scholarly journals 3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1637
Author(s):  
Xiaoling Yu ◽  
Tian Zhang ◽  
Yuan Li
Keyword(s):  
3D Printing ◽  
Peripheral Nerve ◽  
Rapid Development ◽  
Bioactive Molecules ◽  
Neural Engineering ◽  
Future Directions ◽  
Clinical Challenge ◽  
Nerve Conduits ◽  
Manufacturing Technologies ◽  
Extrusion Printing

Fabrication of nerve conduits for perfectly repairing or replacing damaged peripheral nerve is an urgent demand worldwide, but it is also a formidable clinical challenge. In the last decade, with the rapid development of manufacture technologies, 3D printing and bioprinting have been becoming remarkable stars in the field of neural engineering. In this review, we explore that the biomaterial inks (hydrogels, thermoplastic, and thermoset polyesters and composite) and bioinks have been selected for 3D printing and bioprinting of peripheral nerve conduits. This review covers 3D manufacturing technologies, including extrusion printing, inkjet printing, stereolithography, and bioprinting with inclusion of cells, bioactive molecules, and drugs. Finally, an outlook on the future directions of 3D printing and 4D printing in customizable nerve therapies is presented.

scholarly journals 3D Concrete Printing for Sustainable Construction

Energies ◽  
2020 ◽  
Vol 13 (23) ◽  
pp. 6351
Author(s):  
Maria Kaszyńska ◽  
Szymon Skibicki ◽  
Marcin Hoffmann
Keyword(s):  
3D Printing ◽  
Environmental Impact ◽  
Negative Impact ◽  
Rapid Development ◽  
Cementitious Materials ◽  
Sustainable Construction ◽  
Standard Samples ◽  
Negative Environmental Impact ◽  
Extrusion Printing ◽  
Mineral Additives

Despite the rapid development of 3D printing technology for cement composites, there are still a number of unsolved issues related to extrusion printing. One of them is proper mix design that allows for meeting criteria related to the printing of cementitious materials, such as pumpability, buildability, consistency on the materials, flowability and workability, simultaneously incorporating sustainable development ideas. In the case of mixes for 3D printing, the modification of the composition which increases the overall performance does not always go hand in hand with the reduction of negative environmental impact. The article presents the results of tests of eight mixtures modified with reactive and inert mineral additives designed for 3D printing. The mixes were evaluated in terms of their rheological and mechanical properties as well as environmental impact. Initial test results were verified by printing hollow columns up until collapse. Later, the differences between the compressive strength of standard samples and printed columns were determined. In order to summarize the results, a multi-faceted analysis of the properties of the mixes was carried out, introducing assessment indicators for its individual parameters. The article proves that appropriate material modification of mixes for 3D printing can significantly reduce the negative impact on the environment without hindering required 3D printing properties.

scholarly journals The Use of Degradable Nerve Conduits for Human Nerve Repair: A Review of the Literature

2005 ◽  
Vol 2 (1) ◽  
pp. 39-43 ◽  
Author(s):  
M. F. Meek ◽  
K. Jansen ◽  
P. H. Robinson
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Nerve Repair ◽  
Experimental Studies ◽  
Review Of The Literature ◽  
Nerve Grafts ◽  
Nerve Guides ◽  
Clinical Challenge ◽  
Nerve Conduits ◽  
Human Nerve

The management of peripheral nerve injury continues to be a major clinical challenge. The most widely used technique for bridging defects in peripheral nerves is the use of autologous nerve grafts. This technique, however, has some disadvantages. Many alternative experimental techniques have thus been developed, such as degradable nerve conduits. Degradable nerve guides have been extensively studied in animal experimental studies. However, the repair of human nerves by degradable nerve conduits has been limited to only a few clinical studies. In this paper, an overview of the available international published literature on degradable nerve conduits for bridging human peripheral nerve defects is presented for literature available until 2004. Also, the philosophy on the use of nerve guides and nerve grafts is given.

An Experimental Study on Elastic and Strength Properties of Addictively-Manufactured Plastic Materials

2021 ◽  
Vol 1038 ◽  
pp. 162-167
Author(s):  
Kseniia Potopalska ◽  
Olena Tyshkovets ◽  
Andriy Kalinovskyi ◽  
Serhii Vasyliev
Keyword(s):  
3D Printing ◽  
Rapid Development ◽  
Strength Properties ◽  
Geometric Form ◽  
Plastic Materials ◽  
Production Technologies ◽  
3D Printed ◽  
Traditional Production ◽  
Scale Experiment ◽  
Manufacturing Technologies

Additive manufacturing technologies continue to develop extremely fast. Their opportunity of reproducing any given complex geometric form they superior to traditional production technologies. Despite the rapid development and distribution, there are still areas that require special attention for the study of the behavior of materials for 3D printing. This work presents method of defining mechanical property of PLA plastic for 3D printed parts. For this, a full-scale experiment was carried out using specimens created by 3D printing. After carrying out the tensile test, the tensile diagram was determined.

scholarly journals Nerve Repair with Nerve Conduits: Problems, Solutions, and Future Directions

