scholarly journals Study of the Influence of PCL on the In Vitro Degradation of Extruded PLA Monofilaments and Melt-Spun Filaments

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 171
Author(s):  
Vivien Barral ◽  
Sophie Dropsit ◽  
Aurélie Cayla ◽  
Christine Campagne ◽  
Éric Devaux
Keyword(s):  
Melt Spinning ◽  
Large Range ◽  
Hydrolytic Degradation ◽  
In Vitro Degradation ◽  
Crystallinity Degree ◽  
Mechanical And Physical Properties ◽  
Spinning Process ◽  
Bioresorbable Implants ◽  
The Impact

This work presents the effect of a melt-spinning process on the degradation behavior of bioresorbable and immiscible poly(d,l-lactide) (PLA) and polycaprolactone (PCL) polymer blends. A large range of these blends, from PLA90PCL10 (90 wt% PLA and 10 wt% PCL) to PLA60PCL40 in increments of 10%, was processed via extrusion (diameter monofilament: ∅ ≈ 1 mm) and melt spinning (80 filaments: 50 to 70 µm each) to evaluate the impact of the PCL ratio and then melt spinning on the hydrolytic degradation of PLA, which allowed for highlighting the potential of a textile-based scaffold in bioresorbable implants. The morphologies of the structures were investigated via extracting PCL with acetic acid and scanning electron microscopy observations. Then, they were immersed in a Dulbecco’s Modified Eagle Medium (DMEM) media at 50 °C for 35 days and their properties were tested in order to evaluate the relation between the morphology and the evolution of the crystallinity degree and the mechanical and physical properties. As expected, the incorporation of PCL into the PLA matrix slowed down the hydrolytic degradation. It was shown that the degradation became heterogeneous with a small ratio of PCL. Finally, melt spinning had an impact on the morphology, and consequently, on the other properties over time.

scholarly journals In-vitro degradation of the chitosan membranes under various syntheses conditions

2014 ◽  
Vol 60 (6) ◽  
pp. 636-642 ◽  
Author(s):  
O.V. Kalinkevich ◽  
M.V. Pogorielov ◽  
I.M. Babich ◽  
V.N. Deyneka ◽  
A.N. Kalinkevich ◽  
...  
Keyword(s):  
Phosphate Buffer ◽  
Hydrolytic Degradation ◽  
Skin Surface ◽  
In Vitro Degradation ◽  
Ph Values ◽  
Subsequent Degradation ◽  
Surface Damages ◽  
Chitosan Membranes ◽  
Further Development

The hydrolytic degradation of polymer films, which were obtained by application of 2% and 3% chitosan solutions in 1% acetic acid on a base sheet has been investigated. As the solvent was removed, these firms were either treated with 0.5% NaOH for 3 min or with phosphate buffer (рН 8) for 10 min. The degrees of degradation for the obtained samples were studied during 1-96 h in solutions with pH values of 5.0, 7.0 and 8.5. The results revealed resistance of the films within the first 6 h, followed by their subsequent degradation. The rate of degradation depended on pH of the solution, chitosan percentage and the treatment methods of films. The materials with the initial chitosan content of 3% were more resistant to the hydrolytic degradation, but the decreasing in pH accelerated the weight loss of the film. However, if the membranes were treated with phosphate buffer, the rate and degree of sample degradation were slowed down. Thus, the results are considered as a basis for the further development of biomaterials to treat the skin surface damages.

scholarly journals IN VITRO DEGRADATION OF POLYDIOXANONE (PDO) LIFTING THREADS IN HYALURONIC ACID (HA).

2019 ◽  
Vol 10 (1) ◽  
pp. 1-13
Author(s):  
Dubraska Suárez ◽  
Gladys J Velazco de Maldonado ◽  
Reynaldo Ortiz ◽  
Victor Garcia-Guevara ◽  
Blanca Miller-Kobisher
Keyword(s):  
Hyaluronic Acid ◽  
Key Words ◽  
Structural Changes ◽  
Hydrolytic Degradation ◽  
Central Core ◽  
In Vitro Degradation ◽  
Central Column ◽  
Rate Of Hydrolysis

Background: Recently, some clinicians have proposed implanting PDO threads imbibed in hyaluronic acid (HA). However, this is controversial since PDO sutures are hydrophilic and the presence of HA could increase the rate of hydrolysis. Aim: To demonstrate the degradation of PDO lifting threads in HA through ultramicroscopy. Materials and methods: Three, one cm long, segments of 23G PDO threads, where immersed in 1.5 ml non-crosslinked hyaluronic acid in previously labeled, sterile microcentrifuge tubes. These were observed by ultramicroscopy at 4x and 10x after 24, 48 and 72 hours. Results: Microphotographs taken after 24 hours already show structural changes in the fibers, presenting an increase in interlaminar spaces and dilution of violet pigmentation. At 48 hours, degradation continues. PDO hygroscopy is observed as aqueous content between the peripheral layers and the central core of the thread. Some fibers show breakage, and there is an increase in interlaminar and interfibrillar spaces. At 72 hours, as the pigment is released, larger empty spaces are observed in the central column of the thread, and there is disorganization of the peripheral fibrils with fraying all along the fiber. Conclusions: Hyaluronic acid induces rapid biodegradation of the PDO thread by hydrolysis beginning 24 hours after contact of the thread with the biomaterial. We hypothesize that non-crosslinked hyaluronic acid is a powerful catalyzing agent for hydrolytic degradation of the PDO thread, since this thread is highly hydrophilic. Thus, we suggest that clinically embedding PDO threads with HA will only accelerate biodegradation of the suture. Key words: Lifting threads, polydioxanone, hyaluronic acid, biodegradation, PDO hydrolysis

