scholarly journals Polymer-Based Systems for Controlled Release and Targeting of Drugs

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2066 ◽  
Author(s):  
Gaetano Giammona ◽  
Emanuela Fabiola Craparo
Keyword(s):  
Nucleic Acid ◽  
Controlled Release ◽  
Targeted Therapies ◽  
Body Fluids ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Materials ◽  
Active Substances

The current need to find new advanced approaches to carry biologically active substances (conventional organic drugs, peptides, proteins (such as antibodies), and nucleic acid-based drugs (NABDs such as siRNA and miRNA)) in the body fluids, to realize targeted therapies and even personalized ones, goes hand in hand with research on the performance of new materials to better realize appropriate drug vectors [...]

CONSUMER PROPERTIES OF PASTA WITH POWDER FROM MARIGOLD INFLORESCENCES (TAGETES L.)

2021 ◽  
Vol 40 (4) ◽  
pp. 102-112
Author(s):  
SHAPOVALOVA Nataliia ◽  
VEZHLIVTSEVA Svitlana ◽  
ANTIUSHKO Dmytro
Keyword(s):  
Raw Materials ◽  
Experimental Studies ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Organoleptic Properties ◽  
Biological Value ◽  
Plant Raw Materials ◽  
Active Substances

Background. The deficiency of essential nutrients in the human body is the root cause of reduced efficiency, general resistance of the body to various diseases. That is an urgent problem in the context of the spread of coronavirus infection. In this regard, the search for opportunities to meet the needs of the population in food products that contain biologically active substances (BAS) through the use of high-value and at the same time available plant raw materials is extremely important. Marigolds attract special attention among such raw materials. The aim of the work is to study the chemical composition and evaluate the consumer properties of Tagetes L. varieties, zoned in the Kiev region, to prove the possibility of increasing the biological value of pasta by adding to their recipe powder from marigold inflorescences. Materials and methods. The object of research is pasta of B group (noodles). Inflorescences of marigolds of different varieties gathered during the flowering period in July-September 2019–2020 in the territory of Vasylkiv and Obukhiv districts of Kyiv region, Ukraine were used as enriching plant raw materials. The quality of finished pasta was assessed by organoleptic and physicochemical indexes (moisture content and titratable acidity). The content of mineral elements in the fine powder of marigold inflorescences was determined on the EXHERT-3L device, the quantitative composition and BAS identification – by spectrophotometric analysis on the device Specord-200 Analytic Jena UV-vis. The integrated quality index of pasta products was calculated taking into account the importance factors of individual indexes. Results. Comparing the obtained results, we can state that all the studied varieties – Gold Kopfen, Orange Flame, Hawaii, Equinox are characterized by high biological value, regardless of the area of collection. As a result of calculated and experimental studies it was determined that the addition of 7 % of the supplement does not provide the required supply of vitamins and minerals. Replacing the flour in the recipe by 20 % significantly improves the mineral composition, but deteriorates the taste and aromatic properties of pasta. The most optimal and rational amount of added additive is 15 %, as it improves the organoleptic properties of pasta and enriches their BAS. Conclusion. The usage of non-traditional vegetable raw materials, in particular powder from marigold inflorescences, which is rich in biologically active substances, allows not only to expand the range, improve the quality of finished products, but also increase the biological value of the product. The optimal amount of additive –powder from marigold inflorescences, was defined. It is 15 % by weight of flour in the production of noodles. This concentration allows not only to improve the organoleptic properties, but also to increase the content of biologically active substances – vitamins, micro- and macronutrients. The usage of non-traditional natural raw materials (powder from marigold inflorescences) allows to abandon artificial colorsand give the finished pasta a pleasant colorand aroma.

scholarly journals Fruits of plants of Amelanchier genus (Amelanchier Medic) as source of biologically active substances and minerals

2018 ◽  
Vol 26 (2) ◽  
pp. 296-304
Author(s):  
Elena A. Laksaeva
Keyword(s):  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Erythrocyte Membranes ◽  
Human Organism ◽  
High Concentration ◽  
Experimental Animals ◽  
Polysaccharide Complex ◽  
Physiological Processes ◽  
Active Substances