2018 ◽  
Vol 10 (02) ◽  
pp. 61-65 ◽  
Author(s):  
Ryan Rebowe ◽  
Ashley Rogers ◽  
Xuebin Yang ◽  
S. Kundu ◽  
Thomas Smith ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Repair ◽  
Functional Limitations ◽  
Donor Site ◽  
Clinical Problem ◽  
Donor Site Morbidity ◽  
Future Directions ◽  
Nerve Conduits ◽  
Attractive Option ◽  
The Common

AbstractNerve conduits are becoming increasingly popular for the repair of peripheral nerve injuries. Their ease of application and lack of donor site morbidity make them an attractive option for nerve repair in many situations. Today, there are many different conduits to choose in different sizes and materials, giving the reconstructive surgeon many options for any given clinical problem. However, to properly utilize these unique reconstructive tools, the peripheral nerve surgeon must be familiar not only with their standard indications but also with their functional limitations. In this review, the authors identify the common applications of nerve conduits, expected results, and shortcomings of current techniques. Furthermore, future directions for nerve conduit use are identified.

Evaluation of the Effectiveness of Biodegradable “Electrospun Caprolactone” Nerve Conduits in Peripheral Nerve Regenerations

2014 ◽  
Vol 30 (S 01) ◽  
Author(s):  
Mehmet Dadaci ◽  
Nimet Bolgen ◽  
Erhan Sonmez ◽  
Bilsev Ince ◽  
Evren Isci ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Conduits

Surface functionalization – a new functional dimension added to 3D printing

2020 ◽  
Vol 8 (36) ◽  
pp. 12380-12411
Author(s):  
Pan Jiang ◽  
Zhongying Ji ◽  
Xiaolong Wang ◽  
Feng Zhou
Keyword(s):  
3D Printing ◽  
Surface Functionalization ◽  
Rapid Development ◽  
Functional Dimension

Various requirements for 3D printing raised by actual applications in different fields have provoked the rapid development of technologies together with various specific materials.

scholarly journals Foundation Piles—A New Feature for Concrete 3D Printers

Materials ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2545
Author(s):  
Marcin Hoffmann ◽  
Krzysztof Żarkiewicz ◽  
Adam Zieliński ◽  
Szymon Skibicki ◽  
Łukasz Marchewka
Keyword(s):  
3D Printing ◽  
Rapid Development ◽  
Construction Materials ◽  
Shallow Foundation ◽  
Soil Reinforcement ◽  
3D Printer ◽  
Permanent Formwork ◽  
3D Printers ◽  
New Feature ◽  
The Cost

Foundation piles that are made by concrete 3D printers constitute a new alternative way of founding buildings constructed using incremental technology. We are currently observing very rapid development of incremental technology for the construction industry. The systems that are used for 3D printing with the application of construction materials make it possible to form permanent formwork for strip foundations, construct load-bearing walls and partition walls, and prefabricate elements, such as stairs, lintels, and ceilings. 3D printing systems do not offer soil reinforcement by making piles. The paper presents the possibility of making concrete foundation piles in laboratory conditions using a concrete 3D printer. The paper shows the tools and procedure for pile pumping. An experiment for measuring pile bearing capacity is described and an example of a pile deployment model under a foundation is described. The results of the tests and analytical calculations have shown that the displacement piles demonstrate less settlement when compared to the analysed shallow foundation. The authors indicate that it is possible to replace the shallow foundation with a series of piles combined with a printed wall without locally widening it. This type of foundation can be used for the foundation of low-rise buildings, such as detached houses. Estimated calculations have shown that the possibility of making foundation piles by a 3D printer will reduce the cost of making foundations by shortening the time of execution of works and reducing the consumption of construction materials.

scholarly journals Polymeric Bioinks for 3D Hepatic Printing

Chemistry ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 164-181
Author(s):  
Joyita Sarkar ◽  
Swapnil C. Kamble ◽  
Nilambari C. Kashikar
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Stem Cell Differentiation ◽  
Synthetic Polymers ◽  
Bioactive Molecules ◽  
Complex Geometries ◽  
Printing Techniques ◽  
Natural And Synthetic

Three-dimensional (3D) printing techniques have revolutionized the field of tissue engineering. This is especially favorable to construct intricate tissues such as liver, as 3D printing allows for the precise delivery of biomaterials, cells and bioactive molecules in complex geometries. Bioinks made of polymers, of both natural and synthetic origin, have been very beneficial to printing soft tissues such as liver. Using polymeric bioinks, 3D hepatic structures are printed with or without cells and biomolecules, and have been used for different tissue engineering applications. In this review, with the introduction to basic 3D printing techniques, we discuss different natural and synthetic polymers including decellularized matrices that have been employed for the 3D bioprinting of hepatic structures. Finally, we focus on recent advances in polymeric bioinks for 3D hepatic printing and their applications. The studies indicate that much work has been devoted to improvising the design, stability and longevity of the printed structures. Others focus on the printing of tissue engineered hepatic structures for applications in drug screening, regenerative medicine and disease models. More attention must now be diverted to developing personalized structures and stem cell differentiation to hepatic lineage.

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