scholarly journals Intrinsic Fluorescence of PAMAM Dendrimers—Quenching Studies

Polymers ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 540 ◽  
Author(s):  
Malgorzata Konopka ◽  
Anna Janaszewska ◽  
Barbara Klajnert-Maculewicz
Keyword(s):  
Pamam Dendrimers ◽  
Intrinsic Fluorescence

A study using quantum chemical theory methods on the intrinsic fluorescence emission and the possible emission mechanisms of PAMAM

RSC Advances ◽  
2014 ◽  
Vol 4 (102) ◽  
pp. 58788-58794 ◽  
Author(s):  
Yan Ji ◽  
Ying Qian
Keyword(s):  
Quantum Chemical ◽  
Fluorescence Emission ◽  
Pamam Dendrimers ◽  
Intrinsic Fluorescence ◽  
Structural Units ◽  
Chemical Theory

Structural units imidic acid (HO–CN) and tertiary ammonium in PAMAM dendrimers were proven to give fluorescence emission by TDDFT methods.

scholarly journals New insights into the blue intrinsic fluorescence of oxidized PAMAM dendrimers considering their use as bionanomaterials

2020 ◽  
Vol 8 (45) ◽  
pp. 10314-10326
Author(s):  
Cláudia S. Camacho ◽  
Marta Urgellés ◽  
Helena Tomás ◽  
Fernando Lahoz ◽  
João Rodrigues
Keyword(s):  
Fluorescence Intensity ◽  
Pamam Dendrimers ◽  
Intrinsic Fluorescence ◽  
Acidic Environment ◽  
Dendrimer Generation

The fluorescence intensity of oxidized PAMAM dendrimers is not only dependent on the number of HASLs in the dendrimer scaffold (i.e., on dendrimer generation), but also on the rigidification suffered by the dendrimer due to the acidic environment.

Determination of non-traditional intrinsic fluorescence (NTIF) emission sites in 1-(4-carbomethoxypyrrolidone)-PAMAM dendrimers using CNDP-based quenching studies

2018 ◽  
Vol 20 (8) ◽  
Author(s):  
Malgorzata Konopka ◽  
Anna Janaszewska ◽  
Kayla A.M. Johnson ◽  
David Hedstrand ◽  
Donald A. Tomalia ◽  
...  
Keyword(s):  
Pamam Dendrimers ◽  
Intrinsic Fluorescence

pH dependent one-/two-photon fluorescence emission properties and mechanism of the dendrimer PAMAM triphenylamine imine

RSC Advances ◽  
2015 ◽  
Vol 5 (91) ◽  
pp. 74940-74946 ◽  
Author(s):  
Yan Ji ◽  
Ying Qian
Keyword(s):  
Fluorescence Emission ◽  
Pamam Dendrimers ◽  
Intrinsic Fluorescence ◽  
Emission Properties ◽  
Two Photon ◽  
Ph Dependent ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

pH dependent fluorescence emission of PTS-G0 and ETS were compared, to better understand intrinsic fluorescence phenomena of PAMAM dendrimers.

The Effect of PAMAM Dendrimers on Mesenchymal Stem Cell Viability and Differentiation

2012 ◽  
Vol 19 (29) ◽  
pp. 4969-4975 ◽  
Author(s):  
M. Goncalves ◽  
R. Castro ◽  
J. Rodrigues ◽  
H. Tomas
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Viability ◽  
Pamam Dendrimers

Synthesis and Characterization of Ferrocenyl Carboxilic Surface-Functionalized Resorcinaren-PAMAM Dendrimers

2015 ◽  
Vol 19 (19) ◽  
pp. 1954-1960 ◽  
Author(s):  
Sandra Cortez-Maya ◽  
Elena Klimova ◽  
R. I. Puente Lee ◽  
Andres Borja-Miranda ◽  
Marcos Martinez-Garcia
Keyword(s):  
Pamam Dendrimers ◽  
Synthesis And Characterization

Targeting Breast Cancer Cells with G4 PAMAM Dendrimers and Valproic Acid Derivative Complexes

2020 ◽  
Vol 20 (15) ◽  
pp. 1857-1872
Author(s):  
Alberto M. Muñoz ◽  
Manuel J. Fragoso-Vázquez ◽  
Berenice P. Martel ◽  
Alma Chávez-Blanco ◽  
Alfonso Dueñas-González ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cell Lines ◽  
Water Solubility ◽  
Md Simulations ◽  
Pamam Dendrimer ◽  
Pamam Dendrimers ◽  
Force Microscopy ◽  
Micromolar Concentration ◽  
Atomic Force

Background: Our research group has developed some Valproic Acid (VPA) derivatives employed as anti-proliferative compounds targeting the HDAC8 enzyme. However, some of these compounds are poorly soluble in water. Objective: Employed the four generations of Polyamidoamine (G4 PAMAM) dendrimers as drug carriers of these compounds to increase their water solubility for further in vitro evaluation. Methods: VPA derivatives were subjected to Docking and Molecular Dynamics (MD) simulations to evaluate their affinity on G4 PAMAM. Then, HPLC-UV/VIS, 1H NMR, MALDI-TOF and atomic force microscopy were employed to establish the formation of the drug-G4 PAMAM complexes. Results: The docking results showed that the amide groups of VPA derivatives make polar interactions with G4 PAMAM, whereas MD simulations corroborated the stability of the complexes. HPLC UV/VIS experiments showed an increase in the drug water solubility which was found to be directly proportional to the amount of G4 PAMAM. 1H NMR showed a disappearance of the proton amine group signals, correlating with docking results. MALDI-TOF and atomic force microscopy suggested the drug-G4 PAMAM dendrimer complexes formation. Discussion: In vitro studies showed that G4 PAMAM has toxicity in the micromolar concentration in MDAMB- 231, MCF7, and 3T3-L1 cell lines. VPA CF-G4 PAMAM dendrimer complex showed anti-proliferative properties in the micromolar concentration in MCF-7 and 3T3-L1, and in the milimolar concentration in MDAMB- 231, whereas VPA MF-G4 PAMAM dendrimer complex didn’t show effects on the three cell lines employed. Conclusion: These results demonstrate that G4 PAMAM dendrimers are capableof transporting poorly watersoluble aryl-VPA derivate compounds to increase its cytotoxic activity against neoplastic cell lines.

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