scholarly journals Dual Drug Delivery of Sorafenib and Doxorubicin from PLGA and PEG-PLGA Polymeric Nanoparticles

Polymers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 895 ◽  
Author(s):  
György Babos ◽  
Emese Biró ◽  
Mónika Meiczinger ◽  
Tivadar Feczkó
Keyword(s):  
Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Single Agent ◽  
Double Emulsion ◽  
Controlled Drug Release ◽  
Chemical Characteristics ◽  
Solvent Evaporation Method ◽  
Polymeric Carrier ◽  
Sustained Drug Delivery ◽  
Dual Drug

Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a challenge for researchers. Here, we report the efficient entrapment of two clinically used single-agent drugs, doxorubicin and sorafenib, against hepatocellular carcinoma. Biocompatible and biodegradable polymeric nanoparticles provide a promising approach for controlled drug release. In this study, doxorubicin and sorafenib with completely different chemical characteristics were simultaneously entrapped by the same polymeric carrier, namely poly(d,l-lactide-co-glycolide) (PLGA) and polyethylene glycol-poly(d,l-lactide-co-glycolide) (PEG-PLGA), respectively, using the double emulsion solvent evaporation method. The typical mean diameters of the nanopharmaceuticals were 142 and 177 nm, respectively. The PLGA and PEG-PLGA polymers encapsulated doxorubicin with efficiencies of 52% and 69%, respectively, while these values for sorafenib were 55% and 88%, respectively. Sustained drug delivery under biorelevant conditions was found for doxorubicin, while sorafenib was released quickly from the PLGA-doxorubicin-sorafenib and PEG-PLGA-doxorubicin-sorafenib nanotherapeutics.

The Use of Therapeutic Nanoparticulate Systems for Treating Atopic Dermatitis

2017 ◽  
Vol 14 (1) ◽  
pp. 3-16 ◽  
Author(s):  
Yin-Ku Lin ◽  
Wei-Ling Chou ◽  
Pei-Wen Wang ◽  
Shih-Chun Yang ◽  
Jia-You Fang
Keyword(s):  
Drug Delivery ◽  
Atopic Dermatitis ◽  
Barrier Function ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Release ◽  
Systemic Complications ◽  
Abnormal Immune Response ◽  
Skin Targeting ◽  
Inflammatory Drugs ◽  
Inflammatory Skin Disorder

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder involving defects in epidermal barrier function and abnormal immune response to environmental stimuli. Standard treatment of AD involves topical application of emollients and anti-inflammatory drugs such as corticosteroids. Objective: Because of the barrier function defects in AD skin, the topical drug delivery can lead to systemic drug absorption, thereby eliciting systemic complications. Nanoparticles as the carriers used for cutaneous drug delivery provide some benefits over conventional formulations, including enhanced stability, improved epithelium permeability and bioavailability, controlled drug release, skin targeting, and minimal side effects. In recent years, the concept of using nanocarriers as vehicles for drug delivery to manage AD has attracted increasing attention. Polymeric nanoparticles, lipid nanoparticles, and liposomes are the most extensively studied nanocarriers for the treatment of AD. In this review, we highlight the recent progress on the development of nanosystems for AD treatment. Method: We systematically introduce the concepts and amelioration mechanisms of the nanomedical techniques for AD treatment. Different AD animal models for evaluating the efficacy of the therapeutic nanoparticles are described herein. Results: The discrepancy of the nanoparticle skin absorption between healthy skin and AD skin is also discussed. Conclusion: This review aimed to summarize the evidence for the therapeutic advantages of nanoparticles over the conventional AD therapy.

scholarly journals Development of size-tunable polymeric nanoparticles for drug delivery applications

2017 ◽  
Vol 1 (2) ◽  
pp. 31 ◽  
Author(s):  
Komkrich Sawasdee ◽  
Ployphailin Choksawad ◽  
Sopida Pimcharoen ◽  
Kanlaya Prapainop
Keyword(s):  
Drug Delivery ◽  
Organic Solvent ◽  
Size Distribution ◽  
Polymeric Nanoparticles ◽  
Plga Nanoparticles ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Drug Bioavailability ◽  
Evaporation Method ◽  
Drug Delivery Applications