Biodegradable poly (lactic acid)/poly (butylene succinate) fibers with high elongation for health care products

2017 ◽  
Vol 88 (15) ◽  
pp. 1735-1744 ◽  
Author(s):  
Elwathig AM Hassan ◽  
Salah Eldin Elarabi ◽  
You Wei ◽  
Muhuo Yu
Keyword(s):  
Lactic Acid ◽  
Melt Spinning ◽  
Strength Loss ◽  
Poly Lactic Acid ◽  
Butylene Succinate ◽  
Morphological Studies ◽  
Biodegradable Poly ◽  
Spinning Process ◽  
High Elongation ◽  
The Impact

Poly (lactic acid)/poly (butylene succinate) (PLA/PBS) blend fibers with high miscibility and improved elongation with comparable mechanical strength were fabricated using the melt spinning process in order to reduce the impact on the environment by long-lasting plastics-based composites. The PLA/PBS blend fibers produced in different ratios have revealed high miscibility, which has been confirmed by morphological studies. The thermal properties showed the melting temperature of PLA at 167.13℃ and PLA/PBS blends at 169.18℃, and an increased content of PBS in blends also led to improved crystallinity. Importantly, during tensile testing, it is observed that the fracture behavior of the specimen changed from brittle fracture of neat PLA to ductile fracture of the blends, as demonstrated by the significant increase in the elongation at break with comparable tensile strength and modulus. Furthermore, the washing fastness, rubbing fastness, exhaustion values, strength loss, and shade depth ( K/ S value) for the knitted and dyed fibers were explored. It was found that the exhaustion and K/ S value increased when the temperature increased, but the strength decreased. The exhaustion and K/ S value of PLA/PBS blend fabrics improved compared to pure PLA fabric, with excellent washing and rubbing fastness.

scholarly journals Comparative Structure-Property Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)s Films under Hydrolytic and Enzymatic Degradation: Finding a Transition Point in 3-Hydroxyvalerate Content

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 728 ◽  
Author(s):  
Vsevolod A. Zhuikov ◽  
Yuliya V. Zhuikova ◽  
Tatiana K. Makhina ◽  
Vera L. Myshkina ◽  
Alexey Rusakov ◽  
...  
Keyword(s):  
Molecular Mass ◽  
Enzymatic Degradation ◽  
Food Packaging ◽  
Hydrolytic Degradation ◽  
Analytical Techniques ◽  
Degree Of Crystallinity ◽  
Structure Property ◽  
Crystallinity Degree ◽  
Average Value

The hydrolytic and enzymatic degradation of polymer films of poly(3-hydroxybutyrate) (PHB) of different molecular mass and its copolymers with 3-hydroxyvalerate (PHBV) of different 3-hydroxyvalerate (3-HV) content and molecular mass, 3-hydroxy-4-methylvalerate (PHB4MV), and polyethylene glycol (PHBV-PEG) produced by the Azotobacter chroococcum 7B by controlled biosynthesis technique were studied under in vitro model conditions. The changes in the physicochemical properties of the polymers during their in vitro degradation in the pancreatic lipase solution and in phosphate-buffered saline for a long time (183 days) were investigated using different analytical techniques. A mathematical model was used to analyze the kinetics of hydrolytic degradation of poly(3-hydroxyaklannoate)s by not autocatalytic and autocatalytic hydrolysis mechanisms. It was also shown that the degree of crystallinity of some polymers changes differently during degradation in vitro. The total mass of the films decreased slightly up to 8–9% (for the high-molecular weight PHBV with the 3-HV content 17.6% and 9%), in contrast to the copolymer molecular mass, the decrease of which reached 80%. The contact angle for all copolymers after the enzymatic degradation decreased by an average value of 23% compared to 17% after the hydrolytic degradation. Young’s modulus increased up to 2-fold. It was shown that the effect of autocatalysis was observed during enzymatic degradation, while autocatalysis was not available during hydrolytic degradation. During hydrolytic and enzymatic degradation in vitro, it was found that PHBV, containing 5.7–5.9 mol.% 3-HV and having about 50% crystallinity degree, presents critical content, beyond which the structural and mechanical properties of the copolymer have essentially changed. The obtained results could be applicable to biomedical polymer systems and food packaging materials.