An interest in plants of Amelanchier genus is stimulated by the necessity of search for plant sources rich in biologically active substances and possessing the ability to influence different physiological processes in a human organism. The article gives information about places of growth of different species of Amelanchier (Amelanchier Medic) and about the fact that its fruits contain high concentration of free sugars, relatively low level of organic acids, sufficient amounts of various vitamins and provitamins and a complex of mineral substances. Nutritive and biological value of Amelanchier fruits in complex may produce a beneficial effect on different biochemical and physiological processes of normal vital activity of a human organism. The data are given about a positive influence of enteral introduction of polysaccharides isolated from Amelanchier fruits, on different physiological processes that enhance adaptational reserves of an organism of experimental animals. In particular, it was shown that watersoluble polysaccharide complex (WSPC) of Amelanchier fruits activates erythropoiesis increasing the amount of erythrocytes and hemoglobin in blood of experimental animals and raises concentration of iron. WSPC improves physical working capacity and increases the body mass of experimental animals. Addition of watersoluble polysaccharide complex of Amelanchier fruits to blood of a healthy donor increases thermal, osmotic and peroxide resistance of erythrocyte membranes thus protecting cells against damage under action of adverse factors in the experiment. Fruits of plants of Amelanchier genus may be recommended to be used as a food additive or a product in dietary and prophylactic therapy.

COMPLEX FEED ADDITIVE TO NORMALIZE METABOLIC PROCESSES OF COWS

2021 ◽  
pp. 30-33
Author(s):  
Н.В. БОГОЛЮБОВА ◽  
Р.А. РЫКОВ
Keyword(s):  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Feed Additive ◽  
Feed Supplement ◽  
Metabolic Processes ◽  
Activity Of Enzymes ◽  
Experimental Group ◽  
Active Substances ◽  
Alt Activity

Изучен способ нормализации обменных процессов и повышения продуктивности молочных коров при использовании комплекса биологически активных веществ. Эксперимент проведен на коровах голштинской породы (n=12) с продуктивностью за предыдущую лактацию 9000 кг молока. За 20 дней до отела и в течение 65 дней после коровы опытной группы получали комплексную кормовую добавку (ККД), включающую минерал шунгит, холин в «защищенной» форме, пробиотик «Целлобактерин+» и жмых льняной, в количестве 200 г на голову в сутки в смеси с концентратами. Для изучения обменных процессов в организме коров (n=5) в конце опыта отобраны пробы крови и определены основные биохимические показатели. Для оценки продуктивных качеств проводили контрольные дойки. Отмечено повышение в крови коров опытной группы концентрации общего белка на 2,8%, глюкозы — на 26,8% (P≤0,01), фосфолипидов — на 15,2% (P≤0,05), снижение мочевины на 23,6% (P≤0,05), билирубина — на 23,8% (P≤0,01), активности АЛТ на 13,11 (P≤0,05), АСТ — на 14,6% (P≤0,05). Использование ККД позволило снизить и привести в норму активность ферментов: лактатдегидрогеназы (ЛДГ), гаммаглутаминтрансферазы (ГГТ), креатинкиназы. Повышение интенсивности обменных процессов и нормализация показателей, характеризующих работу печени с использованием в питании комплекса биологически активных веществ ферментно-пробиотического, антиоксидантного и липотропно-гепатопротекторного действия, привело к повышению молочной продуктивности. A method of normalizing metabolic processes and increasing the productivity of dairy cows using a complex of biologically active substances has been studied. The experiment was carried out on Holstein cows (n = 12) with a productivity for the previous lactation of 9000 kg of milk. 20 days before calving and within 65 days after the cows of the experimental group received a complex feed supplement (CFS), including the mineral shungite, choline in a "protected" form, the probiotic "Cellobacterin +" and flaxseed cake, in an amount of 200 g per head per day mixed with concentrates. To study metabolic processes in the body of cows (n = 5), at the end of the experiment, blood samples were taken and the main biochemical parameters were determined. To assess the productive qualities, control milking was carried out. An increase in the blood of cows of the experimental group was noted in the concentration of total protein by 2.8%, glucose - by 26.8% (P≤0.01), phospholipids — by 15.2% (P≤0.05), a decrease in urea by 23,6% (P≤0.05), bilirubin - by 23.8% (P≤0.01), ALT activity by 13.11 (P≤0.05), AST — by 14.6% (P≤ 0.05). The use of CFS made it possible to reduce and normalize the activity of enzymes: lactate dehydrogenase (LDH), gamma glutamine transferase (GGT), creatine kinase. An increase in the intensity of metabolic processes and the normalization of indicators characterizing the work of the liver with the use of a complex of biologically active substances of enzymatic-probiotic, antioxidant and lipotropic-hepatoprotective action in the diet led to an increase in milk productivity.

