scholarly journals Polymer Clay Nano-Composites

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1445
Author(s):  
Stefano Leporatti
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Polymer Composite ◽  
State Of The Art ◽  
Environmental Water ◽  
Water Remediation ◽  
Nano Composites ◽  
Special Issue ◽  
Current State ◽  
Exciting Area

Clay–polymer composite materials is an exciting area of research and this Special Issue aims to address the current state-of-the-art of “Polymer Clay Nano-Composites” for several applications, among them antibacterial, environmental, water remediation, dental, drug delivery and others [...]

scholarly journals Multifaceted origins of sex differences in the brain

2016 ◽  
Vol 371 (1688) ◽  
pp. 20150106 ◽  
Author(s):  
Margaret M. McCarthy
Keyword(s):  
Sex Differences ◽  
State Of The Art ◽  
Human Subjects ◽  
Special Issue ◽  
Molecular Analyses ◽  
The Past ◽  
Current State ◽  
Biological Variable ◽  
Males And Females ◽  
The Brain

Studies of sex differences in the brain range from reductionistic cell and molecular analyses in animal models to functional imaging in awake human subjects, with many other levels in between. Interpretations and conclusions about the importance of particular differences often vary with differing levels of analyses and can lead to discord and dissent. In the past two decades, the range of neurobiological, psychological and psychiatric endpoints found to differ between males and females has expanded beyond reproduction into every aspect of the healthy and diseased brain, and thereby demands our attention. A greater understanding of all aspects of neural functioning will only be achieved by incorporating sex as a biological variable. The goal of this review is to highlight the current state of the art of the discipline of sex differences research with an emphasis on the brain and to contextualize the articles appearing in the accompanying special issue.

scholarly journals Paediatric Formulation: Design and Development

2020 ◽  
Vol 21 (19) ◽  
pp. 7118
Author(s):  
Antonio Lopalco ◽  
Nunzio Denora
Keyword(s):  
Drug Delivery ◽  
Patient Population ◽  
State Of The Art ◽  
Original Research ◽  
Special Issue ◽  
Formulation Development ◽  
Design And Development ◽  
Formulation Design ◽  
Age Appropriate ◽  
Paediatric Formulation

The development of medicines designed for children can be challenging since this distinct patient population requires specific needs. A formulation designed for paediatric patients must consider the following aspects: patient population variability; dose flexibility; route of administration; patient compliance; drug and excipient tolerability. The purpose of this Special Issue entitled “Paediatric Formulation: Design and Development” is to provide an update on both state-of-the-art methodology and operational challenges in the design and development of paediatric formulations. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients. This editorial, briefly, summarizes the objects of nine original research and review papers published in this Special Issue.

Special Issue on Multiaxis Control and Multitasking Machine Tools

2007 ◽  
Vol 1 (2) ◽  
pp. 77-77 ◽  
Author(s):  
Yoshimi Takeuchi ◽  
Keyword(s):  
Machine Tools ◽  
State Of The Art ◽  
Numerical Control ◽  
Plant Production ◽  
Precision Machining ◽  
Accuracy Evaluation ◽  
Special Issue ◽  
Complex Products ◽  
Current State ◽  
Control Machine

Machine tools using numerical control (NC) devices are typical mechatronics products and a powerful way to automate plant production. The introduction of multiaxis control and multitasking machine tools to workshops is growing to meet the requirements of highly efficient, precision machining of a variety of complex products and mold dies. The increase in the number of control axes and multitasking capability in one chucking process enable machine tools to manufacture complex products efficiently and accurately. Given the strong attention and interest multiaxis control and multitasking machine tools are attracting, it is about time to introduce the current state of the art of these tools and their practical and applicable technologies, especially in Japan. This special issue covers the development of 5-axis control machining centers, machine tools having multispindle heads with 5-axis control, 5-axis control CAMs, accuracy evaluation for 5-axis control machine tools, and more. We thank the authors for their interesting papers to this special issue, and are certain that both general readers and specialists will find the information they provide both interesting and informative.