Background:  Poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) have been widely used in drug delivery applications because of its excellent properties such as biocompatibility, biodegradability along with its abilities to deliver hydrophobic drugs, increase drug bioavailability, and improve drug absorption to targeted cells in both oral and parenteral administrations. The PLGA NPs can be synthesized using emulsion solvent evaporation method. Each parameter during synthesis play a role in formation of nanoparticles and could affect to form different NP sizes which is an important factor for successful development of drug delivery system.  Aims: The aim of this study is to prepare different sizes of PLGA NPs by investigation of four factors (molecular weight (MW) of PLGA, emulsifier concentrations, organic solvent type and power of ultrasonication) that involve in PLGA nanoparticle synthesis.Methods: PLGA nanoparticles were prepared by emulsion solvent evaporation method. Size and size distribution were analyzed by dynamic light scattering and polydispersity index (PdI).Results: The effect of four parameters: PLGA MW, emulsifier concentrations, solvent types, and amplitude of ultrasonication on PLGA NPs preparation were evaluated. Changing one parameter results in different sizes of PLGA NPs varied from 150-300 nm. PdI which is an indicator for determination of size distribution of NPs are also varied with overall value less than 0.2.Conclusion: MW of PLGA polymer, emulsifier concentration, type of organic solvent and power of ultrasonication affect the size and size distribution of PLGA NPs. 

scholarly journals Surfactant Mediated Synthesis of Polyhydroxybutyrate (PHB) Nanoparticles for Sustained Drug Delivery

2020 ◽  
Vol 2 (1) ◽  
pp. 41
Keyword(s):  
Drug Release ◽  
Functional Group ◽  
Antibacterial Effect ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Release ◽  
Sustained Drug Release ◽  
Bacterial Fermentation ◽  
Sustained Drug Delivery ◽  
Nanoprecipitation Method ◽  
Living Organisms

Polyhydroxyalkanoates are produced by bacterial fermentation that contains ester as their functional group. Polymeric substances derived from living organisms are captivating owing to the fact of their adaptability, biocompatibility, and biodegradability. The main objective of this study is to develop polymeric nanoparticles through the nanoprecipitation method using the PHA extracted from Pseudomonas aeruginosa. In this study, PHA extracted was characterized and determined as Polyhydroxybutyrate. The PHA was further used to produce nanoparticles by nanoprecipitation method using Dichloromethane as a solvent and subjected to various characterizations such as Ultraviolet-Visible spectroscopy (UV-Vis), Fourier Infra-Red spectroscopy (FTIR), Field Emission Scanning Electron microscopy (FeSEM) and further tested for sustained drug release. Nanoparticles prepared by the nanoprecipitation method had a size with invariable dissemination. Curcumin loaded PHA nanoparticles displayed a competent antibacterial effect against Bacillus subtilis. A controlled drug release was exhibited.

scholarly journals Combination Drug Delivery Approaches in Metastatic Breast Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
Jun H. Lee ◽  
Anjan Nan
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Metastatic Breast Cancer ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Single Agent ◽  
Metastatic Breast ◽  
Delivery Systems ◽  
Water Soluble ◽  
Combination Drug

Disseminated metastatic breast cancer needs aggressive treatment due to its reduced response to anticancer treatment and hence low survival and quality of life. Although in theory a combination drug therapy has advantages over single-agent therapy, no appreciable survival enhancement is generally reported whereas increased toxicity is frequently seen in combination treatment especially in chemotherapy. Currently used combination treatments in metastatic breast cancer will be discussed with their challenges leading to the introduction of novel combination anticancer drug delivery systems that aim to overcome these challenges. Widely studied drug delivery systems such as liposomes, dendrimers, polymeric nanoparticles, and water-soluble polymers can concurrently carry multiple anticancer drugs in one platform. These carriers can provide improved target specificity achieved by passive and/or active targeting mechanisms.

scholarly journals Microfluidic assembly of multistage porous silicon–lipid vesicles for controlled drug release

Lab on a Chip ◽  
2014 ◽  
Vol 14 (6) ◽  
pp. 1083-1086 ◽  
Author(s):  
Bárbara Herranz-Blanco ◽  
Laura R. Arriaga ◽  
Ermei Mäkilä ◽  
Alexandra Correia ◽  
Neha Shrestha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Double Emulsion ◽  
Lipid Vesicles ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Lipid Vesicle ◽  
Microfluidic Assembly

Thermally hydrocarbonized porous silicon microparticles are encapsulated into the aqueous cores of double emulsion lipid vesicle drops to form advanced multistage drug delivery systems.

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