scholarly journals 3D Printed Laminated CaCO3-Nanocellulose Films as Controlled-Release 5-Fluorouracil

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 986 ◽  
Author(s):  
Denesh Mohan ◽  
Nur Fatin Khairullah ◽  
Yan Ping How ◽  
Mohd Shaiful Sajab ◽  
Hatika Kaco
Keyword(s):  
Drug Delivery ◽  
Chemical Properties ◽  
Pharmaceutical Compounds ◽  
The Body ◽  
Therapeutic Effects ◽  
Layer By Layer ◽  
3D Printed ◽  
Time Required ◽  
Uptake And Release ◽  
And Chemical Properties

Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO3 took place following the layer-by-layer films. The 3D printed double laminated CaCO3-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner.

scholarly journals Fabrication of Carboxylmethyl Chitosan Nanocarrier via Self-Assembly for Efficient Delivery of Phenylethyl Resorcinol in B16 Cells

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 408 ◽  
Author(s):  
Pei Zhang ◽  
Huixia Guo ◽  
Chenguang Liu
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Self Assembly ◽  
Chemical Properties ◽  
The Body ◽  
Efficient Delivery ◽  
Mean Size ◽  
Physical And Chemical ◽  
Drug Nanocarriers ◽  
And Chemical Properties

Micro-molecular drugs have special advantages to cope with challenging diseases, however their structure, physical and chemical properties, stability, and pharmacodynamics have more requirements for the way they are delivered into the body. Carrier-based drug delivery systems can circumvent many limited factors of drug delivery and increase their bioavailability. In this context, stable drug nanocarriers of alkaline amino acids (arginine, Arg) modified conjugated linoleic acid-carboxymethyl chitosan (CLA-CMCS) conjugate were developed, which could generate supramolecular micelles to effectively encapsulate the tyrosinase inhibitor phenylethyl resorcinol (PR). The resulting CCA-NPs were spherical nanoparticles with a mean size around 175 nm. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cellular uptake investigation demonstrated that the CCA-NPs were non-cytotoxic and had excellent cell transport ability. In addition, these CCA-NPs were able to effectively deliver PR and inhibited melanin formation to reduce pigmentation by enhancing cellular uptake. In conclusion, our research indicated that nanocarriers based on self-assembly amphiphilic polymers constituted a promising and effective drug delivery system in hyperpigmentation targeting.

scholarly journals Physical and Chemical Properties Characterization of 3D-Printed Substrates Loaded with Copper-Nickel Nanowires

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2680
Author(s):  
Ely Dannier V-Niño ◽  
Quentin Lonne ◽  
Andrés Díaz Lantada ◽  
Enrique Mejía-Ospino ◽  
Hugo Armando Estupiñán Durán ◽  
...  
Keyword(s):  
Glass Transition ◽  
Load Transfer ◽  
Chemical Properties ◽  
Layer By Layer ◽  
Copper Nickel ◽  
Nickel Nanowires ◽  
3D Printed ◽  
Nickel Nanowire ◽  
Laser Stereolithography ◽  
And Chemical Properties

This study deals with the laser stereolithography manufacturing feasibility of copper-nickel nanowire-loaded photosensitive resins. The addition of nanowires resulted in a novel resin suitable for additive manufacturing technologies based on layer-by-layer photopolymerization. The pure and nanowire-loaded resin samples were 3D printed in a similar way. Their morphological, mechanical, thermal, and chemical properties were characterized. X-ray computed tomography revealed that 0.06 vol % of the composite resin was filled with nanowires forming randomly distributed aggregates. The increase of 57% in the storage modulus and 50% in the hardness when loading the resin with nanowire was attributed to the load transfer. Moreover, the decrease in the glass transition temperature from 57.9 °C to 52.8 °C in the polymeric matrix with nanowires evidenced a decrease in the cross-linking density, leading to a higher mobility of the polymer chains during glass transition. Consequently, this research demonstrates the successful dispersion and use of copper-nickel nanowires as a reinforcement material in a commercial resin for laser stereolithography.