scholarly journals Digital Archiving in Archaeology: The State of the Art. Introduction

2021 ◽  
Author(s):  
Julian D. Richards ◽  
Ulf Jakobsson ◽  
David Novák ◽  
Benjamin Štular ◽  
Holly Wright
Keyword(s):  
State Of The Art ◽  
The State ◽  
History Of Archaeology ◽  
Special Issue ◽  
Digital Archiving ◽  
Current State ◽  
The World ◽  
History Of

The articles in this special issue demonstrate significant differences in digital archiving capacity in different countries. In part these reflect differences in the history of archaeology in each country, its relationship to the state, whether it is centralised or decentralised, state-led or commercially driven. They also reflect some of the different attitudes to archaeology across the world, most recently explored in a survey conducted under the auspices of the NEARCH project. They reflect a snapshot in time, but our aim is to record the current state-of-the-art in each country, to inform knowledge, stimulate discussion, and to provoke change.

scholarly journals Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

2021 ◽  
Vol 22 (17) ◽  
pp. 9264
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Wlodzimierz A. Stanczyk
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
State Of The Art ◽  
Platinum Drugs ◽  
Research Groups ◽  
Current State ◽  
Delivery Platform ◽  
Silicon Based ◽  
Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

scholarly journals Special Issue: Protein Simulations – Current State of the Art

2020 ◽  
Vol 60 (7) ◽  
pp. 654-654
Author(s):  
Ran Friedman ◽  
Yaakov Levy
Keyword(s):  
State Of The Art ◽  
Special Issue ◽  
Current State

Functions and Kinds of Art Works and Other Artifacts

2019 ◽  
Vol 96 (1) ◽  
pp. 1-18
Author(s):  
Amrei Bahr ◽  
Massimiliano Carrara ◽  
Ludger Jansen
Keyword(s):  
State Of The Art ◽  
Special Importance ◽  
Special Issue ◽  
General Philosophy ◽  
Philosophical Discourse ◽  
Current State ◽  
Art Works

Currently, there is not yet a full-fledged philosophical sub-discipline devoted to artifacts. In order to establish such a general philosophical discourse on artifacts, two topics are of special importance: artifact functionality and artifact categorization. Both are central to the question of what artifacts are in general and in particular. This introduction first presents the current state of the art in the debates on functions, both in general and in the domain of artifacts in particular. It then unfolds the three debates relevant for artifact kinds, namely the ontological, epistemological and semantic debates on artifact categorization, and presents the most important theory options currently under scrutiny in these fields. It proceeds by introducing the contributions in this special issue on the functions and kinds of art works and other artifacts, and discusses possible perspectives for a general philosophy of artifacts.

Telehealth – Future Directions in Cardiovascular Care

2010 ◽  
Vol 6 (3) ◽  
pp. 30 ◽  
Author(s):  
John GF Cleland ◽  
David Barrett ◽  
◽  
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
Future Development ◽  
State Of The Art ◽  
Cardiac Care ◽  
Future Directions ◽  
Heart Failure Patients ◽  
Current State ◽  
Exciting Area ◽  
Cardiovascular Care

Over recent years, telehealth has increasingly demonstrated its value in supporting the delivery of cardiovascular healthcare. From teletriage services as a portal into healthcare through to telemonitoring of heart failure patients, technology is already increasing the ability of practitioners to provide care remotely, empower patients and improve clinical outcomes. In the future, telehealth services have the potential to have an even greater impact on the provision of cardiovascular care. Embedding telehealth services into mainstream cardiac care, the development of more sophisticated devices and the utilisation of technology in a wider range of clinical contexts will help to accelerate the adoption of telehealth throughout healthcare. This article evaluates the current state of the art in telehealth provision and explores some of the areas for future development in this fast-moving and exciting area of clinical practice.

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