scholarly journals Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1592 ◽  
Author(s):  
Hsieh-Chih Tsai ◽  
Hsiao-Ying Chou ◽  
Shun-Hao Chuang ◽  
Juin-Yih Lai ◽  
Yi-Shu Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Death Rate ◽  
Morphological Changes ◽  
Local Treatment ◽  
Acidic Environment ◽  
Breast Cancer Therapy ◽  
Tumor Tissues ◽  
Liposome System ◽  
Extracellular Environment

To reduce the side effects of immune drugs and the sustainable release of immune drugs on local parts, we have designed an injectable thermal-sensitive hydrogel containing an imiquimod-loaded liposome system. In the extracellular environment of tumor tissues (pH 6.4), 50% of the drug was released from the carrier, which could be a result of the morphological changes of the liposomal microstructure in the acidic environment. According to the results in animals, the drug-containing liposomes combined with hydrogel can be effectively applied in breast cancer therapy to delay the growth of tumors as well as to dramatically reduce the death rate of mice.

scholarly journals Drug switch because of treatment-related adverse side effects in endocrine adjuvant breast cancer therapy: how often and how often does it work?

2011 ◽  
Vol 129 (3) ◽  
pp. 799-807 ◽  
Author(s):  
Uwe Güth ◽  
Mary Elizabeth Myrick ◽  
Andreas Schötzau ◽  
Nerbil Kilic ◽  
Seraina Margaretha Schmid
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Therapy ◽  
Breast Cancer Therapy ◽  
Adverse Side Effects ◽  
Adjuvant Breast Cancer

scholarly journals Targeting Engineered Nanoparticles for Breast Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1829
Author(s):  
Kumar Ganesan ◽  
Yan Wang ◽  
Fei Gao ◽  
Qingqing Liu ◽  
Chen Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Exploratory Study ◽  
Engineered Nanoparticles ◽  
Therapeutic Effects ◽  
Breast Cancer Therapy ◽  
Normal Tissues ◽  
Therapeutic Drugs ◽  
Common Cancer ◽  
Important Approach

Breast cancer (BC) is the second most common cancer in women globally after lung cancer. Presently, the most important approach for BC treatment consists of surgery, followed by radiotherapy and chemotherapy. The latter therapeutic methods are often unsuccessful in the treatment of BC because of their various side effects and the damage incurred to healthy tissues and organs. Currently, numerous nanoparticles (NPs) have been identified and synthesized to selectively target BC cells without causing any impairments to the adjacent normal tissues or organs. Based on an exploratory study, this comprehensive review aims to provide information on engineered NPs and their payloads as promising tools in the treatment of BC. Therapeutic drugs or natural bioactive compounds generally incorporate engineered NPs of ideal sizes and shapes to enhance their solubility, circulatory half-life, and biodistribution, while reducing their side effects and immunogenicity. Furthermore, ligands such as peptides, antibodies, and nucleic acids on the surface of NPs precisely target BC cells. Studies on the synthesis of engineered NPs and their impact on BC were obtained from PubMed, Science Direct, and Google Scholar. This review provides insights on the importance of engineered NPs and their methodology for validation as a next-generation platform with preventive and therapeutic effects against BC.

Application of Carbon Nanotubes in Breast Cancer Therapy

Drug Research ◽  
2019 ◽  
Author(s):  
Mahdis Tajabadi
Keyword(s):  
Breast Cancer ◽  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Side Effects ◽  
Tumor Therapy ◽  
Single Walled Carbon Nanotubes ◽  
Low Doses ◽  
High Efficacy ◽  
Breast Cancer Therapy ◽  
Walled Carbon Nanotubes

AbstractConjugated single-walled carbon nanotubes (SWNT) have been shown to be promising in cancer-targeted accumulation and is biocompatible, easily excreted, and possesses little toxicity. The present study aims at reviewing the recent advancements in carbon nanotubes especially SWNT for improving the treatment of breast cancer. Nanotube drug delivery system is a potential high efficacy therapy with minimum side effects for future tumor therapy with low doses of drug.

An amplified platform nanostructure sensor for the analysis of epirubicin in the presence of topotecan as two important chemotherapy drugs for breast cancer therapy

2018 ◽  
Vol 42 (5) ◽  
pp. 3828-3832 ◽  
Author(s):  
Seyed A. R. Alavi-Tabari ◽  
Mohammad A. Khalilzadeh ◽  
Hassan Karimi-Maleh ◽  
Daryoush Zareyee
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Breast Cancer Therapy ◽  
Chemotherapy Drugs

Epirubicin (EB) and topotecan (TP) are two major anticancer drugs that are used in breast cancer therapy with many side effects.

Effects of cisplatin treatment on the rat neurohypophysis

1986 ◽  
Vol 44 ◽  
pp. 122-123
Author(s):  
J.M. Fadool ◽  
P.J. Boyer ◽  
S.K. Aggarwal
Keyword(s):  
Side Effects ◽  
Urine Output ◽  
Morphological Changes ◽  
Limiting Factor ◽  
Antineoplastic Drugs

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.

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