scholarly journals Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Polymers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 7 ◽  
Author(s):  
Marta A. Teixeira ◽  
M. Teresa P. Amorim ◽  
Helena P. Felgueiras
Keyword(s):  
Tissue Engineering ◽  
Vinyl Alcohol ◽  
Mechanical Performance ◽  
Three Dimensional ◽  
Poly Vinyl Alcohol ◽  
Electrospinning Technique ◽  
Electrospun Scaffolds ◽  
Nanofibrous Scaffolds ◽  
The Stability ◽  
The Many

Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

Electrospinning of carboxymethyl chitin/poly(vinyl alcohol) nanofibrous scaffolds for tissue engineering applications

2009 ◽  
Vol 77 (4) ◽  
pp. 863-869 ◽  
Author(s):  
K.T. Shalumon ◽  
N.S. Binulal ◽  
N. Selvamurugan ◽  
S.V. Nair ◽  
Deepthy Menon ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Engineering Applications ◽  
Nanofibrous Scaffolds

scholarly journals Acellular Bioactivity of Sol-Gel Derived Borate Glass-Polycaprolactone Electrospun Scaffolds

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
William C. Lepry ◽  
Sophia Smith ◽  
Liliana Liverani ◽  
Aldo R. Boccaccini ◽  
Showan N. Nazhat
Keyword(s):  
Tissue Engineering ◽  
Composite Scaffold ◽  
Sol Gel ◽  
Three Dimensional ◽  
Apatite Formation ◽  
Electrospinning Technique ◽  
Electrospun Scaffolds ◽  
Conversion Rates ◽  
Potential Applications

AbstractRecently, sol-gel derived borate glasses (BGs) have shown unprecedented conversion rates to bone-like mineral (hydroxycarbonated apatite). In an effort to explore their potential applications in bone tissue engineering, this study reports on the fabrication and characterization of BG particle incorporated electrospun "- polycaprolactone (PCL) fibrous composites. The electrospinning technique successfully incorporated PCL fibres with BG particles at 2.5 and 5 w/v%, with the higher BG loading creating a three-dimensional cotton-wool like morphology. Dynamic vapour sorption showed greater extents of mass change with BG content attributable to water sorption, and indicating greater reactivity in the composite systems. In vitro bioactivity was investigated in simulated body fluid for up to 7 days. Scanning electron microscopy, Fourier-transform infrared spectroscopy and xray diffraction indicated apatite formation in the 5 w/v% incorporated composite scaffold, which initiated as early as day 3. In summary, sol-gel derived BGs incorporatedfibrous electrospun PCL composites indicate rapid reactivity and bioactivity with potential applications in mineralized tissue engineering.

scholarly journals Adipose tissue-derived mesenchymal stem cells and chitosan/poly (vinyl alcohol) nanofibrous scaffolds for cartilage tissue engineering

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Ghada Nour-Eldeen ◽  
Mazen Abdel-Rasheed ◽  
Amira M. EL-Rafei ◽  
Osama Azmy ◽  
Gehan T. El-Bassyouni
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Vinyl Alcohol ◽  
Cartilage Tissue ◽  
Poly Vinyl Alcohol ◽  
Differentiation Potential ◽  
Nanofibrous Scaffolds ◽  
Scanning Electron

AbstractOsteoarthritis (OA) has been defined as a chronic inflammatory joint disease characterized by progressive articular cartilage degeneration. Recently growing interest in regenerative medicine, using cell therapy and tissue engineering, where cellular components in combination with engineered scaffolds and bioactive materials were used to induce functional tissue regeneration. In the present study, nanofibrous scaffold based on chitosan (CS)/poly (vinyl alcohol) (PVA) were used to develop biologically functionalized biomaterial to mimic the extracellular matrix, allowing the human adipose tissue derived mesenchymal stem cells (ADSCs) to proliferate and differentiate to chondrogenic cells. The morphology of the nanofibrous mat was examined using field emission scanning electron microscope (FE/SEM). The characteristic functional groups and the nature of the chemical bonds between atoms were evaluated using Fourier transform infrared spectroscopy (FTIR) spectrum. Characterization of the seeded cells was morphologically evaluated by scanning electron microscopy and by flow cytometry for the expression of the stem cell surface markers. The differentiation potential was verified after chondrogenic induction by analyzing the expression of chondrogenic marker genes using real-time (RT PCR). Current study suggest significant potential for the use of ADSCs with the nanofibrous scaffolds in improving the osteoarthritis pathology.