Film materials with controlled release of biologically active substances

1998 ◽  
Vol 30 (5) ◽  
pp. 332-336
Author(s):  
I. F. Skokova ◽  
T. N. Yudanova ◽  
I. V. Bogdanova ◽  
N. E. Petrova ◽  
L. S. Gal’braikh
Keyword(s):  
Controlled Release ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Substances

scholarly journals DEVELOPMENT OF A NEW METHOD OF PRODUCTION OF PROTEIN VEGETABLE PLANT NANO ADDITIVES USING PAROTHERMOMECHANODESTRUCTION PROCESSES

2020 ◽  
pp. 66-72
Author(s):  
Viktoriya Pogarskaya ◽  
Raisa Pavlyuk ◽  
Tatyana Kotuyk ◽  
Olga Yurieva ◽  
Nadiya Maksymova
Keyword(s):  
Human Body ◽  
Raw Materials ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Method ◽  
Mechanical Destruction ◽  
Biological Potential ◽  
Confectionery Products ◽  
Active Substances

The aim of research is to develop a new method for the production of protein plant nanoadditives from dry chickpea in the form of nanopowders and nanopastes using the processes of steam thermo-mechanical destruction, leading to a high degree of mechanical destruction of biopolymers in separate constituent monomers, without destroying the latter. The new method is based on the use as an innovation of a complex effect on raw materials of steam-thermal treatment in modern steam-thermal devices (at a temperature of +70 °C) and non-enzymatic catalysis, which occurs when using fine grinding. The proposed method makes it possible to more fully reveal the biological potential of plant raw materials and transform hardly soluble, indigestible by the human body components of raw materials (in particular, cellulose, pectin substances, proteins and their nanocomplex and nanoassociates) into components that are easily absorbed by the body. The method makes it possible to more completely remove from the raw materials inactive bound forms of individual monomers of biopolymers, to reduce the molecular weight of biopolymers. At the same time, the efficiency of the resulting product increases significantly when consumed by the human body. New additives from chickpea are fundamentally different from traditional ones in properties and physicochemical state. The developed additives act simultaneously five in one: a source of essential amino acids and other biologically active substances, structure formers, gelling agents, thickeners and yellow dyes. The obtained protein supplements from chickpeas in combination with herbal Nanoadditives (from pumpkin, carrots, lemons, garlic, celery roots, ginger) were used as recipe components in the development of a new generation of confectionery products. The resulting confectionery products differ from the traditional ones in their low sugar and fat content (up to 5 %), high content of complete protein (from 13 to 20 %). In addition, 100 g of new products are able to satisfy the daily requirement for biologically active substances (β-carotene, phenolic compounds) and 0.5 daily requirement for vitamin C. The resulting products are natural, do not contain harmful impurities and exceed the quality of world analogues

scholarly journals EFFECTIVENESS OF MICROELEMENTS IN THE FORMATION OF MECHANISMS OF PROTECTION OF THE BODY UNDER THE INFLUENCE OF ENVIRONMENTAL STRESS FACTORS

2021 ◽  
Vol 22 (1) ◽  
pp. 61-67
Author(s):  
V. O. Velichko
Keyword(s):  
Trace Elements ◽  
Immune Status ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Stress Factors ◽  
Enzymatic System ◽  
Antioxidant Protection ◽  
The Impact ◽  
Active Substances

