NGR enhance solubility and intestinal permeability of this flavonoid and may be useful in improvement of its bioavailability.

scholarly journals Effect of okara and vital gluten on physico-chemical properties of noodle

2018 ◽  
Vol 36 (No. 4) ◽  
pp. 301-306 ◽  
Author(s):  
Pan Wei-Chen ◽  
Liu Yu-Ming ◽  
Shiau Sy-Yu
Keyword(s):  
Total Phenolics ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Chemical Properties ◽  
Cooking Time ◽  
Sensory Acceptability ◽  
Fiber Protein ◽  
Physico Chemical ◽  
Health Promoting

Okara, a by-product during processing of soymilk or tofu, is rich in dietary fiber, protein and phytochemicals. Therefore, it can be useful as a functional ingredient with health-promoting attributes. This study was to investigate the effects of addition of dried okara powder (DOP) and vital gluten (VG) on rheological, antioxidative and sensory properties of noodle. Results showed that high DOP amount (10–15%) significantly reduced optimum cooking time, extensibility, tensile strength and elasticity of noodle. Increasing DOP amount led to the increase in total phenolics and flavonoids, as well as radical-scavenging activity of noodle. Supplement of 6% vital gluten could improve the quality of 10%-DOP noodle, including cooking loss, tensile property, elasticity and sensory acceptability. Therefore, we suggest that enriched noodle can be prepared with 5% DOP or 10% DOP plus 6% VG in order to increase the intake of phytochemicals and maintain the sensory acceptability of consumers.

β-Cyclodextrin as water-solubility enhancer for butylated hydroxytoluene

2015 ◽  
Vol 69 (5) ◽  
Author(s):  
Marcin Lukasiewicz ◽  
Stanislaw Kowalski ◽  
Anna Ptaszek ◽  
Pawel Ptaszek
Keyword(s):  
Water Solubility ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Ternary Systems ◽  
Butylated Hydroxytoluene ◽  
Phase Solubility ◽  
Solubility Study ◽  
Phase Solubility Study ◽  
Endothermic Process

AbstractThe phenomenon of the increase in solubility of the non-polar phenolic antioxidant - butylated hydroxytoluene (BHT) - in aqueous solutions containing β-cyclodextrin (CD) was studied. The complexation of BHT by CD was investigated using a phase solubility study. This method makes it possible to calculate the apparent formation constant for the host-guest complex. In addition, the thermodynamic properties were evaluated, revealing a spontaneous endothermic process of complex formation. Two solubility models were also used to verify their applicability to predicting the BHT concentration in solution. Those models included the modified Apelblat and Buchowski-Ksiazczak equations. In order to investigate the antioxidant properties of the BHT/CD/water ternary systems, a radical scavenging activity using a DPPH stable radical was performed. The experiments indicated that the antioxidant activity is temperature- and CD concentration-dependent. It was shown that complexation may inhibit the radical scavenging by BHT or change the scavenging stoichiometry.

Characterisation of Preformulation Parameters to Design, Develop and Formulate Silymarin loaded PLGA Nanoparticles for Liver Targeted Drug Delivery

2021 ◽  
pp. 5508-5514
Author(s):  
Senthila S ◽  
Manojkumar P. ◽  
Venkatesan P.
Keyword(s):  
Water Solubility ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Chemical Properties ◽  
Water Soluble ◽  
Angle Of Repose ◽  
Effect Of Temperature ◽  
Pharmacokinetic Studies ◽  
Bioavailability Enhancement ◽  
Water Soluble Compound

Silymarin, a flavonolignan,derived from Silybum marianum, family Asteraceae has long been used as a hepatoprotective remedy. Silymarin has cytoprotective activities due to its antioxidant property and free radical scavenging activity. It inhibits the binding of hepatotoxins to receptor sites, protects hepatocyte membranes, enhances liver parenchyma regeneration and increases glutathione levels. The pharmacokinetic studies of past three decades revealed that Silymarin has poor absorption, rapid metabolism especially by Phase II metabolism and ultimately poor oral bioavailability. Typical oral adult dose of Silymarin is 240-800mg /day .It is a non-lipophilic and poorly water soluble compound with water solubility of 0.04mg/ml. Only 20-30% of oral Silymarin is absorbed from gastrointestinal tract where it undergoes extensive entero-hepatic circulation. The advanced type of formulation like polymeric nanoparticles (PNPs) can be successfully utilised for bioavailability enhancement and targeting the Silymarin to hepatocytes. A controlled release PNP of Silymarin was prepared by solvent evaporation method using Poly Lactic-co-Glycolic Acid (PLGA) as biodegradable polymer. Prior to the development of this novel dosage form, it is very important to identify fundamental physical and chemical properties of the drug molecule and other divided properties of the drug powder. This data helps in many of the subsequent events and approaches towards the development of a better formulation. Preformulation studies included determination of solubility, moisture content, partition coefficient, melting point , powder properties like tapped density, bulk density, compressibility index, flow properties like angle of repose, excipient compatibility, entrapment efficiency, release profile of nanoparticles like dissolution, stability studies like effect of temperature and humidity and analysis by scanning Electron Microscopy.

