scholarly journals Recent Advances in Hybrid Biomimetic Polymer-Based Films: from Assembly to Applications

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1003 ◽  
Author(s):  
Agata Krywko-Cendrowska ◽  
Stefano di Leone ◽  
Maryame Bina ◽  
Saziye Yorulmaz-Avsar ◽  
Cornelia G. Palivan ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Synthetic Polymers ◽  
Cell Recognition ◽  
Biological Functions ◽  
Hybrid Films ◽  
Recent Advances ◽  
Polymeric Species ◽  
Biomimetic Polymer ◽  
A Cell ◽  
Planar Systems

Biological membranes, in addition to being a cell boundary, can host a variety of proteins that are involved in different biological functions, including selective nutrient transport, signal transduction, inter- and intra-cellular communication, and cell-cell recognition. Due to their extreme complexity, there has been an increasing interest in developing model membrane systems of controlled properties based on combinations of polymers and different biomacromolecules, i.e., polymer-based hybrid films. In this review, we have highlighted recent advances in the development and applications of hybrid biomimetic planar systems based on different polymeric species. We have focused in particular on hybrid films based on (i) polyelectrolytes, (ii) polymer brushes, as well as (iii) tethers and cushions formed from synthetic polymers, and (iv) block copolymers and their combinations with biomacromolecules, such as lipids, proteins, enzymes, biopolymers, and chosen nanoparticles. In this respect, multiple approaches to the synthesis, characterization, and processing of such hybrid films have been presented. The review has further exemplified their bioengineering, biomedical, and environmental applications, in dependence on the composition and properties of the respective hybrids. We believed that this comprehensive review would be of interest to both the specialists in the field of biomimicry as well as persons entering the field.

From nucleobase to DNA templates for precision supramolecular assemblies and synthetic polymers

2016 ◽  
Vol 7 (25) ◽  
pp. 4137-4150 ◽  
Author(s):  
Mathieu Surin
Keyword(s):  
Synthetic Polymers ◽  
Supramolecular Assemblies ◽  
Supramolecular Polymers ◽  
Dna Templates ◽  
Recent Advances

In this minireview, we report on the recent advances of utilization of nucleobases and DNA as templates to achieve well-defined supramolecular polymers, synthetic polymers, and sequence-controlled polymers.

scholarly journals Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Synthetic Polymers ◽  
Human Environment ◽  
The Past ◽  
Recent Advances ◽  
Nonspecific Protein Adsorption ◽  
Anionic Groups

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

scholarly journals Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 927 ◽  
Author(s):  
Justine Habault ◽  
Jean-Luc Poyet
Keyword(s):  
Tissue Specificity ◽  
Chemical Compounds ◽  
Drug Carriers ◽  
Cell Penetrating Peptides ◽  
Amino Acid Sequences ◽  
Recent Advances ◽  
Cell Penetrating ◽  
A Cell ◽  
Low Toxicity ◽  
Applied Biology

Cell-penetrating-peptides (CPPs) are small amino-acid sequences characterized by their ability to cross cellular membranes. They can transport various bioactive cargos inside cells including nucleic acids, large proteins, and other chemical compounds. Since 1988, natural and synthetic CPPs have been developed for applications ranging from fundamental to applied biology (cell imaging, gene editing, therapeutics delivery). In recent years, a great number of studies reported the potential of CPPs as carriers for the treatment of various diseases. Apart from a good efficacy due to a rapid and potent delivery, a crucial advantage of CPP-based therapies is the peptides low toxicity compared to most drug carriers. On the other hand, they are quite unstable and lack specificity. Higher specificity can be obtained using a cell-specific CPP to transport the therapeutic agent or using a non-specific CPP to transport a cargo with a targeted activity. CPP-cargo complexes can also be conjugated to another moiety that brings cell- or tissue-specificity. Studies based on all these approaches are showing promising results. Here, we focus on recent advances in the potential usage of CPPs in the context of cancer therapy, with a particular interest in CPP-mediated delivery of anti-tumoral proteins.

The social network of a cell: Recent advances in interactome mapping

2008 ◽  
pp. 1-28 ◽  
Author(s):  
Sebastian Charbonnier ◽  
Oriol Gallego ◽  
Anne-Claude Gavin
Keyword(s):  
Social Network ◽  
Recent Advances ◽  
The Social ◽  
A Cell ◽  
Interactome Mapping

scholarly journals Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1165 ◽  
Author(s):  
Tobias Mai ◽  
Karol Wolski ◽  
Agnieszka Puciul-Malinowska ◽  
Alexey Kopyshev ◽  
Ralph Gräf ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Polymer Brushes ◽  
Polymer Brush ◽  
Inorganic Component ◽  
Hybrid Films ◽  
Anionic Polymer ◽  
Phosphate Mineralization ◽  
Application Potential ◽  
Good Biocompatibility ◽  
Growth Experiments

This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.

4. Proteins

2016 ◽  
Author(s):  
Aysha Divan ◽  
Janice A. Royds
Keyword(s):  
Alternative Splicing ◽  
Human Genome ◽  
The Body ◽  
Biological Functions ◽  
Protein Coding ◽  
Post Translational Modifications ◽  
Protein Coding Genes ◽  
Composition And Structure ◽  
A Cell ◽  
Structure Of Proteins

Biological functions require protein and the protein makeup of a cell determines its behaviour and identity. Proteins, therefore, are the most abundant molecules in the body except for water. The approximately 20,000 protein coding genes in the human genome can, by alternative splicing, multiple translation starts, and post-translational modifications, produce over 1,000,000 different proteins, collectively called ‘the proteome’. It is the size of the proteome and not the genome that defines the complexity of an organism. ‘Proteins’ describes the composition and structure of proteins and how they are studied. What information is required in order to understand how proteins work and what happens when this function is impaired in disease?

Sign in / Sign up

Export Citation Format

Share Document