Performance and Friction Properties of Injection Hybrid Moulds with Stereolithography Moulding Zones

2006 ◽  
Vol 514-516 ◽  
pp. 1673-1677 ◽  
Author(s):  
Mathias G. Westphal ◽  
António Sergio Pouzada ◽  
Gean V. Salmoria ◽  
Carlos H. Ahrens
Keyword(s):  
Structural Integrity ◽  
Chemical Properties ◽  
Rapid Manufacturing ◽  
Mechanical And Thermal Properties ◽  
Layer By Layer ◽  
Metallic Materials ◽  
Moulding Process ◽  
Photo Polymerization ◽  
Geometric Precision ◽  
And Chemical Properties

Stereolithography is a rapid manufacturing process that builds objects layer-by-layer based on the photo polymerization of a liquid resin. Due to the good geometric precision, this process has been used in Rapid Tooling for injection moulding. These tools are suitable for the production of short runs of parts and prototypes, where without resorting to the manufacture of a conventional metallic mould. The mechanical and thermal properties of the stereolitography resins, used in the manufacture of hybrid moulds, differ substantially from those of the conventional metallic materials. Particularly they must be known for guaranteeing the structural integrity and the thermal performance of the mould. Also the chemistry behaviour of the resin in contact with the polymer is important when tribological aspects are involved, especially during the ejection of the moulding. In this work, the behaviour of hybrid moulds with SL Vantico 5260 resin moulding cores was assessed. Several thermoplastics (iPP, ABS, PET and PA 6.6) were moulded, and their mechanical, thermal and chemical properties considered and related to the performance of the moulding process. Also, the friction properties of the SL resin in contact with the moulded thermoplastic in moulding conditions were observed and considered in the context of the performance of hybrid moulds.

TO THE QUESTION OF INDUSTRIAL AEROSOL CONTROL IN THE PROCESSING OF BLISTER COPPER

2021 ◽  
Author(s):  
O.G. Drugova ◽  
◽  
A.A. Fedoruk ◽  
T.N. Shtin
Keyword(s):  
Chemical Properties ◽  
The Body ◽  
Industrial Control ◽  
Silicon Iron ◽  
Carcinogenic Effect ◽  
Copper Zinc ◽  
Toxic Potential ◽  
Physical And Chemical ◽  
Industrial Aerosol ◽  
And Chemical Properties

Abstract. Due to the predominance of PM1 particles in the air samples, the following metals were found in the aerosol: copper, zinc, silicon, iron, lead, sulfur, arsenic, aluminum, antimony, tin, magnesium, cadmium and several other metals. The content of sulfates was significantly noted. These physical and chemical properties show a considerable toxic potential of industrial aerosol. The MPC of lead, sulfur and silicon dioxides, as well as nitrogen oxides and formaldehyde were detected in the working air. Meanwhile, copper, zinc, and iron did not exceed their MPC. Moreover, an underestimation of the aerosol was observed within the framework of industrial control. It has been found that the aerosol components may have an irritating, reprotoxic, allergenic, and carcinogenic effect on the body. Further consideration of the dispersed and chemical composition of the aerosol is required to determine the concentration of identified substances in the working air and the limiting components determining its biological effect.

Effects of Gamma Irradiation Upon the Mechanical and Chemical Properties of 3D-Printed Samples of Polylactic Acid

2019 ◽  
Vol 141 (4) ◽  
Author(s):  
Conrad West ◽  
Robert McTaggart ◽  
Todd Letcher ◽  
Douglas Raynie ◽  
Ranen Roy
Keyword(s):  
Polylactic Acid ◽  
Chemical Properties ◽  
Waste Streams ◽  
Exponential Functions ◽  
Destructive Testing ◽  
Space Applications ◽  
Mechanical Responses ◽  
Decomposition Processes ◽  
3D Printed ◽  
And Chemical Properties

3D printing offers the opportunity to design and make replacement parts to exacting specifications when needed. This is particularly helpful for space applications where stand-alone replacement mechanisms are required. Samples of 3D-printed polylactic acid (PLA) were subjected with up to 200 kGy of gamma radiation from a Cobalt-60 irradiator. The mechanical responses to destructive testing were successfully modeled with a combination of linear and exponential functions and may be understood given the underlying chemical changes due to said radiation exposures. We find that for doses up to 50 kGy, the performance of 3D-printed PLA is largely unaffected, which is beneficial for applications in space and in medicine. At larger doses, it appears that decomposition processes win out over cross-linking, which may aid in the degradation of PLA in waste streams.

