scholarly journals Current Insight of Printability Quality Improvement Strategies in Natural-Based Bioinks for Skin Regeneration and Wound Healing

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1011
Author(s):  
Syafira Masri ◽  
Mh Busra Fauzi
Keyword(s):  
Chronic Wound ◽  
Tissue Injury ◽  
Normal Skin ◽  
Advanced Technology ◽  
3D Bioprinting ◽  
Migration Activity ◽  
Diabetic Ulcer ◽  
Injured Tissue ◽  
Printing Techniques

Skin tissue engineering aimed to replace chronic tissue injury commonly occurred due to severe burn and chronic wound in diabetic ulcer patients. The normal skin is unable to be regenerated until the seriously injured tissue is disrupted and losing its function. 3D-bioprinting has been one of the effective methods for scaffold fabrication and is proven to replace the conventional method, which reported several drawbacks. In light of this, researchers have developed a new fabrication approach via 3D-bioprinting by combining biomaterials (bioinks) with cells and biomolecules followed by a suitable crosslinking approach. This advanced technology has been subcategorised into three different printing techniques including inject-based, laser-based, and extrusion-based printing. However, the printable quality of the currently available bioinks demonstrated shortcomings in the physicochemical and mechanical properties. This review aims to identify the limitations raised by using natural-based bioinks and the optimum temperature for various applied printing techniques. It is essential to ensure maintaining the acceptable printed scaffold property such as the optimum pore sizes and porosity that allow cell migration activity. In addition, the properties required for an ideal bioinks design for better scaffold printability were also summarised.

scholarly journals Application of 3D bioprinting in the prevention and the therapy for human diseases

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Hyeonji Kim ◽  
Junyoung Kwon ◽  
Yeong-Jin Choi ◽  
Jinah Jang ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Rapid Development ◽  
In Vitro Models ◽  
Delivery Systems ◽  
Advanced Technology ◽  
3D Bioprinting ◽  
Disease Research ◽  
Infectious Disease Research

AbstractRapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

scholarly journals Review: Sensors for Biosignal/Health Monitoring in Electronic Skin

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2478
Author(s):  
Hyeon Seok Oh ◽  
Chung Hyeon Lee ◽  
Na Kyoung Kim ◽  
Taechang An ◽  
Geon Hwee Kim
Keyword(s):  
High Performance ◽  
Active Component ◽  
Tactile Sensor ◽  
Wearable Devices ◽  
Advanced Technology ◽  
Electronic Skin ◽  
Points Of View ◽  
External Stimuli ◽  
Flexible Component

Skin is the largest sensory organ and receives information from external stimuli. Human body signals have been monitored using wearable devices, which are gradually being replaced by electronic skin (E-skin). We assessed the basic technologies from two points of view: sensing mechanism and material. Firstly, E-skins were fabricated using a tactile sensor. Secondly, E-skin sensors were composed of an active component performing actual functions and a flexible component that served as a substrate. Based on the above fabrication processes, the technologies that need more development were introduced. All of these techniques, which achieve high performance in different ways, are covered briefly in this paper. We expect that patients’ quality of life can be improved by the application of E-skin devices, which represent an applied advanced technology for real-time bio- and health signal monitoring. The advanced E-skins are convenient and suitable to be applied in the fields of medicine, military and environmental monitoring.

Regional features of the anatomical structure of the root canals of the first molars

MedAlliance ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 96-101
Keyword(s):  
Root System ◽  
Anatomical Structure ◽  
System Structure ◽  
Cone Beam ◽  
Migration Activity ◽  
Root Canals ◽  
Regional Features ◽  
Root System Structure ◽  
Regions Of Russia

Unsatisfactory quality of root canal treatment is one of the most important problems of modern dentistry. One of the reasons is the limited knowledge of dentists about the regional features of the endodontic teeth anatomy, which is becoming particularly relevant in the rise of migration activity of the Russian population. But compared to other countries, there are very few studies and publications in this field in Russia. Objective. Study the features of first molars' root canals' anatomy in patients from different regions of Russia. Materials and methods. 363 cone-beam computed tomography (CBCT) scans of the jaws of patients 26 to 64 years of age, living in Moscow and StPetersburg for at least four generations have been considered. The endodontic anatomy of 347 first molars of the upper and 611 lower jaws was studied. The number of roots and root canals, their structure and shape were determined. Results. Anatomical differences in the structure of the first molars' root canals were established in residents who resided in Moscow and StPetersburg for several generations. Variations in the number of roots and root canals were found in the upper jaw molars. As for the canal-root system of the lower molars, most often they were characterised by different variants of the cross-section and the number of canals in the distal root. Conclusions. The results of the study can be used in practical dentistry, as they allow the dentists of StPetersburg and Moscow to expand the current understanding of the root system structure and the frequency of possible variations in these regions.

