scholarly journals Oral Delivery of Curcumin Polymeric Nanoparticles Ameliorates CCl4-Induced Subacute Hepatotoxicity in Wistar Rats

Polymers ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 541 ◽  
Author(s):  
Gregory Marslin ◽  
Jose Prakash ◽  
Shanshan Qi ◽  
Gregory Franklin
Keyword(s):  
Oral Delivery ◽  
Wistar Rats ◽  
Polymeric Nanoparticles

Oral Delivery of Insulin Loaded into Polymeric Nanoparticles in Rats

2011 ◽  
Vol 1 (1) ◽  
pp. 24-31
Author(s):  
G. Tosi ◽  
A. V. Vergoni ◽  
B. Ruozi ◽  
L. Bondioli ◽  
F. Forni ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Polymeric Nanoparticles

scholarly journals An overview on Pharmacokinetics of Polymeric Nanoparticles Intended for Oral Delivery

2020 ◽  
Vol 12 (3) ◽  
pp. 187-189
Author(s):  
Srinu Naik Sapavatu ◽  
Ravikanth Chinthala ◽  
Rajendra Kumar Jadi
Keyword(s):  
Oral Delivery ◽  
Polymeric Nanoparticles

scholarly journals Ciprofloxacin loaded castor oil based emulsion: Its antimicrobial, hematotoxicity and soft tissue pathophysiological study in Wister rats

2020 ◽  
Vol 45 (5) ◽  
Author(s):  
A. Bamisaye ◽  
C. O. Eromosele ◽  
E. O. Dare ◽  
O. A. Akinloye
Keyword(s):  
Oral Delivery ◽  
Castor Oil ◽  
Wistar Rats ◽  
Blood Chemistry ◽  
Diffusion Method ◽  
Hematological Indices ◽  
Control Set ◽  
Set Up ◽  
And Control ◽  
Histological Architecture

The emergence of nanocarrier for drug delivery has been flanked with great achievements in the field of nanomedicine. It is however unsafe to assume their toxicological safety. This necessitated examining the toxico-dynamics of ciprofloxacin loaded castor oil based emulsion (COAB+Cp). The emulsions were prepared by mechano-chemical process. The effects of 10 mL per kg of body-weight (BW) of COAB+Cp was estimated in Adult Wistar rats (n=10) for 21 days vis-à-vis a control set up, treated with equal volume of distilled water. The biochemical and haematological parameters were conducted with histopathology of the heart, kidney, spleen and liver. Also, the antimicrobial study on Bacillus. Subtilis (BS) was carried out using the agar well diffusion method. No observable abnormal change in BW gain of both test and control animals. Treatment of animals with COAB+Cp did not cause any observable significant change at P > 0.05 in the blood-chemistry parameters and hematological indices. The photopathological examinations indicates that the histological architecture of vital organs (heart, liver, kidney and spleen) was not compromised in COAB+Cp treated animals. While the recorded value of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of COAB+Cp corroborated its mean zone of inhibition (ZI) values, signifying a better bioactivity of COAB+Cp compared to Cp on BS. COAB+Cp has no cardiotoxic, hematotoxic and hepatotoxic effects on Wistar rats, with increased potency of the encapsulated Cp thus appears promising as a safe vehicle for oral delivery of ciprofloxacin.

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

scholarly journals Antimicrobial Activity of Ibuprofen against Cystic Fibrosis-Associated Gram-Negative Pathogens

2018 ◽  
Vol 62 (3) ◽  
Author(s):  
Parth N. Shah ◽  
Kimberly R. Marshall-Batty ◽  
Justin A. Smolen ◽  
Jasur A. Tagaev ◽  
Qingquan Chen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Antimicrobial Activity ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Pharmacokinetic Profile ◽  
Lavage Fluid ◽  
Therapeutic Effects ◽  
Content Type ◽  
Biodistribution Studies

ABSTRACTClinical trials have demonstrated the benefits of ibuprofen therapy in cystic fibrosis (CF) patients, an effect that is currently attributed to ibuprofen's anti-inflammatory properties. Yet, a few previous reports demonstrated an antimicrobial activity of ibuprofen as well, although none investigated its direct effects on the pathogens found in the CF lung, which is the focus of this work. Determination of ibuprofen'sin vitroantimicrobial activity againstPseudomonas aeruginosaandBurkholderiaspecies strains through measurements of the endpoint number of CFU and growth kinetics showed that ibuprofen reduced the growth rate and bacterial burden of the tested strains in a dose-dependent fashion. In anin vitroPseudomonasbiofilm model, a reduction in the rate of biomass accumulation over 8 h of growth with ibuprofen treatment was observed. Next, an acutePseudomonaspneumonia model was used to test this antimicrobial activity after the oral delivery of ibuprofen. Following intranasal inoculation, ibuprofen-treated mice exhibited lower CFU counts and improved survival compared with the control animals. Preliminary biodistribution studies performed after the delivery of ibuprofen to mice by aerosol demonstrated a rapid accumulation of ibuprofen in serum and minimum retention in lung tissue and bronchoalveolar lavage fluid. Therefore, ibuprofen-encapsulated polymeric nanoparticles (Ibu-NPs) were formulated to improve the pharmacokinetic profile. Ibu-NPs formulated for aerosol delivery inhibited the growth ofP. aeruginosa in vitroand may provide a convenient dosing method. These results provide an additional explanation for the previously observed therapeutic effects of ibuprofen in CF patients and further strengthen the argument for its use by these patients.

Gastrointestinal Responsive Polymeric Nanoparticles for Oral Delivery of Insulin: Optimized Preparation, Characterization, and In Vivo Evaluation

2019 ◽  
Vol 108 (9) ◽  
pp. 2994-3002 ◽  
Author(s):  
Yan Fang ◽  
Qi Wang ◽  
Xiaojie Lin ◽  
Xuechao Jin ◽  
Dongjuan Yang ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
In Vivo Evaluation

Mucus-penetrating polymeric nanoparticles for oral delivery of curcumin to inflamed colon tissue

2019 ◽  
Vol 52 ◽  
pp. 157-164 ◽  
Author(s):  
Xin Zhou ◽  
Yao Liu ◽  
Yamei Huang ◽  
Ya Ma ◽  
Jun Lv ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Colon Tissue
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