3D Printing Technology in Drug Delivery: Recent Progress and Application

2019 ◽  
Vol 24 (42) ◽  
pp. 5039-5048 ◽  
Author(s):  
Sabna Kotta ◽  
Anroop Nair ◽  
Nimer Alsabeelah
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pharmaceutical Manufacturing ◽  
Layer By Layer ◽  
Printing Technology ◽  
Drug Dosing ◽  
3D Printing Technology ◽  
3D Printed

Background: 3D printing technology is a new chapter in pharmaceutical manufacturing and has gained vast interest in the recent past as it offers significant advantages over traditional pharmaceutical processes. Advances in technologies can lead to the design of suitable 3D printing device capable of producing formulations with intended drug release. Methods: This review summarizes the applications of 3D printing technology in various drug delivery systems. The applications are well arranged in different sections like uses in personalized drug dosing, complex drugrelease profiles, personalized topical treatment devices, novel dosage forms and drug delivery devices and 3D printed polypills. Results: This niche technology seems to be a transformative tool with more flexibility in pharmaceutical manufacturing. Typically, 3D printing is a layer-by-layer process having the ability to fabricate 3D formulations by depositing the product components by digital control. This additive manufacturing process can provide tailored and individualized dosing for treatment of patients different backgrounds with varied customs and metabolism pattern. In addition, this printing technology has the capacity for dispensing low volumes with accuracy along with accurate spatial control for customized drug delivery. After the FDA approval of first 3D printed tablet Spritam, the 3D printing technology is extensively explored in the arena of drug delivery. Conclusion: There is enormous scope for this promising technology in designing various delivery systems and provides customized patient-compatible formulations with polypills. The future of this technology will rely on its prospective to provide 3D printing systems capable of manufacturing personalized doses. In nutshell, the 3D approach is likely to revolutionize drug delivery systems to a new level, though need time to evolve.

Biocompatibility in regenerative nanomedicine

Nanomedicine ◽  
2019 ◽  
Vol 14 (20) ◽  
pp. 2763-2775 ◽  
Author(s):  
Fatih Zor ◽  
Fatma Nurefsan Selek ◽  
Giuseppe Orlando ◽  
David F Williams
Keyword(s):  
Chemical Properties ◽  
The Body ◽  
Common Word ◽  
Target Cells ◽  
Physical And Chemical Properties ◽  
Foreign Material ◽  
Biomaterial Science ◽  
Physical And Chemical ◽  
And Chemical Properties

Biocompatibility is a very common word that is used within biomaterial science and used for description of the interactions between the foreign material and the body. However, the meaning of biocompatibility as well as the mechanisms that collectively constitutes is still unclear. With the advance of nanotechnology, new concerns have been observed related to biocompatibility of these biomaterials. Due to their small size and variability of their physical and chemical properties, nanoparticles’ (NP) distribution within the body and interactions with the target cells and tissues are highly variable. Here, we tried to provide an overview about NPs, the concept of biocompatibility and biocompatibility-related issues in nanomedicine and several different NPs.

Vascular Nanomedicine: Current Status, Opportunities, and Challenges

2019 ◽  
Vol 46 (05) ◽  
pp. 524-544 ◽  
Author(s):  
Michael Sun ◽  
Anirban Sen Gupta
Keyword(s):  
Drug Delivery ◽  
Vascular Diseases ◽  
The Body ◽  
Current Status ◽  
Therapeutic Effects ◽  
Current State ◽  
Challenges And Opportunities ◽  
Disease Site ◽  
Drug Pharmacokinetics