Iodinated poly(p-dioxanone) as a facile platform for X-ray imaging of resorbable implantable medical devices

2020 ◽  
Vol 35 (1) ◽  
pp. 39-48
Author(s):  
Fan Zhao ◽  
Haiyan Xu ◽  
Wen Xue ◽  
Yan Li ◽  
Jing Sun ◽  
...  
Keyword(s):  
Medical Devices ◽  
Melt Spinning ◽  
Imaging Techniques ◽  
Fibrous Materials ◽  
Hybrid Fibers ◽  
Implantable Medical Devices ◽  
X Ray ◽  
The Impact

Currently, implantable fibrous medical devices still suffer from invisibility under current clinical imaging techniques. To address this problem, 2, 3, 5-triiodobenzoic acid (TIBA) was recruited as a contrast agent, and then a set of iodinated poly( p-dioxanone) (PPDO) fibers was fabricated via melt-spinning hybrid blends of PPDO with TIBA (PPDO/TIBA). The impact of TIBA content on the rheological behavior of blends was evaluated firstly. The physical, chemical, and thermal properties of PPDO/TIBA fibers were investigated accordingly by SEM, FTIR, DSC, and TGA. Moreover, the radiopaque property of PPDO/TIBA hybrid fibers as a potential radio-opacifying platform for medical devices was verified in vitro and in vivo. Finally, the accumulated release results of the hybrid fibers during in vitro degradation indicate the continual X-ray visibility of the hybrid fibers maintains for 22 days. This intriguing iodinated platform may pave the way for constructing fibrous materials with in-situ X-ray tracking property.

scholarly journals Electrospinning for polymeric implants in cardiovascular applications

2018 ◽  
Vol 4 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Stefanie Kohse ◽  
Daniela Arbeiter ◽  
Thomas Reske ◽  
Michael Stiehm ◽  
Klaus-Peter Schmitz ◽  
...  
Keyword(s):  
Weight Loss ◽  
Fibrous Material ◽  
Drug Delivery Systems ◽  
Cardiac Tissue ◽  
Hydrolytic Degradation ◽  
Polymer Scaffolds ◽  
In Vitro Degradation ◽  
Polymeric Implants ◽  
Fibrous Polymer

AbstractElectrospinning is a method for producing fibrous polymer scaffolds that can be applied in drug delivery systems as well as for polymer-based implants. Biodegradable polymers for the purpose of cardiac tissue engineering are often applied as fibrous scaffolds for morphological mimikry of natural matrices but also drugeluting approaches are very promising. Hydrolytic degradation is one of the key parameters for successful application. The focus of our investigations is on monitoring accelerated in vitro degradation of electrospun nonwoven scaffolds. In the presented study degradation of poly(Llactide) is accelerated by alkaline hydrolysis. The process is characterized by weight loss, loss of molecular mass, surface morphology and thermal behavior of nonwoven samples, showing a fast degradation of the fibrous material within two weeks.

Processing, Mechanical Property Development and In Vitro Hydrolytic Degradation Studies of a Poly(L-Lactide-co-ε-Caprolactone) Monofilament Fibre for Potential Use as an Absorbable Surgical Suture

2008 ◽  
Vol 55-57 ◽  
pp. 693-696 ◽  
Author(s):  
P. Chooprayoon ◽  
J. Siripitayananon ◽  
Robert Molloy ◽  
S. Bunkird ◽  
T. Soywongsa ◽  
...  
Keyword(s):  
Melt Spinning ◽  
Hydrolytic Degradation ◽  
Feed Ratio ◽  
Small Scale ◽  
Property Development ◽  
Surgical Suture ◽  
Hot Drawing ◽  
Fibre Morphology ◽  
Potential Use

The bulk ring-opening copolymerisation of L-lactide (LL) and ε-caprolactone (CL) with an initial comonomer feed ratio of LL:CL = 75:25 mol % was carried out using stannous acetate as the initiator at 120 oC for 48 hrs. The copolymer was characterised by GPC, DSC and TGA. Due to its ability to biodegrade in the human body, this type of copolymer has potential for use as an absorbable surgical suture. The copolymer obtained was melt spun at 153 oC using a small-scale melt-spinning apparatus and extruded into ice-cooled water to produce an as-spun monofilament fibre which was largely if not completely amorphous. Alternate off-line hot-drawing and annealing (3 cycles) was carried out in order to develop the fibre’s oriented semi-crystalline morphology. To complete the processing operation, thermal treatment was necessary to stabilize the fibre morphology. It was found that fixed annealing at 60 oC followed by free annealing at 60 oC stabilized the fibre morphology as a result of molecular relaxation. In vitro hydrolytic degradation studied in a phosphate buffer saline (PBS) solution of pH 7.4 at 37.0 ± 0.1 oC indicated that, after 6 weeks immersion in the buffer, the fibre’s tensile strength decreased by approximately 50% whereas a commercial ‘PDS’ suture of similar size lost its strength completely after only 4 weeks.

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