Analysis of literature data and the results of our own research show that even with intensive rearing of animals with the use of balanced feeding and keeping them in accordance with the technology - it is almost impossible to avoid stress. And especially, excessive man-made load on agroecosystems also has a negative impact on animal life. Factors that cause a decrease in immune status and the emergence of immune pathology in animals include: industrial technology of animal husbandry, chemicalization in crop and livestock production, man-made pressure, dietary imbalance in nutrients and biologically active substances. This increases the impact on the body of heavy metals, which displace nutrients from body tissues, in particular trace elements and replace them in metabolic processes, which is a potential prerequisite for the development of oxidative stress. The mechanism of development of stress reaction of an organism is closely connected with activity of POL (lipid peroxidation) and depression of antioxidant potential. Under these conditions, the ability of the organism to mobilize protective and adaptive capabilities in response to the action of negative factors becomes especially important. Keeping productive animals in adverse conditions, unbalanced feeding are components of immobilization stress, which reduces their productivity, affects reproductive function, metabolic and functional disorders, reducing nonspecific and specific resistance of the organism (Fedoruk & Kravtsiv, 2003; Velychko, 2008; Velychko, 2011). Under conditions of man-caused load on the environment, respectively, and animals – it is promising to develop effective methods for regulating the activity of the enzymatic system of antioxidant protection with the help of biologically active substances, in particular trace elements. The results of research confirm that this has a positive effect on the formation of productive and adaptive properties of animals. The system of antioxidant protection is a necessary part of non-specific reactions of the organism, a component of the processes of its adaptation to environmental conditions, a component of normal life, a factor in maintaining homeostasis. Widespread immunodeficiency and elucidation of the main links of their pathogenesis have exacerbated the problem of regulating disorders of the immune system. Therefore, knowledge of the patterns of formation of the immune status of animals, especially in the early postnatal period, is important in the development of methods for the correction of immunodeficiency, antioxidant protection.

scholarly journals PROSPECTS FOR THE DEVELOPMENT OF FEED PRODUCTION FOR FUR ANIMALS

2021 ◽  
Vol 21 (2) ◽  
Author(s):  
B. Iegorov ◽  
A. Makarynska ◽  
О. Voietska ◽  
O. Tsiundyk
Keyword(s):  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Metabolic Energy ◽  
High Quality ◽  
Feed Production ◽  
Vital Functions ◽  
Improved Sanitation ◽  
Fur Animals ◽  
Active Substances

The article considers the species of fur animals bred in Ukraine. The volumes of fur production and the number of animal farms in the world and Ukraine are analyzed, of which Denmark, China and Poland are in the top three. The share in the total volume of fur production in Ukraine is only 1%. Domestic enterprises for breeding fur animals, which keep about 700 thousand minks in industrial conditions, are considered.The structure of the gastrointestinal tract of carnivorous and herbivorous fur animals, their consumption of nutrients and biologically active substances in feed were analyzed. Features of feeding fur animals are determined by the seasonality of vital functions, which determines changes in metabolism and nutritional value of feed. The importance of access to fresh drinking water in the diets of carnivorous fur animals is considered.The necessity of production of compound feeds for fur animals, which meet the norms of feeding and restrictions on the introduction of components, is substantiated.The need of fur-bearing animals in nutrients and biologically active substances for the production of high-quality nutritious compound feeds, for obtaining high-quality shine and density of fur, better digestibility by the body is shown. The ratios of digestible nutrients in the diets of minks of domestic and Scandinavian breeds are given, the percentage of metabolic energy in different feeding periods is given. The low percentage of compound feed production for fur farming is substantiated.Types of compound feeds and their advantages are presented. Technological methods of production of compound feeds for fur animals such as extrusion, expansion and granulation with the introduction of fat into the press granulator are analyzed. Finished feed should be solid and have a granule size of 4.5… 5 mm for grinding cutters, with high nutritional properties and biological value, and improved sanitation. Thanks to modern technologies, harmful microflora is disinfected and shelf life is increased.The state of domestic feed mills for the production of quality feed for fur animals is analyzed. Thanks to the emergence of new recipes and compliance with feeding standards, the technology of compound feed production for fur farming is being improved.