A STUDY ON THE ROLE OF EPIDERMAL GROWTH FACTOR IN DIABETIC ULCER MANAGEMENT

2021 ◽  
pp. 62-63
Author(s):  
R. Rani Suganya ◽  
M. Annapoorani ◽  
C. Naveen Kumar
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Diabetic Foot ◽  
Diabetic Ulcer ◽  
Epidermal Growth Factor Treatment ◽  
Epidermal Growth ◽  
Diabetic Foot Disease ◽  
Foot Disease

Diabetes mellitus is a disease of large magnitude with 25 million people affected by the disease in India. One of the common complications of this disease is Diabetic foot disease characterised by non-healing ulcers over the foot predominantly. This study is aimed at evaluating the efcacy and tolerability of Recombinant Epidermal Growth Factor treatment in increasing the rate of healing of ulcers and decreasing the duration of ulcer healing among patients with diabetic foot disease thereby improving the quality of life, preventing further morbidity and mortality and shortening hospital stay.

scholarly journals The RAGE Game Software Components Repository for Supporting Applied Game Development

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Krassen Stefanov ◽  
Atanas Georgiev ◽  
Alexander Grigorov ◽  
Boyan Bontchev ◽  
Pavel Boytchev ◽  
...  
Keyword(s):  
Programming Languages ◽  
Life Cycle Management ◽  
Advanced Technology ◽  
Software Components ◽  
Game Development ◽  
Research And Innovation ◽  
Innovation Project ◽  
Game Engines ◽  
Game Developers

This paper presents the architecture of the RAGE repository, which is a unique and dedicated infrastructure that provides access to a wide variety of advanced technology components for applied game development. The RAGE project, which is the principal Horizon2020 research and innovation project on applied gaming, develops up to three dozens of software components (RAGE software assets) that are reusable across a wide diversity of game engines, game platforms and programming languages. The RAGE repository provides storage space for assets and their artefacts and is designed as an asset life-cycle management system for defining, publishing, updating, searching and packaging for distribution of these assets. It will be embedded in a social platform for asset developers and other users. A dedicated Asset Repository Manager provides the main functionality of the repository and its integration with other systems. Tools supporting the Asset Manager are presented and discussed. When the RAGE repository is in full operation, applied game developers will be able to easily enhance the quality of their games by including selected advanced game software assets. Making available the RAGE repository system and its variety of software assets aims to enhance the coherence and decisiveness of the applied game industry.

scholarly journals The Relationship Between Discharge Planning and The Quality of Life of Patients with Diabetic Ulcer

2019 ◽  
Vol 4 (1) ◽  
pp. 20
Author(s):  
Candra Kusuma Negara ◽  
Abd Basid ◽  
Sri Erliani ◽  
Inaya Turahman
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Planning Process ◽  
Discharge Planning ◽  
Diabetic Ulcer ◽  
Diabetic Ulcers ◽  
Ex Post ◽  
Ex Post Facto ◽  
Ex Post Facto Study

Introduction: Diabetic ulcer is one of the chronic complications of diabetes mellitus. Several studies in Indonesia reported that the mortality rate of gangrene ulcers in people with diabetes ranged from 17-32%, and diabetic ulcers affected the quality of life of sufferers. All patients hospitalized require discharge planning. From the explanation above, it can be concluded that Diabetes Mellitus is a degenerative disease that indeed requires hospitalization. The purpose of this study is to find out whether the Discharge planning process has a relationship with the quality of life of patients with Diabetic Ulcers. Methods: With the Ex post facto study design, 28 respondentwho were in accordance obtained measurements of discharge planning processes using interview methods and measurements on quality of life using the WHOQOL-BREEF questionnaire with spearman rank non parametric correlation analysis methods. Results: The results of the value are obtained: a = 0.05 with = rs table (0.707), RHO count (0.949)>rs table then categorized in the table Relationship Strengths correlation results obtained in this category is very strong / near perfect with the value 0.76- 1.00. Conclusions:This shows that there is a significant relationship with the strength of a very strong / near-perfect relationship according to the table.

scholarly journals Direct Ink Writing of Materials for Electronics-Related Applications: A Mini Review

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhenzhong Hou ◽  
Hai Lu ◽  
Ying Li ◽  
Laixia Yang ◽  
Yang Gao
Keyword(s):  
Human Life ◽  
Electronic Devices ◽  
Electronic Components ◽  
Direct Ink Writing ◽  
Recent Developments ◽  
Print Materials ◽  
On Chip ◽  
Functional Components ◽  
Printing Techniques

