scholarly journals Functional Polymers Structures for (Bio)Sensing Application—A Review

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1154 ◽  
Author(s):  
Kamila Spychalska ◽  
Dorota Zając ◽  
Sylwia Baluta ◽  
Kinga Halicka ◽  
Joanna Cabaj
Keyword(s):  
Technology Development ◽  
Polymeric Materials ◽  
Cost Effective ◽  
Medical Diagnostics ◽  
Biologically Active ◽  
Sensor Technology ◽  
Microporous Polymer ◽  
Wide Range ◽  
Sensitivity And Selectivity ◽  
Analytical Tools

In this review we present polymeric materials for (bio)sensor technology development. We focused on conductive polymers (conjugated microporous polymer, polymer gels), composites, molecularly imprinted polymers and their influence on the design and fabrication of bio(sensors), which in the future could act as lab-on-a-chip (LOC) devices. LOC instruments enable us to perform a wide range of analysis away from the stationary laboratory. Characterized polymeric species represent promising candidates in biosensor or sensor technology for LOC development, not only for manufacturing these devices, but also as a surface for biologically active materials’ immobilization. The presence of biological compounds can improve the sensitivity and selectivity of analytical tools, which in the case of medical diagnostics is extremely important. The described materials are biocompatible, cost-effective, flexible and are an excellent platform for the anchoring of specific compounds.

scholarly journals Fabrication and Characterization of Polylactic Acid Electrospun Scaffolds Modified with Multi-Walled Carbon Nanotubes and Hydroxyapatite Nanoparticles

Biomimetics ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 43
Author(s):  
Athanasios Kotrotsos ◽  
Prokopis Yiallouros ◽  
Vassilis Kostopoulos
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Polylactic Acid ◽  
Physical And Mechanical Properties ◽  
Polymeric Materials ◽  
Cost Effective ◽  
Electrospinning Process ◽  
Wide Range ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

The solution electrospinning process (SEP) is a cost-effective technique in which a wide range of polymeric materials can be electrospun. Electrospun materials can also be easily modified during the solution preparation process (prior SEP). Based on this, the aim of the current work is the fabrication and nanomodification of scaffolds using SEP, and the investigation of their porosity and physical and mechanical properties. In this study, polylactic acid (PLA) was selected for scaffold fabrication, and further modified with multi-walled carbon nanotubes (MWCNTs) and hydroxyapatite (HAP) nanoparticles. After fabrication, porosity calculation and physical and mechanical characterization for all scaffold types were conducted. More precisely, the morphology of the fibers (in terms of fiber diameter), the surface properties (in terms of contact angle) and the mechanical properties under the tensile mode of the fabricated scaffolds have been investigated and further compared against pristine PLA scaffolds (without nanofillers). Finally, the scaffold with the optimal properties was proposed as the candidate material for potential future cell culturing.

scholarly journals The methodology of food design. Part 2. Digital nutritiology in personal food

2022 ◽  
Vol 6 (4) ◽  
pp. 328-334
Author(s):  
A. Y. Prosekov ◽  
A. D. Vesnina ◽  
O. V. Kozlova
Keyword(s):  
Scientific Literature ◽  
Technology Development ◽  
Preventive Measure ◽  
Personal Characteristics ◽  
Biologically Active ◽  
Biological Information ◽  
Free Access ◽  
Dietary Recommendations ◽  
Wide Range ◽  
Food Design

