scholarly journals Studies of the Sulfonated Hydrogenated Styrene–Isoprene–Styrene Block Copolymer and Its Surface Properties, Cytotoxicity, and Platelet-Contacting Characteristics

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 235
Author(s):  
Bin-Hong Tsai ◽  
Tse-An Lin ◽  
Chi-Hui Cheng ◽  
Jui-Che Lin
Keyword(s):  
Block Copolymer ◽  
Biomedical Applications ◽  
Human Life ◽  
Thermoplastic Elastomers ◽  
Wound Dressings ◽  
Tert Butyl ◽  
Soft Segments ◽  
Good Biocompatibility ◽  
Uv Ozone ◽  
Ozone Resistance

Styrenic thermoplastic elastomers (TPEs) consist of styrenic blocks. They are connected with other soft segments by a covalent linkage and are widely used in human life. However, in biomedical applications, TPEs need to be chemically hydrogenated in advance to enhance their properties such as strong UV/ozone resistance and thermal-oxidative stability. In this study, films composed of sulfonated hydrogenated TPEs were evaluated. Hydrogenated tert-butyl styrene–styrene–isoprene block copolymers were synthesized and selectively sulfonated to different degrees by reaction with acetyl sulfate. By controlling the ratio of the hydrogenated tert-butyl styrene–styrene–isoprene block copolymer and acetyl sulfate, sulfonated films were optimized to demonstrate sufficient mechanical integrity in water as well as good biocompatibility. The thermal plastic sulfonated films were found to be free of cytotoxicity and platelet-compatible and could be potential candidates in biomedical film applications such as wound dressings.

Recent Insights on Biomedical Applications of Bacterial Cellulose based Composite Hydrogels

2021 ◽  
Vol 28 ◽  
Author(s):  
Wei Liu ◽  
Haishun Du ◽  
Ting Zheng ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bacterial Cellulose ◽  
High Purity ◽  
Biomedical Applications ◽  
3D Structure ◽  
Wound Dressings ◽  
Tissue Engineering Scaffolds ◽  
Composite Hydrogels ◽  
Good Biocompatibility

Background: Bacterial cellulose (BC) and its derivatives are a rich source of renewable natural ingredients, which are of great significance for biomedical and medical applications but have not yet been fully exploited. BC is a high-purity, biocompatible, and versatile biomaterial that can be used alone or in combination with other ingredients such as polymers and nanoparticles to provide different structural organization and function. This review briefly introduces the research status of BC hydrogels, focusing on the preparation of BC based composite hydrogels and their applications in the field of biomedicine, particularly the wound dressings, tissue engineering scaffolds, and drug delivery. Methods: By reviewing the most recent literature on this subject, we summarized recent advances in the preparation of BC based composite hydrogels and their advances in biomedical applications, including wound dressings, tissue engineering, and drug delivery. Results: BC composite hydrogels have broadened the field of application of BC and developed a variety of BC-based biomaterials with excellent properties. BC-based hydrogels have good biocompatibility and broad application prospects in the biomedical field. Conclusion: BC based composite hydrogels with the advantages of 3D structure, non-toxicity, high purity, and good biocompatibility, have great prospects in the development of sustainable and multifunctional biomaterials for biomedical applications.

Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

2020 ◽  
Vol 27 (28) ◽  
pp. 4622-4646 ◽  
Author(s):  
Huayu Liu ◽  
Kun Liu ◽  
Xiao Han ◽  
Hongxiang Xie ◽  
Chuanling Si ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibrils ◽  
Wound Dressings ◽  
Preparation Methods ◽  
Tissue Scaffold ◽  
Surface Areas ◽  
Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

scholarly journals Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Beilei Gong ◽  
Yuanbing Shen ◽  
Huiyan Li ◽  
Xiaojun Li ◽  
Xia Huan ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications ◽  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Tumour Site ◽  
Polymer Shell ◽  
Potential System ◽  
Responsive Polymer ◽  
Good Biocompatibility ◽  
Spr Effect

AbstractOwing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

scholarly journals Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 906
Author(s):  
Le Minh Tu Phan ◽  
Thuy Anh Thu Vo ◽  
Thi Xoan Hoang ◽  
Sungbo Cho
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
High Light ◽  
Conversion Materials ◽  
Potential Applications ◽  
Good Biocompatibility ◽  
Biomedical Field ◽  
Hydrogel Composites ◽  
Material Fabrication ◽  
Biomedical Fields

Recently, photothermal therapy (PTT) has emerged as one of the most promising biomedical strategies for different areas in the biomedical field owing to its superior advantages, such as being noninvasive, target-specific and having fewer side effects. Graphene-based hydrogels (GGels), which have excellent mechanical and optical properties, high light-to-heat conversion efficiency and good biocompatibility, have been intensively exploited as potential photothermal conversion materials. This comprehensive review summarizes the current development of graphene-integrated hydrogel composites and their application in photothermal biomedicine. The latest advances in the synthesis strategies, unique properties and potential applications of photothermal-responsive GGel nanocomposites in biomedical fields are introduced in detail. This review aims to provide a better understanding of the current progress in GGel material fabrication, photothermal properties and potential PTT-based biomedical applications, thereby aiding in more research efforts to facilitate the further advancement of photothermal biomedicine.

