scholarly journals New Hopes for Plasma-Based Cancer Treatment

Plasma ◽  
2018 ◽  
Vol 1 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Hiromasa Tanaka ◽  
Masaaki Mizuno ◽  
Kenji Ishikawa ◽  
Shinya Toyokuni ◽  
Hiroaki Kajiyama ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Plasma Treatment ◽  
Thermal Plasma ◽  
Plasma Treatments ◽  
Novel Approach ◽  
Non Thermal Plasma

Non-thermal plasma represents a novel approach in cancer treatment. Both direct and indirect plasma treatments are available, with clinical trials of direct plasma treatment in progress. Indirect treatments involve chemotherapy (i.e., plasma-activated medium) and immunotherapy. Recent studies suggest that integrated plasma treatments could be an extremely effective approach to cancer therapy.

scholarly journals Effects of a Non Thermal Plasma Treatment Alone or in Combination with Gemcitabine in a MIA PaCa2-luc Orthotopic Pancreatic Carcinoma Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52653 ◽  
Author(s):  
Laura Brullé ◽  
Marc Vandamme ◽  
Delphine Riès ◽  
Eric Martel ◽  
Eric Robert ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Pancreatic Carcinoma ◽  
Thermal Plasma ◽  
Non Thermal Plasma

Preclinical investigations revealed possibilities for Salmonella tumor treatment. Bacteria can also be coupled to nanomaterials enabling drug-loading, photocatalytic and/or magnetic properties, using the bacteria's net negative charge

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Negative Charge ◽  
Human Cancer ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Preclinical Research ◽  
Immunodeficient Mice ◽  
Virulence Attenuation

Except in human clinical trials, preclinical tests showed the potential of Salmonella bacteria for tumor therapy. There are still various challenges to tackle before salmonella bacteria may be employed to treat human cancer. Due to its pathogenic nature, attenuation is essential to minimize the host's harmful effects of bacterial infection. Loss of anticancer efficacy from bacterial virulence attenuation can be compensated by giving therapeutic payloads to microorganisms. Bacteria can also be linked to micro-or nanomaterials with diverse properties, such as drug-loaded, photocatalytic and/or magnetic-sensing nanoparticles, using the net negative charge of the bacteria. Combining bacteria-mediated cancer treatment with other medicines that have been clinically shown to be helpful but have limits may provide surprising therapeutic results. Recently, this strategy has received attention and is underway. The use of live germs for cancer treatment has not yet been approved for human clinical trials. The non-invasive oral form of administration benefits from safety, making it more suitable for clinical cancer patients.Infection of live germs through systemic means, on the other hand, involves toxicity risk. Although Salmonella bacteria can be genetically manipulated with high tumor targeting, harm to normal tissues can not be excluded when medications with nonspecific toxicity are administered. It is preferred if the action of selected drugs may be restricted to the tumor site rather than healthy tissues, thereby boosting cancer therapy safety. In recent years, many regulatory mechanisms have been developed to manage pharmaceutical distribution through live bacterial vectors. Engineered salmonella can accumulate 1000 times greater than normal tissue density in the tumor. The QS-regulated mechanism, which initiates gene expression when bacterial density exceeds a particular threshold level, also promises Salmonella bacteria for targeted medication delivery. Nanovesicle structures of Salmonella bacteria can also be used as biocompatible nanocarriers to deliver functional medicinal chemicals in cancer therapy. Surface-modified nanovesicles preferably attach to tumor cells and are swallowed by receptor-mediated endocytosis before being destroyed to release packed drugs. The xenograft methodology, which comprises the implantation of cultivated tumor cell lines into immunodeficient mice, has often been used in preclinical research revealing favorable results about the anticancer effects of genetically engineered salmonella.

The Impact Evaluation of Factors on the Adhesion of Modified Polytetrafluoroethylene Films in a Glow Discharge Non-Thermal Plasma

2020 ◽  
Vol 992 ◽  
pp. 658-662
Author(s):  
M.A. Mokeev ◽  
L.A. Urkhanova ◽  
A.N. Khagleev ◽  
Denis B. Solovev
Keyword(s):  
Glow Discharge ◽  
Plasma Treatment ◽  
Thermal Plasma ◽  
Graphical Model ◽  
Polymer Surface ◽  
Practical Method ◽  
Wetting Angle ◽  
Regression Equations ◽  
Non Thermal Plasma ◽  
The Impact

Mechanical, chemical and plasma treatment are the main kind of treatment of polytetrafluoroethylene (PTFE) films. Each method is different from each other by the adhesive force: the value of the wetting angle. Mechanical treatment allows different particles to permeate into the structure of the polymer. Chemical treatment creates new functional groups on the polymer surface, but this method is toxic and dangerous. Plasma treatment, in a glow discharge non-thermal plasma, is a more ecological and practical method. The experiment showed that the plasma treatment successfully increases the adhesion, this has been proven by infrared spectroscopy and scanning electron microscopy. According to the obtained data of the wetting angle, the regression equation was derived. A graphical model is constructed by regression equations allows you to determine the main processing factor and choose the optimal values of treatment.

scholarly journals Response of Human Glioma U87 Xenografted on Mice to Non Thermal Plasma Treatment

2011 ◽  
Vol 1 (1) ◽  
pp. 27-43 ◽  
Author(s):  
Marc Vandamme ◽  
Eric Robert ◽  
Sebastien Dozias ◽  
Julien Sobilo ◽  
Stephanie Lerondel ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Thermal Plasma ◽  
Human Glioma ◽  
Non Thermal Plasma

scholarly journals Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3638
Author(s):  
Moon Jong Kim ◽  
Yuanjian Huang ◽  
Jae-Il Park
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Wnt Signaling ◽  
Gastrointestinal Cancer ◽  
Gastrointestinal Cancers ◽  
Tissue Development ◽  
Major Focus ◽  
Therapeutic Targeting ◽  
Alternative Strategies

Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.

scholarly journals Non-thermal Plasma Treatment of Flowing Water: A Solution to Reduce Water Usage and Soil Treatment Cost without Compromising Yield

2016 ◽  
Vol 6 (3-4) ◽  
pp. 413-427 ◽  
Author(s):  
J. Brar ◽  
J. Jiang ◽  
A. Oubarri ◽  
P. Ranieri ◽  
Alexander A. Fridman ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Thermal Plasma ◽  
Treatment Cost ◽  
Soil Treatment ◽  
Flowing Water ◽  
Water Usage ◽  
Non Thermal Plasma
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