scholarly journals Antimicrobial Activity of Electrospun Polyvinyl Alcohol Nanofibers Filled with Poly[2-(tert-butylaminoethyl) Methacrylate]-Grafted Graphene Oxide Nanosheets

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1449 ◽  
Author(s):  
Chien-Lin Huang ◽  
Kun-Mu Lee ◽  
Zheng-Xian Liu ◽  
Ruo-Yu Lai ◽  
Chih-Kuang Chen ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Radical Polymerization ◽  
Graphene Nanosheets ◽  
Wound Care ◽  
Physical Treatment ◽  
Volume Percentage ◽  
Antimicrobial Efficiency ◽  
Composite Nanofiber ◽  
Potential Applications ◽  
Nanofiber Mats

A novel cationic polymer, poly[2-(tert-butylaminoethyl) methacrylate] (PTA), effectively kills various strains of bacteria with low toxicity to tissue cells. Graphene-based materials demonstrate exceptional electron transport capability, antibacterial activity, favorable nontoxicity, and versatile applicability. PTA can be grafted onto the graphene oxide (GO) surface (GO-g-PTA) to enhance the antimicrobial efficiency of the latter against Staphylococcus aureus (S. aureus). In this study, GO-g-PTA powders were successfully synthesized via free radical polymerization (GO-g-PTA-F) and atom transfer radical polymerization (GO-g-PTA-A). The antimicrobial efficiencies of graphene nanosheets (GNSs), GO-g-PTA-F, and GO-g-PTA-A were then investigated. Addition of GNS, GO-g-PTA-F, and GO-g-PTA-A to the PVA nanofibers was carried out elucidate the effects of filler amount and physical treatment on the morphology, microstructure, crystallization behaviors, antimicrobial efficiency, and cytotoxicity of the composite fibers. Finally, the potential applications of electrospun PVA/GNS, PVA/GO-g-PTA-F, and PVA/GO-g-PTA-A composite nanofiber mats to chronic wound care were evaluated. The resulting PVA/GO-g-PTA-A composite nanofiber mats showed enhanced antimicrobial ability against S. aureus compared with the PVA/GNS and PVA/GO-g-PTA-F composite nanofiber mats at the same filler volume percentage.

scholarly journals Microstructure and Biological Properties of Electrospun In Situ Polymerization of Polycaprolactone-Graft-Polyacrylic Acid Nanofibers and Its Composite Nanofiber Dressings

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4246
Author(s):  
Yi-Jen Huang ◽  
Chien-Lin Huang ◽  
Ruo-Yu Lai ◽  
Cheng-Han Zhuang ◽  
Wei-Hao Chiu ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Chronic Wound ◽  
In Situ Polymerization ◽  
Wound Care ◽  
Healing Process ◽  
Antibacterial Properties ◽  
Electrospun Nanofibers ◽  
Composite Nanofiber ◽  
Nanofiber Mats

In this study, polycaprolactone (PCL)- and poly(acrylic acid) (PAA)-based electrospun nanofibers were prepared for the carriers of antimicrobials and designed composite nanofiber mats for chronic wound care. The PCL- and PAA-based electrospun nanofibers were prepared through in situ polymerization starting from PCL and acrylic acid (AA). Different amounts of AA were introduced to improve the hydrophilicity of the PCL electrospun nanofibers. A compatibilizer and a photoinitiator were then added to the electrospinning solution to form a grafted structure composed of PCL and PAA (PCL-g-PAA). The grafted PAA was mainly located on the surface of a PCL nanofiber. The optimization of the composition of PCL, AA, compatibilizer, and photoinitiator was studied, and the PCL-g-PAA electrospun nanofibers were characterized through scanning electron microscopy and 1H-NMR spectroscopy. Results showed that the addition of AA to PCL improved the hydrophilicity of the electrospun PCL nanofibers, and a PCL/AA ratio of 80/20 presented the best composition and had smooth nanofiber morphology. Moreover, poly[2 -(tert-butylaminoethyl) methacrylate]-grafted graphene oxide nanosheets (GO-g-PTA) functioned as an antimicrobial agent and was used as filler for PCL-g-PAA nanofibers in the preparation of composite nanofiber mats, which exerted synergistic effects promoted by the antibacterial properties of GO-g-PTA and the hydrophilicity of PCL-g-PAA electrospun nanofibers. Thus, the composite nanofiber mats had antibacterial properties and absorbed body fluids in the wound healing process, thereby promoting cell proliferation. The biodegradation of the PCL-g-PAA electrospun nanofibers also demonstrated an encouraging result of three-fold weight reduction compared to the neat PCL nanofiber. Our findings may serve as guidelines for the fabrication of electrospun nanofiber composites that can be used mats for chronic wound care.

scholarly journals Extraordinary thermal behavior of graphene oxide in air for electrode applications

2021 ◽  
Author(s):  
Joong Tark Han ◽  
Joon Young Cho ◽  
Jeong Hoon Kim
Keyword(s):  
Thermal Stability ◽  
Graphene Oxide ◽  
Physical Properties ◽  
Thermal Behavior ◽  
Stability Of Solution ◽  
Exfoliated Graphene ◽  
Potential Applications ◽  
Thermal Stability Of

The thermal stability of solution-exfoliated graphene oxide (GO) in air is one of the most important physical properties influencing its potential applications. To date, majority of the GO prepared by...

scholarly journals Lerf–Klinowski-type models of graphene oxide and reduced graphene oxide are robust in analyzing non-covalent functionalization with porphyrins