Atherosclerosis (the main cause of a wide range of cardiovascular diseases) and other multifactorial diseases depend on several nutrition factors, defined in general by lifestyle that directly and constantly affects the human body. The modern level of science and technology development is able to form a diet, taking into account all personal characteristics in such a way that makes nutrition an effective preventive measure against diseases in order to keep a person healthy. The purpose of this article is to define and study all the limitations (the scope of its coverage in the scientific literature) that arose in the process of research aimed to formation of an integrated personal approach to designing of nutrition to prevent atherosclerosis. The object of the study was scientific literature, which is available in open source and free access databases: PubMed, ScienceDirect, eLIBRARY.RU, www.fips.ru, Patentscope. The language of search is Russian and English, search depth is 12 years. In the course of the research two food design concepts were found that affect process of digitalization in the food sector: the concept “FoodTech” (food technology) and digital nutritiology. It was established that in Russia only one company — LLC “City Supermarket” (Moscow), that works with the brand “Azbuka Vkusa” — acts in the sphere of “FoodTech” on the Russian market. This company selects personalized food, taking into account the results of personal nutrigenetic tests, in cooperation with LLC “Genotech” (Moscow). There is a need to use biological information, statistical information processing (nutrigenetic studies, nutrigenomic research) and machine-aided data processing (machine learning) for further generation of automatic algorithm that compiles personal recommendations. The relevance of generation of a national domestic database on chemical composition of food products (presented in the market) to simplify the preparation of individual personal diets is observed. We underline the necessity to use the test-organisms, i. e. dorio fish / zebrafish (Danio rerio) and nematodes (Caenorhabditis elegans)), which were used to determine the activity of candidate substances — the biologically active substances that feature antiatherosclerotic properties. In the future the authors plan to conduct a nutrigenomic and nutrigenetic study, using digital achievements. To collect information about consumers, it is necessary to apply digital devices, and use biological informatics to process the results; after that it is necessary to generate the algorithm for automatic selection of personalized dietary recommendations.

The applications of medical thermography in alfitherapy

2021 ◽  
Author(s):  
I.V. Pronin ◽  
M.I. Shcherbakov
Keyword(s):  
Medical Diagnostics ◽  
Primary Diagnosis ◽  
Biologically Active ◽  
Entire Body ◽  
Malignant Meningioma ◽  
Balanced Diet ◽  
Primary Diagnostics ◽  
Wide Range ◽  
Oncological Diseases ◽  
Diagnostic Capabilities

Recently, medical thermography has attracted more and more attention from physicians and physiologists, especially in the study of complex diseases. Thermograms show the distribution of thermal fields, corresponding or not corresponding to normal thermography of specific areas. The presence of a pathological thermal picture indicates a certain pathology. Medical thermography makes it possible to conduct an examination in a short time (5-10 minutes) with the construction of accurate heat maps and is a safe method of primary diagnosis. Infrared thermal mapping provides a study of the development of a thermoactive process in time, which increases the diagnostic capabilities of the method, especially in the early stages of disease development. The aim of this work is to study the possibilities of medical thermography in the treatment of malignant meningioma by the method of alfitherapy. Alphitherapy (algo – algae, phyto– plants) is a direction in medicine, veterinary medicine, cosmetology, which is distinguished by the fact that it allows you to completely restore the entire body and get rid of hormonal, chronic, acute and concomitant diseases due to a proper balanced diet, which consists of algae, plants, macro- and microelements, vitamins with the presence of plant microorganisms. The data obtained as a result of many years of research indicate that alpha drugs contain a rich set of biologically active substances with versatile pharmacological activity, which are successfully used to treat a wide range of cardiovascular and oncological diseases, injuries and other health disorders. The results of application of the method of medical thermography in alfitherapy based on the portable thermograph IRTIS-2000 ME are presented. A patient was considered whose results of thermographic examination revealed malignant meningioma (brain cancer). As a result of the use of the alfitherapy method, the malignant meningioma was completely cured without surgery. A description of the biological mechanisms of alfitherapy and alfitherapeutic action for the treatment of cardiovascular and oncological diseases is given. The areas of application of medical thermography in medical diagnostics are presented. It has been shown that the use of medical thermography allows non-invasive primary diagnostics and monitoring of the state of human health, and alfitherapy allows effective non-surgical restoration of the whole organism, regardless of nosology.