scholarly journals Turrón Coproducts as Source of Bioactive Compounds: Assessment of Chemical, Physico-Chemical, Techno-Functional and Antioxidant Properties

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 727
Author(s):  
José Manuel Lorente-Mento ◽  
Raquel Lucas-González ◽  
Estrella Sayas-Barbera ◽  
José Ángel Pérez-Álvarez ◽  
Juana Fernández-López ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Sugar Content ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Chemical Properties ◽  
Ferrous Ions ◽  
Antioxidant Power ◽  
Physico Chemical ◽  
Polyphenolic Profile ◽  
Radical Scavenging Assay

The goals of this research were determined the proximate composition, physico-chemical, techno-functional properties, the polyphenolic profile, the organic acids and sugar content and the antioxidant capacities of flours obtained from almonds skins var. comuna (ASFC) and var. fritz (ASFF) coproducts produced in Turrón industry. The chemical composition and physico-chemical properties (pH, water activity and color) were determined. The water holding, oil holding and swelling capacities were also determined, as well as the polyphenolic profile. For the antioxidant capacity, four different assays were used namely: 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (DPPH•); Ferrous ions chelating activity (FIC); Ferric reducing antioxidant power (FRAP) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging assay (ABTS•+). The flours obtained from ASFC and ASFF had a high content of dietary fiber (70.50 and 69.83 g/100 g, respectively). The polyphenolic profile, determined by High Performance Liquid Chromatography, identified 21 and 19 polyphenolic compounds in both ASFC and ASFF, being epicatechin and catechin the most abundant compounds. In reference to the antioxidant capacity regards, with all methods assayed except FRAP, ASFC had higher antioxidant activity than ASFF. These coproducts show good technological and antioxidant properties, which makes them a good alternative for its use in the development of new foods.

scholarly journals Synthesis and Characterization of Transparent Biodegradable Chitosan: Exopolysaccharide Composite Films Plasticized by Bio-Derived 1,3-Propanediol

2021 ◽  
Vol 2 (1) ◽  
pp. 49-62
Author(s):  
Narisetty Vivek ◽  
Nishant Gopalan ◽  
Satyajit Das ◽  
Keerthi Sasikumar ◽  
Raveendran Sindhu ◽  
...  
Keyword(s):  
Crude Glycerol ◽  
Water Solubility ◽  
Moisture Absorption ◽  
Antioxidant Properties ◽  
Composite Films ◽  
Chemical Properties ◽  
Physico Chemical ◽  
Anti Oxidant ◽  
The Fourier Transform

In this study, chitosan-based composite films blended with a dextran like exopolysaccharide derived from lactic acid bacteria were prepared using the solvent casting method. Later, these composite films were plasticized with 1,3-propanediol (1,3-PDO) produced biologically using biodiesel derived crude glycerol. Further, their physical properties, such as tensile strength, water vapor barrier, thermal behavior, and antioxidant properties, were tested. In comparison to the control chitosan-exopolysaccharide films, 1,3-PDO plasticized films increased tensile strengths (20.08 vs. 43.33 MPa) with an elongation percentage (%E) of 20.73, which was two times more than the control films. As a polymer composite, the Fourier transform infrared (FTIR) spectrum displayed the characteristic peaks at 1000 cm−1, 1500 cm−1, and 3000–3500 cm−1 to describe the functional groups related to chitosan, exopolysaccharide, and 1,3-PDOThe thermogravimetric analysis displayed a significant three-step degradation at 100–105 °C, 250–400 °C, and 600 °C, where 100% of the films were degraded. The plasticized films were observed to have enhanced water solubility (51%) and rate of moisture absorption (193%). The plasticized films displayed enhanced physico-chemical properties, anti-oxidant properties, and were100% biodegradable.