AbstractThe term “nanotechnology” was coined by Norio Taniguchi in the 1970s to describe the manipulation of materials at the nano (10−9) scale, and the term “nanomedicine” was put forward by Eric Drexler and Robert Freitas Jr. in the 1990s to signify the application of nanotechnology in medicine. Nanomedicine encompasses a variety of systems including nanoparticles, nanofibers, surface nano-patterning, nanoporous matrices, and nanoscale coatings. Of these, nanoparticle-based applications in drug formulations and delivery have emerged as the most utilized nanomedicine system. This review aims to present a comprehensive assessment of nanomedicine approaches in vascular diseases, emphasizing particle designs, therapeutic effects, and current state-of-the-art. The expected advantages of utilizing nanoparticles for drug delivery stem from the particle's ability to (1) protect the drug from plasma-induced deactivation; (2) optimize drug pharmacokinetics and biodistribution; (3) enhance drug delivery to the disease site via passive and active mechanisms; (4) modulate drug release mechanisms via diffusion, degradation, and other unique stimuli-triggered processes; and (5) biodegrade or get eliminated safely from the body. Several nanoparticle systems encapsulating a variety of payloads have shown these advantages in vascular drug delivery applications in preclinical evaluation. At the same time, new challenges have emerged regarding discrepancy between expected and actual fate of nanoparticles in vivo, manufacturing barriers of complex nanoparticle designs, and issues of toxicity and immune response, which have limited successful clinical translation of vascular nanomedicine systems. In this context, this review will discuss challenges and opportunities to advance the field of vascular nanomedicine.

Effect of Doping of Fe into TiO2 Layer in Fe2O3/TiO2/FTO System for High Performance of Water Splitting

2014 ◽  
Vol 93 ◽  
pp. 82-89 ◽  
Author(s):  
Aryan Azad ◽  
Eul Noh ◽  
Kang Seop Yun ◽  
Hee June Jeong ◽  
Sang Chul Jung ◽  
...  
Keyword(s):  
Metal Oxides ◽  
Water Splitting ◽  
High Performance ◽  
Chemical Properties ◽  
Layer By Layer ◽  
Energy Problem ◽  
Dipping Process ◽  
Promising Solution ◽  
Physical And Chemical ◽  
And Chemical Properties

Hydrogen has unique physical and chemical properties which present benefits and challenges to its successful widespread adoption as a fuel. The photoelectrochemical (PEC) water splitting process with semiconductor metal oxides can be a promising solution to the global energy problem. Although amongst metal oxides Fe2O3 by 2.2 eV bang gap energy is more applicable, for reducing the recombination of electron and hole, Fe was doped into TiO2. In this study Fe2O3/Fe doped TiO2 photocatalysts were compared with Fe-doped TiO2 and TiO2 structures by using layer by layer-self-assemble (LBL-SA) method and dipping process on FTO glass. According to our results the Fe2O3 coated on Fe doped TiO2 /FTO has had best results.

scholarly journals OPPORTUNITIES OF BIOMEDICAL USE OF CARBON NANOTUBES

2014 ◽  
Vol 13 (1) ◽  
pp. 135-144
Author(s):  
I. V. Mitrofanova ◽  
I. V. Milto ◽  
I. V. Suhodolo ◽  
G. Yu. Vasyukov
Keyword(s):  
Carbon Nanotubes ◽  
Chemical Properties ◽  
Tissue Level ◽  
Pathological Process ◽  
The Body ◽  
Therapeutic Effects ◽  
Target Delivery ◽  
Physico Chemical ◽  
Near Future ◽  
Biological And Medical Applications

Nanomaterials  –  materials,  whouse  structure  elements  has  proportions  doesn’t  exceed  100  nm.  In superdispersed state matter acquire new properties. In the last decade, carbon nanotubes become the most popular nanomaterials, that cause attention of representatives of various scientific field. The сarbon nanotubes offer new opportunities for biological and medical applications: imaging at the molecular, cellular and tissue levels, biosensors and electrodes based on carbon nanotubes, target delivery of various substances, radiation and photothermal therapy. The most promising of carbon nanotubes in the context of biomedical applications is their ability to penetrate the various tissues of the body and carry large doses of agents, providing diagnostic and therapeutic effects. Functionalized nanotubes are biodegradable. Other current direction of using carbon nanotubes in medicine and biology is to visualize objects on the molecular, cellular and tissue level. Associated with carbon nanotubes contrasting substances improve the visualization of cells and tissues, which can detected new patterns of development of the pathological process. Due to the vagueness of the question of biocompatibility and cytotoxicity of carbon nanotubes possibility of their practical application is hampered. Before the introduction of carbon nanotubes into practical health care is necessary to provide all the possible consequences of using nanotubes. High rates of properties and development of new nanostructures based on carbon nanotubes in the near future will lead to new advances related to the application and development of new parameters that will determine their properties and effects. In these review attention is paid to the structure, physico-chemical properties of nanotubes, their functionalization, pharmacokinetics and pharmacodynamics and all aspects of using of carbon nanotubes.

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