Tensioned Metastable Fluid Detectors for Spectrometric Radon–Progeny Detection and AARST-NRPP Standard Qualification

2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Mitch P. Hemesath ◽  
Brian C. Archambault ◽  
Nathan M. Boyle ◽  
Rusi P. Taleyarkhan
Keyword(s):  
Background Radiation ◽  
Cost Effective ◽  
Photon Radiation ◽  
Sensor Technology ◽  
Radon Progeny ◽  
First Order ◽  
Test Parameters ◽  
Wide Range ◽  
Spectroscopic Identification ◽  
Background Photon

Abstract This paper describes how the tensioned metastable fluid detector (TMFD) sensor technology was successfully configured and qualified for efficient, accurate, spectroscopic, and cost-effective radon and progeny spectroscopic detection alongside meeting/exceeding the standards set by the American Association of Radon Scientists and Technologists-National Radon Proficiency Program (AARST-NRPP) Device Evaluation Program (DEP). The DEP represents addressing of a challenging test matrix that assesses a radon collection and measurement device's performance over a variety of functional parameters and environmental conditions. Qualification test conditions covered in this study included performance vetting of the centrifugally tensioned metastable fluid detector (CTMFD) technology under a wide range of temperatures, noncondensing relative humidity (RH) levels, condensing conditions, atmospheric pressures, background photon radiation, nonionizing external electromagnetic (EM) fields, shock and vibration, and air movement. Of all these parameters, only the ambient temperature played a first-order role on radon collection; for this reason, a dynamic compensation algorithm was developed and successfully validated. The remaining AARST-NRPP test parameters were found to have negligible affects. In comparison to state-of-art radon detector systems, the resulting radon specific CTMFD (R-CTMFD) sensor system and protocol are shown to provide for superior sensitivity along with spectroscopic identification of radon–progeny alpha emitters while remaining 100% blind to interfering gamma–beta background radiation.

scholarly journals Clinical feasibility study of an immunotropic drug for treatment of complicated pyodermas

2020 ◽  
Vol 6 (3) ◽  
pp. 51-57
Author(s):  
Roman A. Khmel’nitskij ◽  
Аndrej V. Vislobokov
Keyword(s):  
Cost Effectiveness ◽  
Effective Means ◽  
Clinical Manifestations ◽  
Clinical Effectiveness ◽  
Cost Effective ◽  
Biologically Active ◽  
Cost Effectiveness Ratio ◽  
Transfer Factors ◽  
Wide Range ◽  
The Cost

Introduction: Given a wide range of pathogenesis of the inflammatory process in pyoderma, which involves a variety of links in the immune response, work is underway to find ways to optimize immunocorrection in this pathology. The aim of the study was to evaluate the clinical and economic effectiveness of immunocorrection in severe and chronic forms of pyoderma with drugs from different pharmacological groups. Materials and methods: The data sources were prospective randomized comparative studies of therapy of 107 pyoderma patients aged 18 to 60 years, divided into groups. The patients of the first group additionally used a biologically active additive containing immunoactive molecules and transfer factors (TF) as an immunomodulator; the patients of the second group used glucosaminylmuramildipeptide (GMDP). The clinical effectiveness of regression of inflammatory symptoms on day 10 of treatment was analyzed. Based on the obtained data, the following types of pharmacoeconomical analysis were performed: calculation of the course price, the cost/effectiveness ratio, and the availability coefficient. Results and discussion: The results of the study showed that the number of cured patients was 91.4% in the first group and 97.2% in the second group of patients. The treatment cost when using the drug is by 970 rubles smaller; the cost/effectiveness ratio (CER) per patient was 1.8 higher for a drug containing transfer factors and amounted to 25.9. The calculation of the availability coefficient (AC) revealed a difference in glucosaminylmuramyldipeptide which was 2.1 times smaller. Conclusion: It was found that a drug based on glucosaminylmuramildipeptide is a more effective and cost-effective means of immunocorrection in severe forms of pyoderma. This confirms a faster regression of clinical manifestations of the disease and lower cost/effectiveness ratio and availability coefficient.

scholarly journals New Electrochemical Detection Strategies for Iodinated Compounds