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra Siklitskaya ◽  
Ewelina Gacka ◽  
Daria Larowska ◽  
Marta Mazurkiewicz-Pawlicka ◽  
Artur Malolepszy ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Excited States ◽  
Reduced Graphene ◽  
Simulation Protocol ◽  
Potential Applications ◽  
H 26 ◽  
High Level ◽  
Experimental And Theoretical Studies ◽  
Low Solubility

AbstractGraphene-based nanohybrids are good candidates for various applications. However, graphene exhibits some unwanted features such as low solubility in an aqueous solution or tendency to aggregate, limiting its potential applications. On the contrary, its derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), have excellent properties and can be easily produced in large quantities. GO/RGO nanohybrids with porphyrins were shown to possess great potential in the field of photocatalytic hydrogen production, pollutant photodegradation, optical sensing, or drug delivery. Despite the rapid progress in experimental research on the porphyrin-graphene hybrids some fundamental questions about the structures and the interaction between components in these systems still remain open. In this work, we combine detailed experimental and theoretical studies to investigate the nature of the interaction between the GO/RGO and two metal-free porphyrins 5,10,15,20-tetrakis(4-aminophenyl) porphyrin (TAPP) and 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (TPPH)]. The two porphyrins form stable nanohybrids with GO/RGO support, although both porphyrins exhibited a slightly higher affinity to RGO. We validated finite, Lerf–Klinowski-type (Lerf et al. in J Phys Chem B 102:4477, 1998) structural models of GO ($$\hbox {C}_{59}\hbox {O}_{26}\hbox {H}_{26}$$ C 59 O 26 H 26 ) and RGO ($$\hbox {C}_{59}\hbox {O}_{17}\hbox {H}_{26}$$ C 59 O 17 H 26 ) and successfully used them in ab initio absorption spectra simulations to track back the origin of experimentally observed spectral features. We also investigated the nature of low-lying excited states with high-level wavefunction-based methods and shown that states’ density becomes denser upon nanohybrid formation. The studied nanohybrids are non-emissive, and our study suggests that this is due to excited states that gain significant charge-transfer character. The presented efficient simulation protocol may ease the properties screening of new GO/RGO-nanohybrids.

scholarly journals The Structure–Properties–Cytotoxicity Interplay: A Crucial Pathway to Determining Graphene Oxide Biocompatibility

2021 ◽  
Vol 22 (10) ◽  
pp. 5401
Author(s):  
Marta Dziewięcka ◽  
Mirosława Pawlyta ◽  
Łukasz Majchrzycki ◽  
Katarzyna Balin ◽  
Sylwia Barteczko ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Defense Mechanisms ◽  
Physicochemical Analysis ◽  
Experimental Models ◽  
Acheta Domesticus ◽  
Synthesis Process ◽  
Synthesis Methods ◽  
Toxicity Potential ◽  
Potential Applications

Interest in graphene oxide nature and potential applications (especially nanocarriers) has resulted in numerous studies, but the results do not lead to clear conclusions. In this paper, graphene oxide is obtained by multiple synthesis methods and generally characterized. The mechanism of GO interaction with the organism is hard to summarize due to its high chemical activity and variability during the synthesis process and in biological buffers’ environments. When assessing the biocompatibility of GO, it is necessary to take into account many factors derived from nanoparticles (structure, morphology, chemical composition) and the organism (species, defense mechanisms, adaptation). This research aims to determine and compare the in vivo toxicity potential of GO samples from various manufacturers. Each GO sample is analyzed in two concentrations and applied with food. The physiological reactions of an easy model Acheta domesticus (cell viability, apoptosis, oxidative defense, DNA damage) during ten-day lasting exposure were observed. This study emphasizes the variability of the GO nature and complements the biocompatibility aspect, especially in the context of various GO-based experimental models. Changes in the cell biomarkers are discussed in light of detailed physicochemical analysis.

Synthesis of high-performance graphene nanosheets by thermal reduction of graphene oxide

2011 ◽  
Vol 46 (11) ◽  
pp. 2131-2134 ◽  
Author(s):  
Ang Wei ◽  
Jingxia Wang ◽  
Qing Long ◽  
Xiangmei Liu ◽  
Xingao Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
High Performance ◽  
Graphene Nanosheets ◽  
Thermal Reduction

scholarly journals Fabrication and Characterization of Lignin/Dendrimer Electrospun Blended Fiber Mats

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 518
Author(s):  
Somaye Akbari ◽  
Addie Bahi ◽  
Ali Farahani ◽  
Abbas S. Milani ◽  
Frank Ko
Keyword(s):  
Thermal Characteristics ◽  
Dendritic Polymers ◽  
Amino Groups ◽  
Fiber Mats ◽  
Potential Applications ◽  
Solution Electrospinning ◽  
Nanofiber Mats ◽  
Softwood Kraft Lignin ◽  
First Time

Blending lignin as the second most abundant polymer in Nature with nanostructured compounds such as dendritic polymers can not only add value to lignin, but also increase its application in various fields. In this study, softwood Kraft lignin/polyamidoamine dendritic polymer (PAMAM) blends were fabricated by the solution electrospinning to produce bead-free nanofiber mats for the first time. The mats were characterized through scanning electron microscopy, Fourier transform infrared (FTIR) spectroscopy, zeta potential, and thermogravimetry analyses. The chemical intermolecular interactions between the lignin functional groups and abundant amino groups in the PAMAM were verified by FTIR and viscosity measurements. These interactions proved to enhance the mechanical and thermal characteristics of the lignin/PAMAM mats, suggesting their potential applications e.g. in membranes, filtration, controlled release drug delivery, among others.

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