Development of Collagen/Poly(vinyl alcohol)/Chondroitin Sulfate and Collagen/Poly(vinyl alcohol)/HA Electrospun Scaffolds for Tissue Engineering

2019 ◽  
Vol 20 (12) ◽  
pp. 2470-2484
Author(s):  
Luis Humberto Delgado-Rangel ◽  
Julia Hernández-Vargas ◽  
Marymar Becerra-González ◽  
Ataúlfo Martínez-Torres ◽  
Evgen Prokhorov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Chondroitin Sulfate ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Electrospun Scaffolds

scholarly journals Dual Network Composites of Poly(vinyl alcohol)-Calcium Metaphosphate/Alginate with Osteogenic Ions for Bone Tissue Engineering in Oral and Maxillofacial Surgery

2021 ◽  
Vol 8 (8) ◽  
pp. 107
Author(s):  
Lilis Iskandar ◽  
Lucy DiSilvio ◽  
Jonathan Acheson ◽  
Sanjukta Deb
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Vinyl Alcohol ◽  
Maxillofacial Surgery ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Poly Vinyl Alcohol ◽  
Oral And Maxillofacial Surgery

Despite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic bone substitutes (SBS’s) have not transcended the pre-clinical stage due to inferior clinical performance and translational barriers, which include low scalability, high cost, regulatory restrictions, limited advanced facilities and human resources. The aim of this study is to develop clinically viable alternatives to address the challenges of bone tissue regeneration in the OMF region by developing ‘dual network composites’ (DNC’s) of calcium metaphosphate (CMP)—poly(vinyl alcohol) (PVA)/alginate with osteogenic ions: calcium, zinc and strontium. To fabricate DNC’s, single network composites of PVA/CMP with 10% (w/v) gelatine particles as porogen were developed using two freeze–thawing cycles and subsequently interpenetrated by guluronate-dominant sodium alginate and chelated with calcium, zinc or strontium ions. Physicochemical, compressive, water uptake, thermal, morphological and in vitro biological properties of DNC’s were characterised. The results demonstrated elastic 3D porous scaffolds resembling a ‘spongy bone’ with fluid absorbing capacity, easily sculptable to fit anatomically complex bone defects, biocompatible and osteoconductive in vitro, thus yielding potentially clinically viable for SBS alternatives in OMF surgery.

scholarly journals Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1510 ◽  
Author(s):  
Mohammad Ehsan Taghavizadeh Yazdi ◽  
Simin Nazarnezhad ◽  
Seyed Hadi Mousavi ◽  
Mohammad Sadegh Amiri ◽  
Majid Darroudi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Food Packaging ◽  
Three Dimensional ◽  
Great Promise ◽  
Anionic Polymer ◽  
Gum Tragacanth ◽  
New Horizons ◽  
Tissue Healing ◽  
The Stability ◽  
Therapeutic Substance

The use of naturally occurring materials in biomedicine has been increasingly attracting the researchers’ interest and, in this regard, gum tragacanth (GT) is recently showing great promise as a therapeutic substance in tissue engineering and regenerative medicine. As a polysaccharide, GT can be easily extracted from the stems and branches of various species of Astragalus. This anionic polymer is known to be a biodegradable, non-allergenic, non-toxic, and non-carcinogenic material. The stability against microbial, heat and acid degradation has made GT an attractive material not only in industrial settings (e.g., food packaging) but also in biomedical approaches (e.g., drug delivery). Over time, GT has been shown to be a useful reagent in the formation and stabilization of metal nanoparticles in the context of green chemistry. With the advent of tissue engineering, GT has also been utilized for the fabrication of three-dimensional (3D) scaffolds applied for both hard and soft tissue healing strategies. However, more research is needed for defining GT applicability in the future of biomedical engineering. On this object, the present review aims to provide a state-of-the-art overview of GT in biomedicine and tries to open new horizons in the field based on its inherent characteristics.

scholarly journals Harnessing the Topography of 3D Spongy-Like Electrospun Bundled Fibrous Scaffold via a Sharply Inclined Array Collector

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1444 ◽  
Author(s):  
Sun Hee Cho ◽  
Jeong In Kim ◽  
Cheol Sang Kim ◽  
Chan Hee Park ◽  
In Gi Kim
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Three Dimensional ◽  
Living System ◽  
Pivotal Role ◽  
Skin Tissue ◽  
Target Tissue ◽  
Fibrous Scaffold ◽  
Electrospun Scaffolds ◽  
Directional Change

To date, many researchers have studied a considerable number of three-dimensional (3D) cotton-like electrospun scaffolds for tissue engineering, including the generation of bone, cartilage, and skin tissue. Although numerous 3D electrospun fibrous matrixes have been successfully developed, additional research is needed to produce 3D patterned and sophisticated structures. The development of 3D fibrous matrixes with patterned and sophisticated structures (FM-PSS) capable of mimicking the extracellular matrix (ECM) is important for advancing tissue engineering. Because modulating nano to microscale features of the 3D fibrous scaffold to control the ambient microenvironment of target tissue cells can play a pivotal role in inducing tissue morphogenesis after transplantation in a living system. To achieve this objective, the 3D FM-PSSs were successfully generated by the electrospinning using a directional change of the sharply inclined array collector. The 3D FM-PSSs overcome the current limitations of conventional electrospun cotton-type 3D matrixes of random fibers.

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