Recently, the fabrication of electronics-related components via direct ink writing (DIW) has attracted much attention. Compared to the conventionally fabricated electronic components, DIW-printed ones have more complicated structures, higher accuracy, improved efficiency, and even enhanced performances that arise from well-designed architectures. The DIW technology allows directly print materials on a variety of flat substrates, even a conformal one, well suiting them to applications such as wearable devices and on-chip integrations. Here, recent developments in DIW printing of emerging components for electronics-related applications are briefly reviewed, including electrodes, electronic circuits, and functional components. The printing techniques, processes, ink materials, advantages, and properties of DIW-printed architectures are discussed. Finally, the challenges and outlooks on the manufacture of 3D structured electronic devices by DIW are outlined, pointing out future designs and developments of DIW technology for electronics-related applications. The combination of DIW and electronic devices will help to improve the quality of human life and promote the development of science and society.

Can Pre-Service Teachers Create Digital Game-Based Activities Without Coding Knowledge?

2018 ◽  
pp. 159-172 ◽  
Author(s):  
Phu Vu ◽  
Martonia Gaskill
Keyword(s):  
Training Session ◽  
Digital Games ◽  
Public University ◽  
Advanced Technology ◽  
Technology Skills ◽  
Digital Game ◽  
Research Procedure ◽  
Interview Training ◽  
Electronic Games

This chapter examined five cases of pre-service teachers' abilities and attitudes towards creating and using digital games in their future teaching. Participants included five pre-service teachers at a Midwest public university. The participants underwent the same research procedure including: pre-project open-ended interview, training session, and post-project open-ended interview. The researchers analyzed participants' responses to the interviews and the quality of the games they created, using the Educational Electronic Games Rubric. Results showed that students not only enjoyed learning about digital games, but also were able to create quality games without coding knowledge or advanced technology skills. Five participants indicated that they plan on creating and integrating digital games into their future teaching.

scholarly journals Implications of Concepts of Consciousness for Understanding Pain Behaviour and the Definitiion of Pain

1997 ◽  
Vol 2 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Kenneth D Craig
Keyword(s):  
Life Experiences ◽  
Tissue Injury ◽  
Conscious Experience ◽  
Self Report ◽  
Older Children ◽  
Explicit Recognition ◽  
Definition Of ◽  
Inherent Quality

Judgements of the nature and severity of pain others may be experiencing are heavily influenced by an observer's preconceptions about the nature of the experience. Our personal sense of conscious experience dictates a search for consciousness characterized by the state of awareness found in competent adults, including constructive memories and thoughts, images and feelings. People incapable of verbally articulating experiences akin to those reported by competent older children and adults are at risk of having other evidence of pain denied, minimized or ignored. Despite substantial behavioural evidence for pain in the neonate and infant, and findings indicating destructive immediate and long term consequences if pain is not controlled, pain in infants and children often continues to be discounted. An alternative perspective on infant consciousness of pain focusing upon sensory and emotional components is presented. The current prominent definition of pain supports the prejudice favouring adult conceptions of consciousness by emphasizing the importance of self-report in assessing pain. Explanatory notes accompanying this definition also perpetrate the misguided belief that the experience of pain emerges as a product of early life experiences. The case for using nonverbal as well as verbal expression in the process of inferring states of pain is presented. As well, the proposition is supported that there should be explicit recognition that the experience of pain is an inherent quality of life present in all viable newborns, with the nature of the experience and its expression changing in the course of maturation and as a result of exposure to life experiences related to tissue injury.

Nano-Precision Finishing Technology Based on Magnetorheological Finishing

2009 ◽  
Vol 416 ◽  
pp. 118-122 ◽  
Author(s):  
Yao Ming Li ◽  
Xing Quan Shen ◽  
Ai Ling Wang
Keyword(s):  
Surface Roughness ◽  
Advanced Technology ◽  
Technological Parameters ◽  
Magnetorheological Finishing ◽  
Shape Precision ◽  
Surface Destruction ◽  
Series Of Experiments ◽  
Precision Finishing ◽  
Better Than

Surface roughness is normally regarded as an important criterion for assessing the quality of optic elements; surface roughness of a high-quality optic element is required to be less than RMS1nm. In this paper, a series of experiments has been conducted on the sample magnetorheological finishing machine by using self-prepared magnetorheological liquid as finishing liquid, to assess the removing efficiency of magnetorheological finishing. Optimization of technological parameters enables the authors to obtain a glass-ware with an ideal surface roughness of RMS0.56nm. Magnetorheological finishing (MRF) is an advanced technology for processing optic elements that has been developed in recent years. The technology polishes optic elements by using viscoplastic soft media produced by the MRF liquid under the variation of gradient magnetic field. Better than traditional polishing method in shape precision, surface roughness and inner surface destruction, MRF is an ideal technology for obtaining super-precision optic surface.

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