scholarly journals Protein and Polysaccharide-Based Electroactive and Conductive Materials for Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4499
Author(s):  
Xiao Hu ◽  
Samuel Ricci ◽  
Sebastian Naranjo ◽  
Zachary Hill ◽  
Peter Gawason
Keyword(s):  
Cell Biology ◽  
Biomedical Applications ◽  
Human Life ◽  
Electrically Conductive ◽  
Conductive Materials ◽  
Production Strategies ◽  
Integral Role ◽  
Material Sciences ◽  
Novel Drug

Electrically responsive biomaterials are an important and emerging technology in the fields of biomedical and material sciences. A great deal of research explores the integral role of electrical conduction in normal and diseased cell biology, and material scientists are focusing an even greater amount of attention on natural and hybrid materials as sources of biomaterials which can mimic the properties of cells. This review establishes a summary of those efforts for the latter group, detailing the current materials, theories, methods, and applications of electrically conductive biomaterials fabricated from protein polymers and polysaccharides. These materials can be used to improve human life through novel drug delivery, tissue regeneration, and biosensing technologies. The immediate goal of this review is to establish fabrication methods for protein and polysaccharide-based materials that are biocompatible and feature modular electrical properties. Ideally, these materials will be inexpensive to make with salable production strategies, in addition to being both renewable and biocompatible.

Injectable keratin hydrogels as hemostatic and wound dressing materials

2021 ◽  
Author(s):  
Ao Tang ◽  
Ying Li ◽  
Yiqian Yao ◽  
Xuexia Yang ◽  
Zhangjun Cao ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Good Biocompatibility ◽  
Dressing Materials ◽  
Administration Procedure ◽  
Wound Dressing Materials

Injectable hydrogels hold promise in biomedical applications due to their noninvasive administration procedure, and capacity enabling the filling of irregularly shaped defects. Protein-based hydrogels provide features including good biocompatibility and...

In vivo metabolizable branched poly(ester amide) based on inositol and amino acids as drug nanocarrier for cancer therapy

2021 ◽  
Author(s):  
Jun Wu ◽  
Qi-Juan Yuan ◽  
Li Wang ◽  
Jun Huang ◽  
Wei Zhao
Keyword(s):  
Mechanical Property ◽  
Amino Acids ◽  
Amino Acid ◽  
Cancer Therapy ◽  
Biomedical Applications ◽  
Bioactive Components ◽  
Good Biocompatibility

Amino acid-based poly(ester amide) (PEA) has been utilized for various biomedical applications for its tunable mechanical property, good biocompatibility, and biodegradability. However, bioactive components have rarely been incorporated into the...

A Review of Water-Resistant Cellulose-Based Materials in Pharmaceutical and Biomedical Application

2021 ◽  
Vol 28 ◽  
Author(s):  
Bei He ◽  
Xinxin Liu ◽  
Shi Qi ◽  
Run Zheng ◽  
Minmin Chang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biomedical Application ◽  
Drug Loading ◽  
Cellulose Fibers ◽  
Dip Coating ◽  
Wound Dressings ◽  
Attractive Alternative ◽  
Natural Polymers ◽  
Insoluble Drugs ◽  
Good Biocompatibility

Background: Cellulose, huge reserves of natural polymers, have been widely applied in pharmaceutical and biomedicine fields due to its good biocompatibility, biodegradability, non-toxicity and excellent mechanical properties. At present, water-resistant metal-based and petroleum-based materials applied in medical field exists obvious problems of poor biocompatibility and high cost. Therefore, water-resistant cellulose-based materials with good biocompatibility and low price will become an attractive alternative. This review aims to summarize the preparation of water-resistant cellulose-based materials and their potential application in pharmaceutical and biomedical in recent years. Methods: Common hydrophobic treatments of cellulose fibers or paper were overviewed. The preparation, properties and applications of water-resistant cellulose-based materials in the pharmaceutical and biomedical fields were summarized. Results: Common hydrophobic treatments of cellulose fibers or paper were divided into chemical modification (graft polymerization, crosslinking, solution casting or dip-coating), physico-chemical surface modifications (plasma treatments, surface patterning, electrostatic spraying and electrowetting) and physical processing (electrostatic spinning, SAS process and 3D EHD printing). These hydrophobically processed cellulose fibers or paper could be prepared into various water-resistant cellulose-based materials and applied in pharmaceutical excipients, drug-loaded amphiphilic micelles, drug-loaded composite fibers, hydrophobic biocomposite film/coatings and paper-based detectors. They presented excellent water resistance and biocompatibility, low cytotoxicity and high drug loading ability, and stable drug release rate, etc., which could be used for water-insoluble drugs carriers, wound dressings, and medical testing equipment. Conclusion: Currently, water-resistant cellulose-based materials were mainly applied in water-insoluble drugs delivery carriers, wound dressing and medical diagnosis and presented great application prospects. However, the contradiction between hydrophobicity and mechanical properties of these reported water-resistant cellulose-based materials limited their wider application in biomedicine such as tissue engineering. In the future, attention will be focused on the higher hydrophobicity of water-resistant cellulose-based materials with excellent mechanical properties. In addition, clinical medical research of water-resistant cellulose-based materials should be strengthened.

Toward Strong Thermoplastic Elastomers with Asymmetric Miktoarm Block Copolymer Architectures

2014 ◽  
Vol 47 (6) ◽  
pp. 2037-2043 ◽  
Author(s):  
Weichao Shi ◽  
Nathaniel A. Lynd ◽  
Damien Montarnal ◽  
Yingdong Luo ◽  
Glenn H. Fredrickson ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Thermoplastic Elastomers
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