Effect of Different Drying Methods on the Physico-Chemical Properties of Tomato Variety 'Rio Grande'

2012 ◽  
Vol 8 (2) ◽  
Author(s):  
Ridha Fethi Mechlouch ◽  
Walid Elfalleh ◽  
Manel Ziadi ◽  
Hédia Hannachi ◽  
Mabrouka Chwikhi ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Chemical Properties ◽  
Rio Grande ◽  
Microwave Drying ◽  
Drying Methods ◽  
Sun Drying ◽  
Methanolic Extracts ◽  
Solar Dryer ◽  
Physico Chemical

The aim of this work is to study the physico-chemical properties of dried tomatoes, variety Rio grande using direct solar dryer (DSD), open-air sun drying (OASD) and microwave drying (MW) with three output powers density (1w/g; 2w/g; 3w/g) at different temperatures (57, 67°C). Radical scavenging activity of tomatoes extracts was investigated. Results indicated that drying tomatoes by microwave (3W/g; 67°C) is faster than open-air sun drying (OASD) and direct solar dryer (DSD). The studied parameters (moisture, pH, °Brix, total phenolics, total flavonoids, and carotenoids content) were significantly affected by different drying processes, with minimal effects on pH. The highest activity against the DPPH radical oxidation is investigated in methanolic extracts of tomatoes dried by direct solar dryer (DSD). Nevertheless, the highest ABTS value was observed in methanolic extracts of tomatoes dried by microwave (MW) with 3w/g at 57°C.

scholarly journals Free Radical Scavenging Activity of Copper Nanoparticles Synthesized from Dried Ginger

2020 ◽  
pp. 1-7
Author(s):  
R. Shruthi Devi ◽  
M. Jeevitha ◽  
S. Preetha ◽  
S. Rajeshkumar
Keyword(s):  
Copper Nanoparticles ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Synthesis Method ◽  
Radical Scavenging ◽  
Antimicrobial Properties ◽  
Chemical Properties ◽  
Antioxidant Property ◽  
Synthesis Of Nanoparticles ◽  
Vis Spectroscopy

Nano science is considered to be an important area in research in which developing nontoxic, reliable and ecofriendly synthesis of nanoparticles by the green approach has a vital part. Nanoparticles that contain antimicrobial and antioxidant properties are considered to be a new trend for developing therapeutic agents that help in killing drug resistant pathogenic microorganisms. The present study is focused on discovering the antioxidant properties of copper nanoparticles synthesized from dried ginger. Dried ginger is a traditional medicine used widely and has shown to possess good antioxidant and antimicrobial properties. The phytochemical compounds of dried ginger can act as a reducing agent to synthesize copper nanoparticles. Copper nanoparticles were preferred for this study as it has unique physical and chemical properties. There are various methods used to synthesize nanoparticles and here in this study we have used the green synthesis method for synthesizing the copper nanoparticles. The copper nanoparticles were characterized by UV-vis spectroscopy and its antioxidant property was evaluated by DPPH assay.

scholarly journals Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1445 ◽  
Author(s):  
Nareekan Chaiwong ◽  
Pimporn Leelapornpisid ◽  
Kittisak Jantanasakulwong ◽  
Pornchai Rachtanapun ◽  
Phisit Seesuriyachan ◽  
...  
Keyword(s):  
Water Solubility ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Carboxymethyl Chitosan ◽  
Scavenging Activity ◽  
Molecular Weights ◽  
Pig Skin ◽  
Ic50 Values ◽  
Radical Scavenging Assay

This research aimed to synthesize carboxymethyl chitosan (CMCH) from different molecular weights of chitosan including low MW (L, 50–190 kDa), medium MW (M, 210–300 kDa) and high MW (H, 310–375 kDa) on the antioxidant and moisturizing properties. The L-CMCH, M-CMCH and H-CMCH improved the water solubility by about 96%, 90% and 89%, respectively when compared to native chitosan. Higher MW resulted in more viscous of CMCH. For antioxidant properties, IC50 values of DPPH and ABTS radical scavenging activity for L-CMCH were 1.70 and 1.37 mg/mL, respectively. The L-CMCH had higher antioxidant properties by DPPH and ABTS radical scavenging assay and FRAP. The moisturizing properties on pig skin using a Corneometer® showed that 0.5% H-CMCH significantly presented (p ≤ 0.05) greater moisturizing effect than that of untreated-skin, distilled water, propylene glycol and pure chitosan from three molecular weights.

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