scholarly journals Selenonium Polyelectrolyte Synthesis through Post-Polymerization Modifications of Poly (Glycidyl Methacrylate) Scaffolds

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2685
Author(s):  
Taejun Eom ◽  
Anzar Khan
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Glycidyl Methacrylate ◽  
Ambient Conditions ◽  
Poly Ethylene Glycol ◽  
Ring Opening Reaction ◽  
Methacrylate Monomer ◽  
Poly Ethylene ◽  
Alkylation Reactions ◽  
Nucleophilic Ring Opening

Atom transfer radical polymerization of glycidyl methacrylate monomer with poly(ethylene glycol)-based macroinitiators leads to the formation of reactive block copolymers. The epoxide side-chains of these polymers can be subjected to a regiospecific base-catalyzed nucleophilic ring-opening reaction with benzeneselenol under ambient conditions. The ß-hydroxy selenide linkages thus formed can be alkylated to access polyselenonium salts. 77Se-NMR indicates the formation of diastereomers upon alkylation. In such a manner, sequential post-polymerization modifications of poly(glycidyl methacrylate) scaffolds via selenium-epoxy and selenoether alkylation reactions furnish practical access to poly(ethylene glycol)-based cationic organoselenium copolymers.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

Fabrication of color changeable CO2 sensitive nanofibers

2017 ◽  
Vol 8 (48) ◽  
pp. 7446-7451 ◽  
Author(s):  
Jiaojiao Shang ◽  
Shaojian Lin ◽  
Patrick Theato
Keyword(s):  
Ring Opening ◽  
Glycidyl Methacrylate ◽  
Ring Opening Reaction ◽  
Nucleophilic Ring Opening

A CO2 sensor was fabricated by attaching CO2-sensitive spiropyran groups onto versatile photo-crosslinked poly(glycidyl methacrylate) (PGMA) precursor nanofibers via a nucleophilic ring-opening reaction.

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