2019 ◽  
Vol 70 (3) ◽  
pp. 919-924
Author(s):  
Ligia Chelmea ◽  
Federico Di Modugno ◽  
Iosif Samota ◽  
Elena Bobescu ◽  
Laura Floroian ◽  
...  
Keyword(s):  
Biological Fluids ◽  
Cost Effective ◽  
Differential Pulse ◽  
Redox Status ◽  
Wide Range ◽  
Significant Difference ◽  
Printed Sensors ◽  
Compounds Stability ◽  
Analytical Tools ◽  
Detection Strategies

Iodine is a micronutrient of high importance for the health and good development of individuals. It is contained in many foods, but it is also part of the chemical component of oceans and soil. Its deficiency is still a problem of humanity, which has a serious repercussion on our health. It is therefore important to have specific, fast and cost effective methods of iodine detection from different samples. This work aims to identify optimal parameters for potassium iodide (KI) detection from different media, to be further applied to real samples: plant extracts, water, biological fluids. Results showed a significant difference in electrochemical results, depending on the pH values of the mixture and also on the time which influences the compounds stability. Differential pulse voltammetry and cyclic voltammetry using carbon printed sensors, as well as microsensors for redox status or direct iodide detection are important analytical tools which have a wide range of applications in the food, medicine, toxicology and other domains.

scholarly journals Phenomes: the current frontier in animal breeding

2021 ◽  
Vol 53 (1) ◽  
Author(s):  
Miguel Pérez-Enciso ◽  
Juan P. Steibel
Keyword(s):  
Animal Breeding ◽  
Point Of View ◽  
Sensor Technology ◽  
Or Efficiency ◽  
Computational Point ◽  
Genomic Technologies ◽  
Use Of Resources ◽  
Large Numbers ◽  
Wide Range ◽  
Analytical Tools

AbstractImprovements in genomic technologies have outpaced the most optimistic predictions, allowing industry-scale application of genomic selection. However, only marginal gains in genetic prediction accuracy can now be expected by increasing marker density up to sequence, unless causative mutations are identified. We argue that some of the most scientifically disrupting and industry-relevant challenges relate to ‘phenomics’ instead of ‘genomics’. Thanks to developments in sensor technology and artificial intelligence, there is a wide range of analytical tools that are already available and many more will be developed. We can now address some of the pressing societal demands on the industry, such as animal welfare concerns or efficiency in the use of resources. From the statistical and computational point of view, phenomics raises two important issues that require further work: penalization and dimension reduction. This will be complicated by the inherent heterogeneity and ‘missingness’ of the data. Overall, we can expect that precision livestock technologies will make it possible to collect hundreds of traits on a continuous basis from large numbers of animals. Perhaps the main revolution will come from redesigning animal breeding schemes to explicitly allow for high-dimensional phenomics. In the meantime, phenomics data will definitely enlighten our knowledge on the biological basis of phenotypes.

2D Color-Intensity Representation of Ultrasonic Thickness Gauge Measurements

2020 ◽  
pp. 1192-1198
Author(s):  
M.S. Mohammad ◽  
Tibebe Tesfaye ◽  
Kim Ki-Seong
Keyword(s):  
Cost Effective ◽  
The Other ◽  
Thickness Gauge ◽  
Color Intensity ◽  
Digital Readout ◽  
Flat Surfaces ◽  
Video Cameras ◽  
Wide Range ◽  
Cost Effective Alternative ◽  
Ultrasonic Thickness

Ultrasonic thickness gauges are easy to operate and reliable, and can be used to measure a wide range of thicknesses and inspect all engineering materials. Supplementing the simple ultrasonic thickness gauges that present results in either a digital readout or as an A-scan with systems that enable correlating the measured values to their positions on the inspected surface to produce a two-dimensional (2D) thickness representation can extend their benefits and provide a cost-effective alternative to expensive advanced C-scan machines. In previous work, the authors introduced a system for the positioning and mapping of the values measured by the ultrasonic thickness gauges and flaw detectors (Tesfaye et al. 2019). The system is an alternative to the systems that use mechanical scanners, encoders, and sophisticated UT machines. It used a camera to record the probe’s movement and a projected laser grid obtained by a laser pattern generator to locate the probe on the inspected surface. In this paper, a novel system is proposed to be applied to flat surfaces, in addition to overcoming the other limitations posed due to the use of the laser projection. The proposed system uses two video cameras, one to monitor the probe’s movement on the inspected surface and the other to capture the corresponding digital readout of the thickness gauge. The acquired images of the probe’s position and thickness gauge readout are processed to plot the measured data in a 2D color-coded map. The system is meant to be simpler and more effective than the previous development.

