scholarly journals Improving Diagnosis of Cervical Pre-Cancer: Combination of PCA and SVM Applied on Fluorescence Lifetime Images

Photonics ◽  
2018 ◽  
Vol 5 (4) ◽  
pp. 57 ◽  
Author(s):  
Gyana Sahoo ◽  
Pankaj Singh ◽  
Kiran Pandey ◽  
Chayanika Kala ◽  
Asima Pradhan

We report a significant improvement in the diagnosis of cervical cancer through a combined application of principal component analysis (PCA) and support vector machine (SVM) on the average fluorescence decay profile of Fluorescence Lifetime Images (FLI) of epithelial hyperplasia (EH) and CIN-I cervical tissue samples, obtained ex-vivo. The fast and slow components of double exponential fitted fluorescence lifetimes were found to be higher for EH compared to the lifetimes of CIN-I samples. Application of PCA to the average time-resolved fluorescence decay profiles showed that the 2nd PC, in combination with 1st PC, enhanced the discrimination between EH and CIN-I tissues. Fluorescence lifetime and PC scores were then classified separately by using SVM support vector machine to identify the two. On applying SVM to a combination of fluorescence lifetime and PC scores, diagnostic capability improved significantly.

2021 ◽  
Author(s):  
Tim Brandes ◽  
Stefano Scarso ◽  
Christian Koch ◽  
Stephan Staudacher

Abstract A numerical experiment of intentionally reduced complexity is used to demonstrate a method to classify flight missions in terms of the operational severity experienced by the engines. In this proof of concept, the general term of severity is limited to the erosion of the core flow compressor blade and vane leading edges. A Monte Carlo simulation of varying operational conditions generates a required database of 10000 flight missions. Each flight is sampled at a rate of 1 Hz. Eleven measurable or synthesizable physical parameters are deemed to be relevant for the problem. They are reduced to seven universal non-dimensional groups which are averaged for each flight. The application of principal component analysis allows a further reduction to three principal components. They are used to run a support-vector machine model in order to classify the flights. A linear kernel function is chosen for the support-vector machine due to its low computation time compared to other functions. The robustness of the classification approach against measurement precision error is evaluated. In addition, a minimum number of flights required for training and a sensible number of severity classes are documented. Furthermore, the importance to train the algorithms on a sufficiently wide range of operations is presented.


Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 8017
Author(s):  
Nurfazrina M. Zamry ◽  
Anazida Zainal ◽  
Murad A. Rassam ◽  
Eman H. Alkhammash ◽  
Fuad A. Ghaleb ◽  
...  

Wireless Sensors Networks have been the focus of significant attention from research and development due to their applications of collecting data from various fields such as smart cities, power grids, transportation systems, medical sectors, military, and rural areas. Accurate and reliable measurements for insightful data analysis and decision-making are the ultimate goals of sensor networks for critical domains. However, the raw data collected by WSNs usually are not reliable and inaccurate due to the imperfect nature of WSNs. Identifying misbehaviours or anomalies in the network is important for providing reliable and secure functioning of the network. However, due to resource constraints, a lightweight detection scheme is a major design challenge in sensor networks. This paper aims at designing and developing a lightweight anomaly detection scheme to improve efficiency in terms of reducing the computational complexity and communication and improving memory utilization overhead while maintaining high accuracy. To achieve this aim, one-class learning and dimension reduction concepts were used in the design. The One-Class Support Vector Machine (OCSVM) with hyper-ellipsoid variance was used for anomaly detection due to its advantage in classifying unlabelled and multivariate data. Various One-Class Support Vector Machine formulations have been investigated and Centred-Ellipsoid has been adopted in this study due to its effectiveness. Centred-Ellipsoid is the most effective kernel among studies formulations. To decrease the computational complexity and improve memory utilization, the dimensions of the data were reduced using the Candid Covariance-Free Incremental Principal Component Analysis (CCIPCA) algorithm. Extensive experiments were conducted to evaluate the proposed lightweight anomaly detection scheme. Results in terms of detection accuracy, memory utilization, computational complexity, and communication overhead show that the proposed scheme is effective and efficient compared few existing schemes evaluated. The proposed anomaly detection scheme achieved the accuracy higher than 98%, with (𝑛𝑑) memory utilization and no communication overhead.


2022 ◽  
pp. 146808742110707
Author(s):  
Aran Mohammad ◽  
Reza Rezaei ◽  
Christopher Hayduk ◽  
Thaddaeus Delebinski ◽  
Saeid Shahpouri ◽  
...  

The development of internal combustion engines is affected by the exhaust gas emissions legislation and the striving to increase performance. This demands for engine-out emission models that can be used for engine optimization for real driving emission controls. The prediction capability of physically and data-driven engine-out emission models is influenced by the system inputs, which are specified by the user and can lead to an improved accuracy with increasing number of inputs. Thereby the occurrence of irrelevant inputs becomes more probable, which have a low functional relation to the emissions and can lead to overfitting. Alternatively, data-driven methods can be used to detect irrelevant and redundant inputs. In this work, thermodynamic states are modeled based on 772 stationary measured test bench data from a commercial vehicle diesel engine. Afterward, 37 measured and modeled variables are led into a data-driven dimensionality reduction. For this purpose, approaches of supervised learning, such as lasso regression and linear support vector machine, and unsupervised learning methods like principal component analysis and factor analysis are applied to select and extract the relevant features. The selected and extracted features are used for regression by the support vector machine and the feedforward neural network to model the NOx, CO, HC, and soot emissions. This enables an evaluation of the modeling accuracy as a result of the dimensionality reduction. Using the methods in this work, the 37 variables are reduced to 25, 22, 11, and 16 inputs for NOx, CO, HC, and soot emission modeling while maintaining the accuracy. The features selected using the lasso algorithm provide more accurate learning of the regression models than the extracted features through principal component analysis and factor analysis. This results in test errors RMSETe for modeling NOx, CO, HC, and soot emissions 19.22 ppm, 6.46 ppm, 1.29 ppm, and 0.06 FSN, respectively.


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