scholarly journals Biopolymer Coatings for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3061
Author(s):  
A. Joseph Nathanael ◽  
Tae Hwan Oh
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Proliferation ◽  
Biomedical Applications ◽  
Antimicrobial Agents ◽  
Inorganic Ions ◽  
Polymer Coatings ◽  
Tissue Growth ◽  
Modify Surface ◽  
Broad Overview

Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

scholarly journals Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications

Crystals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 199
Author(s):  
Arputharaj Joseph Nathanael ◽  
Tae Hwan Oh
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Inorganic Ions ◽  
Electrospun Nanofibers ◽  
Future Perspectives ◽  
Versatile Technique ◽  
Nanocomposite Fibers ◽  
Good Biocompatibility ◽  
Broad Overview

In the field of tissue engineering, electrospinning is a versatile technique that provides nanofibers with structure similar to that of the extracellular matrix owing to their flexible functionalization. Considerable developments in electrospinning have been made to produce engineered electrospun nanofibers for different biomedical applications. Various biopolymers possess good biocompatibility and biodegradability and are nontoxic in nature. Modification of these biopolymers can enhance or elicit certain properties. One technique of modification is the incorporation of certain inorganic ions or components that can enhance its specific functional characteristics such as mineralization, osseointegration, and bioactivity. Incidentally, calcium phosphate (CaP) materials have proven to be suitable and versatile for biopolymer incorporation and exploration because of their inherent bioactivity and being key mineral constituents of bone and teeth. The addition of CaP materials to polymers enhances cell infiltration, differentiation, and biomineralization. We aim to provide a broad overview of CaP material (particularly hydroxyapatite (HA))-incorporated electrospun nanocomposite fibers and their possible applications in tissue engineering. Some key polymer/HA composites were discussed in detail, and a brief discussion on other polymer/HA composites was also provided. Finally, we discussed the future perspectives of this interesting and emerging composite material fabricated via electrospinning.

Scaffolds for Drug Delivery in Tissue Engineering

2008 ◽  
Vol 1 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Vikas V. Gaikwad ◽  
Abasaheb B. Patil ◽  
Madhuri V. Gaikwad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Heart Diseases ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
The Body ◽  
Patient Specific ◽  
In Situ Gel ◽  
Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth.  Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

scholarly journals Surface Modification of Bacterial Cellulose for Biomedical Applications

2022 ◽  
Vol 23 (2) ◽  
pp. 610
Author(s):  
Teresa Aditya ◽  
Jean Paul Allain ◽  
Camilo Jaramillo ◽  
Andrea Mesa Restrepo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Surface Modification ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Human Tissues ◽  
Naturally Occurring ◽  
Microstructure And Mechanical Properties

Bacterial cellulose is a naturally occurring polysaccharide with numerous biomedical applications that range from drug delivery platforms to tissue engineering strategies. BC possesses remarkable biocompatibility, microstructure, and mechanical properties that resemble native human tissues, making it suitable for the replacement of damaged or injured tissues. In this review, we will discuss the structure and mechanical properties of the BC and summarize the techniques used to characterize these properties. We will also discuss the functionalization of BC to yield nanocomposites and the surface modification of BC by plasma and irradiation-based methods to fabricate materials with improved functionalities such as bactericidal capabilities.

Aerogels for Biomedical Applications

2021 ◽  
pp. 23-42
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Biomedical Applications ◽  
Implantable Devices ◽  
Strategic Development ◽  
The World ◽  
Biomedical Field ◽  
Materials Used

The researchers across the world are actively engaged in strategic development of new porous aerogel materials for possible application of these extraordinary materials in the biomedical field. Due to their excellent porosity and established biocompatibility, aerogels are now emerging as viable solutions for drug delivery and other biomedical applications. This chapter aims to cover the diverse aerogel materials used across the globe for different biomedical applications including drug delivery, implantable devices, regenerative medicine encompassing tissue engineering and bone regeneration, and biosensing.

scholarly journals Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 654 ◽  
Author(s):  
Ana Isabel Barbosa ◽  
Ana Joyce Coutinho ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Final Section ◽  
Biological Properties ◽  
Production Methods ◽  
Bioactive Properties ◽  
Wide Range ◽  
Per Se

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

scholarly journals Recent advances on polydiacetylene-based smart materials for biomedical applications

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Smart Biomaterials

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.

scholarly journals Electrospinning of Nanofibers for Tissue Engineering Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Haifeng Liu ◽  
Xili Ding ◽  
Gang Zhou ◽  
Ping Li ◽  
Xing Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Fiber Morphology ◽  
Hard Tissue ◽  
Nanoscale Material ◽  
Considerable Potential ◽  
Recent Interest ◽  
Material Fabrication

Electrospinning is a method in which materials in solution are formed into nano- and micro-sized continuous fibers. Recent interest in this technique stems from both the topical nature of nanoscale material fabrication and the considerable potential for use of these nanoscale fibres in a range of applications including, amongst others, a range of biomedical applications processes such as drug delivery and the use of scaffolds to provide a framework for tissue regeneration in both soft and hard tissue applications systems. The objectives of this review are to describe the theory behind the technique, examine the effect of changing the process parameters on fiber morphology, and discuss the application and impact of electrospinning on the fields of vascular, neural, bone, cartilage, and tendon/ligament tissue engineering.

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