Aspergillus sydowii Strain SCAU066 and Aspergillus versicolor Isolate BAB-6580: Potential Source of Xylanolytic, Cellulolytic and Amylolytic Enzymes

2020 ◽  
Vol 14 (2) ◽  
pp. 15
Author(s):  
Zaidah Zainal ariffin
Keyword(s):  
Extracellular Enzymes ◽  
Biologically Active ◽  
Aspergillus Versicolor ◽  
Aspergillus Sydowii ◽  
Aspergillus Tamarii ◽  
Alternative Source ◽  
Amylolytic Enzymes ◽  
Potato Dextrose Broth ◽  
Wide Range ◽  
Pharmaceutical Industries

Fungi is known to produce a wide range of biologically active metabolites and enzymes. Enzymes produced by fungi are utilized in food and pharmaceutical industries because of their rich enzymatic profile. Filamentous fungi are particularly interesting due to their high production of extracellular enzymes which has a large industrial potential. The aim of this study is to isolate potential soil fungi species that are able to produce functional enzymes for industries. Five Aspergillus species were successfully isolated from antibiotic overexposed soil (GPS coordinate of N3.093219 E101.40269) by standard microbiological method. The isolated fungi were identified via morphological observations and molecular tools; polymerase chain reactions, ITS 1 (5’- TCC GTA GGT GAA CCT GCG G3’) forward primer and ITS 4 (5’-TCC TCC GCT TAT TGA TAT GC-3’) reverse primer. The isolated fungi were identified as Aspergillus sydowii strain SCAU066, Aspergillus tamarii isolate TN-7, Aspergillus candidus strain KUFA 0062, Aspergillus versicolor isolate BAB-6580, and Aspergillus protuberus strain KAS 6024. Supernatant obtained via submerged fermentation of the isolated fungi in potato dextrose broth (PDB) and extracted via centrifugation was loaded onto specific media to screen for the production of xylanolytic, cellulolytic and amylolytic enzymes. The present findings indicate that Aspergillus sydowii strain SCAU066 and Aspergillus versicolor isolate BAB-6580 have great potential as an alternative source of xylanolytic, cellulolytic and amylolytic enzymes.

The content of decenoic acids in drone brood preparations and combined preparations based on it

Biomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 389-393
Author(s):  
D.V. Mitrofanov ◽  
N.V. Budnikova
Keyword(s):  
Royal Jelly ◽  
Storage Conditions ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strict Adherence ◽  
Drone Brood ◽  
Wide Range ◽  
Active Substances ◽  
Melanin Complex

The drone brood contains a large number of substances with antioxidant activity. These substances require stabilization and strict adherence to storage conditions. Among these substances are unique decenoic acids, the content of which is an indicator of the quality of drone brood and products based on it. The ability of drone brood to reduce the manifestations of oxidative stress is shown. There are dietary supplements for food and drugs based on drone brood, which are used for a wide range of diseases. Together with drone brood, chitosan-containing products, propolis, royal jelly can be used. They enrich the composition with their own biologically active substances and affect the preservation of the biologically active substances of the drone brood. Promising are the products containing, in addition to the drone brood, a chitin-chitosan-melanin complex from bees, propolis, royal jelly. The chitin-chitosan-melanin complex in the amount of 5% in the composition of the adsorbent practically does not affect the preservation of decenic acids, while in the amount of 2% and 10% it somewhat worsens. The acid-soluble and water-soluble chitosan of marine crustaceans significantly worsens the preservation of decenoic acids in the product. Drone brood with royal jelly demonstrates a rather high content of decenoic acids. When propolis is introduced into the composition of the product, the content of decenoic acids increases according to the content of propolis.

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