Improving the fattening and meat traits of broiler chickens

2021 ◽  
pp. 38-51
Author(s):  
G. N. Vyayzenen ◽  
S. V. Razaev ◽  
A. G. Vyayzenen ◽  
N. S. Prodanov ◽  
A. E. Barashkov ◽  
...  
Keyword(s):  
Amino Acids ◽  
Laser Beam ◽  
Broiler Chickens ◽  
The Body ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Poultry Meat ◽  
Control Group ◽  
Active Substances

In order to save the cost of expensive compound feed, a number of biologically active substances (vitamins and amino acids) and improve the digestibility of nutrients for the first time in poultry meat using laser technology there is a real possibility of “transferring” the studied amino acids (methionine, glycine) and all water-soluble vitamins using a laser beam through the skin in the breast area of broiler chickens. The research has been carried out in Belgrankorm-Veliky Novgorod LLC in the Krestetsky district in the Novgorod region with a large-cage housing method of broiler chickens of the cross Hubbard. The duration of broilers rearing was 39 days, 4 recipes of compound feed based on wheat grain, corn, soybeen meal with the inclusion of fish flour, sunflower oil, corn gluten, sunflower meal, meat and bone meal and mineral additives (monocalcium phosphate, lime flour) have been used. For better assimilation of nutrients and biologically active substances by the body amino acids (methionine, glycine) and water-soluble vitamins Undevit, both individually and in combination with them in a ratio of 1:1 (by weight), in the form of powders passed through an infra-red laser beam in a spatial modulator, which were attached to two emitters (simultaneously) of the “Uzor-2K-Super” laser in the chest area have been used. Broilers of the experimental groups ate feed more often and faster than the herdmates of the control group. Air ozonation in the poultry house and broilers has been carried out in a mobile way using the Rios ozonator of the Decont series (mode 3, with a capacity of 20 g/m3 ). Innovative methods of influencing on the body caused the increase in the intensity of metabolic processes, growth and development, fattening and meat traits, and feed conversion in broilers.

EFFECT OF SORPTION-DETOXIFYING COMPLEXES ON THE ACCUMULATION OF CADMIUM AND LEAD IN ORGANS AND TISSUES OF WHITE RATS

2021 ◽  
Vol 1 (4) ◽  
pp. 514-520
Author(s):  
Lyubov L. Zakharova ◽  
◽  
Natalia A. Brichko ◽  
Georgy А. Zhorov ◽  
Viktor N. Obryvin ◽  
...  
Keyword(s):  
Ecological Factors ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Farm Animals ◽  
Pharmacological Agents ◽  
Animal Products ◽  
White Rats ◽  
Cadmium And Lead ◽  
Active Substances

The environmental consequences of technogenic pressure pose a real threat to the health of the population and animals. The main danger to humans is the presence of pollutants of radiation and chemical nature in food. The production of animal products that meet the regulatory requirements, and the ensure of veterinary and sanitary welfare in regions with increased anthropogenic load is impossible without the use of effective methods of reduce the intake and accumulation of pollutants in the organism of animals. Therefore, in areas with a difficult environmental situation, when performing general detoxification, it is necessary to use a wider range of pharmacological agents, including antioxidants, immunomodulators, vitamin and mineral supplements and other biologically active substances that compensate for the negative effects that develop in the body as a result of exposure to harmful ecological factors, contribute to the restoration of health, increase the productivity of farm animals and product quality. In this regard, the combined use of anti-toxic and biologically active substances in the composition of sorption-detoxifying complexes is rational. As a result of testing the effectiveness of seven samples of sorption-detoxifying complex compositions in terms of their effect on the accumulation of Cd and Pb in the body of white rats, it was found that studied formulations reduce their intake to organs and tissues by 1.2-2.9 times, depending on the composition of the detoxifier, both separately and with the presence of heavy metals when combined with radioactive substances in the feed.

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